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Journal Article
Journal Article
The FEBS Journal, ISSN 1742-464X, 06/2017, Volume 284, Issue 11, pp. 1657 - 1671
Snake venom metalloproteases ( SVMP s) are members of the a disintegrin and metalloprotease ( ADAM ) family of proteins, as they possess similar domains. SVMP... 
ADAM | SVMP | haemorrhage | vascular barrier | Wnt signalling | APOPTOSIS | DOMAIN | ACTIVATION | CANCER CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | BETA-CATENIN | LRP6 | TRIMERESURUS-FLAVOVIRIDIS | PURIFICATION | PROTEINS | Human Umbilical Vein Endothelial Cells | Low Density Lipoprotein Receptor-Related Protein-6 - physiology | Low Density Lipoprotein Receptor-Related Protein-5 - physiology | Species Specificity | ADAM12 Protein - metabolism | Humans | Low Density Lipoprotein Receptor-Related Protein-5 - chemistry | Wnt Signaling Pathway - physiology | Male | Metalloendopeptidases - metabolism | Membrane Proteins - pharmacology | Low Density Lipoprotein Receptor-Related Protein-6 - chemistry | ADAM Proteins - pharmacology | Protein Domains | Membrane Proteins - metabolism | Crotalid Venoms - metabolism | Drug Resistance | Recombinant Proteins - metabolism | Amino Acid Sequence | Models, Molecular | Antibodies, Neutralizing - pharmacology | Cell Adhesion - drug effects | Fibronectins - metabolism | Apoptosis Regulatory Proteins - metabolism | Sequence Homology, Amino Acid | ADAM Proteins - metabolism | Sequence Alignment | Animals | Wnt Signaling Pathway - drug effects | Cell Adhesion - physiology | Protein Structure, Secondary - drug effects | Fibrinogen - metabolism | Hydrophobic and Hydrophilic Interactions | Mice | Molecular Docking Simulation | ADAM12 Protein - pharmacology | HeLa Cells | Hemorrhage - chemically induced | Vertebrates - metabolism | Adhesions | Proteases | Proteolysis | Low density lipoproteins | Venom | Physiological aspects | Snakes | Target recognition | Wnt protein | Bites | Cytosol | Hemorrhage | Cell adhesion & migration | Proteins | β-catenin | Receptors | Cell adhesion | LRP5 protein | Cleavage | Metalloproteinase | Relocation | Recombinant | ADAM8 protein | Cadherin | Signaling | Vascular apoptosis-inducing protein 1 | Receptor density | Disruption | In vitro methods and tests | Apoptosis | Index Medicus
Journal Article
by Yan, L and Chen, J and Zhu, XC and Sun, JW and Wu, XT and Shen, WM and Zhang, WY and Tao, QH and Meng, AM
SCIENCE, ISSN 0036-8075, 11/2018, Volume 362, Issue 6417, pp. 910 - 910
Journal Article
Molecular neurobiology, ISSN 0893-7648, 03/2019, pp. 1 - 15
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with no cure, and elucidation of the mechanisms mediating neuronal death in this... 
Immunohistochemistry | Ventral horn | Spinal cord | Animal models | Wnt protein | Neurodegenerative diseases | Neuropathology | Astrocytes | Immunomodulation | Amyotrophic lateral sclerosis | Substantia alba | Gene expression | Neuromodulation | Sclerosis | Polymerase chain reaction | Proteins | LRP5 protein | Protein expression
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, pp. e0172217 - e0172217
Dysregulated Wnt signaling pathway is highly associated with the pathogenesis of several human cancers. Dickkopf proteins (DKKs) are thought to inhibit Wnt... 
MOLECULAR-DYNAMICS | PROTEIN | INHIBITION | STABILITY | MULTIDISCIPLINARY SCIENCES | DRIVEN | IDENTIFICATION | BINDING | CANCER | WEB SERVER | PREDICTION | Protein Engineering - methods | Signal Transduction | Humans | Low Density Lipoprotein Receptor-Related Protein-5 - chemistry | Intercellular Signaling Peptides and Proteins - chemistry | Peptide Library | Antineoplastic Agents - chemistry | Low Density Lipoprotein Receptor-Related Protein-6 - antagonists & inhibitors | Low Density Lipoprotein Receptor-Related Protein-6 - chemistry | Static Electricity | Wnt Proteins - chemistry | Molecular Dynamics Simulation | Thermodynamics | Wnt Signaling Pathway - drug effects | Computer Simulation | Drug Design | Protein Binding | Protein Domains | Molecular Docking Simulation | Imaging, Three-Dimensional | Wnt Proteins - antagonists & inhibitors | Binding Sites | Low Density Lipoprotein Receptor-Related Protein-5 - antagonists & inhibitors | Cellular signal transduction | Genetic aspects | Models | Disease susceptibility | Health aspects | Protein binding | Biotechnology | Wnt protein | Peptides | Pathogenesis | Molecular dynamics | Amino acids | Homology | Antagonists | Servers | Proteins | Design | Signal transduction | LRP5 protein | Docking | Bioinformatics | Heparan sulfate | Evaluation | Computer simulation | Stability analysis | Peptide inhibitors | Electrostatic properties | Embryos | Medicine | Signaling | Molecular modelling | Computer applications | Dynamic stability | Packaging | Ligands | Molecular biology | Physicochemical properties | Binding sites | Cancer | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 551 - 562
Journal Article
eLife, ISSN 2050-084X, 06/2015, Volume 4, Issue 2015, pp. 1 - 27
Wnt signalling regulates multiple processes including angiogenesis, inflammation, and tumorigenesis. Norrin (Norrie Disease Protein) is a cystine-knot like... 
blood brain barrier | mouse | stem cells | retinal disease | Wnt signalling | angiogenesis | developmental biology | crystal structure | structural biology | cystine-knot growth factor | biophysics | human | CYSTEINE-RICH DOMAIN | DENSITY MODIFICATION | PROTEIN EXPRESSION | GROWTH-FACTORS | BIOLOGY | RETINAL VASCULAR DEVELOPMENT | HEPARAN-SULFATE PROTEOGLYCANS | MACROMOLECULAR CRYSTALLOGRAPHY | CANDIDATE GENE | FAMILIAL EXUDATIVE VITREORETINOPATHY | MAMMALIAN-CELLS | Humans | Mutant Proteins - genetics | Eye Proteins - chemistry | Frizzled Receptors - metabolism | Proteoglycans - metabolism | Scattering, Small Angle | Crystallography, X-Ray | Mutant Proteins - metabolism | Nerve Tissue Proteins - genetics | Proteoglycans - chemistry | Nerve Tissue Proteins - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Nerve Tissue Proteins - chemistry | Eye Proteins - metabolism | Frizzled Receptors - chemistry | Mutant Proteins - chemistry | Low Density Lipoprotein Receptor-Related Protein-5 - metabolism | Protein Conformation | Eye Proteins - genetics | Binding Sites | Norrie disease | Glycosaminoglycans | Wnt protein | Disease | Frizzled protein | Drug development | Chromatography | Proteins | β-catenin | Angiogenesis | Signal transduction | X-ray scattering | Plasmids | Low density lipoprotein receptors | Receptor density | LRP5 protein | Tumorigenesis | Deoxyribonucleic acid--DNA | Crystal structure | Index Medicus
Journal Article
Journal of Cell Science, ISSN 0021-9533, 06/2006, Volume 119, Issue 12, pp. 2613 - 2620
Journal Article
Human Mutation, ISSN 1059-7794, 04/2009, Volume 30, Issue 4, pp. 641 - 648
Journal Article
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