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Nature Cell Biology, ISSN 1465-7392, 2009, Volume 11, Issue 2, pp. 162 - 171
EpCAM was found to be overexpressed on epithelial progenitors, carcinomas and cancer-initiating cells. The role of EpCAM in proliferation, and its association... 
BREAST-CANCER | TARGET | STEM-CELLS | ADHESION MOLECULE | DEPENDENT GAMMA-SECRETASE | EP-CAM | COLORECTAL-CANCER | C-MYC | CELL-PROLIFERATION | BETA-CATENIN | CELL BIOLOGY | ADAM17 Protein | NIH 3T3 Cells | Cell Adhesion Molecules - genetics | Colonic Neoplasms - genetics | Cell Proliferation | Active Transport, Cell Nucleus - physiology | Homeodomain Proteins - metabolism | Humans | Lymphoid Enhancer-Binding Factor 1 - genetics | Male | Presenilin-2 - metabolism | Cell Membrane - genetics | Colonic Neoplasms - metabolism | Epithelial Cell Adhesion Molecule | Cell Nucleus - metabolism | Cell Transformation, Neoplastic - genetics | Muscle Proteins - metabolism | Antigens, Neoplasm - metabolism | Cell Membrane - metabolism | Protein Structure, Tertiary | Antigens, Neoplasm - genetics | Transcription Factors - genetics | Cell Adhesion Molecules - metabolism | Cell Transformation, Neoplastic - metabolism | Lymphoid Enhancer-Binding Factor 1 - metabolism | beta Catenin - metabolism | Homeodomain Proteins - genetics | beta Catenin - genetics | Muscle Proteins - genetics | Transcription Factors - metabolism | ADAM Proteins - metabolism | Animals | Cell Nucleus - genetics | Mitosis - physiology | Carcinoma - genetics | LIM-Homeodomain Proteins | Signal Transduction - physiology | Mice | Carcinoma - metabolism | Tumor antigens | Physiological aspects | Genetic aspects | Research | Health aspects | Cell adhesion molecules | Membrane proteins
Journal Article
Nature Neuroscience, ISSN 1097-6256, 11/2003, Volume 6, Issue 11, pp. 1162 - 1168
The generation of neurons from stem cells involves the activity of proneural basic helix-loop-helix (bHLH) proteins, but the mechanism by which these proteins... 
VENTRAL NEURAL-TUBE | SOX2 | NERVOUS-SYSTEM | STEM-CELLS | BHLH PROTEIN | GENE-EXPRESSION | NEURONAL DIFFERENTIATION | CHICK-EMBRYO | ACHAETE-SCUTE | FATE | NEUROSCIENCES | Helix-Loop-Helix Motifs - physiology | Homeodomain Proteins - metabolism | PAX7 Transcription Factor | Phosphopyruvate Hydratase - metabolism | DNA-Binding Proteins - metabolism | Stem Cells | Tubulin - metabolism | Time Factors | Gene Expression Regulation, Developmental | Neurons - metabolism | Bromodeoxyuridine - metabolism | Membrane Glycoproteins | Spinal Cord - cytology | SOXB1 Transcription Factors | Cell Differentiation - physiology | Basic Helix-Loop-Helix Transcription Factors | DNA-Binding Proteins - physiology | HMGB Proteins | High Mobility Group Proteins - metabolism | Drosophila | Embryonic Induction | Neuropeptides - metabolism | Nuclear Proteins - metabolism | Electroporation - methods | Chick Embryo | Proto-Oncogene Proteins c-myc - metabolism | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Spinal Cord - embryology | Vertebrates | Animals | Eye Proteins - metabolism | Spinal Cord - physiology | Avian Proteins | LIM-Homeodomain Proteins | High Mobility Group Proteins - physiology | Mice | Nuclear Proteins - physiology | Neurofilament Proteins - metabolism | Physiological aspects | Research | DNA binding proteins | Neurons | Cell cycle
Journal Article
Blood, ISSN 0006-4971, 09/2007, Volume 110, Issue 6, pp. 1906 - 1915
Familial hemophagocytic lymphohistiocytosis (FHL) is typically an early onset, fatal disease characterized by a sepsislike illness with cytopenia,... 
NATURAL-KILLER-CELLS | GRANULE EXOCYTOSIS | IMMUNE-SYSTEM | MEDIATED CYTOTOXICITY | NK CELLS | DENDRITIC CELLS | FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS | CLASS-I | PERFORIN GENE-MUTATIONS | INHIBITORY RECEPTORS | HEMATOLOGY | Lymphohistiocytosis, Hemophagocytic - pathology | Pore Forming Cytotoxic Proteins - genetics | Cell Proliferation | Membrane Glycoproteins - metabolism | Homeodomain Proteins - metabolism | Humans | Child, Preschool | Infant | Male | Intracellular Signaling Peptides and Proteins - metabolism | Muscle Proteins - metabolism | Qa-SNARE Proteins - genetics | Adult | Female | Membrane Proteins - metabolism | Lymphohistiocytosis, Hemophagocytic - genetics | Perforin | Intracellular Signaling Peptides and Proteins - genetics | Lymphocytes - metabolism | Pore Forming Cytotoxic Proteins - metabolism | Cytokines - metabolism | LIM Domain Proteins | Membrane Proteins - genetics | Gene Expression Regulation | Lymphocytes - cytology | Transcription Factors - genetics | Mutation - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Homeodomain Proteins - genetics | Membrane Glycoproteins - genetics | Muscle Proteins - genetics | Transcription Factors - metabolism | Killer Cells, Natural - cytology | Lymphocyte Subsets | Lymphohistiocytosis, Hemophagocytic - metabolism | Qa-SNARE Proteins - metabolism | LIM-Homeodomain Proteins | Killer Cells, Natural - metabolism | Immunobiology
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2009, Volume 11, Issue 6, pp. 739 - 746
Sonic hedgehog (Shh) and its main receptor, Patched (Ptc), are implicated in both neural development and tumorigenesis(1,2). Besides its classic morphogenic... 
PROTEIN | INHIBITION | GENE | MECHANISM | SONIC HEDGEHOG | NEURONAL DEATH | PRODUCT INDUCES APOPTOSIS | KAPPA-B | CASPASE ACTIVATION | CELL-DEATH | CELL BIOLOGY | RNA, Small Interfering - genetics | Caspase 9 - metabolism | Homeodomain Proteins - metabolism | Humans | Hedgehog Proteins - metabolism | Neoplasm Proteins - metabolism | CARD Signaling Adaptor Proteins - genetics | Multiprotein Complexes - metabolism | CARD Signaling Adaptor Proteins - metabolism | Hedgehog Proteins - genetics | Muscle Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | Patched Receptors | Neoplasm Proteins - genetics | Cell Line | Receptors, Cell Surface - metabolism | Transcription Factors - genetics | Chick Embryo | Homeodomain Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Muscle Proteins - genetics | Transcription Factors - metabolism | Two-Hybrid System Techniques | Animals | Adaptor Proteins, Signal Transducing - genetics | LIM-Homeodomain Proteins | Signal Transduction - physiology | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Causes of | Physiological aspects | Cell receptors | Research | Proteases | Apoptosis | Caspase 9 | Signal Transduction | Multiprotein Complexes | Receptors, Cell Surface | Cellular Biology | Hedgehog Proteins | Life Sciences | Muscle Proteins | Adaptor Proteins, Signal Transducing | Apoptosis Regulatory Proteins | Homeodomain Proteins | Neoplasm Proteins | CARD Signaling Adaptor Proteins | RNA, Small Interfering | Transcription Factors | Development Biology | physiology | genetics | metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e91997
Introduction: Brown adipose tissue (BAT) is a potential therapeutic target to reverse obesity. The purpose of this study was to determine whether primary... 
THERMOGENESIS | ACTIVATION | MESSENGER-RNA | COLD-EXPOSURE | METABOLISM | MULTIDISCIPLINARY SCIENCES | INCREASES | ADULT HUMANS | ADIPOGENESIS | EXPRESSION | BROWN FAT | Adipocytes, Brown - metabolism | LIM-Homeodomain Proteins - metabolism | Homeodomain Proteins - metabolism | Humans | Ion Channels - genetics | Male | Mitochondrial Proteins - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | Fatty Acid-Binding Proteins - metabolism | PPAR gamma - metabolism | Obesity - genetics | Case-Control Studies | Subcutaneous Fat - metabolism | Mitochondrial Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Adult | Cell Differentiation | Nuclear Proteins - genetics | PPAR gamma - genetics | Biomarkers - metabolism | Adipocytes, Brown - pathology | Gene Expression | Retinoblastoma Protein - metabolism | Nuclear Proteins - metabolism | Tumor Necrosis Factor Receptor Superfamily, Member 9 - metabolism | Transcription Factors - genetics | Fatty Acid-Binding Proteins - genetics | Subcutaneous Fat - pathology | Homeodomain Proteins - genetics | Obesity - metabolism | Obesity - pathology | Transcription Factors - metabolism | LIM-Homeodomain Proteins - genetics | Adipocytes, White - pathology | Ion Channels - metabolism | Retinoblastoma Protein - genetics | Primary Cell Culture | Uncoupling Protein 1 | Adipocytes, White - metabolism | Adipose tissues | Obesity | Gene expression | Health aspects | Genes | Heart | Adipose tissue | Laboratories | Adipocytes | Males | Tissues | Proteins | Uncoupling protein 1 | Rodents | Penicillin | Physiology | Cardiology | Adipose tissue (brown) | CD137 antigen | Markers | Preadipocytes | Cultures | Metabolism | Insulin | Lipolysis | Abdomen | Musculoskeletal system | Weight control | Thermogenesis | Cell lines | Stem cells | Diabetes | Peroxisome proliferator-activated receptors | Differentiation
Journal Article
Development, ISSN 0950-1991, 11/2003, Volume 130, Issue 21, pp. 5155 - 5167
Several eye-field transcription factors (EFTFs) are expressed in the anterior region of the vertebrate neural plate and are essential for eye formation. The... 
Noggin | Optx2 | Xenopus laevis | Eye field specification | Pax6 | Rx1 | Lhx2 | Tll | Neural patterning | Six3 | Transcription factor cocktails | Ectopic eye formation | Otx2 | Genetic network | ANTERIOR NEUROECTODERM | ECTOPIC EYES | noggin | CELL-PROLIFERATION | DEVELOPMENTAL BIOLOGY | genetic network | neural patterning | eye field specification | ectopic eye formation | RETINAL DEVELOPMENT | transcription factor cocktails | BRAIN-DEVELOPMENT | XENOPUS HOMOLOG | T-BOX GENES | SINE OCULIS GENE | DROSOPHILA | ET | HOMEOBOX GENE | Drosophila melanogaster - embryology | Xenopus Proteins - genetics | Xenopus laevis - anatomy & histology | Homeodomain Proteins - metabolism | Humans | Otx Transcription Factors | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | DNA-Binding Proteins - metabolism | Morphogenesis | Eye - embryology | In Situ Hybridization | Gene Expression Regulation, Developmental | Body Patterning | Trans-Activators - genetics | Xenopus laevis - genetics | Eye Proteins - genetics | Drosophila melanogaster - anatomy & histology | Repressor Proteins - metabolism | Carrier Proteins | Eye - metabolism | Xenopus laevis - embryology | Paired Box Transcription Factors | Repressor Proteins - genetics | PAX6 Transcription Factor | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Proteins - metabolism | Eye Proteins - metabolism | Xenopus laevis - metabolism | LIM-Homeodomain Proteins | Trans-Activators - metabolism | Xenopus Proteins - metabolism | Drosophila Proteins - genetics
Journal Article
The EMBO Journal, ISSN 0261-4189, 01/2008, Volume 27, Issue 2, pp. 350 - 360
The muscle‐specific RING finger proteins MuRF1 and MuRF2 have been proposed to regulate protein degradation and gene expression in muscle tissues. We have... 
muscle hypertrophy and atrophy | Z‐disks | ubiquitin ligases MuRF1 and MuRF2 | striated muscle | Muscle hypertrophy and atrophy | Striated muscle | Z-disks | Ubiquitin ligases MuRF1 and MuRF2 | PROTEIN | ATROPHY | TITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | UBIQUITIN-LIGASE | CELL BIOLOGY | SKELETAL-MUSCLE | HYPERTROPHY | IN-VIVO | FILAMENT | GENE-EXPRESSION | Sequestosome-1 Protein | Homeodomain Proteins - metabolism | Male | Muscle, Skeletal - metabolism | Gene Expression Profiling | Muscle, Skeletal - cytology | Ubiquitin-Protein Ligases - physiology | Tripartite Motif Proteins | Heat-Shock Proteins - genetics | Myocardium - metabolism | Muscle Proteins - metabolism | Muscle, Striated - ultrastructure | Female | Muscle Proteins - physiology | Muscle, Striated - cytology | Myocardium - ultrastructure | Carps - metabolism | Microscopy, Electron, Transmission | Muscular Diseases - metabolism | Heat-Shock Proteins - metabolism | Mice, Inbred C57BL | Muscle Cells - metabolism | Muscle, Skeletal - ultrastructure | Ubiquitin-Protein Ligases - metabolism | Muscular Diseases - pathology | Signal Transduction - genetics | Transcription Factors - genetics | Mice, Inbred Strains | Blotting, Western | Homeodomain Proteins - genetics | Mice, Knockout | Muscle Cells - cytology | Myocardium - cytology | Muscle Proteins - genetics | Transcription Factors - metabolism | Animals | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | LIM-Homeodomain Proteins | Signal Transduction - physiology | Mice | Muscular Diseases - genetics | Adaptor Proteins, Signal Transducing - metabolism | Muscle, Striated - metabolism | Ubiquitin-Protein Ligases - genetics | Microscopy, Fluorescence | Proteins | Cellular biology | Rodents | Muscular system | Molecular biology | Gene expression | Metabolism
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2009, Volume 11, Issue 8, pp. 951 - 957
Regulation of multipotent cardiac progenitor cell (CPC) expansion and subsequent differentiation into cardiomyocytes, smooth muscle or endothelial cells is a... 
MAMMALIAN HEART | MYOCARDIN | SMOOTH-MUSCLE | MULTIPOTENT | GENE NKX2-5 | EMBRYONIC STEM-CELLS | SERUM RESPONSE FACTOR | DIFFERENTIATION | BETA-CATENIN | EXPRESSION | CELL BIOLOGY | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Oligonucleotide Array Sequence Analysis | Homeodomain Proteins - metabolism | Male | Gene Expression Profiling | Stem Cells - cytology | Stem Cells - metabolism | Embryo, Mammalian - metabolism | DNA-Binding Proteins - metabolism | Flow Cytometry | In Situ Hybridization | Chromatin Immunoprecipitation | RNA Interference | Gene Expression Regulation, Developmental | Myocardium - metabolism | Muscle Proteins - metabolism | Trans-Activators - genetics | Female | Cell Differentiation | Nuclear Proteins - genetics | Cells, Cultured | Nuclear Proteins - metabolism | Receptor, Notch1 - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | beta Catenin - metabolism | Blotting, Western | Homeodomain Proteins - genetics | beta Catenin - genetics | Mice, Knockout | Myocardium - cytology | Muscle Proteins - genetics | Transcription Factors - metabolism | Animals | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | LIM-Homeodomain Proteins | Trans-Activators - metabolism | Mice | Receptor, Notch1 - genetics | Myocd | β-Catenin | Notch1 | Isl1 | cardiac progenitors
Journal Article
Neuron, ISSN 0896-6273, 2005, Volume 46, Issue 4, pp. 647 - 660
In mammals, innate reproductive and defensive behaviors are mediated by anatomically segregated connections between the amygdala and hypothalamus. This... 
SYRIAN-HAMSTER BRAIN | INHIBIT MATERNAL-BEHAVIOR | TRANSCRIPTIONAL CODES | SEX-DISCRIMINATION | POSTERIOR PARAVENTRICULAR THALAMUS | C-FOS | DIFFERENTIAL PROJECTIONS | CENTRAL-NERVOUS-SYSTEM | CEREBRAL HEMISPHERE REGULATION | NEUROSCIENCES | MOTOR-NEURON POOL | Aggression - physiology | Homeodomain Proteins - metabolism | Male | Neural Pathways - physiology | Odorants | Behavior, Animal | Sexual Behavior, Animal - physiology | Vesicular Glutamate Transport Protein 2 | Isoenzymes - metabolism | Conflict (Psychology) | Female | Membrane Transport Proteins - metabolism | In Situ Hybridization - methods | Neural Networks (Computer) | Urine | Green Fluorescent Proteins - metabolism | Nerve Tissue Proteins - physiology | Cholera Toxin - metabolism | Hypothalamus - physiology | Mice, Inbred C57BL | Stilbamidines - pharmacokinetics | Proto-Oncogene Proteins c-fos - metabolism | Amygdala - cytology | Mice, Transgenic | Nerve Tissue Proteins - genetics | Stimulation, Chemical | Homeodomain Proteins - genetics | Immunohistochemistry - methods | Nerve Tissue Proteins - metabolism | Proteins - genetics | Animals | Proteins - metabolism | Hypothalamus - cytology | Glutamate Decarboxylase - metabolism | LIM-Homeodomain Proteins | Proto-Oncogene Proteins c-fos - genetics | Mice | Transcription Factors | Homeodomain Proteins - physiology | Amygdala - physiology | Proteins | Neurons | Neurosciences | Brain | Animal reproduction | Transcription factors | Odors | Animal behavior | Rodents | Control theory | Hybridization | Gene expression | Aggressiveness
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2017, Volume 127, Issue 1, pp. 215 - 229
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 27, pp. 10921 - 10926
Progenitor cells of the first and second heart fields depend on cardiac-specific transcription factors for their differentiation. Using conditional mutagenesis... 
Heart | Transcription factors | Genes | Stem cells | Cellular immunity | Embryonic stem cells | In situ hybridization | Progenitor cells | Embryos | Cellular differentiation | Mesoderm patterning | Progenitor differentiation in culture | MesP1-cre | Canonical Wnt | Cardiogenesis | HEART FIELD | cardiogenesis | MULTIDISCIPLINARY SCIENCES | MOUSE | progenitor differentiation in culture | mesoderm patterning | BETA-CATENIN | CULTURE | NEGATIVE FEEDBACK LOOP | STEM | MESODERM | canonical Wnt | DIFFERENTIATION | PROTEINS | EMBRYOS | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Axin Protein - genetics | LIM-Homeodomain Proteins - metabolism | Receptors, Notch - metabolism | Homeodomain Proteins - metabolism | Wnt Signaling Pathway - physiology | Male | Bone Morphogenetic Protein 4 - metabolism | Axin Protein - metabolism | Flow Cytometry | Mice, Mutant Strains | Muscle Proteins - metabolism | Female | Cell Differentiation - physiology | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | GATA4 Transcription Factor - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Myocytes, Cardiac - cytology | GATA4 Transcription Factor - genetics | Transcription Factors - genetics | beta Catenin - metabolism | Homeodomain Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Muscle Proteins - genetics | Pregnancy | Transcription Factors - metabolism | Homeobox Protein Nkx-2.5 | LIM-Homeodomain Proteins - genetics | Animals | Mice | Lac Operon | Index Medicus | Biological Sciences
Journal Article