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Cell, ISSN 0092-8674, 2001, Volume 107, Issue 4, pp. 513 - 523
In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that LRP5, encoding the low-density lipoprotein receptor-related protein... 
MINERAL DENSITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | OSTEOBLAST LINEAGE | MOLECULAR-CLONING | MICE | DIFFERENTIATION | BETA-CATENIN | OSTEOPOROSIS | CELL-DEATH | FAMILY | CELL BIOLOGY | Wnt2 Protein | Humans | Child, Preschool | Male | Bone Density - genetics | Wnt Proteins | Mesoderm - cytology | Wnt-5a Protein | Eye - embryology | Osteoporosis - genetics | Animals, Outbred Strains | Dishevelled Proteins | Bone Morphogenetic Proteins - pharmacology | Child | Organ Culture Techniques | Transforming Growth Factor beta | Signal Transduction | Chromosomes, Human, Pair 11 - genetics | Adaptor Proteins, Signal Transducing | Skull - cytology | Wnt3 Protein | Mice | Receptors, LDL - physiology | COS Cells | Species Specificity | LDL-Receptor Related Proteins | DNA, Complementary - genetics | Recombinant Fusion Proteins - physiology | Cercopithecus aethiops | Culture Media, Conditioned - pharmacology | Recombinant Proteins | Transfection | Receptors, LDL - deficiency | Stromal Cells - drug effects | Adult | Female | Phosphoproteins - physiology | Proteins - physiology | Receptors, LDL - genetics | Bone Morphogenetic Protein 2 | Low Density Lipoprotein Receptor-Related Protein-5 | Mice, Inbred C57BL | Zebrafish Proteins | Proto-Oncogene Proteins - genetics | Phosphoproteins - genetics | Eye Abnormalities - genetics | Genes, Recessive | Syndrome | Proteins - genetics | Animals | Proto-Oncogene Proteins - physiology | Heterozygote | Osteoblasts - metabolism | Stromal Cells - cytology | Wnt4 Protein | Proteins | Cell research | Lipoproteins | Growth | Analysis | Physiological aspects | Bones | LDL receptor-related protein 5 | LRP5 protein | low density lipoprotein receptor-related protein 5 | osteoporosis-pseudoglioma syndrome | Index Medicus | Receptors, LDL | Mesoderm | Osteoblasts | Recombinant Fusion Proteins | Eye | Life Sciences | Osteoporosis | Stromal Cells | Eye Abnormalities | Phosphoproteins | Proto-Oncogene Proteins | Bone Density | Biochemistry, Molecular Biology | Culture Media, Conditioned | Skull | Chromosomes, Human, Pair 11 | Bone Morphogenetic Proteins | DNA, Complementary
Journal Article
Genes and Development, ISSN 0890-9369, 07/2006, Volume 20, Issue 14, pp. 1933 - 1945
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2007, Volume 402, Issue 3, pp. 515 - 523
Wnt-5a is a representative ligand that activates a beta-catenin-independent pathway in Writ signalling. In the present paper, the roles of the... 
Posttranslational modification | Frizzled 5 (Fz5) | Glycosylation | Palmitoylation | Wnt-5a | PROTEIN | PHOSPHORYLATION | frizzled 5 (Fz5) | BIOCHEMISTRY & MOLECULAR BIOLOGY | glycosylation | post-translational modification | BETA-CATENIN | INVASION | PATHWAY | CELL-MIGRATION | GROWTH | FOCAL ADHESION KINASE | DEPENDENT ACTIVATION | EXPRESSION | palmitoylation | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Cell Line | Signal Transduction | Humans | Molecular Sequence Data | Proto-Oncogene Proteins - genetics | Proto-Oncogene Proteins - chemistry | Wnt-5a Protein | Wnt Proteins - metabolism | Transcription Factor 7-Like 2 Protein | Wnt Proteins - chemistry | Wnt Proteins - isolation & purification | TCF Transcription Factors - metabolism | Sequence Alignment | Animals | Wnt Proteins - genetics | Fatty Acids, Monounsaturated - metabolism | Protein Binding | Mice | Protein Processing, Post-Translational | Proto-Oncogene Proteins - isolation & purification | Cell Movement | Index Medicus | HEK-293T cells, HEK-293 cells expressing the large T-antigen of SV40 (simian virus 40) | CM, conditioned medium | WT, wild-type | ECM, extracellular matrix | NLK, Nemo-like kinase | LRP5 | JNK, c-Jun N-terminal kinase | GFP, green fluorescent protein | Fz, Frizzled | PKC, protein kinase C | FAK, focal adhesion kinase | CRD, cysteine-rich domain | Lef, lymphoid enhancer factor | MALDI–TOF-MS, matrix-assisted laser-desorption ionization–time-of-flight MS | 6, lipoprotein receptor-related protein 5 | siRNA, small interfering RNA | Tcf, T-cell factor | PNGase F, peptide N-glycosidase F | HEK-293, human embryonic kidney-293 | TFA, trifluoroacetic acid
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 9, pp. 1 - 17
Journal Article
The FEBS Journal, ISSN 1742-464X, 06/2017, Volume 284, Issue 11, pp. 1657 - 1671
Snake venom metalloproteases ( SVMP s) are members of the a disintegrin and metalloprotease ( ADAM ) family of proteins, as they possess similar domains. SVMP... 
ADAM | SVMP | haemorrhage | vascular barrier | Wnt signalling | APOPTOSIS | DOMAIN | ACTIVATION | CANCER CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | BETA-CATENIN | LRP6 | TRIMERESURUS-FLAVOVIRIDIS | PURIFICATION | PROTEINS | Human Umbilical Vein Endothelial Cells | Low Density Lipoprotein Receptor-Related Protein-6 - physiology | Low Density Lipoprotein Receptor-Related Protein-5 - physiology | Species Specificity | ADAM12 Protein - metabolism | Humans | Low Density Lipoprotein Receptor-Related Protein-5 - chemistry | Wnt Signaling Pathway - physiology | Male | Metalloendopeptidases - metabolism | Membrane Proteins - pharmacology | Low Density Lipoprotein Receptor-Related Protein-6 - chemistry | ADAM Proteins - pharmacology | Protein Domains | Membrane Proteins - metabolism | Crotalid Venoms - metabolism | Drug Resistance | Recombinant Proteins - metabolism | Amino Acid Sequence | Models, Molecular | Antibodies, Neutralizing - pharmacology | Cell Adhesion - drug effects | Fibronectins - metabolism | Apoptosis Regulatory Proteins - metabolism | Sequence Homology, Amino Acid | ADAM Proteins - metabolism | Sequence Alignment | Animals | Wnt Signaling Pathway - drug effects | Cell Adhesion - physiology | Protein Structure, Secondary - drug effects | Fibrinogen - metabolism | Hydrophobic and Hydrophilic Interactions | Mice | Molecular Docking Simulation | ADAM12 Protein - pharmacology | HeLa Cells | Hemorrhage - chemically induced | Vertebrates - metabolism | Adhesions | Proteases | Proteolysis | Low density lipoproteins | Venom | Physiological aspects | Snakes | Target recognition | Wnt protein | Bites | Cytosol | Hemorrhage | Cell adhesion & migration | Proteins | β-catenin | Receptors | Cell adhesion | LRP5 protein | Cleavage | Metalloproteinase | Relocation | Recombinant | ADAM8 protein | Cadherin | Signaling | Vascular apoptosis-inducing protein 1 | Receptor density | Disruption | In vitro methods and tests | Apoptosis | Index Medicus
Journal Article
Human Mutation, ISSN 1059-7794, 2010, Volume 31, Issue 6, pp. 656 - 666
Journal Article
Journal Article
eLife, ISSN 2050-084X, 06/2015, Volume 4, Issue 2015, pp. 1 - 27
Wnt signalling regulates multiple processes including angiogenesis, inflammation, and tumorigenesis. Norrin (Norrie Disease Protein) is a cystine-knot like... 
blood brain barrier | mouse | stem cells | retinal disease | Wnt signalling | angiogenesis | developmental biology | crystal structure | structural biology | cystine-knot growth factor | biophysics | human | CYSTEINE-RICH DOMAIN | DENSITY MODIFICATION | PROTEIN EXPRESSION | GROWTH-FACTORS | BIOLOGY | RETINAL VASCULAR DEVELOPMENT | HEPARAN-SULFATE PROTEOGLYCANS | MACROMOLECULAR CRYSTALLOGRAPHY | CANDIDATE GENE | FAMILIAL EXUDATIVE VITREORETINOPATHY | MAMMALIAN-CELLS | Humans | Mutant Proteins - genetics | Eye Proteins - chemistry | Frizzled Receptors - metabolism | Proteoglycans - metabolism | Scattering, Small Angle | Crystallography, X-Ray | Mutant Proteins - metabolism | Nerve Tissue Proteins - genetics | Proteoglycans - chemistry | Nerve Tissue Proteins - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Nerve Tissue Proteins - chemistry | Eye Proteins - metabolism | Frizzled Receptors - chemistry | Mutant Proteins - chemistry | Low Density Lipoprotein Receptor-Related Protein-5 - metabolism | Protein Conformation | Eye Proteins - genetics | Binding Sites | Norrie disease | Glycosaminoglycans | Wnt protein | Disease | Frizzled protein | Drug development | Chromatography | Proteins | β-catenin | Angiogenesis | Signal transduction | X-ray scattering | Plasmids | Low density lipoprotein receptors | Receptor density | LRP5 protein | Tumorigenesis | Deoxyribonucleic acid--DNA | Crystal structure | Index Medicus
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 10/2003, Volume 18, Issue 10, pp. 1842 - 1853
Wnt/β‐catenin signaling has recently been suggested to be involved in bone biology. The precise role of this cascade in osteoblast differentiation was... 
LRP5 | alkaline phosphatase | osteoblast | β‐catenin | Wnt | Osteoblast | β-catenin | Alkaline phosphatase | beta-catenin | MOLECULAR-MECHANISM | BONE MORPHOGENETIC PROTEIN-2 | MICE DEFICIENT | SONIC HEDGEHOG | EYE VASCULARIZATION | SIGNAL-TRANSDUCTION | TRABECULAR BONE | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | RECEPTOR-RELATED PROTEIN-5 | Luciferases - metabolism | Coloring Agents - pharmacology | LDL-Receptor Related Proteins | Alkaline Phosphatase - metabolism | Adipocytes - cytology | Wnt Proteins | Dose-Response Relationship, Drug | Hedgehog Proteins | Bone Morphogenetic Proteins - metabolism | Transfection | Time Factors | Cell Division | Cytoskeletal Proteins - metabolism | Cell Differentiation | Osteoblasts - cytology | Protein Synthesis Inhibitors - pharmacology | Azo Compounds - pharmacology | Transforming Growth Factor beta | RNA - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Osteoblasts - enzymology | Signal Transduction | beta Catenin | Bone Morphogenetic Protein 2 | Low Density Lipoprotein Receptor-Related Protein-5 | Cells, Cultured | Zebrafish Proteins | Receptors, LDL - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Cycloheximide - pharmacology | Mice, Inbred C3H | Point Mutation | Phenotype | Animals | Alkaline Phosphatase - biosynthesis | Models, Biological | Trans-Activators - metabolism | Mice | Osteoblasts - metabolism | Wnt protein | lipoprotein receptor-related protein 5 | Index Medicus
Journal Article