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PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e92259
ZASP is a cytoskeletal PDZ-LIM protein predominantly expressed in striated muscle. It forms multiprotein complexes and plays a pivotal role in the structural... 
SKELETAL-MUSCLE | SEVERE FORM | SARCOMERIC Z-DISC | MYOGENIC DIFFERENTIATION | MULTIDISCIPLINARY SCIENCES | PDZ | TRANSCRIPTIONAL REPRESSION | LIM-DOMAIN | DILATED CARDIOMYOPATHY | BINDING | ALPHA-ACTININ | Adaptor Proteins, Signal Transducing - chemistry | Proto-Oncogene Proteins c-mdm2 - genetics | Fluorescence Recovery After Photobleaching | Humans | Transcriptional Activation | LIM Domain Proteins - metabolism | Promoter Regions, Genetic - genetics | Protein Isoforms - metabolism | Muscle Proteins - metabolism | Binding Sites | Proto-Oncogene Proteins c-mdm2 - metabolism | LIM Domain Proteins - chemistry | Repressor Proteins - metabolism | bcl-2-Associated X Protein - genetics | Actinin - metabolism | Cell Line | Repressor Proteins - chemistry | Signal Transduction | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | Ankyrin Repeat | Nuclear Proteins - chemistry | Protein Transport | Animals | Intracellular Space - metabolism | Protein Binding | Mice | Muscle Proteins - chemistry | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Muscle, Striated - metabolism | Tumor proteins | Gene expression | Structural integrity | Competition | Heart | Neonates | Biotechnology | Alternative splicing | Bax protein | Cardiomyopathy | p53 Protein | Homology | Lethality | Compaction | Protein turnover | Proteins | SUMO protein | Signal transduction | Rodents | Cell cycle | Cardiology | Bioinformatics | MDM2 protein | Nomenclature | Muscles | Cell division | Muscle contraction | Ablation | Skeletal muscle | Mutants | Musculoskeletal system | Signaling | Dilated cardiomyopathy | Insects | LIM protein | Isoforms | Cytoskeleton | Genetic engineering | Ventricle | Sarcomeres | Binding sites | Tumors | Myopathy
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2014, Volume 457, Issue 3, pp. 451 - 461
PKD (protein kinase D) is a serine/threonine kinase implicated in multiple cardiac roles, including the phosphorylation of the class II HDAC5 (histone... 
Histone deacetylase | Signal transduction | Four-and-a-half LIM (FHL) | Cardiac myocyte | Neurohormonal stimulation | Protein kinase | four-and-a-half LIM (FHL) | PRESSURE-OVERLOAD | HISTONE-DEACETYLASE KINASE | neurohormonal stimulation | signal transduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | FHL2 | NUCLEAR EXPORT | CARDIOMYOCYTES | histone deacetylase | cardiac myocyte | protein kinase | TROPONIN-I | HYPERTROPHIC RESPONSE | GENE-EXPRESSION | METABOLIC ENZYMES | TRANSCRIPTION FACTOR | Protein Kinase C - genetics | Heart Ventricles - cytology | Phosphorylation | Transcription Factors - chemistry | LIM-Homeodomain Proteins - metabolism | Humans | Intracellular Signaling Peptides and Proteins - metabolism | LIM-Homeodomain Proteins - antagonists & inhibitors | LIM Domain Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Isoenzymes - metabolism | Protein Kinase C - metabolism | Muscle Proteins - metabolism | Muscle Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - genetics | Peptide Fragments - genetics | LIM Domain Proteins - chemistry | Animals, Newborn | Peptide Fragments - metabolism | Myocytes, Cardiac - cytology | Endothelin-1 - metabolism | Isoenzymes - genetics | LIM-Homeodomain Proteins - chemistry | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | LIM Domain Proteins - antagonists & inhibitors | Cells, Cultured | Rats | Histone Deacetylases - metabolism | Transcription Factors - antagonists & inhibitors | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | Muscle Proteins - genetics | Transcription Factors - metabolism | LIM-Homeodomain Proteins - genetics | Peptide Fragments - chemistry | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Peptide Fragments - antagonists & inhibitors | MEF2 Transcription Factors - metabolism | Myocytes, Cardiac - metabolism | LIM Domain Proteins - genetics | Heart Ventricles - metabolism | Mice | Muscle Proteins - chemistry | Protein Processing, Post-Translational | Enzyme Activation | FHL, four-and-a-half LIM domains | PKD, protein kinase D | MEF2, myocyte enhancer factor 2 | MuRF, muscle RING finger | ARVM, adult rat ventricular myocyte | ERK, extracellular-signal-regulated kinase | caPKD, constitutively active catalytic domain of PKD | BPKDi, bipyridyl PKD inhibitor | CaMK, Ca2 | PE, phenylephrine | HDAC, histone deacetylase | calmodulin-dependent protein kinase | PKC, protein kinase C | cMyBP-C, cardiac myosin-binding protein C | IVK, in vitro kinase | TAC, transverse aortic constriction | CRM1, chromosome region maintenance 1 | pfu, plaque-forming unit | ET1, endothelin 1 | cTnI, inhibitory subunit of cardiac troponin | MOI, multiplicity of infection | NRVM, neonatal rat ventricular myocyte
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 42, pp. 30172 - 30180
Background: Vesiculation of tubular recycling endosomes is essential for the recycling of receptors and lipids to the plasma membrane. Results: A novel... 
Membrane Trafficking | Membrane Biogenesis | Subcellular Organelles | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | EHD1 INTERACT | Cell Biology | Membrane Recycling | Protein Sorting | Vesicles | TRANSPORT | Liposomes | Receptor Recycling | CAVEOLAE | ASSOCIATION | Endosomes | INSIGHTS | Adaptor Proteins, Signal Transducing - chemistry | Cytoskeletal Proteins - genetics | Vesicular Transport Proteins - metabolism | Humans | LIM Domain Proteins - metabolism | Endosomes - metabolism | DNA-Binding Proteins - metabolism | Endosomes - ultrastructure | Carrier Proteins - chemistry | Cytoskeletal Proteins - metabolism | Nuclear Proteins - genetics | LIM Domain Proteins - chemistry | Endosomes - genetics | Vesicular Transport Proteins - genetics | Adenosine Triphosphatases - metabolism | Nuclear Proteins - metabolism | Vesicular Transport Proteins - chemistry | Cytoskeletal Proteins - chemistry | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Intracellular Membranes - chemistry | Carrier Proteins - genetics | Carrier Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | Endosomes - chemistry | Adenosine Triphosphatases - chemistry | LIM Domain Proteins - genetics | Adenosine Triphosphatases - genetics | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Intracellular Membranes - metabolism
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 39, pp. 16310 - 16320
Oxidative stress has been implicated in multiple human neurological and other disorders. Proteasomes are multi-subunit proteases critical for the removal of... 
REGULATORY PARTICLE | INTERACTION NETWORK | STRATEGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEAR-PORE COMPLEX | MOLECULAR ARCHITECTURE | AFFINITY PURIFICATION | DEGRADATION | S-PROTEASOME | MASS-SPECTROMETRY | CORE PARTICLE | Adaptor Proteins, Signal Transducing - chemistry | Affinity Labels | Transcription Factors - chemistry | Oxidative Stress | Ubiquitins - genetics | Cross-Linking Reagents - pharmacology | Humans | Protein Multimerization | Ubiquitins - chemistry | LIM Domain Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Tandem Mass Spectrometry | RNA Interference | Proteolysis | HEK293 Cells | Isotope Labeling | Protein Interaction Domains and Motifs | Ubiquitins - metabolism | LIM Domain Proteins - chemistry | ATPases Associated with Diverse Cellular Activities | Models, Molecular | Proteasome Endopeptidase Complex - chemistry | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | Protein Interaction Mapping | Proteasome Endopeptidase Complex - genetics | Transcription Factors - metabolism | Adaptor Proteins, Signal Transducing - genetics | LIM Domain Proteins - genetics | Protein Conformation | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | proteasome | Protein Synthesis and Degradation | protein purification | protein–protein interaction | oxidative stress | protein cross-linking | structural model
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4465 - 15
Dynamic communication between integrin-containing complexes (focal adhesions, FAs) and actin filaments is critical for regulating cell adhesion. Pseudokinase... 
NMR | INTEGRIN-LINKED KINASE | PINCH | COMPLEX REVEALS | MULTIDISCIPLINARY SCIENCES | ADAPTER | MATRIX ADHESION | PROTEIN COMPLEXES | ACTIN DYNAMICS | ALPHA-PARVIN | FOCAL ADHESIONS | Adaptor Proteins, Signal Transducing - chemistry | Humans | LIM Domain Proteins - metabolism | Protein Interaction Domains and Motifs - genetics | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | Microfilament Proteins - genetics | LIM Domain Proteins - chemistry | Protein-Serine-Threonine Kinases - metabolism | Microfilament Proteins - chemistry | Actin Cytoskeleton - metabolism | Membrane Proteins - genetics | Catalytic Domain - genetics | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | Stress Fibers - metabolism | Membrane Proteins - chemistry | Cell Adhesion - physiology | Focal Adhesions - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Cytoskeleton - metabolism | Protein Binding | LIM Domain Proteins - genetics | Protein-Serine-Threonine Kinases - chemistry | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Cell Movement | ILK protein | Adaptor proteins | Homology | Adaptors | Cell interactions | Adhesion | Cell spreading | Cell adhesion & migration | Fibers | Bundling | Filaments | Actin | Cell adhesion | Signal processing | Cytoskeleton | Catalysis | Cell migration | Structure-function relationships
Journal Article
Science Signaling, ISSN 1945-0877, 09/2013, Volume 6, Issue 292, pp. ra81 - ra81
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 10/2013, Volume 24, Issue 20, pp. 3215 - 3226
Journal Article
Structure, ISSN 0969-2126, 01/2014, Volume 22, Issue 1, pp. 70 - 81
Notch refers to a highly conserved cell-to-cell signaling pathway with essential roles in embryonic development and tissue maintenance. Dysfunctional signaling... 
LIM PROTEIN | DOMAIN | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR RBP-J | TRANSCRIPTION | EBNA2 | CELL BIOLOGY | EFFECTOR | BIOPHYSICS | CSL | BINDING | INSIGHTS | Receptors, Notch - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | LIM Domain Proteins - metabolism | Thermodynamics | Escherichia coli - metabolism | Muscle Proteins - metabolism | Transcription, Genetic | Binding Sites | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Genes, Reporter | LIM Domain Proteins - chemistry | Immunoglobulin J Recombination Signal Sequence-Binding Protein - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Signal Transduction | Gene Expression Regulation | Cell Communication | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Muscle Proteins - genetics | Animals | Receptors, Notch - chemistry | Escherichia coli - genetics | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | LIM Domain Proteins - genetics | Mice | Muscle Proteins - chemistry | Mutation | Proteins | Embryonic development | Genetic transcription
Journal Article
Journal of Cell Science, ISSN 0021-9533, 02/2012, Volume 125, Issue 3, pp. 614 - 624
The Drosophila melanogaster MICAL protein is essential for the neuronal growth cone machinery that functions through plexin- and semaphorin-mediated axonal... 
Actin-rich protrusions | MICAL2 | Reactive oxygen species | Actin | Microfilaments | MICAL1 | CYTOSKELETON | AXON GUIDANCE | FLAVOPROTEIN MONOOXYGENASES | DROSOPHILA | SEMAPHORINS | CELL BIOLOGY | MOTOR | RHO | EXPRESSION | Adaptor Proteins, Signal Transducing - chemistry | Oxidoreductases - antagonists & inhibitors | RNA, Small Interfering - genetics | Reactive Oxygen Species - metabolism | Cytoskeletal Proteins - antagonists & inhibitors | Cytoskeletal Proteins - genetics | Humans | Actin Cytoskeleton - chemistry | DNA Primers - genetics | LIM Domain Proteins - metabolism | Oxidoreductases - chemistry | DNA-Binding Proteins - metabolism | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Base Sequence | Cytoskeletal Proteins - metabolism | Microfilament Proteins - metabolism | Protein Interaction Domains and Motifs | Microfilament Proteins - genetics | LIM Domain Proteins - chemistry | Cell Line | Microfilament Proteins - chemistry | Actin Cytoskeleton - metabolism | Oxidoreductases - metabolism | Signal Transduction | Oxidoreductases - genetics | LIM Domain Proteins - antagonists & inhibitors | Axons - metabolism | Semaphorins - metabolism | Cytoskeletal Proteins - chemistry | Cell Adhesion Molecules - metabolism | Nerve Tissue Proteins - metabolism | Animals | Microfilament Proteins - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - genetics | LIM Domain Proteins - genetics | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism
Journal Article
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 2012, Volume 31, Issue 1, pp. 58 - 58
Background: This study was performed to investigate the effect of microRNA-203 (miR-203) on cell proliferation and migration in triple-negative breast cancer... 
Lim and SH3 domain protein 1 | MiR-203 | Proliferation | Migration | baculoviral IAP repeat-containing protein 5 | Triple-negative breast cancer | APOPTOSIS | Lim and SH3 domain | SURVIVIN | protein 1 | LIM | INHIBITION | GENE | ONCOLOGY | EXPRESSION | RNA, Small Interfering - genetics | Receptors, Estrogen - metabolism | Cytoskeletal Proteins - genetics | Inhibitor of Apoptosis Proteins - genetics | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | LIM Domain Proteins - biosynthesis | MicroRNAs - metabolism | LIM Domain Proteins - metabolism | RNA, Messenger - metabolism | Cell Movement - genetics | Breast Neoplasms - metabolism | Receptors, Progesterone - metabolism | Transfection | Cytoskeletal Proteins - metabolism | Female | Inhibitor of Apoptosis Proteins - metabolism | Cell Growth Processes - genetics | Cytoskeletal Proteins - biosynthesis | Inhibitor of Apoptosis Proteins - biosynthesis | Down-Regulation | RNA, Messenger - genetics | MicroRNAs - biosynthesis | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | LIM Domain Proteins - genetics | Adaptor Proteins, Signal Transducing - biosynthesis | MicroRNAs - genetics | Adaptor Proteins, Signal Transducing - metabolism | RNA, Small Interfering - administration & dosage | Cell proliferation | Medicine, Experimental | Medical research | Breast cancer | MicroRNA | Luciferase | Proteins | Cell culture | Experiments | Cell adhesion & migration | Triple-negative breast cancer, MiR-203 | baculoviral IAP repeat-containing protein 5, Lim and SH3 domain protein 1, Proliferation, Migration
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2011, Volume 286, Issue 50, pp. 42971 - 42980
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 04/2013, Volume 425, Issue 7, pp. 1101 - 1110
Journal Article