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science & technology (28) 28
lrh-1 (27) 27
life sciences & biomedicine (26) 26
receptors, cytoplasmic and nuclear - genetics (15) 15
animals (14) 14
humans (14) 14
receptors, cytoplasmic and nuclear - metabolism (13) 13
biochemistry & molecular biology (10) 10
cell biology (10) 10
gene expression (10) 10
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nuclear receptor (9) 9
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oncology (7) 7
liver (6) 6
liver cancer (6) 6
nr5a2 (6) 6
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gene expression regulation, neoplastic (5) 5
physiological aspects (5) 5
proteins (5) 5
binding sites (4) 4
breast cancer (4) 4
cell cycle (4) 4
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cell proliferation (4) 4
deoxyribonucleic acid--dna (4) 4
genetic aspects (4) 4
genetics & heredity (4) 4
health aspects (4) 4
ligands (4) 4
liver - metabolism (4) 4
metabolism (4) 4
nuclear receptors (4) 4
research (4) 4
review (4) 4
tumors (4) 4
biophysics (3) 3
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chromatin immunoprecipitation (3) 3
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dna-binding proteins - metabolism (3) 3
inflammatory bowel disease (3) 3
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life sciences (3) 3
liver receptor homolog-1 (3) 3
liver receptor homologue-1 (3) 3
medical prognosis (3) 3
molecular sequence data (3) 3
physiology (3) 3
promoter regions, genetic (3) 3
receptors, cytoplasmic and nuclear - antagonists & inhibitors (3) 3
receptors, cytoplasmic and nuclear - chemistry (3) 3
shp (3) 3
transcription factors - metabolism (3) 3
amino acid sequence (2) 2
analysis (2) 2
apoptosis (2) 2
bile acids (2) 2
biological sciences (2) 2
biology (2) 2
biomedicine general (2) 2
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blotting, western (2) 2
bsep, bile salt export pump (2) 2
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1. Full Text Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket
by Sablin, Elena P and Blind, Raymond D and Uthayaruban, Rubatharshini and Chiu, Hsiu-Ju and Deacon, Ashley M and Das, Debanu and Ingraham, Holly A and Fletterick, Robert J
Journal of structural biology, ISSN 1047-8477, 12/2015, Volume 192, Issue 3, pp. 342 - 348
Nuclear receptor | LRH-1 | NR5A2 | Ligand | Liver Receptor Homolog-1 | PIP3 | Crystal structure | PIP | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Structure, Tertiary | Receptors, Cytoplasmic and Nuclear - ultrastructure | Phosphatidylinositols - chemistry | Steroidogenic Factor 1 - ultrastructure | Humans | Receptors, Cytoplasmic and Nuclear - chemistry | Binding Sites - physiology | Models, Molecular | Crystallography, X-Ray | DAX-1 Orphan Nuclear Receptor - chemistry | Steroidogenic Factor 1 - chemistry | Protein Binding - physiology | Index Medicus
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2. Full Text Therapeutic potential of Liver Receptor Homolog-1 modulators
by Lazarus, Kyren A and Wijayakumara, Dhilushi and Chand, Ashwini L and Simpson, Evan R and Clyne, Colin D
The Journal of steroid biochemistry and molecular biology, ISSN 0960-0760, 07/2012, Volume 130, Issue 3-5, pp. 138 - 146
Orphan nuclear receptor | NR5A2 | LRH-1 | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Neoplasms - metabolism | Embryonic Stem Cells - metabolism | Humans | Rats | Male | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Cholesterol - metabolism | Neoplasms - drug therapy | Animals | Embryonic Stem Cells - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Female | Ovary - drug effects | Mice | Phospholipids - metabolism | Ovary - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
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3. Full Text Bile acid transporters and regulatory nuclear receptors in the liver and beyond
by Halilbasic, Emina and Claudel, Thierry and Trauner, Michael
Journal of hepatology, ISSN 0168-8278, 2012, Volume 58, Issue 1, pp. 155 - 168
Gastroenterology and Hepatology | Gallstones | Liver cancer | Bile acids | Fatty liver disease | Cholestasis | Liver regeneration | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Animals | Carrier Proteins - metabolism | Cholestasis - metabolism | Membrane Glycoproteins - metabolism | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Liver Diseases - metabolism | Liver Regeneration - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Drug resistance in microorganisms | Corticosteroids | Glucagon | Calcifediol | Ursodiol | Deoxycholic acid | Epidermal growth factor | Vitamin D | Physiological aspects | Fibroblast growth factors | Alfacalcidol | Index Medicus | IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 | PFIC, progressive familial intrahepatic cholestasis | TNFα, tumor necrosis factor α | 3 (human) | SRC2, p160 steroid receptor coactivator | NAFLD, non-alcoholic fatty liver disease | BA, bile acid | bile acid receptor | 8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5 | UDCA, ursodeoxycholic acid | LRH-1 (NR5A2), liver receptor homolog-1 | LCA, lithocholic acid | LXRα (NR1H3), liver X receptor alpha | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | OSTαβ, organic solute transporter alpha | ABCG5 | AMPK, AMP activated protein kinase | NASH, non-alcoholic steatohepatitis | SHP (NR0B2), short heterodimer partner | OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 | EGFR, epidermal growth factor receptor | IL6, interleukin 6 | TGR5, G protein-coupled bile acid receptor | PH, partial hepatectomy | AE2, anion exchanger 2 | PSC, primary sclerosing cholangitis | OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 | RARα (NR1B1), retinoic acid receptor alpha | GLP-1, glucagon like peptide 1 | VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents | MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 | NTCP (SLC10A1), sodium | CAR (NR1I3), constitutive androstane receptor | taurocholate cotransporting polypeptide, solute carrier family 10, member 1 | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | GR (NR3C1), glucocorticoid receptor | Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer | 19, fibroblast growth factor 15 | Mdr2 | ICP, intrahepatic cholestasis of pregnancy | BRIC, benign recurrent intrahepatic cholestasis | OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 | MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 | beta | MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 | norUDCA, norursodeoxycholic acid | 6-ECDCA, 6-ethylchenodeoxycholic acid | FXR (NR1H4), farnesoid X receptor | BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 | HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha | PBC, primary biliary cirrhosis | MDR3 (ABCB4), multidrug resistance protein 2 (rodents) | HNF1α, hepatocyte nuclear factor 1 alpha | NR, nuclear receptor | FGF15 | RXRα (NR2B1), retinoid X receptor alpha | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | HCC, hepatocellular carcinoma | MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 | TPN, total parenteral nutrition
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4. Full Text LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer
by Xu, Pan and Oosterveer, Maaike H and Stein, Sokrates and Demagny, Haien and Ryu, Dongryeol and Moullan, Norman and Wang, Xu and Can, Emine and Zamboni, Nicola and Comment, Arnaud and Auwerx, Johan and Schoonjans, Kristina
Genes & development, ISSN 0890-9369, 06/2016, Volume 30, Issue 11, pp. 1255 - 1260
NADPH | nuclear receptor NR5A2 | mitochondria | Hepatocellular carcinoma | PROLIFERATION | CELL-GROWTH | DEFICIENCY | cancer metabolism | LRH-1 | METABOLISM | PATHWAY | anaplerosis | LIPOGENESIS | IN-VIVO | BIOLOGY | mTOR | RECEPTOR HOMOLOG-1 | Mitochondria | Cancer metabolism | Anaplerosis | Nuclear receptor NR5A2 | Genetics & Heredity | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Liver - enzymology | TOR Serine-Threonine Kinases - metabolism | Carcinogenesis - chemically induced | Gene Expression Regulation, Neoplastic | Glutamine - metabolism | Liver Neoplasms - chemically induced | Male | Multiprotein Complexes - genetics | Liver - physiopathology | Carcinogenesis - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | Diethylnitrosamine | Liver Neoplasms - physiopathology | Liver Neoplasms - enzymology | Signal Transduction | Liver - metabolism | Glutaminase - metabolism | Mitochondria - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Mice, Knockout | Carcinogenesis - pathology | Animals | Liver Neoplasms - metabolism | Mice | Glutaminase - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Liver cancer | Analysis | Cell metabolism | Genetic aspects | Cellular signal transduction | Research | Glutamine | Index Medicus | Research Communication
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5. Full Text The new therapeutic frontier – Nuclear receptors and the liver
by Karpen, Saul J and Trauner, Michael
Journal of hepatology, ISSN 0168-8278, 2009, Volume 52, Issue 3, pp. 455 - 462
Gastroenterology and Hepatology | Nuclear receptor | Fatty liver | Gene expression | Ligand | Cholestasis | Fibrosis | HNF | glucocorticoid receptor | GWAS | hepatitis B virus | AR (NR3C4) | MTP | nuclear (hormone) receptor | double knockout | pregnane X receptor | VDR (NR1I2) | PBC | androgen receptor | fibroblast growth factor | RARα (NR1B1) | primary biliary cirrhosis | HSC | vitamin D receptor | Abbreviations | HBV | hepatocellular carcinoma | hepatocyte nuclear factor | retinoid X receptor | GR (NR3C1) | PSC | hepatic stellate cells | peroxisomal proliferator-activated receptor gamma | LRH-1 (NR5A2) | FGF | bile acid | DKO | HCC | CAR (NR1I3) | non alcoholic fatty liver disease | SHP (NR0B2) | HCV | FA | peroxisomal proliferator-activated receptor alpha | primary sclerosing cholangitis | BA | NAFLD | NR | white adipose tissue | fatty acid | PPARα (NR1C1) | WAT | hepatitis C virus | genome wide association study | farnesoid X receptor/bile acid receptor | liver receptor homolog-1 | microsomal transfer protein | estrogen receptor | RXRα (NR2B1) | intrahepatic cholestasis of pregnancy | retinoic acid receptor | PPARγ (NR1C3) | PXR (NR1I2) | ER (NR3A1) | constitutive androstane receptor | ICP | short heterodimer partner | FXR (NR1H4) | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Transcription Factors - physiology | Inactivation, Metabolic - physiology | Polymorphism, Genetic - physiology | Humans | Liver - physiology | Liver Diseases - therapy | Receptors, Cytoplasmic and Nuclear - physiology | Receptors, Cytoplasmic and Nuclear - genetics | Liver Diseases - physiopathology | Liver Regeneration - physiology | Lipid Metabolism - physiology | Inflammation - physiopathology | Index Medicus
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6. Full Text Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition
by Cornelison, Jeffery L and Cato, Michael L and Johnson, Alyssa M and D'Agostino, Emma H and Melchers, Diana and Patel, Anamika B and Mays, Suzanne G and Houtman, René and Ortlund, Eric A and Jui, Nathan T
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 08/2020, Volume 30, Issue 16, pp. 127293 - 127293
Metabolic disease | Nuclear receptor | Agonist | LRH-1 | Photoredox | Index Medicus
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7. Targeting LRH‑1 in hepatoblastoma cell lines causes decreased proliferation
by Jin, Jingling and Jin, Jingling and Jin, Junliang and Woodfield, Sarah E and Patel, Roma H and Jin, Nan Ge and Shi, Yan and Shi, Yan and Liu, Bin and Liu, Bin and Sun, Wenjing and Sun, Wenjing and Chen, Xiangmei and Chen, Xiangmei and Yu, Yang and Vasudevan, Sanjeev A and Vasudevan, Sanjeev A
Oncology reports, ISSN 1021-335X, 01/2019, Volume 41, Issue 1, pp. 143 - 153
Cell proliferation | C-Myc | CCND1 | LRH-1/NR5A2 | Hepatoblastoma | Life Sciences & Biomedicine | Oncology | Science & Technology
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8. Full Text Liver receptor homolog-1 (LRH-1): a potential therapeutic target for cancer
by Nadolny, Christina and Dong, Xiaoqun
Cancer biology & therapy, ISSN 1538-4047, 07/2015, Volume 16, Issue 7, pp. 997 - 1004
breast cancer | liver receptor homolog-1 (LRH-1) | pancreatic cancer | wnt/β-catenin | gastrointestinal cancer | Breast cancer | Liver receptor homolog-1 (LRH-1) | Gastrointestinal cancer | Pancreatic cancer | Wnt/β-catenin | Life Sciences & Biomedicine | Oncology | Science & Technology | Cell Proliferation - genetics | Gastrointestinal Neoplasms - genetics | Pancreatic Neoplasms - metabolism | Gastrointestinal Neoplasms - drug therapy | Humans | Pancreatic Neoplasms - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Breast Neoplasms - drug therapy | Breast Neoplasms - metabolism | Pancreatic Neoplasms - drug therapy | Breast Neoplasms - genetics | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Female | Cell Proliferation - drug effects | Models, Genetic | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | Molecular Targeted Therapy - methods | Gastrointestinal Neoplasms - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
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9. The orphan nuclear receptor, liver receptor homolog-1 (LRH-1, NR5A2) regulates decidualization
by Ruiz, Sandra
ligands | décidualisation | LRH-1 | immunoprécipitation de la chromatine | decidualization | co-culture | Biology - Molecular / Biologie - Biologie moléculaire (UMI : 0307) | chromatin immunoprecipitation
Dissertation
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