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Plant Cell, ISSN 1040-4651, 5/2015, Volume 27, Issue 5, pp. 1497 - 1511
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 05/2018, Volume 175, Issue 9, pp. 1451 - 1470
Background and Purpose Regulating P2X7 receptor‐mediated activation of NLRP3 inflammasomes could be a therapeutic strategy to treat alcoholic hepatosteatosis.... 
DANGER SIGNALS | FATTY LIVER | HEPG2 CELLS | INJURY | ETHANOL | PHARMACOLOGY & PHARMACY | MICE | SHORT-TERM SURVIVAL | NLRP3 INFLAMMASOME | HEPATIC STEATOSIS | URIC-ACID | Iridoid Glucosides - pharmacology | AMP-Activated Protein Kinases - metabolism | Inflammasomes - metabolism | Receptors, Purinergic P2X7 - drug effects | Humans | Male | Purinergic P2X Receptor Antagonists - pharmacology | Adenosine Triphosphate | Fatty Liver, Alcoholic - prevention & control | Fatty Liver, Alcoholic - metabolism | Lipopolysaccharides | Interleukin-1beta - metabolism | Lipid Peroxidation - drug effects | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Cells, Cultured | Down-Regulation - drug effects | Up-Regulation - drug effects | Ethanol - pharmacology | Macrophages - metabolism | Animals | Lipogenesis - drug effects | Triglycerides - blood | Receptors, Purinergic P2X7 - metabolism | Transaminases - blood | Mice | PPAR alpha - metabolism | Ethanol - antagonists & inhibitors | Acetyl-CoA Carboxylase - metabolism | Macrophages | Protein kinases | Liver | Animal models | Lipid peroxidation | Alcohol | Activation | Kinases | Bisphosphonates | Accumulation | LKB1 protein | Receptors | Bone marrow | Oxidation | Lipogenesis | Ethanol | AMP | Pharmacology | Inflammation | IL-1β | Clodronic acid | Feeding | Signaling | Hepatocytes | Protein kinase | Alcoholic beverages | Liposomes | ATP
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 2, pp. 523 - 540
Reactive oxygen and nitrogen species change cellular responses through diverse mechanisms that are now being defined. At low levels, they are signalling... 
Mitochondrion | Oxidative stress | Redox signalling | Neurodegeneration | Autophagy | Nitrative stress | autophagy | CHAPERONE-MEDIATED AUTOPHAGY | ANTIOXIDANT RESPONSIVE ELEMENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPOFUSCINOSES BATTEN-DISEASE | neurodegeneration | AMYOTROPHIC-LATERAL-SCLEROSIS | mitochondrion | redox signalling | MOTOR-NEURON DEGENERATION | MANGANESE SUPEROXIDE-DISMUTASE | nitrative stress | SMOOTH-MUSCLE-CELLS | PATHOGENIC DJ-1 MUTATIONS | HYPOXIA-INDUCED AUTOPHAGY | oxidative stress | COMPLEX-I DEFICIENCY | Protein Kinases - metabolism | Transcription, Genetic - drug effects | Cardiovascular Diseases - physiopathology | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Reactive Nitrogen Species - metabolism | Humans | Oxidative Stress - physiology | Hydrogen Peroxide - pharmacology | Oncogene Proteins - metabolism | Nitric Oxide - physiology | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Parkinson Disease - physiopathology | Lysosomes - physiology | Protein Deglycase DJ-1 | Animals | Signal Transduction - physiology | TOR Serine-Threonine Kinases - physiology | Neoplasms - physiopathology | AMPK, 5′-AMP-activated protein kinase | NBR1, neighbour of BRCA1 (breast cancer early-onset 1) | NGF, nerve growth factor | LC3, light chain 3 | NOX, NADPH oxidase | EM, electron microscopy | TOR, target of rapamycin | ULK, unc (unco-ordinated family member)-51-like kinase | mtDNA, mitochondrial DNA | mTOR, mammalian target of rapamycin | IKKβ, IκB kinase β | LRRK2, leucine-rich repeat kinase 2 | NAC, N-acetyl-L-cysteine | Nrf2, nuclear factor-erythroid 2-related factor 2 | PI3P, phosphatidylinositol 3-phosphate | ECH, enoyl-CoA hydratase | BNIP3L, BNIP3-like | Drp1, dynamin-related protein 1 | tfLC3, tandem fluorescently tagged LC3 | NF-κB, nuclear factor κB | BAG, Bcl-2-associated athanogene | Keap1, Kelch-like ECH-associated protein 1 | PE, phosphatidylethanolamine | 3-MA, 3-methyladenine | UCP, uncoupling protein | IκB, inhibitor of nuclear factor κB | FIP200, focal adhesion kinase family-interacting protein of 200 kDa | PI3K, phosphoinositide 3-kinase | HNE, 4-hydroxynonenal | Review | ALS, amyotrophic lateral sclerosis | ATG, AuTophaGy-related | adenovirus E18 19-kDa-interacting protein | Tzb, trastuzumab | mETC, mitochondrial electron-transport chain | Rubicon, RUN domain- and cysteine-rich domain-containing beclin-1-interacting protein | VDAC, voltage-dependent anion channel | IP3, inositol 1,4,5-trisphosphate | RFP, red fluorescent protein | ROS, reactive oxygen species | TNFα, tumour necrosis factor α | PINK1, PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced kinase 1 | GFP, green fluorescent protein | LAMP, lysosome-associated membrane protein | JNK1, c-Jun N-terminal kinase 1 | TAC, transverse aortic constriction | GABARAP, GABAA (γ-aminobutyric acid type A)-receptor-associated protein | HIF-1, hypoxia-inducible factor 1 | NOS, nitric oxide synthase | siRNA, small interfering RNA | SOD, superoxide dismutase | RLS, reactive lipid species | RNS, reactive nitrogen species | ER, endoplasmic reticulum | TIGAR, TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator | Vps34, vacuolar protein sorting 34 | BNIP, Bcl-2
Journal Article