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Acta Pharmacologica Sinica, ISSN 1671-4083, 11/2018, Volume 39, Issue 11, pp. 1804 - 1815
Xuezhikang capsule (XZK) is a traditional Chinese medicine that contains lovastatin (Lv) for hyperlipidemia treatment, although it has fewer side effects than... 
hyperlipidemia | isoflavones | inflammation | carboxylesterase | pharmacokinetics | Xuezhikang capsules | lovastatin | lovastatin acid | C57BL/6 MOUSE | CHOLESTEROL | INDUCED INFLAMMATION | CHEMISTRY, MULTIDISCIPLINARY | RED-YEAST-RICE | MONASCUS-PURPUREUS | FUNCTIONAL EXPRESSION | PURIFICATION | PURPUREUS-FERMENTED RICE | PHARMACOLOGY & PHARMACY | MOLECULAR-CLONING | RAT PLASMA | Lovastatin - therapeutic use | Administration, Oral | Lovastatin - pharmacokinetics | Humans | Hyperlipidemias - drug therapy | Isoflavones - pharmacology | Mice, Inbred C57BL | Lovastatin - metabolism | Male | Lovastatin - analogs & derivatives | Down-Regulation - drug effects | Drugs, Chinese Herbal - metabolism | Up-Regulation - drug effects | Drugs, Chinese Herbal - pharmacokinetics | Animals | Inflammation - drug therapy | Carboxylesterase - genetics | Cell Line, Tumor | Pregnane X Receptor - genetics | Lovastatin - administration & dosage | Drugs, Chinese Herbal - administration & dosage | Drugs, Chinese Herbal - therapeutic use | Transformation | Hyperlipidemia | Liver | Oral administration | Phytosterols | Traditional Chinese medicine | Muscles | Lovastatin | Pharmacology | Inflammation | Exposure | Carboxylesterase | Conversion | High fat diet | Herbal medicine | Side effects | Acids | Diet | Intestine | Rodents | Mice | Inhibition | Isoflavones
Journal Article
Journal Article
Cell cycle (Georgetown, Tex.), ISSN 1551-4005, 2015, Volume 14, Issue 10, pp. 1583 - 1595
Statins are largely used in clinics in the treatment of patients with cardiovascular diseases for their effect on lowering circulating cholesterol. Lectin-like... 
molecular docking | statin | LOX-1 receptor | substrate recognition | molecular dynamics simulation | monomer-dimer ratio | Molecular dynamics simulation | Monomer-dimer ratio | Statin | Molecular docking | Substrate recognition | Lov, lovastatin | PROTEIN | Mab, monoclonal antibody | HEK, human embryonic kidney | LOW-DENSITY-LIPOPROTEIN | Cav-1, caveolin-1 | CTLD, C-type lectin-like domain | CELL BIOLOGY | DMEM, Dulbecco's modified Eagle's medium | LDL-C, low-density lipoprotein-cholesterol | HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A | Ato, atorvastatin | OLIGOMERIZATION | LDL, low-density lipoprotein | ox-LDL, oxidized low-density lipoprotein | DiI, 1,1 '-dioctadecyl-3,3,3 ',3 '-tetramethyllindocarbocyanine perchlorate | Pra, pravastatin | CRYSTAL-STRUCTURE | ACUTE CORONARY SYNDROMES | Flu, fluvastatin | DYNAMICS SIMULATION | LOX-1, lectin-like oxidized low-density lipoprotein receptor-1 | FORCE-FIELD | RECEPTOR FUNCTION | ISCHEMIA-REPERFUSION | HUMAN LECTIN-LIKE | Protein Structure, Tertiary | Fluorescent Dyes - chemistry | Lipoproteins, LDL - chemistry | Scavenger Receptors, Class E - genetics | Lovastatin - pharmacology | Humans | Lovastatin - chemistry | Lovastatin - metabolism | Cercopithecus aethiops | Scavenger Receptors, Class E - antagonists & inhibitors | Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry | Scavenger Receptors, Class E - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Protein Stability - drug effects | HEK293 Cells | Protein Binding | Lipoproteins, LDL - metabolism | Molecular Docking Simulation | Binding Sites | COS Cells | Dimerization | Microscopy, Fluorescence | Life Sciences
Journal Article
International Journal of Nanomedicine, ISSN 1176-9114, 01/2016, Volume 11, pp. 285 - 297
Chronic periodontitis is characterized by inflammation of periodontal tissues, leading to bone resorption and tooth loss. The goal of treatment is to... 
Periodontal regeneration | Lovastatin | Chitosan | Poly(D,L-lactide-co-glycolide acid) | Tetracycline | chitosan | ALVEOLAR BONE | MICROSPHERES | RANDOMIZED CLINICAL-TRIAL | NANOSCIENCE & NANOTECHNOLOGY | poly(D,L-lactide-co-glycolide acid) | LOCAL-DRUG DELIVERY | periodontal regeneration | IN-VITRO | THERAPY | PLGA | SUBGINGIVALLY DELIVERED SIMVASTATIN | DISEASE | DEGRADATION | PHARMACOLOGY & PHARMACY | tetracycline | lovastatin | Bone Regeneration - drug effects | Microscopy, Electron, Transmission | Lactic Acid - chemistry | Lovastatin - pharmacology | Nanoparticles - chemistry | Osteoblasts - drug effects | Tetracycline - chemistry | Tetracycline - pharmacology | Alkaline Phosphatase - metabolism | Bacteria - drug effects | Lovastatin - chemistry | Drug Carriers - administration & dosage | Male | Drug Carriers - chemistry | Delayed-Action Preparations - administration & dosage | Animals | Chitosan - chemistry | Polyglycolic Acid - chemistry | Dogs | Anti-Bacterial Agents - pharmacology | Lovastatin - administration & dosage | Nanoparticles - administration & dosage | Osteoblasts - cytology | Tetracycline - administration & dosage | Nanoparticles | Infection control | Antilipemic agents | Drug delivery systems | Fourier transforms | Particle size | Hydrogels | Clinical trials | Alcohol | Systematic review | Dentistry | Molecular weight | Defects | Biomedical materials | Acids | Antibiotics | Spectrum analysis | Diabetes | Polymers
Journal Article
Journal Article
Journal Article
Biomaterials, ISSN 0142-9612, 2014, Volume 35, Issue 27, pp. 8002 - 8014
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 1, p. e0171157
Glioblastoma is a common malignant brain tumor and it is refractory to therapy because it usually contains a mixture of cell types. The tumor necrosis... 
OVARIAN-CANCER CELLS | BREAST-CANCER | DEATH RECEPTORS | PROTEIN | HUMAN HEPATOMA-CELLS | MULTIDISCIPLINARY SCIENCES | RESISTANCE | PROLIFERATION | MEDIATED APOPTOSIS | UP-REGULATION | EXPRESSION | Glioblastoma - enzymology | Lovastatin - pharmacology | Apoptosis - drug effects | Humans | NF-kappa B - metabolism | Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | TNF-Related Apoptosis-Inducing Ligand - pharmacology | HEK293 Cells | Lovastatin - administration & dosage | Disease Models, Animal | Subcutaneous Tissue - pathology | Lovastatin - therapeutic use | TNF-Related Apoptosis-Inducing Ligand - therapeutic use | Up-Regulation - drug effects | Animals | MAP Kinase Signaling System - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Models, Biological | Glioblastoma - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice, Inbred BALB C | Glioblastoma - drug therapy | Subcutaneous Tissue - drug effects | Brain | Therapy | Biotechnology | Brain tumors | Brain cancer | Glioblastoma | Lovastatin | Neurosurgery | Kinases | Inactivation | Anticancer properties | Proteins | Cell growth | Pathways | Rodents | Surgery | Coinjection | Cell cycle | Tumor necrosis factor-TNF | NF-κB protein | Medical research | Deactivation | Extracellular signal-regulated kinase | MAP kinase | JNK protein | Breast cancer | Injection | Signaling | Tumor necrosis factor | Cell death | Ligands | TRAIL protein | Mice | Glioblastoma cells | In vivo methods and tests | Combined treatment | Apoptosis
Journal Article
AAPS PharmSciTech, ISSN 1530-9932, 3/2007, Volume 8, Issue 1, pp. E162 - E170
Journal Article
14.