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by Wei, G and Xu, QQ and Liu, L and Zhang, HH and Tan, X and Zhang, CH and Han, CY and Guo, YX and Han, GW and Zhang, CM
ARCHIVES OF DERMATOLOGICAL RESEARCH, ISSN 0340-3696, 10/2018, Volume 310, Issue 8, pp. 615 - 623
Hypertrophic scars (HS) are fibro-hyperproliferative dermal lesions with effusive continuous accumulation of extracellular matrix components, particularly... 
FIBROSIS | CELLS | TGF-BETA | METASTASIS | Hypertrophic scars | TISSUE | Transforming growth factor beta | KELOID FIBROBLASTS | CANCER | DERMATOLOGY | LY2109761 | GROWTH-FACTOR-BETA | alpha-Smooth muscle actin | Collagen | INHIBITOR | EXPRESSION | Bone morphogenetic proteins | Muscle proteins | Transforming growth factors | Cell differentiation | Actin
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 09/2018, Volume 355, pp. 127 - 137
Fibrosis is a pathophysiological state characterized by the excessive formation/deposition of fibrous extracellular matrix. Transforming growth factor-beta... 
LY2109761 | TGF-β | Ex vivo | In vitro | Fibrosis | To be checked by Faculty | RECEPTOR-TYPE-I | CUT LIVER SLICES | BONE MORPHOGENETIC PROTEIN | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | GALUNISERTIB LY2157299 | Er vivo | TGF-beta | HEPATIC STELLATE CELLS | COLLAGEN TYPE-I | SIGNALING PATHWAY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | EXPRESSION | Index Medicus
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 10/2016, Volume 139, Issue 8, pp. 1894 - 1903
Journal Article
European Review for Medical and Pharmacological Sciences, ISSN 1128-3602, 2015, Volume 19, Issue 7, pp. 1182 - 1190
OBJECTIVE: Studies have shown that transforming growth factor-beta (TGF-beta) is associated with metastasis and chemoresistance of osteosarcoma. The TGF-beta... 
LY2109761 | Transforming growth factor-beta | Chemotherapy | Metastasis | Osteosarcoma | CARCINOMA-CELLS | PANCREATIC-CANCER | S100A4 EXPRESSION | growth factor-beta | OVARIAN-CARCINOMA | EPITHELIAL-MESENCHYMAL TRANSITION | OVEREXPRESSION | GROWTH-FACTOR-BETA | IN-VITRO | INVASION | Transforming | PHARMACOLOGY & PHARMACY | CALCIUM-BINDING PROTEIN
Journal Article
Journal Article
Archives of Dermatological Research, ISSN 0340-3696, 10/2018, Volume 310, Issue 8, pp. 615 - 623
Journal Article
DNA and Cell Biology, ISSN 1044-5498, 11/2018, Volume 37, Issue 11, pp. 909 - 916
To understand the molecular mechanism underlying the causal relationship between aberrant upregulation of transforming growth factor beta (TGF-β) and... 
LY2109761 | glioma | TGF-β | radiation | DNA repair | RNA, Small Interfering - genetics | Neuroglia - pathology | Humans | Gamma Rays - therapeutic use | DNA Repair - radiation effects | MutS Homolog 2 Protein - metabolism | Glioma - genetics | ATP-Binding Cassette Transporters - genetics | Glioma - pathology | Brain Neoplasms - mortality | DNA Glycosylases - metabolism | DNA Repair - drug effects | Tumor Suppressor Proteins - metabolism | Glioma - mortality | DNA Modification Methylases - metabolism | Signal Transduction | Brain Neoplasms - genetics | Smad Proteins - genetics | MutS Homolog 2 Protein - genetics | Cell Movement - drug effects | MutL Protein Homolog 1 - genetics | Brain Neoplasms - therapy | Survival Analysis | Cell Line, Tumor | Mice | DNA Damage | RNA, Small Interfering - metabolism | Tumor Suppressor Proteins - antagonists & inhibitors | DNA Modification Methylases - antagonists & inhibitors | Brain Neoplasms - pathology | DNA Repair Enzymes - genetics | Gene Expression Regulation, Neoplastic | Neuroglia - drug effects | Tumor Suppressor Proteins - genetics | DNA Repair Enzymes - metabolism | Glioma - therapy | ATP-Binding Cassette Transporters - metabolism | Transforming Growth Factor beta - antagonists & inhibitors | DNA Repair Enzymes - antagonists & inhibitors | Pyrazoles - pharmacology | DNA Glycosylases - genetics | Cell Movement - radiation effects | Xenograft Model Antitumor Assays | Neuroglia - radiation effects | DNA Modification Methylases - genetics | Pyrroles - pharmacology | Animals | Transforming Growth Factor beta - genetics | Neuroglia - metabolism | Cell Proliferation - drug effects | MutL Protein Homolog 1 - metabolism | Smad Proteins - metabolism | Transforming Growth Factor beta - metabolism | Cell Proliferation - radiation effects | VITRO | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA | CELL BIOLOGY | BREAST-CANCER | TGF-beta | GROWTH | GENETICS & HEREDITY | RESISTANCE | I KINASE INHIBITOR | Radiation effects | Smad protein | Transforming growth factor-b | Genes | Xenotransplantation | Radiation | Gene expression | Real time | Survival | Western blotting | Polymerase chain reaction | Signal transduction | Signaling | Glioma cells | Xenografts | Irradiation | In vivo methods and tests | Repair | Growth factors | Deoxyribonucleic acid--DNA | Tumors
Journal Article
Journal of Crohn's and Colitis, ISSN 1873-9946, 02/2015, Volume 9, Issue suppl 1
Intestinal fibrosis (IF) is a common complication in Crohn's disease. Currently, there are no drugs registered to treat IF and the sole therapy is intestinal... 
sunitinib | platelet derived growth factor | sorafenib | imatinib | alpha smooth muscle actin | valproic acid | connective tissue growth factor | mouse | heat shock protein 47 | fibronectin | pirfenidone | transforming growth factor beta1 | collagen type 1 | jejunum | intestinal fibrosis | ly2109761 | tetrandrine | gene expression
Journal Article
OncoImmunology, ISSN 2162-4011, 09/2012, Volume 1, Issue 6, pp. 943 - 945
To improve multimodal glioblastoma treatment strategies, it appears useful to integrate a selective inhibitor of the TβR-I kinase, which may be able to... 
TGFβ | radiotherapy | stem cells | combination therapy | glioblastoma | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Combination therapy | Radiotherapy | Glioblastoma | Stem cells | CELLS | ONCOLOGY | PROGNOSIS | GLIOMA | IMMUNOLOGY | TGF beta | KINASE INHIBITOR LY2109761 | Author's View
Journal Article
International Journal of Clinical and Experimental Pathology, ISSN 1936-2625, 2015, Volume 8, Issue 5, pp. 4923 - 4932
Background and Objective: Ovarian cancer is among the most lethal of all malignancies in women. While chemotherapy is the preferred treatment modality,... 
LY2109761 | Transforming growth factor-beta | Chemotherapy | Ovarian cancer | TGF-BETA | PATHOLOGY | MESENCHYMAL TRANSITION | chemotherapy | transforming growth factor-beta | GROWTH-FACTOR-BETA | ONCOLOGY | TRANSFORMING GROWTH-FACTOR-BETA-1 | RESISTANCE | CHEMORESISTANCE | INHIBITOR | RECEPTORS | CARCINOMA | EXPRESSION | Receptor, Transforming Growth Factor-beta Type I | Phosphorylation | Apoptosis - drug effects | Humans | Ovarian Neoplasms - pathology | Drug Resistance, Neoplasm | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Receptor, Transforming Growth Factor-beta Type II | Time Factors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Ovarian Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Cell Survival - drug effects | Neoplasms, Glandular and Epithelial - pathology | Smad2 Protein - metabolism | Cisplatin - pharmacology | Mice, SCID | Mice, Inbred ICR | Ovarian Neoplasms - enzymology | Neoplasms, Glandular and Epithelial - enzymology | Xenograft Model Antitumor Assays | Pyrroles - pharmacology | Animals | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Tumor Burden - drug effects | Neoplasms, Glandular and Epithelial - drug therapy | Carcinoma, Ovarian Epithelial | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Transforming Growth Factor beta - metabolism
Journal Article
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