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Methods (San Diego, Calif.), ISSN 1046-2023, 01/2017, Volume 113, pp. 64 - 71
•AARS protein stability can be evaluated by differential scanning fluorimetry (DSF).•DSF can be used for determining the stability of AARS enzyme... 
Amino acid | tRNA | Differential scanning fluorimetry | Aminoacyl-tRNA synthetase | Histidyl-tRNA synthetase | SYPRO Orange | CRYSTALLIZATION | CARBONIC-ANHYDRASE | PROTEIN | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | THERMAL SHIFT ASSAYS | BOMBYX-MORI | INHIBITION | STRUCTURAL BASIS | PURIFICATION | BINDING | Histidine-tRNA Ligase - antagonists & inhibitors | Protein Unfolding | Amino Acids - chemistry | RNA, Transfer, Amino Acid-Specific - metabolism | Substrate Specificity | Fluorometry - methods | Threonine-tRNA Ligase - genetics | Phase Transition | Histidine-tRNA Ligase - genetics | Threonine-tRNA Ligase - antagonists & inhibitors | Benzopyrans - chemistry | Amino Acids - metabolism | Threonine-tRNA Ligase - chemistry | Alanine-tRNA Ligase - genetics | Enzyme Inhibitors - chemistry | Escherichia coli Proteins - antagonists & inhibitors | Alanine-tRNA Ligase - metabolism | Fluorescent Dyes - chemistry | Transfer RNA Aminoacylation | Histidine-tRNA Ligase - metabolism | Escherichia coli - enzymology | Alanine-tRNA Ligase - antagonists & inhibitors | Muramidase - chemistry | Enzyme Stability | RNA, Transfer, Amino Acid-Specific - genetics | Escherichia coli Proteins - metabolism | Muramidase - metabolism | Histidine-tRNA Ligase - chemistry | Alanine-tRNA Ligase - chemistry | Escherichia coli - genetics | Escherichia coli Proteins - genetics | Protein Binding | Escherichia coli Proteins - chemistry | Threonine-tRNA Ligase - metabolism | Ligases | Transfer RNA | Amino acids | Usage | Analysis
Journal Article
Biophysical journal, ISSN 0006-3495, 02/2016, Volume 110, Issue 3, pp. 378a - 378a
Journal Article
2020, ISBN 3030382656, 350
eBook
Journal Article
Oncogene, ISSN 1476-5594, 2012, Volume 32, Issue 14, pp. 1784 - 1793
Resistance to imatinib (IM) and other tyrosine kinase inhibitors (TKI)s is an increasing problem in leukemias caused by expression of BCR-ABL1. As chronic... 
chronic myeloid leukemia | DNA ligase IIIα | NHEJ | PARP1 | PARP inhibitors | DNA ligase I and III inhibitors | ABL MUTATIONS | BCR/ABL | STI571 | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA ligase III alpha | DRUG-RESISTANCE | CELL BIOLOGY | ONCOLOGY | IMATINIB | GENETICS & HEREDITY | LIGASE-III | CLINICAL RESISTANCE | PROMOTES | BINDING | RNA, Small Interfering - genetics | Apoptosis - drug effects | DNA Ligases - genetics | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Immunoenzyme Techniques | DNA Ligases - metabolism | Poly-ADP-Ribose Binding Proteins | DNA Breaks, Double-Stranded - drug effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Benzamides - pharmacology | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | DNA End-Joining Repair - drug effects | RNA, Messenger - genetics | Enzyme Inhibitors - pharmacology | Antineoplastic Combined Chemotherapy Protocols | Pyrimidines - pharmacology | Xenopus Proteins | Reverse Transcriptase Polymerase Chain Reaction | Imatinib Mesylate | Piperazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | Blotting, Western | Poly(ADP-ribose) Polymerases - metabolism | Poly(ADP-ribose) Polymerases - genetics | Comparative Genomic Hybridization | Fluorescent Antibody Technique | DNA Ligase ATP | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Poly (ADP-Ribose) Polymerase-1 | DNA Ligases - antagonists & inhibitors | Fusion Proteins, bcr-abl - metabolism | Drug Resistance, Neoplasm - drug effects | Care and treatment | Genetic aspects | Enzyme inhibitors | Chronic myeloid leukemia | Research | DNA repair | Kinases | Gene expression | Drug resistance | Leukemia
Journal Article