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Nature Structural and Molecular Biology, ISSN 1545-9993, 03/2017, Volume 24, Issue 3, pp. 258 - 269
Expression of rRNA affects cell growth and proliferation, but mechanisms that modulate rRNA levels are poorly understood. We conducted a genetic screen for... 
PERLMAN SYNDROME | LIN28-LET-7 PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEGRADATION PATHWAY | DISTINCT CLASS | LOW-TEMPERATURE | CELL BIOLOGY | CAENORHABDITIS-ELEGANS | BIOPHYSICS | MESSENGER-RNA | EPIGENETIC MEMORY | C-ELEGANS | SCHIZOSACCHAROMYCES-POMBE | Temperature | Caenorhabditis elegans Proteins - chemistry | RNA Replicase - metabolism | Caenorhabditis elegans Proteins - metabolism | Ribosomes - metabolism | Down-Regulation - radiation effects | RNA, Ribosomal - genetics | Cell Nucleus - metabolism | Ultraviolet Rays | RNA Interference | Cell Nucleus - radiation effects | RNA Precursors - metabolism | Amino Acid Sequence | Green Fluorescent Proteins - metabolism | Caenorhabditis elegans - metabolism | RNA, Ribosomal - metabolism | RNA Precursors - genetics | Mutation - genetics | Subcellular Fractions - metabolism | Caenorhabditis elegans - radiation effects | Down-Regulation - genetics | Sequence Homology, Amino Acid | Animals | Sequence Analysis, RNA | Ribosomes - genetics | Models, Biological | RNA, Antisense - metabolism | Subcellular Fractions - radiation effects | Uridine - metabolism | High-Throughput Nucleotide Sequencing | RNA Stability - radiation effects | RNA, Antisense - genetics | RNA, Small Interfering - metabolism | RNA | Homeostasis | Genetic research | Genetic aspects | Research | Gene expression | Properties | RNA polymerases | Ribonucleic acid--RNA | Genetics | Cell growth | Index Medicus
Journal Article
RNA, ISSN 1355-8382, 03/2017, Volume 23, Issue 3, pp. 317 - 332
Lin28a inhibits the biogenesis of let-7 miRNAs by triggering the polyuridylation and degradation of their precursors by terminal uridylyltransferases TUT4/7... 
Lin28a | Neuronal differentiation | miRNA-9 | Let-7 | HUMAN NEURONAL DIFFERENTIATION | POSTTRANSCRIPTIONAL REGULATION | let-7 | PERLMAN SYNDROME | LIN28-LET-7 PATHWAY | LET-7 MICRORNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEGRADATION PATHWAY | neuronal differentiation | MESSENGER-RNAS | CAENORHABDITIS-ELEGANS | EMBRYONIC STEM-CELLS | MICRORNA EXPRESSION | RNA-Binding Proteins - genetics | Exoribonucleases - genetics | Humans | MicroRNAs - metabolism | Neurons - cytology | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Base Sequence | RNA Precursors - metabolism | Neurons - metabolism | Neurons - drug effects | Nucleic Acid Conformation | Tretinoin - pharmacology | Green Fluorescent Proteins - metabolism | Pluripotent Stem Cells - cytology | Gene Expression Regulation | RNA Cleavage | RNA Precursors - genetics | Poly U - metabolism | DNA-Binding Proteins - genetics | RNA Nucleotidyltransferases - metabolism | Pluripotent Stem Cells - metabolism | Animals | Base Pairing | Cell Differentiation - drug effects | RNA Nucleotidyltransferases - genetics | Pluripotent Stem Cells - drug effects | Cell Line, Tumor | Protein Binding | Recombinant Fusion Proteins - genetics | Mice | MicroRNAs - genetics | HeLa Cells | Exoribonucleases - metabolism | RNA-Binding Proteins - metabolism | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2017, Volume 66, Issue 2, pp. 270 - 284.e13
During microRNA (miRNA) biogenesis, two endonucleolytic reactions convert stem-loop-structured precursors into mature miRNAs. These processing steps can be... 
TRIM71 | ZC3H10 | regulation of microRNA biogenesis | siRNA pool | LIN28 | microRNA-guided gene silencing | RNA pull-down | ZC3H7 | RNA processing | RNA binding proteins | TARGET | SEQUENCE DETERMINANTS | RECOGNITION | LIN28-LET-7 PATHWAY | URIDYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-REGULATION | SECONDARY STRUCTURE | HNRNP A1 | PRE-MICRORNA | DROSOPHILA | CELL BIOLOGY | RNA Precursors - chemistry | RNA-Binding Proteins - genetics | RNA Precursors - biosynthesis | Humans | Databases, Genetic | Structure-Activity Relationship | RNA, Messenger - biosynthesis | Transfection | MCF-7 Cells | RNA Interference | HEK293 Cells | Transcription, Genetic | Proteomics - methods | DEAD-box RNA Helicases - metabolism | Genomics - methods | Nucleic Acid Conformation | Binding Sites | A549 Cells | Ribonuclease III - metabolism | RNA Processing, Post-Transcriptional | Jurkat Cells | RNA, Messenger - genetics | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Tripartite Motif Proteins - genetics | MicroRNAs - biosynthesis | RNA Precursors - genetics | Hep G2 Cells | Sequence Analysis, RNA | CRISPR-Cas Systems | Protein Binding | High-Throughput Nucleotide Sequencing | MicroRNAs - genetics | Tripartite Motif Proteins - metabolism | HeLa Cells | Ubiquitin-Protein Ligases - genetics | MicroRNAs - chemistry | RNA-Binding Proteins - metabolism | Biosynthesis | MicroRNA | Binding proteins | Mass spectrometry | Analysis | Protein binding | Messenger RNA | Genetic engineering | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2015, Volume 59, Issue 2, pp. 203 - 216
Journal Article
Cell Reports, ISSN 2211-1247, 10/2015, Volume 13, Issue 2, pp. 260 - 266
Journal Article
Journal Article