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Biochemical Journal, ISSN 0264-6021, 04/2011, Volume 435, Issue 2, pp. 297 - 312
Assessing mitochondrial dysfunction requires definition of the dysfunction to be investigated... 
Mitochondrion | Membrane potential | Respiration | Respiratory control | Mitochondrial function | respiratory control | CEREBELLAR GRANULE NEURONS | SPARE RESPIRATORY CAPACITY | BROWN-ADIPOSE-TISSUE | mitochondrial function | ELECTROCHEMICAL POTENTIAL GRADIENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | respiration | DOWN ELASTICITY ANALYSIS | RAT-LIVER MITOCHONDRIA | mitochondrion | SKELETAL-MUSCLE MITOCHONDRIA | INS-1E INSULINOMA CELLS | membrane potential | PANCREATIC BETA-CELLS | METABOLIC CONTROL-THEORY | Mitochondrial Diseases - pathology | Protons | Clinical Laboratory Techniques | Humans | Mitochondrial Diseases - metabolism | Cells - ultrastructure | Mitochondria - metabolism | Mitochondria - pathology | Cells - pathology | Animals | Energy Metabolism | Models, Biological | Cells - metabolism | Electron Transport - physiology | Mitochondria - physiology | Mitochondrial Diseases - physiopathology | Mitochondrial Diseases - diagnosis | FCCP, carbonyl cyanide p-trifluoromethoxyphenylhydrazone | state 4o, state 4oligomycin | TPMP, triphenylmethylphosphonium | TMRM, tetramethylrhodamine methyl ester | PMPI, plasma membrane potential indicator | UQ, ubiquinone | Review | pmf, protonmotive force | state 4 | Δψm, mitochondrial membrane potential | state 3u, uncoupled state | Δψp, plasma membrane potential | TPP, tetraphenylphosphonium | ΔpH, pH gradient | RCR, respiratory control ratio (state 3 | R123, rhodamine 123
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2011, Volume 470, Issue 7334, pp. 359 - 365
Telomere dysfunction activates p53-mediated cellular growth arrest, senescence and apoptosis to drive progressive atrophy and functional decline in high-turnover tissues... 
STEM-CELLS | HOMEOSTASIS | BIOGENESIS | PGC-1-ALPHA | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | LEADS | MICE | CARCINOMA | DAMAGE | COACTIVATORS | Cell Proliferation | Reactive Oxygen Species - metabolism | Hematopoietic Stem Cells - pathology | DNA, Mitochondrial - analysis | Adenosine Triphosphate - biosynthesis | Tumor Suppressor Protein p53 - genetics | RNA - genetics | Telomerase - deficiency | Cardiomyopathies - physiopathology | Telomerase - genetics | Myocardium - metabolism | Telomere - metabolism | Gluconeogenesis | Telomere - genetics | Liver - metabolism | Tumor Suppressor Protein p53 - metabolism | Cardiomyopathies - pathology | Transcription Factors - antagonists & inhibitors | Hematopoietic Stem Cells - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Tumor Suppressor Protein p53 - deficiency | Doxorubicin - toxicity | Aging - pathology | Myocardium - cytology | Transcription Factors - metabolism | Telomere - pathology | Animals | Cardiomyopathies - metabolism | Telomere - enzymology | Liver - cytology | Mice | Aging - metabolism | Cardiomyopathies - chemically induced | Telomeres | Mitochondria | Genetic aspects | Chemical properties | Abnormalities | Liver | Cell division | Mitochondrial DNA | Biosynthesis | Biology | DNA repair | Proteins | Studies | Aging | Telomerase | Binding sites | Apoptosis
Journal Article
Experimental and Clinical Endocrinology & Diabetes, ISSN 0947-7349, 06/2009, Volume 117, Issue 6, pp. 241 - 250
.... Adipocyte and adipose tissue dysfunction belong to the primary defects in obesity and may link obesity to several health problems including increased risk of insulin resistance, type 2 diabetes... 
Review | Visceral fat | Adipocyte | Adipose tissue dysfunction | Obesity | Insulin resistance | Inflammation | Adipokines | MACROPHAGE INFILTRATION | adipose tissue dysfunction | RIBONUCLEIC-ACID EXPRESSION | WEIGHT-LOSS | EARLY-ONSET OBESITY | inflammation | GLUCOSE-METABOLISM | INSULIN-RESISTANCE | adipocyte | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | BODY-MASS INDEX | adipokines | visceral fat | insulin resistance | TYPE-2 DIABETES-MELLITUS | obesity | MECHANISMS LINKING OBESITY | Neoplasms - etiology | Fatty Liver - pathology | Atherosclerosis - genetics | Humans | Dementia - physiopathology | Dyslipidemias - pathology | Diabetes Mellitus, Type 2 - epidemiology | Incidence | Adipose Tissue - metabolism | Adipokines - genetics | Diabetes Mellitus, Type 2 - etiology | Hypertension - genetics | Dyslipidemias - etiology | Atherosclerosis - pathology | Dementia - pathology | Atherosclerosis - physiopathology | Obesity - complications | Adipose Tissue - pathology | Lipid Metabolism | Obesity - physiopathology | Adipokines - metabolism | Hypertension - pathology | Obesity - pathology | Models, Biological | Insulin Resistance - genetics | Lung Diseases - physiopathology | Diabetes Mellitus, Type 2 - pathology | Cell Hypoxia - genetics | Fatty Liver - epidemiology | Lung Diseases - epidemiology | Neoplasms - epidemiology | Fatty Liver - etiology | Dyslipidemias - genetics | Diabetes Mellitus, Type 2 - genetics | Adipose Tissue - physiopathology | Dementia - epidemiology | Dementia - genetics | Atherosclerosis - epidemiology | Obesity - genetics | Lung Diseases - etiology | Hypertension - etiology | Atherosclerosis - etiology | Neoplasms - genetics | Hypertension - epidemiology | Neoplasms - physiopathology | Fatty Liver - genetics | Fatty Liver - physiopathology | Adipocytes - pathology | Hypertension - physiopathology | Obesity - metabolism | Dementia - etiology | Lung Diseases - genetics | Diabetes Mellitus, Type 2 - physiopathology | Dyslipidemias - epidemiology | Adipocytes - metabolism | Obesity - epidemiology | Lung Diseases - pathology | Neoplasms - pathology | Dyslipidemias - physiopathology
Journal Article
Journal Article