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1. Full Text Polymer-based nanocapsules for drug delivery
by Mora-Huertas, C.E and Fessi, H and Elaissari, A
International Journal of Pharmaceutics, ISSN 0378-5173, 2010, Volume 385, Issue 1, pp. 113 - 142
A review of the state of knowledge on nanocapsules prepared from preformed polymers as active substances carriers is presented. This entails a general review... 
Characterization | Nanoencapsulation methods | Therapeutic application | Polymers | Active substance | Nanocapsules | COLLOIDAL PARTICLES | BIODEGRADABLE POLYMERSOMES | POLY(EPSILON-CAPROLACTONE) NANOCAPSULES | RELEASE PROFILES | LOADED NANOCAPSULES | POLYELECTROLYTE NANOCAPSULES | ATOMIC-FORCE MICROSCOPY | PHOTON-CORRELATION SPECTROSCOPY | PHYSICOCHEMICAL CHARACTERIZATION | PHARMACOLOGY & PHARMACY | EMULSIFICATION-DIFFUSION TECHNIQUE | Emulsions | Chemical Precipitation | Drug Stability | Humans | Solubility | Technology, Pharmaceutical - methods | Chemistry, Pharmaceutical | Drug Carriers | Particle Size | Animals | Polymers - chemistry | Nanotechnology | Hydrogen-Ion Concentration | Drugs | Drug delivery systems | Analysis | Vehicles | Life Sciences | Engineering Sciences | Chemical and Process Engineering | Pharmaceutical sciences
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2. Full Text Formulation of lipid core nanocapsules
by Venturini, Cristina G and Jäger, Eliézer and Oliveira, Catiuscia P and Bernardi, Andressa and Battastini, Ana M.O and Guterres, Silvia S and Pohlmann, Adriana R
Colloids and Surfaces A: Physicochemical and Engineering Aspects, ISSN 0927-7757, 2011, Volume 375, Issue 1, pp. 200 - 208
â–¶ A study of the quality of nanoparticulated formulations was carried out to obtain lipid-core nanocapsules (LNC). â–¶ Those new nanocarriers can present higher... 
Density gradient | Multiple light scattering | Polymeric nanoparticles | Control of assembly | Lipid-core nanocapsules | Indomethacin ethyl ester | INDOMETHACIN ETHYL-ESTER | CONCENTRATED DISPERSIONS | DELIVERY-SYSTEMS | CHEMISTRY, PHYSICAL | LOADED NANOCAPSULES | PHOTON-CORRELATION SPECTROSCOPY | POLYESTER NANOCAPSULES | PHYSICOCHEMICAL CHARACTERIZATION | ANTIEDEMATOGENIC ACTIVITY | IN-WATER EMULSIONS | Indomethacin | Nanocomposites | Density gradients | Colloids | Light scattering | Nanomaterials | Mathematical models | Nanostructure | Polyester resins | Triacylglycerols
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3. Full Text Poly( -caprolactone) microcapsules and nanocapsules in drug delivery
by Pohlmann, Adriana Raffin and Fonseca, Francisco Noe and Paese, Karina and Detoni, Cassia Britto and Coradini, Karine and Beck, Ruy CR and Guterres, Silvia S
Expert Opinion on Drug Delivery, ISSN 1742-5247, 05/2013, Volume 10, Issue 5, pp. 623 - 638
Introduction: Poly( -caprolactone) (PCL), a biodegradable and biocompatible polymer, is useful to encapsulate a wide range of drugs making it an interesting... 
polymer | nanocapsules | drug delivery systems | microcapsules | lipid-core nanocapsules | poly(ϵ-caprolactone) | Microcapsules | Poly(ε-caprolactone) | Polymer | Drug delivery systems | Lipid-core nanocapsules | Nanocapsules | POLYMERIC NANOCAPSULES | CONTROLLED-RELEASE | TRETINOIN DEVELOPMENT | INDOMETHACIN-LOADED NANOCAPSULES | NANOSTRUCTURED SYSTEMS | ALKALINE-HYDROLYSIS | POLYESTER NANOCAPSULES | PHYSICOCHEMICAL CHARACTERIZATION | IN-VITRO PERMEATION | PHARMACOLOGY & PHARMACY | poly(epsilon-caprolactone) | Polymers - administration & dosage | Skin - metabolism | Drug Stability | Humans | Solubility | Capsules - chemistry | Nanocapsules - chemistry | Chemistry, Pharmaceutical | Drug Delivery Systems | Sunscreening Agents - administration & dosage | Polyesters - chemistry | Animals | Sunscreening Agents - pharmacokinetics | Drug Compounding | Biocompatible Materials
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4. Full Text Diverse deformation properties of polymeric nanocapsules and lipid-core nanocapsules
by Fiel, Luana Almeida and Rebêlo, Luciana Magalhães and De Melo Santiago, Thiago and Adorne, Márcia Duarte and Guterres, Sílvia Stanisuaski and Soares De Sousa, Jeanlex and Pohlmann, Adriana Raffin
Soft Matter, ISSN 1744-683X, 08/2011, Volume 7, Issue 16, pp. 7240 - 7247
The deformation properties of submicrometric drug carriers can influence their tissue-penetration ability and thus the drug targeting. The aim of this study... 
POLYMER SCIENCE | PHYSICS, MULTIDISCIPLINARY | MATERIALS SCIENCE, MULTIDISCIPLINARY | ENCAPSULATION | CHEMISTRY, PHYSICAL | OCTYL METHOXYCINNAMATE | RELEASE PROFILES | TURBIDIMETRIC DETECTION | INDOMETHACIN-LOADED NANOCAPSULES | NANOPARTICLES | IN-VITRO | ATOMIC-FORCE MICROSCOPY | ALKALINE-HYDROLYSIS | PHYSICOCHEMICAL CHARACTERIZATION
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5. Full Text Characterization of antioxidant methylcellulose film incorporated with α-tocopherol nanocapsules
by Noronha, Carolina Montanheiro and de Carvalho, Sabrina Matos and Lino, Renata Calegari and Barreto, Pedro Luiz Manique
Food Chemistry, ISSN 0308-8146, 09/2014, Volume 159, pp. 529 - 535
Biodegradable and antioxidant films based on methylcellulose (MC) and α-tocopherol nanocapsule suspension (NCs) were developed. MC and NCs films were prepared... 
α-Tocopherol | Methylcellulose | Active and biodegradable packaging | Antioxidant properties | Biofilms | Nanocapsules | ALGINATE | FOOD SCIENCE & TECHNOLOGY | alpha-Tocopherol | RELEASE | LOADED NANOCAPSULES | BHT | PHYSICOCHEMICAL PROPERTIES | NUTRITION & DIETETICS | OIL | EDIBLE FILMS | VITAMIN | CHEMISTRY, APPLIED | Tensile Strength | Microscopy, Electron, Scanning | Antioxidants - chemistry | Oxidation-Reduction | Food Analysis - methods | Stress, Mechanical | Chromatography, High Pressure Liquid | Nanocapsules - chemistry | Spectrophotometry, Ultraviolet | Methylcellulose - chemistry | Wettability | Light | Surface Properties | Hydrophobic and Hydrophilic Interactions | Food Packaging | Food Preservatives | Antioxidants - analysis | alpha-Tocopherol - chemistry
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6. Full Text Polyglutamic acid–PEG nanocapsules as long circulating carriers for the delivery of docetaxel
by Lollo, Giovanna and Rivera-Rodriguez, Gustavo R and Bejaud, Jerome and Montier, Tristan and Passirani, Catherine and Benoit, Jean-Pierre and García-Fuentes, Marcos and Alonso, Maria José and Torres, Dolores
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 05/2014, Volume 87, Issue 1, pp. 47 - 54
Recently we reported for the first time a new type of nanocapsules consisting of an oily core and a polymer shell made of a polyglutamic acid–polyethylene... 
Biocompatibility | Drug targeting | PEGylation | Polyaminoacids | Nanotechnology | Anticancer drug delivery | ACTIVATION | DRUG-DELIVERY | POLYMERIC MICELLES | PACLITAXEL | COMPLEMENT-SYSTEM | LOADED LIPID NANOCAPSULES | PLASMA | CISPLATIN | PHARMACOLOGY & PHARMACY | CHAIN-LENGTH | LIPOSOMES | Hemolysis - drug effects | Rats, Wistar | Humans | Polyethylene Glycols - chemistry | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Nanocapsules - chemistry | Drug Carriers - chemistry | Tissue Distribution | Taxoids - therapeutic use | Surface Properties | Erythrocytes - pathology | Female | Antineoplastic Agents - pharmacokinetics | Kaplan-Meier Estimate | Polyglutamic Acid - blood | Erythrocytes - drug effects | Taxoids - pharmacokinetics | Particle Size | Xenograft Model Antitumor Assays | Polyglutamic Acid - chemistry | Taxoids - administration & dosage | Animals | Drug Carriers - pharmacokinetics | Mice | Delayed-Action Preparations | Antimitotic agents | Antineoplastic agents
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7. Full Text p,p’-Methoxyl-diphenyl diselenideincorporation into polymeric nanocapsules improves its antinociceptive action: Physicochemical and behavioral studies
by Sari, Marcel Henrique Marcondes and Ferreira, Luana Mota and AngonesiZborowski, Vanessa and Araujo, Paulo Cesar Oliveira and Nadal, Jessica Mendes and Farago, Paulo Vitor and Cruz, Letícia and Nogueira, Cristina Wayne
Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, 09/2017, Volume 157, pp. 464 - 472
The (OMePhSe) nanocapsules formulation increased the compound thermal stability and the antinociceptive action. The p,p'-methoxyl-diphenyl diselenide... 
Nociception | Mice | Selenium | Organoselenium | Nanotechnology | MATERIALS SCIENCE, BIOMATERIALS | ALTERNATE-DAY | CHRONIC PAIN | DRUG-DELIVERY | RATS | CHEMISTRY, PHYSICAL | LOADED NANOCAPSULES | HOT-PLATE TEST | BIOPHYSICS | MODELS | DIPHENYL DISELENIDE | IN-VIVO | Animals | Nanotechnology - methods | Nanocapsules - chemistry | Organoselenium Compounds - chemistry | Bisphenol-A | Analysis | Index Medicus
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8. Full Text Nanocapsule Technology: A Review
by Patrick Couvreur and Gillian Barratt and Elias Fattal and Christine Vauthier
Critical Reviewsâ„¢ in Therapeutic Drug Carrier Systems, ISSN 0743-4863, 2002, Volume 19, Issue 2, pp. 99 - 134
Nanocapsules are submicroscopic colloidal drug carrier systems composed of an oily or an aqueous core surrounded by a thin polymer membrane. Two technologies... 
Interfacial polymerization | Drug targeting | Solvent evaporation | Nanodeposition | Nanocapsules | IN-VITRO RELEASE | POLYMERIC NANOCAPSULES | solvent evaporation | nanocapsules | COLLOIDAL DRUG CARRIERS | PEG CHAIN-LENGTH | nanodeposition | interfacial polymerization | drug targeting | INDOMETHACIN-LOADED NANOCAPSULES | POLYLACTIC ACID NANOCAPSULES | POLYISOBUTYLCYANOACRYLATE NANOCAPSULES | POLY(D,L-LACTIDE) NANOCAPSULES | POLYESTER NANOCAPSULES | PHARMACOLOGY & PHARMACY | POLYALKYLCYANOACRYLATE NANOCAPSULES | Capsules - therapeutic use | Animals | Nanotechnology - methods | Humans | Capsules - administration & dosage | Drug Delivery Systems - trends | Drug Delivery Systems - methods
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9. Full Text Acute and subchronic toxicity evaluation of poly(ε-Caprolactone) lipid-core nanocapsules in rats
by Bulcão, Rachel P and Freitas, Fernando A and Venturini, Cristina G and Dallegrave, Eliane and Durgante, Juliano and Göethel, Gabriela and Cerski, Carlos Thadeu S and Zielinsky, Paulo and Pohlmann, Adriana R and Guterres, Sílvia S and Garcia, Solange C
Toxicological Sciences, ISSN 1096-6080, 03/2013, Volume 132, Issue 1, pp. 162 - 176
Owing to concerns over the effects of the physicochemical properties of nanoparticles and their interaction with biological systems, further investigation is... 
Polymeric | Nanotoxicity | Biodegradable | Nanotoxicology | In vivo test | SYSTEM | biodegradable | PROTEIN | nanotoxicity | DRUG-DELIVERY | NANOMATERIALS | CARBON NANOTUBES | INDOMETHACIN-LOADED NANOCAPSULES | in vivo test | polymeric | TRACKING ANALYSIS | IN-VIVO | MICE | TOXICOLOGY | nanotoxicology | BIODEGRADABLE POLYMERIC NANOPARTICLES | Microscopy, Electron, Transmission | Microscopy, Electron, Scanning | Rats, Wistar | Nanocapsules | Body Weight - drug effects | Rats | Male | Polyesters - toxicity | Dose-Response Relationship, Drug | Polyesters - chemistry | Lipids - chemistry | Organ Size - drug effects | Animals | Index Medicus
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10. Full Text Neuroprotective Effects of Resveratrol Against Aβ Administration in Rats are Improved by Lipid-Core Nanocapsules
by Frozza, Rudimar L and Bernardi, Andressa and Hoppe, Juliana B and Meneghetti, André B and Matté, Aline and Battastini, Ana M. O and Pohlmann, Adriana R and Guterres, Sílvia S and Salbego, Christianne
Molecular Neurobiology, ISSN 0893-7648, 6/2013, Volume 47, Issue 3, pp. 1066 - 1080
Alzheimer’s disease (AD), a neurodegenerative disorder exhibiting a gradual decline in cognitive function, is characterized by the presence of neuritic plaques... 
Neurology | Neuroprotection | Neurosciences | Biomedicine | Alzheimer’s disease | Neurobiology | Resveratrol | Drug delivery | Amyloid-β peptide | Hippocampus | Cell Biology | Alzheimer's disease | NEURODEGENERATIVE DISORDERS | PROTEIN | DRUG-DELIVERY | ALZHEIMERS-DISEASE | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | INDOMETHACIN-LOADED NANOCAPSULES | NANOPARTICLES | PATHWAY | AMYLOID-BETA | Amyloid-beta peptide | TRANS-RESVERATROL | Neuroprotective Agents - therapeutic use | Stilbenes - adverse effects | Microglia - metabolism | Rats, Wistar | Stilbenes - therapeutic use | Astrocytes - pathology | Injections, Intraventricular | Glycogen Synthase Kinase 3 beta | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Hippocampus - drug effects | Stilbenes - pharmacology | Synapses - pathology | Nanocapsules - chemistry | Lipids - chemistry | Neuroprotective Agents - pharmacology | Cytoprotection - drug effects | Microglia - pathology | Hippocampus - enzymology | Amyloid beta-Peptides - administration & dosage | Astrocytes - drug effects | Synapses - drug effects | Tissue Distribution - drug effects | Microglia - drug effects | Amyloid beta-Peptides - toxicity | Rats | Hippocampus - pathology | Enzyme Activation - drug effects | Glycogen Synthase Kinase 3 - metabolism | beta Catenin - metabolism | Animals | Memory Disorders - drug therapy | Signal Transduction - drug effects | Protein Stability - drug effects | Astrocytes - metabolism
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11. Full Text New strategy to surface functionalization of polymeric nanoparticles: one-pot synthesis of scFv anti-LDL(−)-functionalized nanocapsules
by Bender, Eduardo A and Cavalcante, Marcela F and Adorne, Márcia D and Colomé, Letícia M and Guterres, Sílvia S and Abdalla, Dulcinéia S. P and Pohlmann, Adriana R
Pharmaceutical Research, ISSN 0724-8741, 11/2014, Volume 31, Issue 11, pp. 2975 - 2987
In general, the surface functionalization of polymeric nanoparticles is carried out by covalently bounding ligands to the nanoparticle surface. This process... 
Biochemistry, general | Biomedical Engineering | lipid-core nanocapsules | Biomedicine | ligand-metal-chitosan-lecithin | Pharmacy | polycaprolactone | LDL single-chain fragment variable | Medical Law | Pharmacology/Toxicology | DRUG-DELIVERY | CHITOSAN | LOW-DENSITY-LIPOPROTEIN | LIGHT-SCATTERING | ATHEROSCLEROSIS | PEROXIDATION | ADSORPTION | CHEMISTRY, MULTIDISCIPLINARY | TRACKING ANALYSIS | PHARMACOLOGY & PHARMACY | LOADED NANOPARTICLES | Catalytic Domain | Chemistry, Pharmaceutical - methods | Nanoparticles - chemistry | Nanocapsules - chemistry | Particle Size | Chitosan - chemistry | Lecithins - chemistry | Metals - chemistry | Lipid Peroxidation - drug effects | Ligands | Polymers - chemistry | Oxidative Stress - drug effects | Lipoproteins, LDL - immunology | Single-Chain Antibodies - chemistry | Single-Chain Antibodies - immunology | Nanoparticles | Enzymes | Plant lipids | Lecithin | Low density lipoproteins | Biosynthesis | Pharmacology | Low density lipoprotein
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12. Full Text Co-encapsulation of resveratrol and curcumin in lipid-core nanocapsules improves their in vitro antioxidant effects
by Coradini, K and Lima, F.O and Oliveira, C.M and Chaves, P.S and Athayde, M.L and Carvalho, L.M and Beck, R.C.R
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 09/2014, Volume 88, Issue 1, pp. 178 - 185
Resveratrol and curcumin are natural antioxidants found in the human diet that have been used in the prevention and treatment of different diseases associated... 
Antioxidants | Nanoparticles | Curcumin | Photostability | Lipid-core nanocapsules | Resveratrol | CELLS | VIVO | GLIOMA | RATS | CANCER | BIOAVAILABILITY | INDOMETHACIN-LOADED NANOCAPSULES | POLY(D,L-LACTIDE-CO-GLYCOLIDE) NANOPARTICLES | TRANS-RESVERATROL | PHARMACOLOGY & PHARMACY | CLOBETASOL PROPIONATE | Microscopy, Electron, Transmission | Stilbenes - administration & dosage | Antioxidants - chemistry | Free Radicals | Nanoparticles - chemistry | Oxidative Stress | Humans | Inflammation | Chromatography, High Pressure Liquid | Curcumin - administration & dosage | Nanocapsules - chemistry | Drug Delivery Systems | Particle Size | Lipids - chemistry | Polyphenols - chemistry | Nanotechnology | Hydrogen-Ion Concentration
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13. Full Text Improving drug biological effects by encapsulation into polymeric nanocapsules
by Frank, Luiza A and Contri, Renata V and Beck, Ruy C. R and Pohlmann, Adriana R and Guterres, Silvia S
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, ISSN 1939-5116, 09/2015, Volume 7, Issue 5, pp. 623 - 639
This review is based on selected reports from 2004 to 2014 and provides a comprehensive and updated overview of the state of the art related to the drug... 
INDOMETHACIN-LOADED NANOCAPSULES | MEDICINE, RESEARCH & EXPERIMENTAL | LIPID-CORE NANOCAPSULES | PHYSICOCHEMICAL CHARACTERIZATION | TRETINOIN DEVELOPMENT | NANOENCAPSULATION | NANOSCIENCE & NANOTECHNOLOGY | ANTIPSYCHOTIC TREATMENT | SKIN PENETRATION | SUSTAINED-RELEASE | VITRO ANTIOXIDANT ACTIVITY | DELIVERY | Animals | Humans | Pharmaceutical Preparations - chemistry | Polymers - chemistry | Nanocapsules - chemistry | Drug Carriers | Drug Delivery Systems | Encapsulation | Drugs | Drug delivery systems | Nanomaterials | Drug delivery | Bioavailability | Tissues | Nanoparticles | Biological effects | Toxicology | Biocompatibility | Drug interaction | In vivo methods and tests | Nanotechnology
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