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Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4465 - 15
Dynamic communication between integrin-containing complexes (focal adhesions, FAs) and actin filaments is critical for regulating cell adhesion. Pseudokinase... 
NMR | INTEGRIN-LINKED KINASE | PINCH | COMPLEX REVEALS | MULTIDISCIPLINARY SCIENCES | ADAPTER | MATRIX ADHESION | PROTEIN COMPLEXES | ACTIN DYNAMICS | ALPHA-PARVIN | FOCAL ADHESIONS | Adaptor Proteins, Signal Transducing - chemistry | Humans | LIM Domain Proteins - metabolism | Protein Interaction Domains and Motifs - genetics | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | Microfilament Proteins - genetics | LIM Domain Proteins - chemistry | Protein-Serine-Threonine Kinases - metabolism | Microfilament Proteins - chemistry | Actin Cytoskeleton - metabolism | Membrane Proteins - genetics | Catalytic Domain - genetics | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | Stress Fibers - metabolism | Membrane Proteins - chemistry | Cell Adhesion - physiology | Focal Adhesions - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Cytoskeleton - metabolism | Protein Binding | LIM Domain Proteins - genetics | Protein-Serine-Threonine Kinases - chemistry | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Cell Movement | ILK protein | Adaptor proteins | Homology | Adaptors | Cell interactions | Adhesion | Cell spreading | Cell adhesion & migration | Fibers | Bundling | Filaments | Actin | Cell adhesion | Signal processing | Cytoskeleton | Catalysis | Cell migration | Structure-function relationships
Journal Article
FEBS Letters, ISSN 0014-5793, 12/2015, Volume 589, Issue 24PartA, pp. 3760 - 3772
Glial cell line‐derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in... 
MAOA/MAOB | orphan nuclear receptor and transcription factor | cytoplasmic SH2 domain containing protein tyrosine phosphatase | Ras | RRF | COMT | PTEN-induced putative kinase 1 | SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) | PI3K | sorting protein-related receptor with A-type repeats, a member of the mammal Vps10p domain receptor | subunits of the Ca2+-sensitive, voltage gated A-type K+ channel | SH2 domain containing transforming protein 1 | Nurr1 | proprotein convertases | protein kinase B, serine/threonine-specific protein kinase | calcium-calmodulin-dependent protein kinase II β isoform | FRS2 | phosphatase and tensin homolog | catecholamine | SHP-2 | growth factor receptor-bound protein 2, 7 and 10, adaptor proteins | fibroblast growth factor receptor substrate 2, adaptor protein | monoamine oxidases A and B | carbonyl cyanide m-chlorophenyl hydrazone | ERK | brain derived neurotrophic factor | deglycase, oxidative stress sensor and redox-sensitive chaperone and protease | VTA | tyrosines, which can be phosphorylated | Parkinson disease | cAMP | extracellular-signal-regulated kinases, classical MAPKs | CaMKIIβ | Kv4.3 and KChip3 | GRB2/7/10 | Ser/Thr | SNP | endoplasmatic reticulum | nerve growth factor | monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) | TGF-β | Akt, PKB | phospholipase γ cleaves the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) ppp3R1/ppp3CB, calcineurin subunits | PC5A, PC5B, and PC7 | EGR1 | proprotein convertase subtilisin/kexin type 6 | substantia nigra | phosphotyrosine-interaction domain | BDNF | adaptor protein of the PDZ-LIM family | γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system | Tyr | FosB/ΔFosB | IRS1/2 | LIM | dopamine transporter | enhanced green fluorescent protein | GDNF | DAT | SOS | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | retro-rubal field | transforming growth factor β is a secreted protein that controls proliferation and cellular differentiation | Mouse model | MPTP | GTPase | hypoxia-inducible factor-1alpha | GDNF family of ligands | Ret | GPI | Shank3 | NCAM | Enigma | JNK | (rearranged during transfection) canonical GDNF receptor, a receptor tyrosine kinase | PTEN | 6-OHDA | DJ-1 | (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase | SHC | NF-κB | (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain | phosphotyrosine-binding domains | insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain | Rac1 | GFRα | nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) | Dopaminergic system | catechol-O-methyltransferase | early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor | serine and threonine, which can be phosphorylated | GDNF family receptor α | PKA | protein kinase A, a family of cAMP-dependent protein kinase | MAPK | NGF | SorLA | ventral tegmental area | son of sevenless, family of guanine nucleotide exchange factors that act on Ras | GABA | HIF-1a | Ras-related C3 botulinum toxin substrate 1 (Rho family), a small GTPase, like CDC42 | GAP1/2 | PTB | (Rat sarcoma) family of small membrane-associated GTPase | cycles between an active GTP-bound and an inactive GDP-bound state | glycogen synthase kinase 3β | Src | glia cell line-derived neurotrophic factor | PACE4, PCSK6 | pleckstrin homology domain | co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex | c-Jun N-terminal kinases, members of the MAPK family of proteins | EGFP | cell division control protein 42 homolog, a plasma membrane-associated small GTPase of the Rho family | (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker | CCCP | (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases | DOK1/4/5/6 | (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA | single-nucleotide polymorphism analysis | VPS10P | Rho | MEN2B | phosphatidylinositol-4,5-bisphosphate 3-kinase | 6-hydroxy-dopamine | mitogen-activated protein kinase, can phosphorylate serine, threonine, and tyrosine, e.g. p38MAPK | Cdc42 | Drug addiction | docking proteins, have a PH and SH3 domain | GFLs | PDZ | vacuolar protein sorting 10 protein-domain receptors are type 1 transmembrane proteins | PLCγ | GTPase-activating proteins 1 and 2 | 3′,5′-cyclic adenosine monophosphate | neuronal cell adhesion molecule | TIEG | TGF-β-inducible early-response gene, a zinc finger transcription factor Vav2, adaptor protein and guanine nucleotide exchange factor for the Rho family of Ras-related GTPases | PINK1 | Raf | CoREST | Rearranged during transfection | multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor | dopaminergic | glycosylphosphatidylinositol | FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form | gsk3β | Glia cell line-derived neurotrophic factor | ENTERIC NERVOUS-SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBSTANTIA-NIGRA | CELL BIOLOGY | MICE LACKING GDNF | C-RET | BIOPHYSICS | NEUROTROPHIC FACTOR PROMOTES | MULTIPLE ENDOCRINE NEOPLASIA | SURVIVAL IN-VIVO | RECEPTOR TYROSINE KINASE | CELL-LINE | EARLY-ONSET PARKINSONISM | Glial Cell Line-Derived Neurotrophic Factor - physiology | Parkinson Disease - pathology | Animals | Proto-Oncogene Proteins c-ret - physiology | Dopamine - physiology | Mesencephalon - metabolism | Humans | Dopaminergic Neurons - physiology | Parkinson Disease - metabolism | Synaptic Transmission | Mesencephalon - pathology | Physiological aspects | Neurons | Parkinson's disease
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 39, pp. 16310 - 16320
Oxidative stress has been implicated in multiple human neurological and other disorders. Proteasomes are multi-subunit proteases critical for the removal of... 
REGULATORY PARTICLE | INTERACTION NETWORK | STRATEGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEAR-PORE COMPLEX | MOLECULAR ARCHITECTURE | AFFINITY PURIFICATION | DEGRADATION | S-PROTEASOME | MASS-SPECTROMETRY | CORE PARTICLE | Adaptor Proteins, Signal Transducing - chemistry | Affinity Labels | Transcription Factors - chemistry | Oxidative Stress | Ubiquitins - genetics | Cross-Linking Reagents - pharmacology | Humans | Protein Multimerization | Ubiquitins - chemistry | LIM Domain Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Tandem Mass Spectrometry | RNA Interference | Proteolysis | HEK293 Cells | Isotope Labeling | Protein Interaction Domains and Motifs | Ubiquitins - metabolism | LIM Domain Proteins - chemistry | ATPases Associated with Diverse Cellular Activities | Models, Molecular | Proteasome Endopeptidase Complex - chemistry | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | Protein Interaction Mapping | Proteasome Endopeptidase Complex - genetics | Transcription Factors - metabolism | Adaptor Proteins, Signal Transducing - genetics | LIM Domain Proteins - genetics | Protein Conformation | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | proteasome | Protein Synthesis and Degradation | protein purification | protein–protein interaction | oxidative stress | protein cross-linking | structural model
Journal Article
Science Signaling, ISSN 1945-0877, 09/2013, Volume 6, Issue 292, pp. ra81 - ra81
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2012, Volume 109, Issue 45, pp. 18273 - 18280
During cardiogenesis, Fibroblast Growth Factor (Fgf10) is expressed in the anterior second heart field. Together with Fibroblast growth factor 8 (Fgf8), Fgf10... 
Heart | Transgenic animals | Heart ventricles | Genes | Myocardium | Promoter regions | Transgenes | Embryos | Progenitor cells | Binding sites | Transcriptional regulation | Mouse embryo | TRANSCRIPTION FACTORS | CELLS | ARTERIAL POLE | MOUSE HEART | transcriptional regulation | MULTIDISCIPLINARY SCIENCES | OUTFLOW TRACT | mouse embryo | ENHANCER | ISL1 | DIFFERENTIATION | EXPRESSION | FGF10 | Protein Binding - genetics | LIM-Homeodomain Proteins - metabolism | Heart - embryology | Homeodomain Proteins - metabolism | Molecular Sequence Data | Chromosomes, Artificial, Bacterial - genetics | Gene Expression Regulation, Developmental | Base Pairing - genetics | Base Sequence | Myocardium - metabolism | Transcription, Genetic | Fibroblast Growth Factor 10 - genetics | Binding Sites | Fibroblast Growth Factor 10 - metabolism | Transgenes - genetics | Mice, Transgenic | Transcription Factors - genetics | T-Box Domain Proteins - genetics | Down-Regulation - genetics | Homeodomain Proteins - genetics | Regulatory Sequences, Nucleic Acid - genetics | T-Box Domain Proteins - metabolism | Transcription Factors - metabolism | Homeobox Protein Nkx-2.5 | LIM-Homeodomain Proteins - genetics | Animals | Genes, Switch - genetics | Models, Biological | Mice | Physiological aspects | Fibroblast growth factors | Genetic aspects | Research | Genetic transcription | Genetic regulation | Health aspects | Heart muscle | Regulatory Sequences, Nucleic Acid | Cellular Biology | Life Sciences | Chromosomes, Artificial, Bacterial | Genes, Switch | Down-Regulation | Base Pairing | Fibroblast Growth Factor 10 | Homeodomain Proteins | Protein Binding | LIM-Homeodomain Proteins | Transcription Factors | T-Box Domain Proteins | Biological Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 42, pp. 30172 - 30180
Background: Vesiculation of tubular recycling endosomes is essential for the recycling of receptors and lipids to the plasma membrane. Results: A novel... 
Membrane Trafficking | Membrane Biogenesis | Subcellular Organelles | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | EHD1 INTERACT | Cell Biology | Membrane Recycling | Protein Sorting | Vesicles | TRANSPORT | Liposomes | Receptor Recycling | CAVEOLAE | ASSOCIATION | Endosomes | INSIGHTS | Adaptor Proteins, Signal Transducing - chemistry | Cytoskeletal Proteins - genetics | Vesicular Transport Proteins - metabolism | Humans | LIM Domain Proteins - metabolism | Endosomes - metabolism | DNA-Binding Proteins - metabolism | Endosomes - ultrastructure | Carrier Proteins - chemistry | Cytoskeletal Proteins - metabolism | Nuclear Proteins - genetics | LIM Domain Proteins - chemistry | Endosomes - genetics | Vesicular Transport Proteins - genetics | Adenosine Triphosphatases - metabolism | Nuclear Proteins - metabolism | Vesicular Transport Proteins - chemistry | Cytoskeletal Proteins - chemistry | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Intracellular Membranes - chemistry | Carrier Proteins - genetics | Carrier Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | Endosomes - chemistry | Adenosine Triphosphatases - chemistry | LIM Domain Proteins - genetics | Adenosine Triphosphatases - genetics | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Intracellular Membranes - metabolism
Journal Article
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 2012, Volume 31, Issue 1, pp. 58 - 58
Background: This study was performed to investigate the effect of microRNA-203 (miR-203) on cell proliferation and migration in triple-negative breast cancer... 
Lim and SH3 domain protein 1 | MiR-203 | Proliferation | Migration | baculoviral IAP repeat-containing protein 5 | Triple-negative breast cancer | APOPTOSIS | Lim and SH3 domain | SURVIVIN | protein 1 | LIM | INHIBITION | GENE | ONCOLOGY | EXPRESSION | RNA, Small Interfering - genetics | Receptors, Estrogen - metabolism | Cytoskeletal Proteins - genetics | Inhibitor of Apoptosis Proteins - genetics | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | LIM Domain Proteins - biosynthesis | MicroRNAs - metabolism | LIM Domain Proteins - metabolism | RNA, Messenger - metabolism | Cell Movement - genetics | Breast Neoplasms - metabolism | Receptors, Progesterone - metabolism | Transfection | Cytoskeletal Proteins - metabolism | Female | Inhibitor of Apoptosis Proteins - metabolism | Cell Growth Processes - genetics | Cytoskeletal Proteins - biosynthesis | Inhibitor of Apoptosis Proteins - biosynthesis | Down-Regulation | RNA, Messenger - genetics | MicroRNAs - biosynthesis | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | LIM Domain Proteins - genetics | Adaptor Proteins, Signal Transducing - biosynthesis | MicroRNAs - genetics | Adaptor Proteins, Signal Transducing - metabolism | RNA, Small Interfering - administration & dosage | Cell proliferation | Medicine, Experimental | Medical research | Breast cancer | MicroRNA | Luciferase | Proteins | Cell culture | Experiments | Cell adhesion & migration | Triple-negative breast cancer, MiR-203 | baculoviral IAP repeat-containing protein 5, Lim and SH3 domain protein 1, Proliferation, Migration
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2011, Volume 286, Issue 50, pp. 42971 - 42980
Journal Article
Structure, ISSN 0969-2126, 01/2014, Volume 22, Issue 1, pp. 70 - 81
Notch refers to a highly conserved cell-to-cell signaling pathway with essential roles in embryonic development and tissue maintenance. Dysfunctional signaling... 
LIM PROTEIN | DOMAIN | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR RBP-J | TRANSCRIPTION | EBNA2 | CELL BIOLOGY | EFFECTOR | BIOPHYSICS | CSL | BINDING | INSIGHTS | Receptors, Notch - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | LIM Domain Proteins - metabolism | Thermodynamics | Escherichia coli - metabolism | Muscle Proteins - metabolism | Transcription, Genetic | Binding Sites | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Genes, Reporter | LIM Domain Proteins - chemistry | Immunoglobulin J Recombination Signal Sequence-Binding Protein - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Signal Transduction | Gene Expression Regulation | Cell Communication | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Muscle Proteins - genetics | Animals | Receptors, Notch - chemistry | Escherichia coli - genetics | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | LIM Domain Proteins - genetics | Mice | Muscle Proteins - chemistry | Mutation | Proteins | Embryonic development | Genetic transcription
Journal Article