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JACC: Cardiovascular Imaging, ISSN 1936-878X, 2012, Volume 5, Issue 8, pp. 819 - 828
OBJECTIVES The aim of this study was to noninvasively detect the anti-inflammatory properties of the novel liver X receptor agonist R211945. BACKGROUND R211945... 
Comparative Study | Research Support, Non-U.S. Gov't | Journal Article | Research Support, N.I.H., Extramural | ABCA1 | computed tomography | arbitrary units | VEGF | LXR | standard uptake value | FDG | a.u | area under the curve | fluorodeoxyglucose | AUC | SUV | vascular endothelial growth factor | ATP-binding cassette transporter A1 | liver X receptor | positron emission tomography | dynamic contrast-enhanced cardiac magnetic resonance | PET | DCE-CMR | atherosclerosis | F-18-FDG-PET/CT | PATHWAYS | CARDIAC & CARDIOVASCULAR SYSTEMS | MACROPHAGES | dynamic contrast-enhanced | MECHANISMS | PLAQUES | HYPOXIA | LXR agonist | HIGH-DENSITY-LIPOPROTEIN | CHOLESTEROL TRANSPORT | DISEASE | cardiac magnetic resonance | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | CARDIOVASCULAR RISK | ENDOTHELIAL GROWTH-FACTOR | Immunohistochemistry | Rabbits | Apolipoproteins B - metabolism | Plaque, Atherosclerotic - metabolism | Heptanoic Acids - therapeutic use | Orphan Nuclear Receptors - agonists | Tomography, X-Ray Computed | Treatment Outcome | Positron-Emission Tomography | Disease Progression | Atorvastatin Calcium | Multimodal Imaging | Macrophages - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Liver X Receptors | Fluorodeoxyglucose F18 | Plaque, Atherosclerotic - drug therapy | Pyrroles - therapeutic use | Radiopharmaceuticals | 18F-FDG–PET
Journal Article
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 07/2014, Volume 62, Issue 26, pp. 6130 - 6137
Journal Article
Advanced Healthcare Materials, ISSN 2192-2640, 10/2017, Volume 6, Issue 20, p. n/a
The pharmacological manipulation of liver X receptors (LXRs) has been an attractive therapeutic strategy for atherosclerosis treatment as they control reverse... 
atherosclerosis | targeted drug delivery | nanoparticles | liver X receptor (LXR) | GW3965 | PEGYLATED LIPOSOMAL DOXORUBICIN | MATERIALS SCIENCE, BIOMATERIALS | CHOLESTEROL | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | RESOLUTION | CARDIOTOXICITY | NANOSCIENCE & NANOTECHNOLOGY | CELLULAR UPTAKE | INFLAMMATION | GENE-EXPRESSION | POLYMER HYBRID NANOPARTICLES | Liver - pathology | Benzoates - therapeutic use | Nanoparticles - chemistry | Benzoates - chemistry | Cholesterol - blood | Polyethylene Glycols - chemistry | Collagen Type IV - chemistry | Drug Carriers - chemistry | Liver - drug effects | Liver X Receptors - agonists | Nanoparticles - metabolism | Receptors, LDL - deficiency | Nanomedicine | Disease Models, Animal | Collagen Type IV - metabolism | Receptors, LDL - genetics | Atherosclerosis - pathology | Atherosclerosis - drug therapy | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Macrophages - cytology | Atherosclerosis - metabolism | Mice, Knockout | Benzylamines - chemistry | Macrophages - metabolism | Animals | Lipid Metabolism - drug effects | Triglycerides - blood | Benzoates - pharmacology | Macrophages - drug effects | Mice | Benzylamines - pharmacology | Benzylamines - therapeutic use | Drugs | Complications and side effects | Drug delivery systems | Liver | Atherosclerosis | Physiological aspects | Polyols | Vehicles | Encapsulation | Polyethylenes | Lipids | Inflammatory response | Biosynthesis | Macrophages | Nanoparticles | Receptors | Polyethylene glycol | Rodents | liver X receptors | Lipoprotein (low density) receptors | Collagen (type IV) | Lipid metabolism | Lesions | Polyethylene | Hyperlipidemia | Pharmacology | Inflammation | Metabolism | Cholesterol | Arteriosclerosis
Journal Article
Journal Article
Journal of Biomolecular Screening, ISSN 1087-0571, 4/2014, Volume 19, Issue 4, pp. 566 - 574
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 2009, Volume 50, Issue 2, pp. 312 - 326
Liver X receptors (LXRs) are important regulators of cholesterol and lipid metabolism. LXR agonists have been shown to limit the cellular cholesterol content... 
Liver X receptor | Atherogenesis | Gene expression | ABC transporter | Cholesterol catabolism | atherogenesis | CELLULAR CHOLESTEROL | DIETARY-CHOLESTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN | X-RECEPTOR | PLASMA HDL CHOLESTEROL | cholesterol catabolism | NUCLEAR RECEPTOR LXR | OXYSTEROL RECEPTORS | GENE-EXPRESSION | LIGAND | liver X receptor | TRANSCRIPTION FACTOR | gene expression | Male | Fatty Liver - chemically induced | RNA, Messenger - metabolism | Apolipoproteins E - metabolism | DNA-Binding Proteins - metabolism | ATP-Binding Cassette Transporters - genetics | DNA-Binding Proteins - agonists | Time Factors | Liver X Receptors | ATP-Binding Cassette Transporters - metabolism | Female | Orphan Nuclear Receptors | ATP Binding Cassette Transporter 1 | Cholic Acids - therapeutic use | Foam Cells - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Atherosclerosis - pathology | Atherosclerosis - drug therapy | Mice, Inbred C57BL | Mice, Transgenic | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | DNA-Binding Proteins - genetics | Hypertriglyceridemia - chemically induced | Macrophages - metabolism | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Apolipoproteins E - genetics | Mice | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2008, Volume 233, Issue 2, pp. 193 - 202
Chlordecone (CD) is one of many banned organochlorine (OC) insecticides that are widespread persistent organic pollutants. OC insecticides alter lipid... 
Estrogen receptor α | Liver X receptors | Chlordecone | Pregnane X receptor | Organochlorine insecticides | Apolipoproteins | Cholesterol | CELLS | LIPID-METABOLISM | RAINBOW-TROUT | NUCLEAR RECEPTORS | DEFICIENT MICE | INDUCTION | LXR-ALPHA | LIVER | PHARMACOLOGY & PHARMACY | Estrogen receptor alpha | TOXICOLOGY | BINDING | BILE-ACIDS | Humans | Microsomes, Liver - metabolism | Apolipoprotein B-48 - metabolism | Chlordecone - toxicity | Male | Receptors, Steroid - agonists | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Insecticides - administration & dosage | Apolipoprotein B-100 - metabolism | Estrogen Receptor alpha - agonists | Microsomes, Liver - drug effects | Liver X Receptors | Lipoproteins - metabolism | Membrane Proteins - metabolism | Cytochrome P-450 CYP3A - drug effects | Homeostasis - drug effects | Orphan Nuclear Receptors | Apolipoprotein A-I - drug effects | Cell Line | Chlordecone - administration & dosage | Receptors, Cytoplasmic and Nuclear - drug effects | Mice, Inbred C57BL | DNA-Binding Proteins - drug effects | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Animals | Cytochrome P-450 CYP3A - metabolism | Membrane Proteins - drug effects | Genes, Reporter - drug effects | Mice | Transcription Factors | Lipoproteins - drug effects | Apolipoprotein B-100 - drug effects | Apolipoprotein B-48 - drug effects | Insecticides - toxicity | Receptors, Cytoplasmic and Nuclear - metabolism | Proteolipids | Lipoproteins | Estrogen | Physiological aspects | Homeostasis | Phenols | Blood lipoproteins | Organic compounds | Index Medicus | ESTROGENS | HOMEOSTASIS | ORGANIC CHLORINE COMPOUNDS | CHOLESTEROL | POLLUTANTS | CARBON 14 | RATS | APOLIPOPROTEINS | 60 APPLIED LIFE SCIENCES | METABOLISM | DOSES | IN VITRO | MICROSOMES | TISSUE DISTRIBUTION | ESTERS | MICE | RECEPTORS | INSECTICIDES
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, p. e0172161
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 12/2014, Volume 92, Issue 3, pp. 438 - 447
Liver X receptor α (LXRα) plays an important role in the cholesterol metabolism process, and LXRα activation can reduce atherosclerosis. In the present study,... 
LXRα | Partial agonist | Atherosclerosis | Cholesterol efflux | TRANSCRIPTION FACTORS | ACTIVATION | STIMULATION | NUCLEAR RECEPTOR | EFFLUX | GENE | PATHWAY | LXR alpha | PHARMACOLOGY & PHARMACY | LIPID HOMEOSTASIS | EXPRESSION | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Humans | Hydrocarbons, Fluorinated - pharmacology | Orphan Nuclear Receptors - metabolism | Apolipoproteins E - metabolism | ATP Binding Cassette Transporter 1 - metabolism | Hep G2 Cells - drug effects | Lipogenesis - genetics | Liver X Receptors | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Caco-2 Cells - metabolism | Membrane Proteins - metabolism | Binding Sites | Quinazolinones - pharmacology | Recombinant Proteins - metabolism | Drug Evaluation, Preclinical - methods | Orphan Nuclear Receptors - agonists | Recombinant Proteins - genetics | Cholesterol - metabolism | Sulfonamides - pharmacology | Orphan Nuclear Receptors - genetics | Caco-2 Cells - drug effects | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Lipogenesis - drug effects | Lipid Metabolism - drug effects | Macrophages - drug effects | ATP Binding Cassette Transporter, Sub-Family G, Member 8 | Mice | Molecular Docking Simulation | Benzodioxoles - pharmacology | ATP Binding Cassette Transporter, Sub-Family G, Member 5
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 09/2019, Volume 63, Issue 9
The mosquito-borne chikungunya virus (CHIKV) causes acute pain and joint inflammation, and in recent years the virus has caused large epidemics in previously... 
CHOLESTEROL | LXR | host-targeting antiviral | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | INFECTION | virus | chikungunya
Journal Article