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A High-Performance Liquid Chromatographic Assay for the Determination of Losartan in Plasma, 12/2003
A rapid and sensitive HPLC method was developed for determination of losartan in plasma. Losartan was extracted from plasma by a two-step extraction procedure... 
Losartan, Plasma, Extraction, HPLC analysis
Journal
The New England Journal of Medicine, ISSN 0028-4793, 07/2009, Volume 361, Issue 1, pp. 40 - 51
This study aimed to determine whether early administration of drugs that block the renin–angiotensin system slows the progression of change in glomerular... 
CONTROLLED-TRIAL | MEDICINE, GENERAL & INTERNAL | STRUCTURAL-FUNCTIONAL RELATIONSHIPS | CORTICAL INTERSTITIUM | BLOOD-PRESSURE CONTROL | EARLY NATURAL-HISTORY | RETINOPATHY | ANGIOTENSIN-CONVERTING ENZYME | NEPHROPATHY | PROGRESSION | ENDOTHELIAL GROWTH-FACTOR | Retina - drug effects | Angiotensin II Type 1 Receptor Blockers - adverse effects | Follow-Up Studies | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Humans | Male | Albuminuria | Angiotensin II Type 1 Receptor Blockers - pharmacology | Enalapril - therapeutic use | Enalapril - adverse effects | Mesangial Cells - drug effects | Glomerular Filtration Rate - drug effects | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Angiotensin-Converting Enzyme Inhibitors - adverse effects | Adult | Female | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Diabetic Nephropathies - prevention & control | Double-Blind Method | Diabetes Mellitus, Type 1 - physiopathology | Kidney Glomerulus - drug effects | Diabetes Mellitus, Type 1 - pathology | Kaplan-Meier Estimate | Losartan - pharmacology | Logistic Models | Kidney Glomerulus - pathology | Disease Progression | Diabetes Mellitus, Type 1 - drug therapy | Diabetic Retinopathy - prevention & control | Enalapril - pharmacology | Losartan - therapeutic use | Mesangial Cells - pathology | Losartan - adverse effects | Renin-Angiotensin System - drug effects | Retina - pathology | Diabetic retinopathy | Control | Usage | Enalapril | Type 1 diabetes | Patient outcomes | Losartan | Enalaprilat | Drug therapy | Kidneys | Diabetes | Drug dosages | Index Medicus | Abridged Index Medicus
Journal Article
07/2013
Purpose: To develop a new spectrophotometric method for the analysis of losartan potassium in pharmaceutical formulations by making its complex with copper.... 
Validation | Losartan | Copper complex | Spectrophotometry
Web Resource
ORIGINAL ARTICLE - COMPARATIVE EFFECTS OF LOSARTAN AND ENALAPRIL ON SERUM DIGOXIN LEVELS IN PATIENTS WITH CONGESTIVE HEART FAILURE, 07/2004
The aim of this study was to investigate the effect of AT1-receptor antagonist, losartan usage in place of angiotensin converting enzyme (ACE) inhibitor,... 
Medicine | Digoxin, enalapril, losartan, pharmacokinetics. gm04025
Journal
The New England Journal of Medicine, ISSN 0028-4793, 11/2014, Volume 371, Issue 22, pp. 2061 - 2071
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 06/2008, Volume 358, Issue 23, pp. 2433 - 2446
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2011, Volume 108, Issue 7, pp. 2909 - 2914
The dense collagen network in tumors significantly reduces the penetration and efficacy of nanotherapeutics. We tested whether losartan—a clinically approved... 
Nanoparticles | Receptors | Medical treatment | Collagens | Antineoplastics | Viruses | Dosage | Pancreatic neoplasms | Tumors | Cancer | Thrombospondin-1 | Drug delivery | Transport | Transforming growth factor β | Matrix modifier | INTERSTITIAL FLUID PRESSURE | SOLID TUMORS | transforming growth factor beta | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | drug delivery | transport | BLOOD-FLOW | ANGIOTENSIN | CONVERTING-ENZYME-INHIBITORS | GROWTH-FACTOR-BETA | MOUSE MODEL | TYPE-1 RECEPTOR BLOCKADE | thrombospondin-1 | RENAL INJURY | matrix modifier | Immunohistochemistry | Skin Neoplasms - drug therapy | Fluorescence Recovery After Photobleaching | Humans | DNA Primers - genetics | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | Doxorubicin - analogs & derivatives | Polymerase Chain Reaction | Female | Collagen - biosynthesis | Losartan - pharmacokinetics | Doxorubicin - administration & dosage | Carcinoma - drug therapy | Nanotechnology - methods | Losartan - pharmacology | Mice, SCID | Breast Neoplasms - drug therapy | Polyethylene Glycols - administration & dosage | Oncolytic Virotherapy - methods | Simplexvirus | Animals | Analysis of Variance | Mice | Drug Delivery Systems - methods | Drugs | Care and treatment | Drug delivery systems | Medical technology | Research | Properties | Vehicles | Medical laboratory technology | Collagen | Losartan | Nanotechnology | Proteins | Nanoscience | Pharmacology | Drug therapy | Protein synthesis | Index Medicus | Biological Sciences | Physical Sciences | transforming growth factor β
Journal Article