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1. Full Text Neuregulin-1 is concentrated in the postsynaptic subsurface cistern of C-bouton inputs to α-motoneurons and altered during motoneuron diseases
by Gallart-Palau, Xavier and Tarabal, Olga and Casanovas, Anna and Sábado, Javier and Correa, Francisco J and Hereu, Marta and Piedrafita, Lídia and Calderó, Jordi and Esquerda, Josep E
FASEB Journal, ISSN 0892-6638, 2014, Volume 28, Issue 8, pp. 3618 - 3632
C boutons are large, cholinergic, synaptic terminals that arise from local interneurons and specifically contact spinal alpha-motoneurons (MNs). C boutons... 
Amyotrophic lateral sclerosis | Interneurons | Spinal cord ventral horn | erbB receptors | Spinal muscular atrophy | GENE-RELATED PEPTIDE | SOD1(G93A) MOUSE MODEL | DIFFERENTIAL EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | spinal cord ventral horn | AMYOTROPHIC-LATERAL-SCLEROSIS | amyotrophic lateral sclerosis | CELL BIOLOGY | PERIPHERAL-NERVE INJURY | CHOLINERGIC SYNAPSES | LUMBAR MOTONEURONS | SPINAL MUSCULAR-ATROPHY | BIOLOGY | spinal muscular atrophy | SIGMA-1 RECEPTOR | NEUROMUSCULAR-JUNCTIONS | interneurons | Organelles - chemistry | Sciatic Nerve - injuries | Spinal Cord - growth & development | Humans | Male | Post-Synaptic Density - chemistry | Sciatic Nerve - ultrastructure | Neuregulin-1 - biosynthesis | Presynaptic Terminals - ultrastructure | Motor Neurons - pathology | Neuregulin-1 - genetics | Female | Neuregulin-1 - analysis | Spinal Cord - cytology | Muscular Atrophy, Spinal - metabolism | Presynaptic Terminals - chemistry | Mice, Inbred C57BL | Avian Proteins - analysis | Neuregulin-1 - physiology | Mice, Transgenic | Post-Synaptic Density - ultrastructure | Receptor, Epidermal Growth Factor - analysis | Chick Embryo | Muscular Atrophy, Spinal - pathology | Motor Neurons - metabolism | Avian Proteins - physiology | Spinal Cord - embryology | Amyotrophic Lateral Sclerosis - pathology | Animals | Chickens | Amyotrophic Lateral Sclerosis - metabolism | Mice | Receptor, ErbB-2 - analysis | Receptor, ErbB-4
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2. Full Text Whither motoneurons?
by Brownstone, Robert M and Stuart, Douglas G
Brain Research, ISSN 0006-8993, 2011, Volume 1409, pp. 93 - 103
Abstract In the preceding series of articles, the history of vertebrate motoneuron and motor unit neurobiological studies has been discussed. In this article,... 
Neurology | Development | Embryonic stem cell | Spinal cord | Optogenetics | Motoneuron disease | Modeling | MOTOR-NEURONS | HAND MUSCLE | CONTRACTILE PROPERTIES | PERSISTENT INWARD CURRENTS | TIME-COURSE | NEUROSCIENCES | PLURIPOTENT STEM-CELLS | LUMBAR MOTONEURONS | MOUSE MODEL | NEURAL ACTIVITY | SPINAL-CORD-INJURY | Neural Stem Cells - physiology | Motor Neurons - physiology | Movement - physiology | Muscle, Skeletal - physiology | Humans | Muscle Contraction - physiology | Embryonic development | Amyotrophic lateral sclerosis | Superoxide | Embryonic stem cells | Analysis
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3. Full Text Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability
by Devlin, Anna-Claire and Burr, Karen and Borooah, Shyamanga and Foster, Joshua D and Cleary, Elaine M and Geti, Imbisaat and Vallier, Ludovic and Shaw, Christopher E and Chandran, Siddharthan and Miles, Gareth B
Nature Communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, p. 5999
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease for which a greater understanding of early disease mechanisms is needed to... 
PLURIPOTENT STEM-CELLS | AXONAL EXCITABILITY PROPERTIES | LUMBAR MOTONEURONS | CORTICAL HYPEREXCITABILITY | TDP-43 | MULTIDISCIPLINARY SCIENCES | SPINAL-CORD | AMYOTROPHIC-LATERAL-SCLEROSIS | MOTOR-NEURON DISEASE | TRANSGENIC MOUSE MODEL | HEXANUCLEOTIDE REPEAT | Cell Line | Sodium - chemistry | Cell Survival | Amyotrophic Lateral Sclerosis - genetics | Humans | Open Reading Frames | Genotype | Male | DNA-Binding Proteins - genetics | Motor Neurons - pathology | Potassium - chemistry | Action Potentials | Proteins - genetics | Patch-Clamp Techniques | Female | C9orf72 Protein | Mutation | Induced Pluripotent Stem Cells - metabolism
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4. Full Text Histamine modulates spinal motoneurons and locomotor circuits
by Coslovich, Tamara and Brumley, Michele R and D'Angelo, Giuseppe and Della Mora, Alberto and Swann, Hillary E and Ortolani, Fulvia and Taccola, Giuliano
Journal of Neuroscience Research, ISSN 0360-4012, 05/2018, Volume 96, Issue 5, pp. 889 - 900
Spinal motoneurons and locomotor networks are regulated by monoamines, among which, the contribution of histamine has yet to be fully addressed. The present... 
motoneuron | sustained depolarization | fictive locomotion | central pattern generator | BISTABLE BEHAVIOR | CORD | PLATEAU POTENTIALS | ACTIVATION | NEUROSCIENCES | LUMBAR MOTONEURONS | NEURONS | H-3 RECEPTORS | SEROTONIN | BRAIN | Marine toxins | Glutamate | Histamine | Tetrodotoxin | Neonates | Spinal cord | Glutamic acid receptors (ionotropic) | Action potential | Glutamic acid receptors | Monoamines | Subgroups | Blockage | Depolarization | Receptors | Rodents | Membrane potential | Locomotor activity | Reflexes | Tachyphylaxis | Motor neurons | Desensitization | Periodicity | Periodic variations | Locomotion | Neurology | Ventral roots | Perfusion | Rehabilitation
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5. Full Text Neuroprotection through Excitability and mTOR Required in ALS Motoneurons to Delay Disease and Extend Survival
by Saxena, Smita and Roselli, Francesco and Singh, Katyayani and Leptien, Kerstin and Julien, Jean-Pierre and Gros-Louis, Francois and Caroni, Pico
Neuron, ISSN 0896-6273, 10/2013, Volume 80, Issue 1, pp. 80 - 96
Delaying clinical disease onset would greatly reduce neurodegenerative disease burden, but the mechanisms influencing early preclinical progression are poorly... 
WILD-TYPE | LUMBAR MOTONEURONS | MOTOR-NEURON DEGENERATION | ALZHEIMERS-DISEASE | ER STRESS | CALCIUM | DEATH | AMYOTROPHIC-LATERAL-SCLEROSIS | ENDOPLASMIC-RETICULUM STRESS | TRANSGENIC MOUSE MODEL | NEUROSCIENCES | TOR Serine-Threonine Kinases - metabolism | Amyotrophic Lateral Sclerosis - genetics | Cell Survival - genetics | Male | Mice, Transgenic | Mutation - genetics | Motor Neurons - pathology | Brain - metabolism | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Animals | Amyotrophic Lateral Sclerosis - metabolism | Brain - pathology | Signal Transduction - physiology | Mice | Amyotrophic Lateral Sclerosis - chemically induced | Superoxide Dismutase-1 | Superoxide Dismutase - metabolism | Disease Models, Animal | Amyotrophic lateral sclerosis | Development and progression | Nervous system diseases | Neurosciences | Analysis | Studies | Medical research | Pathology | Biomedical research | Disease | Neurodegeneration | Rodents | Software
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6. Full Text Spinal Cholinergic Interneurons Regulate the Excitability of Motoneurons during Locomotion
by Gareth B. Miles and Robert Hartley and Andrew J. Todd and Robert M. Brownstone
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2007, Volume 104, Issue 7, pp. 2448 - 2453
To effect movement, motoneurons must respond appropriately to motor commands. Their responsiveness to these inputs, or excitability, is regulated by... 
Cholinergics | Locomotion | Spinal cord | Receptors | Interneurons | Neurons | Canals | Physiological regulation | Muscarinic receptors | Anatomy | Afterhyperpolarization | C bouton | Central pattern generator muscarinic receptors | MOTOR-NEURONS | CORD | DIFFERENTIAL EXPRESSION | RAT | central pattern generator | MULTIDISCIPLINARY SCIENCES | ACETYLCHOLINE-RECEPTOR | muscarinic receptors | IN-VITRO | LUMBAR MOTONEURONS | MUSCARINIC RECEPTOR SUBTYPES | spinal cord | C-TERMINALS | afterhyperpolarization | MODULATION | Action Potentials | Interneurons - physiology | Motor Neurons - physiology | Animals | Spinal Cord - physiology | Acetylcholine | Mice | Spinal Cord - cytology | Locomotion - physiology | Motor Activity | Receptor, Muscarinic M2 | Motor neurons | Research | Biological Sciences
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7. Full Text Persistent Inward Currents in Spinal Motoneurons and Their Influence on Human Motoneuron Firing Patterns
by Heckman, C.J and Johnson, Michael and Mottram, Carol and Schuster, Jenna
The Neuroscientist, ISSN 1073-8584, 06/2008, Volume 14, Issue 3, pp. 264 - 275
Persistent inward currents (PICs) are present in many types of neurons and likely have diverse functions. In spinal motoneurons, PICs are especially strong,... 
Electrophysiology | Spinal neuron | Norepinephrine | Serotonin | Neuromodulation | Motor unit | motor unit | norepinephrine | CAT LUMBAR MOTONEURONS | PLATEAU-LIKE BEHAVIOR | AMYOTROPHIC-LATERAL-SCLEROSIS | NEUROSCIENCES | CLINICAL NEUROLOGY | neuromodulation | MOTOR-UNIT RECRUITMENT | ACTIVE DENDRITIC CURRENTS | serotonin | VENTRAL HORN NEURONS | electrophysiology | IN-VIVO | spinal neuron | CALCIUM CURRENTS | SYNAPTIC INPUT SYSTEMS | RAT HYPOGLOSSAL MOTONEURONS | Motor Neurons - physiology | Synaptic Transmission - physiology | Humans | Muscle, Skeletal - innervation | Dendrites - ultrastructure | Ion Channels - physiology | Muscle, Skeletal - physiology | Action Potentials - physiology | Neural Inhibition - physiology | Animals | Dendrites - physiology | Spinal Cord - physiology | Biogenic Monoamines - physiology | Spinal Cord - cytology | Motor neurons | Spine | Physiological aspects | Influence | Research | Properties | Noradrenaline | Electric properties
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8. Full Text Transcriptional changes in rat α-motoneurons resulting from increased physical activity
by Woodrow, L and Sheppard, P and Gardiner, P.F
Neuroscience, ISSN 0306-4522, 2013, Volume 255, pp. 45 - 54
Highlights • Rat lumbar motoneurons from exercised rats were harvested by laser capture microdissection for the analysis of specific mRNAs. • mRNA contents of... 
Neurology | α-motoneurons | laser capture microdissection | gene expression | exercise training | Laser capture microdissection | Exercise training | Gene expression | PLATEAU POTENTIALS | TURTLE MOTONEURONS | METABOTROPIC GLUTAMATE RECEPTORS | NEUROSCIENCES | HUMAN SKELETAL-MUSCLE | SUBUNIT MESSENGER-RNAS | SCIATIC-NERVE | LUMBAR SPINAL-CORD | GENE-EXPRESSION | GABA(A) RECEPTORS | GABAERGIC TERMINALS | alpha-motoneurons | Motor Neurons - physiology | Transcriptome | Laser Capture Microdissection | Rats | Physical Conditioning, Animal - physiology | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Animals | Lumbosacral Region | Gene Expression - physiology | Female | Transcription, Genetic | RNA, Messenger
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9. Full Text Spike threshold dynamics in spinal motoneurons during scratching and swimming
by Grigonis, Ramunas and Alaburda, Aidas
The Journal of Physiology, ISSN 0022-3751, 09/2017, Volume 595, Issue 17, pp. 5843 - 5855
Action potential threshold can vary depending on firing history and synaptic inputs. We used an ex vivo carapace–spinal cord preparation from adult turtles to... 
action potential threshold | motoneuron excitability | motor network activity | NEURONS IN-VIVO | PHYSIOLOGY | HIGH-CONDUCTANCE STATES | RESPONSE PROPERTIES | LUMBAR MOTONEURONS | FREQUENCY ADAPTATION | COINCIDENCE DETECTION | FICTIVE LOCOMOTION | NETWORK ACTIVITY | VOLTAGE THRESHOLD | INJECTED CURRENTS | NEUROSCIENCES | Action Potentials | Swimming - physiology | Motor Neurons - physiology | Animals | Turtles - physiology | Spinal Cord - physiology | Behavior, Animal - physiology | Female | Male | In Vitro Techniques | Neural networks | Swimming | Spinal cord | Stabilization | Action potential | Activation | Motor task performance | Reptiles & amphibians | Recruitment | Depolarization | Dynamics | Scratching | Commands | Behavior | Membrane potential | Motor neurons | Firing pattern | Integration | Firing | Excitability | Muscle contraction | Spikes | Dynamic tests | Bursts | Turtles | Bursting | Research Paper | Neuroscience ‐ Cellular | Molecular
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10. Full Text Motoneuron output regulated by ionic channels: a modeling study of motoneuron frequency-current relationships during fictive locomotion
by Dai, Yue and Dai, Yue and Cheng, Yi and Fedirchuk, Brent and Jordan, Larry M and Jordan, Larry M and Chu, Junhao and Chu, Junhao
Journal of neurophysiology, ISSN 0022-3077, 10/2018, Volume 120, Issue 4, pp. 1840 - 1858
Cat lumbar motoneurons display changes in membrane properties during fictive locomotion. These changes include reduction of input resistance and... 
motoneuron excitability | modeling | F-I relationship | ion channels | locomotion | SODIUM CURRENT | PLATEAU POTENTIALS | PHYSIOLOGY | PERSISTENT INWARD CURRENT | SYSTEMATIC VARIATIONS | ALPHA-MOTONEURONS | SPINAL MOTONEURONS | NEUROSCIENCES | LUMBAR MOTONEURONS | HINDLIMB MOTONEURONS | VOLTAGE THRESHOLD | ACTIVITY-RELATED NEURONS
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11. Full Text Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion
by Bos, Rémi and Harris-Warrick, Ronald M and Brocard, Cécile and Brocard, Frédéric and Demianenko, Liliia E and Manuel, Marin and Zytnicki, Daniel and Korogod, Sergiy M
Cell Reports, ISSN 2211-1247, 03/2018, Volume 22, Issue 12, pp. 3315 - 3327
Spinal motoneurons are endowed with nonlinear spiking behaviors manifested by a spike acceleration whose functional significance remains uncertain. Here, we... 
motoneuron | bistability | spinal cord | Kv1.2 | potassium channels | locomotion | FIRING PROPERTIES | MOTOR UNIT RECRUITMENT | LUMBAR MOTONEURONS | INTRINSIC-PROPERTIES | POTASSIUM CHANNELS | PLATEAU-LIKE BEHAVIOR | HINDLIMB MOTONEURONS | MOUSE SPINAL MOTONEURONS | ELECTRICAL-PROPERTIES | K+ CHANNELS | CELL BIOLOGY | Life Sciences | Neurons and Cognition | Neurobiology
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