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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 22, pp. 8882 - 8887
Journal Article
Toxicon, ISSN 0041-0101, 12/2018, Volume 156, p. S119
Journal Article
Hepatology, ISSN 0270-9139, 06/2011, Volume 53, Issue 6, pp. 1895 - 1905
Drug‐induced liver injury occurs in general after several weeks and is often unpredictable. It is characterized by a large spectrum of lesions that includes... 
MITOCHONDRIAL BETA-OXIDATION | MICROVESICULAR STEATOSIS | IN-VITRO | DRUG-INDUCED PHOSPHOLIPIDOSIS | LIPID-METABOLISM | EXPRESSION ANALYSIS | HUMAN HEPATOCYTES | CYTOCHROMES P450 | FATTY LIVER-DISEASE | HEPATOTOXICITY | GASTROENTEROLOGY & HEPATOLOGY | Fatty Acid Synthase, Type I - genetics | Fatty Liver - pathology | Humans | Fatty Liver - chemically induced | Phosphoproteins - metabolism | Amiodarone - adverse effects | Oleic Acid - pharmacology | Lipogenesis - genetics | Up-Regulation - physiology | Lipid Metabolism - genetics | Liver Neoplasms - pathology | Membrane Proteins - metabolism | Lipogenesis - physiology | Amiodarone - pharmacology | Carrier Proteins | Fatty Liver - metabolism | Membrane Proteins - genetics | Tetracycline - pharmacology | Up-Regulation - genetics | Tetracycline - adverse effects | Phosphoproteins - genetics | Down-Regulation - drug effects | Fatty Acid Synthase, Type I - metabolism | Stearoyl-CoA Desaturase - genetics | Down-Regulation - genetics | Triglycerides - metabolism | Down-Regulation - physiology | Up-Regulation - drug effects | Lipogenesis - drug effects | Carcinoma, Hepatocellular - pathology | Lipid Metabolism - drug effects | Liver Neoplasms - metabolism | Cell Line, Tumor | Stearoyl-CoA Desaturase - metabolism | Perilipin-4 | Lipid Metabolism - physiology | Perilipin-2 | Carcinoma, Hepatocellular - metabolism | Drugs | Fatty acids | Genes | Rodents | Index Medicus | Up-Regulation | Hépatology and Gastroenterology | Oleic Acid | Down-Regulation | Lipid Metabolism | Amiodarone | Triglycerides | Liver Neoplasms | Fatty Acid Synthetase Complex, Type I | Tetracycline | Membrane Proteins | Fatty Liver | Life Sciences | Human health and pathology | Stearoyl-CoA Desaturase | Phosphoproteins | Carcinoma, Hepatocellular | Lipogenesis
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, pp. e31812 - e31812
The pathogenesis of fatty liver is not understood in detail, but lipid overflow as well as de novo lipogenesis (DNL) seem to be the key points of hepatocyte... 
DE-NOVO LIPOGENESIS | INSULIN-RESISTANCE | BIOLOGY | GENE-EXPRESSION | ACID SYNTHESIS | LIPID HOMEOSTASIS | CULTURED-CELLS | HEPATIC STEATOSIS | ALPHA-FETOPROTEIN | TRANSGENIC MICE | ADIPOSE-TISSUE | Organ Specificity - drug effects | Sterol Regulatory Element Binding Protein 1 - chemistry | Transcription, Genetic - drug effects | Acetyltransferases - metabolism | Adipocytes - secretion | Liver - pathology | Liver - enzymology | Fatty Liver - pathology | Humans | Male | Adipocytes - drug effects | Lipogenesis - genetics | Liver - drug effects | Body Composition - drug effects | Intra-Abdominal Fat - drug effects | Fatty Acids - metabolism | Cytokines - blood | Fatty Liver - genetics | Protein Structure, Tertiary | Insulin - pharmacology | Adiposity - drug effects | Fatty Liver - blood | Liver - metabolism | Cytokines - secretion | Insulin Resistance | Mice, Transgenic | Intra-Abdominal Fat - metabolism | Gene Expression Regulation - drug effects | Organ Size - drug effects | Phenotype | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Lipogenesis - drug effects | Stearoyl-CoA Desaturase - metabolism | Mice | Intra-Abdominal Fat - pathology | Type 2 diabetes | Enzymes | Obesity | Liver | Genes | Albumin | Amino acids | Triglycerides | Genetic transcription | Fatty acids | Fatty liver | Analysis | Physiological aspects | Insulin resistance | Protein binding | Transcription factors | Lipid composition | Adipose tissue | Body fat | Pathogenesis | Homeostasis | Lipids | Biochemistry | Adipocytes | Medical diagnosis | Accumulation | Overflow | Sterols | Transgenic animals | Rodents | Atherosclerosis | Sterol regulatory element-binding protein | Lipid metabolism | Lipogenesis | Desaturation | Hypertension | Carbohydrates | Phenotypes | Liver diseases | Internal medicine | Nutrition | Metabolism | Gene expression | Insulin | Overexpression | Epigenetics | Growth hormones | Diabetes | Metabolic disorders | Index Medicus
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2010, Volume 54, Issue 6, pp. 1214 - 1223
Background & Aims Glucagon-like peptide-1 (GLP-1), a gut-derived peptide degraded by dipeptidyl peptidase-4 (DPP4), stimulates insulin secretion in response to... 
Gastroenterology and Hepatology | Incretins | Inflammatory cytokines | Liver | AMPK | Dipeptidylpetidase 4 | Lipogenesis | Glucagon-like peptide 1 | Gluconeogenesis | RAT-LIVER | METFORMIN | CELLS | HEPATOCYTES | INDUCED INSULIN-RESISTANCE | TISSUE GROWTH-FACTOR | GLUCOSE-METABOLISM | STEATOSIS | MICE | GASTROENTEROLOGY & HEPATOLOGY | AMP-Activated Protein Kinases - metabolism | Dipeptidyl Peptidase 4 - metabolism | Fatty Liver - pathology | Rats, Inbred F344 | Male | DNA Primers - genetics | Hepatocytes - metabolism | RNA, Messenger - metabolism | AMP-Activated Protein Kinases - deficiency | Liver - drug effects | Base Sequence | Lipids - blood | Inflammation Mediators - metabolism | Cyclic AMP - metabolism | Lipogenesis - physiology | Hepatocytes - drug effects | Fatty Liver - metabolism | Cytokines - metabolism | Glucagon-Like Peptide 1 - metabolism | Rats, Transgenic | Liver - metabolism | RNA, Messenger - genetics | Cells, Cultured | Glucagon-Like Peptide 1 - pharmacology | Rats | Dipeptidyl Peptidase 4 - genetics | Enzyme Activation - drug effects | Animals | Dipeptidyl Peptidase 4 - deficiency | Lipogenesis - drug effects | Metabolic Networks and Pathways - drug effects | AMP-Activated Protein Kinases - genetics | Fatty Liver - etiology | Phosphatases | Glucagon | Triglycerides | Glucose | Transforming growth factors | Fatty acids | Dextrose | Carnitine | Glucose metabolism | Angiotensin | Physiological aspects | Protein kinases | Protein binding | Index Medicus
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 12/2017, Volume 313, Issue 6, pp. E710 - E720
Stearoyl-CoA desaturase-1 (SCD1) is a key player in lipid metabolism. SCD1 catalyzes the synthesis of monounsaturated fatty acids (MUFA). MUFA are then... 
β-oxidation | Sterol receptor element binding protein-1 | Fatty acid protein modification | Stearoyl-CoA desaturase-1 | De novo lipogenesis | stearoyl-CoA desaturase-1 | PPAR-ALPHA | CELLS | PHYSIOLOGY | LIPID-METABOLISM | fatty acid protein modification | sterol receptor clement binding protein-1 | TRIACYLGLYCEROL SYNTHESIS | PROTEIN-KINASE | de novo lipogenesis | DIET | beta-oxidation | FATTY-ACID OXIDATION | LIVER | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | Humans | Liver - metabolism | Mice, Inbred C57BL | Male | Mice, Transgenic | Signal Transduction - genetics | Hepatocytes - metabolism | Stearoyl-CoA Desaturase - genetics | Hep G2 Cells | Oleic Acid - pharmacology | Animals | Lipogenesis - genetics | Liver - drug effects | Signal Transduction - drug effects | Sterol Regulatory Element Binding Protein 1 - genetics | Lipogenesis - drug effects | Lipid Metabolism - drug effects | Stearoyl-CoA Desaturase - metabolism | Lipid Metabolism - genetics | Mice | Hepatocytes - drug effects | Sterol Regulatory Element Binding Protein 1 - metabolism | Liver | Transgenic mice | Lipids | Stearoyl-CoA desaturase | Phospholipids | Triglycerides | Metabolism | Desaturase | Fatty acids | Cells | Proteins | Signaling | Hepatocytes | Rodents | Sterol regulatory element-binding protein | Oxidation | Lipid metabolism | Lipogenesis | Chemical synthesis | Index Medicus | sterol receptor element binding protein-1
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2017, Volume 127, Issue 11, pp. 4059 - 4074
Overconsumption of high-fat diet (HFD) and sugar-sweetened beverages are risk factors for developing obesity, insulin resistance, and fatty liver disease. Here... 
MEDICINE, RESEARCH & EXPERIMENTAL | BODY-WEIGHT | LIPID-METABOLISM | INDUCED METABOLIC SYNDROME | DE-NOVO LIPOGENESIS | FATTY LIVER-DISEASE | RESISTANCE | SUGAR-SWEETENED BEVERAGES | NONALCOHOLIC STEATOHEPATITIS | MICE | DIETARY FRUCTOSE | Up-Regulation | Liver - enzymology | Insulin - physiology | Humans | Transcriptional Activation | Transcriptome | Diet, High-Fat - adverse effects | Non-alcoholic Fatty Liver Disease - etiology | Male | Glucose Intolerance | Liver - drug effects | Fructose - pharmacology | Non-alcoholic Fatty Liver Disease - enzymology | Mice, Inbred C57BL | Insulin Resistance | Enzyme Induction | Glucose - pharmacology | Transcription Factors - genetics | Fructokinases - metabolism | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Lipogenesis - drug effects | Adolescent | Fructokinases - genetics | Obesity - enzymology | Fatty Acids - biosynthesis | RNA sequencing | Glucose metabolism | Obesity | Care and treatment | Usage | Liver diseases | Insulin resistance | Research | Diagnosis | Health aspects | Drinking water | Transcription factors | Lipids | Glucose | Metabolic syndrome | Risk factors | High fat diet | Ketohexokinase | Disease resistance | Fatty liver | Hepatology | Teenagers | Supplementation | Beverages | Lipogenesis | Sugar | Enzymes | Nucleotide sequence | Dietary supplements | Ribonucleic acid--RNA | Fatty acids | Insulin | Fructose | Steatosis | Glucose tolerance | Intolerance | Diet | Diabetes | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2016, Volume 126, Issue 11, pp. 4372 - 4386
Obese, insulin-resistant states are characterized by a paradoxical pathogenic condition in which the liver appears to be selectively insulin resistant.... 
RAT-LIVER | MEDICINE, RESEARCH & EXPERIMENTAL | METABOLIC SYNDROME | DE-NOVO LIPOGENESIS | TRANSCRIPTION FACTOR FOXO1 | FATTY LIVER-DISEASE | OB/OB MICE | ELEMENT-BINDING PROTEIN | HEPATIC STEATOSIS | ADIPOSE-TISSUE | PLASMA TRIGLYCERIDES | Glucose Intolerance - metabolism | Glucose-6-Phosphatase - genetics | Fatty Liver - pathology | Humans | Male | Glucose - biosynthesis | Glucose Intolerance - pathology | Fatty Liver - chemically induced | Glycolysis - drug effects | Glycolysis - genetics | Lipogenesis - genetics | Female | Glucose Intolerance - chemically induced | Insulin - genetics | Nuclear Proteins - genetics | Fatty Liver - genetics | Forkhead Box Protein O1 - metabolism | Glucose Intolerance - genetics | Fatty Liver - metabolism | Fructose - toxicity | Insulin Resistance | Glucose - genetics | Nuclear Proteins - metabolism | Signal Transduction - genetics | Transcription Factors - genetics | Glucose-6-Phosphatase - metabolism | Mice, Knockout | Transcription Factors - metabolism | Insulin - metabolism | Animals | Signal Transduction - drug effects | Lipogenesis - drug effects | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Forkhead Box Protein O1 - genetics | Obesity | Analysis | Insulin resistance | Genetic aspects | Genetic transcription | Research | Risk factors | Protein binding | Glucose | Metabolites | Rodents | Liver | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 2008, Volume 49, Issue 10, pp. 2079 - 2088
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, pp. e28784 - e28784
Background: Mechanisms underlying the attenuation of body weight gain and insulin resistance in response to high fat diet (HFD) by the curry compound curcumin... 
3T3-L1 ADIPOCYTES | CANCER-CELLS | DIABETES-MELLITUS | OXIDATIVE STRESS | METABOLIC SYNDROME | WNT SIGNALING PATHWAYS | INDUCED SUPPRESSION | MULTIDISCIPLINARY SCIENCES | ELEMENT-BINDING PROTEIN | BETA-CATENIN | GENE-TRANSCRIPTION | Inflammation - pathology | Liver - pathology | Humans | Male | Adipocytes - drug effects | Curcumin - administration & dosage | Adipose Tissue - metabolism | Lipogenesis - genetics | Liver - drug effects | Time Factors | Dietary Fats - pharmacology | Weight Gain - drug effects | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Insulin - pharmacology | Adiposity - drug effects | Liver - metabolism | Mice, Inbred C57BL | Adipose Tissue - pathology | Curcumin - pharmacology | Insulin Resistance | Rats | Adipocytes - pathology | Hep G2 Cells | Obesity - metabolism | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Adipocytes - metabolism | Lipogenesis - drug effects | Obesity - prevention & control | Glucose - metabolism | Inflammation - genetics | Mice | Adipose Tissue - drug effects | Dietary Supplements | Type 2 diabetes | Prevention | Liver | Body weight | Insulin resistance | Glucose | Gene expression | Reducing diets | Dextrose | Adipose tissue | Wnt protein | Inflammatory response | Adipocytes | Kinases | Macrophages | Low fat | High fat diet | Signal transduction | Rodents | Polyphenols | Attenuation | Curcumin | Lipogenesis | Nutrient deficiency | Inflammation | Insulin | Body weight gain | Signaling | Diet | Low fat diet | Infiltration | Index Medicus
Journal Article