Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, 11/2011, Volume 3, Issue 11, pp. a002642 - a002642
Sperm and egg production requires a robust stem cell system that balances self-renewal with differentiation. Self-renewal at the expense of differentiation can...
SPERMATOGENESIS | UNDIFFERENTIATED SPERMATOGONIA | JAK/STAT PATHWAY | NEUROTROPHIC FACTOR | MOUSE | LINE | SELF-RENEWAL | DROSOPHILA OVARIAN | ASYMMETRIC DIVISION | NICHE OCCUPANCY | CELL BIOLOGY | Testis - cytology | Drosophila - cytology | Male | Stem Cells - cytology | Ovary - cytology | Cell Lineage | Animals | Models, Biological | Cell Division | Female | Cell Differentiation | Germ Cells - cytology | Mammals - anatomy & histology | 018
SPERMATOGENESIS | UNDIFFERENTIATED SPERMATOGONIA | JAK/STAT PATHWAY | NEUROTROPHIC FACTOR | MOUSE | LINE | SELF-RENEWAL | DROSOPHILA OVARIAN | ASYMMETRIC DIVISION | NICHE OCCUPANCY | CELL BIOLOGY | Testis - cytology | Drosophila - cytology | Male | Stem Cells - cytology | Ovary - cytology | Cell Lineage | Animals | Models, Biological | Cell Division | Female | Cell Differentiation | Germ Cells - cytology | Mammals - anatomy & histology | 018
Journal Article
Science, ISSN 0036-8075, 3/2006, Volume 311, Issue 5769, pp. 1880 - 1885
A constellation of intrinsic and extrinsic cellular mechanisms regulates the balance of self-renewal and differentiation in all stem cells. Stem cells, their...
Epithelial cells | Crypts | Epidermal cells | Stem cells | Multipotent stem cells | Cell lines | Hair follicles | Review | Progenitor cells | Mesenchymal stem cells | Daughter cells | PROGENITOR CELLS | TRANSIENT ACTIVATION | LABEL-RETAINING CELLS | MOUSE EPIDERMIS | MULTIDISCIPLINARY SCIENCES | BONE-MARROW NICHE | IN-VIVO | HAIR FOLLICLE MORPHOGENESIS | SELF-RENEWAL | BETA-CATENIN | HEMATOPOIETIC STEM | Signal Transduction | Bone Marrow Cells - cytology | Osteoblasts - physiology | Bone Marrow Cells - physiology | Homeostasis | Stem Cells - cytology | Mesoderm - cytology | Intestinal Mucosa - cytology | Stem Cell Transplantation | Cell Lineage | Hair Follicle - cytology | Animals | Multipotent Stem Cells - cytology | Cell Division | Epidermis - physiology | Hematopoietic Stem Cells - cytology | Hematopoietic Stem Cells - physiology | Mesoderm - physiology | Stem Cells - physiology | Cell Differentiation | Dermis - cytology | Multipotent Stem Cells - physiology | Dermis - physiology | Epidermis - cytology | Research | Structure | Analysis
Epithelial cells | Crypts | Epidermal cells | Stem cells | Multipotent stem cells | Cell lines | Hair follicles | Review | Progenitor cells | Mesenchymal stem cells | Daughter cells | PROGENITOR CELLS | TRANSIENT ACTIVATION | LABEL-RETAINING CELLS | MOUSE EPIDERMIS | MULTIDISCIPLINARY SCIENCES | BONE-MARROW NICHE | IN-VIVO | HAIR FOLLICLE MORPHOGENESIS | SELF-RENEWAL | BETA-CATENIN | HEMATOPOIETIC STEM | Signal Transduction | Bone Marrow Cells - cytology | Osteoblasts - physiology | Bone Marrow Cells - physiology | Homeostasis | Stem Cells - cytology | Mesoderm - cytology | Intestinal Mucosa - cytology | Stem Cell Transplantation | Cell Lineage | Hair Follicle - cytology | Animals | Multipotent Stem Cells - cytology | Cell Division | Epidermis - physiology | Hematopoietic Stem Cells - cytology | Hematopoietic Stem Cells - physiology | Mesoderm - physiology | Stem Cells - physiology | Cell Differentiation | Dermis - cytology | Multipotent Stem Cells - physiology | Dermis - physiology | Epidermis - cytology | Research | Structure | Analysis
Journal Article
1992, Modern genetics, ISBN 9783718652051, Volume 1., ix, 147
Book
Cell, ISSN 0092-8674, 01/2017, Volume 168, Issue 3, pp. 473 - 486.e15
Interspecies blastocyst complementation enables organ-specific enrichment of xenogenic pluripotent stem cell (PSC) derivatives. Here, we establish a versatile...
organ and tissue generation | human naïve pluripotent stem cells | pluripotent stem cells | interspecies chimera | zygote genome editing | human-pig chimeric embryo | CRISPR-Cas9 | interspecies blastocyst complementation | human-cattle chimeric embryo | DEFINED FACTORS | MULTIPLE GENES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VITRO PRODUCTION | GENE-EXPRESSION | STATE | GENERATION | HUMAN SOMATIC-CELLS | HUMAN BLASTOCYSTS | NAIVE | LINES | CELL BIOLOGY | Mammals - classification | Humans | Mice, Inbred C57BL | Blastocyst | Rats | Male | Rats, Sprague-Dawley | Gene Editing | Mice, Inbred ICR | Animals | Pluripotent Stem Cells | Cattle | Embryo, Mammalian - cytology | CRISPR-Cas Systems | Mammals - embryology | Female | Mice | Chimerism | Sus scrofa | Derivatives (Financial instruments) | Developmental biology | Swine | Genomics | Stem cells | Beef cattle
organ and tissue generation | human naïve pluripotent stem cells | pluripotent stem cells | interspecies chimera | zygote genome editing | human-pig chimeric embryo | CRISPR-Cas9 | interspecies blastocyst complementation | human-cattle chimeric embryo | DEFINED FACTORS | MULTIPLE GENES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VITRO PRODUCTION | GENE-EXPRESSION | STATE | GENERATION | HUMAN SOMATIC-CELLS | HUMAN BLASTOCYSTS | NAIVE | LINES | CELL BIOLOGY | Mammals - classification | Humans | Mice, Inbred C57BL | Blastocyst | Rats | Male | Rats, Sprague-Dawley | Gene Editing | Mice, Inbred ICR | Animals | Pluripotent Stem Cells | Cattle | Embryo, Mammalian - cytology | CRISPR-Cas Systems | Mammals - embryology | Female | Mice | Chimerism | Sus scrofa | Derivatives (Financial instruments) | Developmental biology | Swine | Genomics | Stem cells | Beef cattle
Journal Article
Seminars in Cancer Biology, ISSN 1044-579X, 2012, Volume 22, Issue 3, pp. 187 - 193
Abstract Cancer stem cells (CSCs) represent a subpopulation of tumour cells endowed with self-renewal and multi-lineage differentiation capacity but also with...
Hematology, Oncology and Palliative Medicine | Tumour dormancy | Metastasis | Cancer stem cells | Cancer therapy | BONE-MARROW | PANCREATIC-CANCER | ALDEHYDE DEHYDROGENASE 1 | BETA-CATENIN | HUMAN COLORECTAL-CANCER | SMALL-MOLECULE INHIBITOR | TUMOR-INITIATING CELLS | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | COLON-CANCER | ONCOLOGY | Gene Expression | Epithelial-Mesenchymal Transition - physiology | Humans | Antineoplastic Agents - therapeutic use | Cell Transformation, Neoplastic - metabolism | Neoplasms - drug therapy | Neoplasm Metastasis - genetics | Animals | Neoplasms - genetics | Neoplastic Stem Cells - metabolism | Cell Transformation, Neoplastic - genetics | Neoplasm Metastasis - pathology | Neoplasm Metastasis - physiopathology | Mice | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | Cell Differentiation - physiology | Pyrans - therapeutic use | Care and treatment | Transplantation | Stem cells | Cancer | Tumors
Hematology, Oncology and Palliative Medicine | Tumour dormancy | Metastasis | Cancer stem cells | Cancer therapy | BONE-MARROW | PANCREATIC-CANCER | ALDEHYDE DEHYDROGENASE 1 | BETA-CATENIN | HUMAN COLORECTAL-CANCER | SMALL-MOLECULE INHIBITOR | TUMOR-INITIATING CELLS | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | COLON-CANCER | ONCOLOGY | Gene Expression | Epithelial-Mesenchymal Transition - physiology | Humans | Antineoplastic Agents - therapeutic use | Cell Transformation, Neoplastic - metabolism | Neoplasms - drug therapy | Neoplasm Metastasis - genetics | Animals | Neoplasms - genetics | Neoplastic Stem Cells - metabolism | Cell Transformation, Neoplastic - genetics | Neoplasm Metastasis - pathology | Neoplasm Metastasis - physiopathology | Mice | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | Cell Differentiation - physiology | Pyrans - therapeutic use | Care and treatment | Transplantation | Stem cells | Cancer | Tumors
Journal Article
Science, ISSN 0036-8075, 2/2000, Volume 287, Issue 5457, pp. 1433 - 1438
Neural stem cells exist not only in the developing mammalian nervous system but also in the adult nervous system of all mammalian organisms, including humans....
Brain | Adult stem cells | Reviews | Neurons | Neuroglia | Stem cells | Multipotent stem cells | Cell lines | Neural stem cells | Cellular differentiation | Tissue grafting | ADULT-MOUSE BRAIN | IN-VITRO | ADHESION MOLECULE | OLFACTORY-BULB | RAT CEREBRAL-CORTEX | MULTIDISCIPLINARY SCIENCES | FIBROBLAST GROWTH-FACTOR | CENTRAL-NERVOUS-SYSTEM | SUBVENTRICULAR ZONE | DENTATE GYRUS | HIPPOCAMPAL-NEURONS | Brain - cytology | Brain - embryology | Cell Separation | Humans | Neurons - cytology | Stem Cells - cytology | Stem Cell Transplantation | Spinal Cord - embryology | Animals | Embryo, Mammalian - cytology | Cell Division | Cell Death | Neurons - physiology | Stem Cells - physiology | Cell Differentiation | Spinal Cord - cytology | Cell Movement | Nervous system | Cellular biology | Mammals | Embryos
Brain | Adult stem cells | Reviews | Neurons | Neuroglia | Stem cells | Multipotent stem cells | Cell lines | Neural stem cells | Cellular differentiation | Tissue grafting | ADULT-MOUSE BRAIN | IN-VITRO | ADHESION MOLECULE | OLFACTORY-BULB | RAT CEREBRAL-CORTEX | MULTIDISCIPLINARY SCIENCES | FIBROBLAST GROWTH-FACTOR | CENTRAL-NERVOUS-SYSTEM | SUBVENTRICULAR ZONE | DENTATE GYRUS | HIPPOCAMPAL-NEURONS | Brain - cytology | Brain - embryology | Cell Separation | Humans | Neurons - cytology | Stem Cells - cytology | Stem Cell Transplantation | Spinal Cord - embryology | Animals | Embryo, Mammalian - cytology | Cell Division | Cell Death | Neurons - physiology | Stem Cells - physiology | Cell Differentiation | Spinal Cord - cytology | Cell Movement | Nervous system | Cellular biology | Mammals | Embryos
Journal Article
Nature, ISSN 0028-0836, 12/2016, Volume 540, Issue 7631, pp. 51 - 59
Chimaeras are both monsters of the ancient imagination and a long-established research tool. Recent advances, particularly those dealing with the...
EPIBLAST | GROUND-STATE | RAT | MULTIDISCIPLINARY SCIENCES | IN-VIVO | NAIVE PLURIPOTENCY | MOUSE | HUMAN-NONHUMAN CHIMERAS | GENERATION | LINES | NEURAL CREST CELLS | Biological Evolution | Stem Cell Research - legislation & jurisprudence | Cell Lineage | Stem Cell Research - ethics | Animals | Chimera - embryology | Species Specificity | Humans | Blastocyst - cytology | Stem Cells - cytology | Drug Evaluation, Preclinical | Genetic aspects | Transplantation | Hybridization | Methods | Muridae | Stem cells | Studies | Ethics | Biomedical research | Researchers | Fetuses | Mammals | Deoxyribonucleic acid--DNA
EPIBLAST | GROUND-STATE | RAT | MULTIDISCIPLINARY SCIENCES | IN-VIVO | NAIVE PLURIPOTENCY | MOUSE | HUMAN-NONHUMAN CHIMERAS | GENERATION | LINES | NEURAL CREST CELLS | Biological Evolution | Stem Cell Research - legislation & jurisprudence | Cell Lineage | Stem Cell Research - ethics | Animals | Chimera - embryology | Species Specificity | Humans | Blastocyst - cytology | Stem Cells - cytology | Drug Evaluation, Preclinical | Genetic aspects | Transplantation | Hybridization | Methods | Muridae | Stem cells | Studies | Ethics | Biomedical research | Researchers | Fetuses | Mammals | Deoxyribonucleic acid--DNA
Journal Article
2012, Methods in molecular biology, ISBN 1617797936, Volume 873., xi, 313
Book
Nature, ISSN 0028-0836, 2013, Volume 504, Issue 7479, pp. 282 - 286
Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like...
INACTIVATION | BLASTOCYSTS | MULTIDISCIPLINARY SCIENCES | LINES | Chromatin - metabolism | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Epigenesis, Genetic | Humans | Male | Regenerative Medicine | Promoter Regions, Genetic - genetics | Cellular Reprogramming | DNA Methylation | Chimera - embryology | Female | Germ Layers - cytology | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Reproducibility of Results | Signal Transduction | Induced Pluripotent Stem Cells - transplantation | Blastocyst - cytology | Morula - cytology | Organogenesis | Animals | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Mice | Histones - metabolism | X Chromosome Inactivation | Epigenetic inheritance | Stem cells | Blastocyst | Physiological aspects | Genetic aspects | Research | Genetic transcription | Molecular biology | Methylation | Cell culture | Cytokines | DNA methylation | Epigenetics | Kinases | Embryos
INACTIVATION | BLASTOCYSTS | MULTIDISCIPLINARY SCIENCES | LINES | Chromatin - metabolism | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Epigenesis, Genetic | Humans | Male | Regenerative Medicine | Promoter Regions, Genetic - genetics | Cellular Reprogramming | DNA Methylation | Chimera - embryology | Female | Germ Layers - cytology | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Reproducibility of Results | Signal Transduction | Induced Pluripotent Stem Cells - transplantation | Blastocyst - cytology | Morula - cytology | Organogenesis | Animals | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Mice | Histones - metabolism | X Chromosome Inactivation | Epigenetic inheritance | Stem cells | Blastocyst | Physiological aspects | Genetic aspects | Research | Genetic transcription | Molecular biology | Methylation | Cell culture | Cytokines | DNA methylation | Epigenetics | Kinases | Embryos
Journal Article
Cell, ISSN 0092-8674, 06/2013, Volume 153, Issue 6, pp. 1228 - 1238
Reprogramming somatic cells into pluripotent embryonic stem cells (ESCs) by somatic cell nuclear transfer (SCNT) has been envisioned as an approach for...
NUMBER | ACTIVATION | CLONING | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | PREIMPLANTATION DEVELOPMENT | MG132 | OOCYTES | TRICHOSTATIN-A | PRIMATES | FIBROBLASTS | CELL BIOLOGY | Gene expression | Embryonic stem cells | Chromosomes | Genomics
NUMBER | ACTIVATION | CLONING | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | PREIMPLANTATION DEVELOPMENT | MG132 | OOCYTES | TRICHOSTATIN-A | PRIMATES | FIBROBLASTS | CELL BIOLOGY | Gene expression | Embryonic stem cells | Chromosomes | Genomics
Journal Article
Nature Protocols, ISSN 1754-2189, 02/2013, Volume 8, Issue 2, pp. 223 - 253
Characterization of pluripotent stem cells is required for the registration of stem cell lines and allows for an impartial and objective comparison of the...
GENERATION | DIFFERENTIATION | EXPRESSION | LINES | BIOCHEMICAL RESEARCH METHODS | Pluripotent Stem Cells - cytology | Oligonucleotide Array Sequence Analysis | Species Specificity | DNA Fingerprinting | Humans | Cell Culture Techniques - methods | Immunohistochemistry - methods | Animals | Cell Culture Techniques - standards | Embryoid Bodies - cytology | Flow Cytometry | Protein Isoforms - metabolism | Karyotyping | Octamer Transcription Factor-3 - metabolism | Mice | Germ Layers - cytology | Immunohistochemistry | Stem cell research | Research | Immunocytochemistry | Methods | Index Medicus
GENERATION | DIFFERENTIATION | EXPRESSION | LINES | BIOCHEMICAL RESEARCH METHODS | Pluripotent Stem Cells - cytology | Oligonucleotide Array Sequence Analysis | Species Specificity | DNA Fingerprinting | Humans | Cell Culture Techniques - methods | Immunohistochemistry - methods | Animals | Cell Culture Techniques - standards | Embryoid Bodies - cytology | Flow Cytometry | Protein Isoforms - metabolism | Karyotyping | Octamer Transcription Factor-3 - metabolism | Mice | Germ Layers - cytology | Immunohistochemistry | Stem cell research | Research | Immunocytochemistry | Methods | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7570, pp. 538 - 542
Bromodomain and extra terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a newtherapeutic opportunity by directly targeting...
SELECTIVE-INHIBITION | ACCURATE | CHROMATIN | MECHANIS
SELECTIVE-INHIBITION | ACCURATE | CHROMATIN | MECHANIS