X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (19029) 19029
Publication (4038) 4038
Book Chapter (149) 149
Book Review (147) 147
Dissertation (39) 39
Conference Proceeding (37) 37
Reference (9) 9
Book / eBook (3) 3
Government Document (3) 3
Newspaper Article (2) 2
Data Set (1) 1
Magazine Article (1) 1
Streaming Video (1) 1
Web Resource (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (11706) 11706
index medicus (9030) 9030
humans (8761) 8761
mice (7006) 7006
basic helix-loop-helix transcription factors - metabolism (5751) 5751
basic helix-loop-helix transcription factors - genetics (5508) 5508
biochemistry & molecular biology (4566) 4566
cell biology (4119) 4119
expression (4027) 4027
transcription factors - genetics (3742) 3742
transcription factors - metabolism (3454) 3454
basic helix-loop-helix transcription factors (3445) 3445
transcription factors (3308) 3308
molecular sequence data (3307) 3307
male (3110) 3110
female (3083) 3083
gene expression (2919) 2919
dna-binding proteins - genetics (2720) 2720
developmental biology (2531) 2531
differentiation (2492) 2492
proteins (2463) 2463
dna-binding proteins - metabolism (2447) 2447
base sequence (2439) 2439
research (2353) 2353
amino acid sequence (2259) 2259
signal transduction (2134) 2134
gene-expression (2122) 2122
article (2020) 2020
helix-loop-helix motifs (2006) 2006
cell differentiation (1958) 1958
gene expression regulation, developmental (1950) 1950
genes (1945) 1945
gene expression regulation (1875) 1875
cells, cultured (1809) 1809
genetic aspects (1765) 1765
cell line (1740) 1740
analysis (1730) 1730
oncology (1678) 1678
gene (1668) 1668
rats (1663) 1663
mutation (1657) 1657
protein binding (1636) 1636
genetics & heredity (1600) 1600
transcription, genetic (1588) 1588
promoter regions, genetic (1569) 1569
neurosciences (1530) 1530
nerve tissue proteins - genetics (1527) 1527
nerve tissue proteins - metabolism (1522) 1522
transcription factor (1513) 1513
research article (1466) 1466
loop-helix proteins (1462) 1462
physiological aspects (1454) 1454
multidisciplinary sciences (1443) 1443
cell line, tumor (1436) 1436
dna-binding (1433) 1433
homeodomain proteins - genetics (1433) 1433
homeodomain proteins - metabolism (1358) 1358
mice, inbred c57bl (1351) 1351
mice, knockout (1314) 1314
transcription (1299) 1299
rna, messenger - metabolism (1296) 1296
protein (1293) 1293
repressor proteins - genetics (1282) 1282
cancer (1247) 1247
transfection (1231) 1231
binding sites (1221) 1221
immunohistochemistry (1195) 1195
mice, transgenic (1187) 1187
cells (1163) 1163
repressor proteins - metabolism (1162) 1162
basic helix-loop-helix leucine zipper transcription factors (1150) 1150
cell proliferation (1132) 1132
activation (1128) 1128
adult (1049) 1049
stem cells (1029) 1029
transcriptional activation (1029) 1029
transcription factors - physiology (1021) 1021
basic helix-loop-helix leucine zipper transcription factors - metabolism (1010) 1010
phenotype (1006) 1006
reverse transcriptase polymerase chain reaction (1006) 1006
rna, messenger - genetics (998) 998
apoptosis (987) 987
neurogenesis (952) 952
drosophila (938) 938
nuclear proteins - metabolism (938) 938
neurons (928) 928
hypoxia (920) 920
basic helix-loop-helix transcription factors - physiology (916) 916
middle aged (907) 907
biology (905) 905
mouse (900) 900
basic helix-loop-helix leucine zipper transcription factors - genetics (891) 891
nuclear proteins - genetics (881) 881
growth (874) 874
transcription factor hes-1 (854) 854
cell differentiation - physiology (850) 850
dna-binding proteins (834) 834
gene expression regulation, neoplastic (823) 823
molecular biology (810) 810
trans-activators - genetics (810) 810
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (18827) 18827
Chinese (127) 127
Japanese (116) 116
French (33) 33
Russian (23) 23
German (12) 12
Korean (3) 3
Polish (3) 3
Dutch (2) 2
Hungarian (1) 1
Spanish (1) 1
Ukrainian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Blood, ISSN 0006-4971, 08/2008, Volume 112, Issue 4, pp. 1503 - 1509
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2015, Volume 58, Issue 7, pp. 3002 - 3024
Journal Article
Developmental Cell, ISSN 1534-5807, 03/2012, Volume 22, Issue 3, pp. 501 - 514
Gradients of vascular endothelial growth factor (VEGF) induce single endothelial cells to become leading tip cells of emerging angiogenic sprouts. Tip cells... 
DEFECTS | TIP CELLS | ANGIOGENESIS | VEGF | ENDOTHELIAL-CELLS | ID PROTEINS | HES1 | DEVELOPMENTAL BIOLOGY | DIFFERENTIATION | EXPRESSION | INHIBITS TUMOR-GROWTH | CELL BIOLOGY | Transcription Factor HES-1 | Humans | Intercellular Signaling Peptides and Proteins - biosynthesis | Intracellular Signaling Peptides and Proteins - metabolism | Inhibitor of Differentiation Proteins - biosynthesis | Inhibitor of Differentiation Protein 1 - biosynthesis | Serrate-Jagged Proteins | Smad5 Protein - metabolism | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Smad1 Protein - genetics | Membrane Proteins - metabolism | Smad5 Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - biosynthesis | Homeodomain Proteins - biosynthesis | Signal Transduction | Inhibitor of Differentiation Protein 2 - biosynthesis | Membrane Proteins - genetics | Down-Regulation | Cells, Cultured | Mice, Transgenic | Cell Cycle Proteins - biosynthesis | Vascular Endothelial Growth Factor Receptor-1 - biosynthesis | Mice, Knockout | Membrane Proteins - biosynthesis | Phenotype | Animals | Smad1 Protein - metabolism | Mice | Neovascularization, Physiologic | Proteins | Endothelial growth factors | Genes | Genetic aspects | Transforming growth factors | Vascular endothelial growth factor | Endothelium | Dll4 | tip cell | lateral inhibition | sprouting angiogenesis | BMP | directed migration | Notch | stalk cell | mouse embryo | Smad | polarity
Journal Article
Biochemistry, ISSN 0006-2960, 05/2017, Volume 56, Issue 18, pp. 2379 - 2384
Appropriate integration of cellular signals requires a delicate balance of ligand–target binding affinities. Increasing the level of residual structure in... 
UNSTRUCTURED PROTEINS | IMPROVED SENSITIVITY | SPECTROSCOPY | BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | KIX DOMAIN | Myeloid-Lymphoid Leukemia Protein - metabolism | Proline - metabolism | Humans | Myeloid-Lymphoid Leukemia Protein - chemistry | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Tumor Suppressor Protein p53 - genetics | Cloning, Molecular | Escherichia coli - metabolism | Conserved Sequence | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Histone-Lysine N-Methyltransferase - genetics | Membrane Proteins - genetics | Tumor Suppressor Protein p53 - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Phosphoproteins - genetics | Intrinsically Disordered Proteins - genetics | Protein Folding | Proline - chemistry | Histone-Lysine N-Methyltransferase - chemistry | Sequence Homology, Amino Acid | Sequence Alignment | Animals | Histone-Lysine N-Methyltransferase - metabolism | Membrane Proteins - chemistry | Escherichia coli - genetics | Intrinsically Disordered Proteins - chemistry | Myeloid-Lymphoid Leukemia Protein - genetics | Protein Binding | Mice | Tumor Suppressor Protein p53 - chemistry | Mutation | Intrinsically Disordered Proteins - metabolism | Helix-loop-helix motif | Protein deficiency | Research
Journal Article
Oncogene, ISSN 0950-9232, 10/2017, Volume 36, Issue 42, pp. 5852 - 5860
Journal Article
2001, Methods in enzymology, ISBN 0121822419, Volume 340., xxxiv, 705
This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from... 
Ligand binding (Biochemistry) | Molecular Biology | methods | drug effects | Nucleic acids | RNA-Binding Proteins | Molecular pharmacology | DNA-ligand interactions | DNA-Binding Proteins | DNA-drug interactions
Book
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/1997, Volume 94, Issue 22, pp. 11786 - 11791
Journal Article
Autophagy, ISSN 1554-8627, 12/2014, Volume 10, Issue 12, pp. 2251 - 2268
How autophagic degradation is linked to endosomal trafficking routes is little known. Here we screened a collection of uncharacterized Drosophila mutants... 
Socs36E, suppressor of cytokine signaling at 36E | Vps25, vacuolar protein sorting 25 | dome | ESCRT, endosomal sorting complex required for transport | Syb, Synaptobrevin | hop-Stat92E, hopscotch-signal transducer and activator of transcription protein at 92E | SNARE | EM, electron microscopy | FE, follicular epithelium | usnp | CEDNIK, cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma | V-ATPase, vacuolar H | dome, domeless | NECD, N extracellular domain | Vamp, vesicle-associated membrane protein | trafficking | N, Notch | CFP, cyan fluorescent protein | Atg, autophagy-related | GFP, green fluorescent protein | autophagy | MENE, mutant eye no eclosion | ATPase | Notch | WT, wild type | refP, refractory to sigma P | MVB, multivesicular body | + | Snap29 | NPF, asparagine-proline-phenylalanine | SNARE, soluble NSF attachment protein receptor | os, outstretched | E(spl)mβ-HLH, enhancer of split mβ, helix-loop-helix | Syx, syntaxin | histone H3, His3 | Snap29, synaptosomal-associated protein 29 kDa | Dome | Trafficking | Usnp | Autophagy | ACTIVATION | FUSION | ATPASE | COMPLEX GENES | CELL BIOLOGY | GENETIC SCREEN | SNAP-29 | PATHWAY | NOTCH RECEPTOR | UNCONVENTIONAL SECRETION | MELANOGASTER | Exosomes - metabolism | Vesicular Transport Proteins - metabolism | Humans | Phagosomes - metabolism | Qb-SNARE Proteins - metabolism | Protein Transport - physiology | Autophagy - physiology | Drosophila Proteins - metabolism | Cell Movement - physiology | Endosomes - metabolism | Drosophila melanogaster - metabolism | Animals | Qc-SNARE Proteins - metabolism | SNARE Proteins - metabolism | Protein Binding - physiology
Journal Article
The Journal of Immunology, ISSN 0022-1767, 12/2008, Volume 181, Issue 11, pp. 7617 - 7629
The magnitude of T cell responses is determined by proliferation and survival decisions made by the responding cells. We now demonstrate that the Erk MAPK... 
LOOP-HELIX PROTEINS | IMMUNE-RESPONSE | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | SIGNALING PATHWAYS | ACTIVATED PROTEIN-KINASE | IN-VIVO | NEGATIVE SELECTION | IMMUNOLOGY | FAMILY-MEMBER BIM | VIRAL-INFECTION | THYMOCYTE DIFFERENTIATION | Cell Proliferation | bcl-X Protein - genetics | Cell Survival - genetics | MAP Kinase Signaling System - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | MAP Kinase Signaling System - genetics | Bcl-2-Like Protein 11 | Mitogen-Activated Protein Kinase 1 - genetics | Proto-Oncogene Proteins - immunology | bcl-X Protein - immunology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Mitogen-Activated Protein Kinase 3 - immunology | Apoptosis Regulatory Proteins - immunology | Mitogen-Activated Protein Kinase 1 - immunology | Mitogen-Activated Protein Kinase 3 - genetics | Membrane Proteins - genetics | Membrane Proteins - immunology | Proto-Oncogene Proteins - genetics | Cell Survival - immunology | Apoptosis Regulatory Proteins - metabolism | CD8-Positive T-Lymphocytes - enzymology | Mice, Knockout | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Transcription, Genetic - immunology | Mice | Transcription, Genetic - genetics | CD8-Positive T-Lymphocytes - immunology | bcl-X Protein - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 39, pp. 16333 - 16350
Sterol regulatory element-binding proteins (SREBPs) in the fission yeast Schizosaccharomyces pombe regulate lipid homeostasis and the hypoxic response under... 
VALOSIN-CONTAINING PROTEIN | COMPLEX | SREBP CLEAVAGE | UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | VCP MUTATIONS | HMG-COA REDUCTASE | AAA-ATPASE | MEMBRANE-PROTEINS | MITOCHONDRIAL QUALITY-CONTROL | SCHIZOSACCHAROMYCES-POMBE | Golgi Apparatus - enzymology | Schizosaccharomyces pombe Proteins - chemistry | Immunoprecipitation | Transcription Factors - chemistry | Peptide Hydrolases - genetics | Protein Multimerization | Valosin Containing Protein | Recombinant Fusion Proteins - metabolism | Cell Cycle Proteins - chemistry | Gene Deletion | Schizosaccharomyces pombe Proteins - metabolism | Cell Cycle Proteins - genetics | Carrier Proteins - chemistry | Protein Interaction Domains and Motifs | Sterol Regulatory Element Binding Protein 2 - metabolism | Peptide Fragments - genetics | Sterol Regulatory Element Binding Protein 1 - metabolism | Peptide Hydrolases - metabolism | Peptide Fragments - metabolism | Schizosaccharomyces pombe Proteins - genetics | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Adenosine Triphosphatases - metabolism | Glycosylation | Transcription Factors - genetics | Ubiquitin-Protein Ligases - chemistry | Peptide Hydrolases - chemistry | Protein Transport | Transcription Factors - metabolism | Carrier Proteins - genetics | Schizosaccharomyces - metabolism | Peptide Fragments - chemistry | Carrier Proteins - metabolism | Adenosine Triphosphatases - chemistry | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Golgi Apparatus - metabolism | Schizosaccharomyces - enzymology | Adenosine Triphosphatases - genetics | Protein Processing, Post-Translational | Ubiquitin-Protein Ligases - genetics | hypoxia | transcription regulation | VCP | SREBP | Protein Synthesis and Degradation | Schizosaccharomyces pombe | membrane transport | Cdc48 | E3 ubiquitin ligase | ATPases associated with diverse cellular activities (AAA) | p97
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 08/2016, Volume 55, Issue 36, pp. 10612 - 10615
The design of inhibitors of intracellular protein–protein interactions (PPIs) remains a challenge in chemical biology and drug discovery. We propose a cyclized... 
protein–protein interactions | helix-loop-helix peptides | inhibitors | cell-penetrating peptides | epitope grafting | P53-MDM2 INTERACTION | DOMAIN | LIBRARY | CHEMISTRY, MULTIDISCIPLINARY | CANCER-THERAPY | protein-protein interactions | P53 | IN-VIVO ACTIVATION | MDM2 | ANTAGONISTS | SELECTION | TUMOR-SUPPRESSOR PATHWAY | Amino Acid Sequence | Protein Conformation, alpha-Helical | Tumor Suppressor Protein p53 - antagonists & inhibitors | Protein Interaction Maps - drug effects | Humans | Tumor Suppressor Protein p53 - metabolism | Peptides, Cyclic - pharmacology | Proto-Oncogene Proteins c-mdm2 - chemistry | Arginine - analogs & derivatives | Peptides, Cyclic - chemistry | Protein Interaction Mapping | Arginine - pharmacology | Drug Design | Cell Line, Tumor | Molecular Docking Simulation | Tumor Suppressor Protein p53 - chemistry | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Peptides | Arginine | Drug discovery | Permeability | Tumor proteins | Protein-protein interactions | Antigenic determinants | Proteins | Binding | Residues | p53 Protein | Confocal microscopy | Biology | Confocal | Design analysis | Grafting | Design | Penetration | Inhibitors | Microscopy | Computer applications | Helix-loop-helix proteins | Inhibition | Intracellular | Position (location) | Localization | Protein interaction | Cancer
Journal Article
PLoS Pathogens, ISSN 1553-7366, 09/2011, Volume 7, Issue 9, p. e1002245
Intrinsic antiviral resistance represents the first line of intracellular defence against virus infection. During herpes simplex virus type-1 (HSV-1) infection... 
MUTANT | SIMPLEX-VIRUS TYPE-1 | BINDING MOTIF | MICROBIOLOGY | REGULATORY PROTEIN ICP0 | MUTATIONAL ANALYSIS | PML | E3 LIGASE | NUCLEAR-BODIES | VIROLOGY | RING FINGER | INFECTION | PARASITOLOGY | Humans | Substrate Specificity | Viral Proteins - metabolism | Immediate-Early Proteins - metabolism | Ubiquitination | Protein Isoforms - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | SUMO-1 Protein - genetics | Immediate-Early Proteins - chemistry | Herpesvirus 1, Human - immunology | Protein Interaction Domains and Motifs | Repressor Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Herpesvirus 1, Human - metabolism | Trans-Activators | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Viral Proteins - genetics | Nuclear Proteins - metabolism | Ubiquitin-Protein Ligases - chemistry | Transcription Factors - metabolism | Immediate-Early Proteins - genetics | Gene Expression Regulation, Viral | Herpesvirus 1, Human - genetics | SUMO-1 Protein - metabolism | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | Herpesvirus 1, Human - pathogenicity | Promyelocytic Leukemia Protein | Antiviral agents | Ligases | Herpesvirus diseases | Physiological aspects | Herpes | Research | Drug therapy | Health aspects | Proteins | Enzymes | Viruses | Genomes | Mutation | Gene expression
Journal Article