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Neurobiology of Disease, ISSN 0969-9961, 12/2018, Volume 120, pp. 21 - 33
Fibrillization of α-synuclein is instrumental for the development of Parkinson's disease (PD), thus modulating this process can have profound impact on disease... 
iba-1 | Parkinson's disease | G2019S knock-in mice | LRRK2 | α-synuclein | Microglia | CHAPERONE-MEDIATED AUTOPHAGY | NEURODEGENERATION | PATHOLOGY | alpha-synuclein | SUBSTANTIA-NIGRA | NEUROSCIENCES | OVEREXPRESSION | TRANSMISSION | REPEAT KINASE 2 | MOUSE MODEL | MOTOR BEHAVIOR | PARKINSONS-DISEASE
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 05/2008, Volume 105, Issue 3, pp. 1048 - 1056
Neuritic retraction represents a prominent feature of the degenerative phenotype associated with mutations in leucine rich repeat kinase 2 (LRRK2) that are... 
autophagy | leucine‐rich repeat kinase 2 | neurite degeneration | Parkinson’s disease | extracellular signal regulated protein kinase | Neurite degeneration | Leucine-rich repeat kinase 2 | Parkinson's disease | Autophagy | Extracellular signal regulated protein kinase | leucine-rich repeat kinase 2 | DISEASE-ASSOCIATED MUTATIONS | LOCALIZATION | LEUCINE-RICH-REPEAT-KINASE-2 LRRK2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | REGULATED PROTEIN-KINASES | GTP-BINDING | NEUROSCIENCES | DEGENERATION | GENE | NEURONS | PARKINSON-DISEASE | MAP Kinase Signaling System - physiology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | DNA, Complementary - genetics | Nerve Degeneration - physiopathology | Nerve Degeneration - genetics | Vacuoles - pathology | Nerve Degeneration - metabolism | Transfection - methods | Parkinson Disease - metabolism | Autophagy - genetics | Protein Synthesis Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | Microscopy, Electron, Transmission | Ubiquitin-Activating Enzymes - genetics | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | MAP Kinase Kinase 1 - metabolism | Neurites - metabolism | Parkinson Disease - genetics | Mutation - genetics | Parkinson Disease - physiopathology | Ubiquitin-Activating Enzymes - metabolism | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Neurites - pathology | Autophagy-Related Protein 7 | MAP Kinase Signaling System - drug effects | Cell Line, Tumor | Vacuoles - metabolism | Protein kinases | Neurology | Genotype & phenotype | Biochemistry | Mutation | Cellular biology
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 4, p. e18568
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to... 
DISEASE-ASSOCIATED MUTATIONS | KINASE-ACTIVITY | R1441C MUTATION | LOCALIZATION | GENE LRRK2 | MODELS | MULTIDISCIPLINARY SCIENCES | NEURODEGENERATION | ALPHA-SYNUCLEIN | GTP-BINDING | PARKINSONS-DISEASE | Mesencephalon - metabolism | Humans | Mice, Transgenic | Mutant Proteins - metabolism | Chromatography, High Pressure Liquid | Motor Activity | Autophagy | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Protein Transport | Behavior, Animal | Neurites - pathology | Animals | Neurites - ultrastructure | Amino Acid Substitution - genetics | Mice | Dopamine - metabolism | Organ Culture Techniques | Protein-Serine-Threonine Kinases - metabolism | Mesencephalon - pathology | Mesencephalon - ultrastructure | Neurons | Genetic aspects | Neurosciences | Parkinson's disease | Parkinsons disease | Biology | Leucine | Kinases | Complexity | Engineering | Mitochondria | Neurodegeneration | Transgenic animals | Rodents | Genetics | Life sciences | Degeneration | LRRK2 protein | Age | Movement disorders | Dopamine receptors | Medical research | Dopamine | Neurodegenerative diseases | Research & development--R&D | Abnormalities | Transgenic mice | Gene expression | Mutants | Medicine | Neurology | Pathology | Brain research | Microscopy | Stem cells | Mutation | Alzheimers disease | Neurotransmission | Cancer | Research & development | R&D
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2015, Volume 78, pp. 172 - 195
Journal Article
Journal Article
Cellular and molecular life sciences, ISSN 1420-9071, 01/2013, Volume 70, Issue 1, pp. 121 - 36
Journal Article
Parkinsonism and Related Disorders, ISSN 1353-8020, 2009, Volume 16, Issue 4, pp. 237 - 242
Journal Article