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Science, ISSN 0036-8075, 3/2009, Volume 323, Issue 5920, pp. 1488 - 1492
Most of the immunoglobulin A (IgA) in the gut is generated by B cells in the germinal centers of Peyer's patches through a process that requires the presence... 
T lymphocytes | Spleen | Molecules | Peyers patches | Cytokines | B lymphocytes | Plasma cells | AIDS | Reports | Mice | Small intestine | GERMINAL CENTER FORMATION | CXC CHEMOKINE RECEPTOR-5 | POPULATION | ACTIVATION | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | RETINOIC-ACID | DIFFERENTIATION | INTERLEUKIN-21 | LAMINA PROPRIA | EXPRESSION | T-Lymphocyte Subsets - immunology | T-Lymphocytes, Regulatory - metabolism | Spleen - immunology | T-Lymphocyte Subsets - cytology | Dendritic Cells - immunology | Germinal Center - immunology | Gene Expression Profiling | Adoptive Transfer | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | CD40 Antigens - metabolism | Forkhead Transcription Factors - metabolism | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - cytology | T-Lymphocytes, Regulatory - cytology | Cell Differentiation | Intestine, Small - immunology | T-Lymphocytes, Helper-Inducer - metabolism | Lymphocyte Activation | CD4-Positive T-Lymphocytes - cytology | Down-Regulation | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | Spleen - cytology | Lymph Nodes - immunology | Forkhead Transcription Factors - genetics | Lymph Nodes - cytology | Peyer's Patches - cytology | Animals | B-Lymphocytes - immunology | Intestine, Small - cytology | T-Lymphocyte Subsets - metabolism | Dendritic Cells - cytology | Immunoglobulin A, Secretory - biosynthesis | Peyer's Patches - immunology | Lymphatic system | Immunology | Cellular biology | Gene expression | Rodents | Index Medicus
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 4/2014, Volume 63, Issue 4, pp. 395 - 406
The programmed death-1 (PD-1) molecule is mainly expressed on functionally “exhausted” CD8+ T cells, dampening the host antitumor immune response. We evaluated... 
Immunology | Medicine & Public Health | Oncology | Cancer Research | Breast cancer | Immune evasion | Regulatory T cells | Cancer immunotherapy | PD-1 | APOPTOSIS | PROGNOSIS | TUMOR | RISK | ANTIBODY | IMMUNOLOGY | CHEMOTHERAPY | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | IMMUNOTHERAPY | CD8(+) T-LYMPHOCYTES | B7-H1 | Carcinoma, Lobular - pathology | Follow-Up Studies | Breast Neoplasms - immunology | Humans | Middle Aged | Programmed Cell Death 1 Receptor - analysis | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Antigens, Differentiation, T-Lymphocyte - analysis | Aged, 80 and over | Carcinoma, Ductal, Breast - pathology | Lymphocytes, Tumor-Infiltrating - chemistry | T-Lymphocytes, Regulatory - chemistry | Carcinoma, Lobular - immunology | CD8-Positive T-Lymphocytes - chemistry | Combined Modality Therapy | Carcinoma, Lobular - radiotherapy | T-Lymphocyte Subsets - pathology | Carcinoma, Ductal, Breast - radiotherapy | Forkhead Transcription Factors - analysis | Survival Analysis | CD8-Positive T-Lymphocytes - immunology | Lymphocytes, Tumor-Infiltrating - immunology | T-Lymphocyte Subsets - immunology | Breast Neoplasms - surgery | CD8-Positive T-Lymphocytes - pathology | Prognosis | Carcinoma, Ductal, Breast - immunology | Carcinoma, Ductal, Breast - mortality | Carcinoma, Lobular - mortality | T-Lymphocytes, Cytotoxic - pathology | T-Lymphocyte Subsets - chemistry | Mastectomy | Adult | Female | Radiotherapy, Adjuvant | T-Lymphocytes, Cytotoxic - immunology | Carcinoma, Ductal, Breast - surgery | Carcinoma, Lobular - surgery | Kaplan-Meier Estimate | Disease-Free Survival | Breast Neoplasms - radiotherapy | T-Lymphocytes, Cytotoxic - chemistry | Apoptosis - immunology | Lymphocytes, Tumor-Infiltrating - pathology | Breast Neoplasms - pathology | Lymphocyte Count | Breast Neoplasms - mortality | Aged | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, pp. e31318 - e31318
Background: Ursolic acid (UA), a pentacyclic triterpenoid carboxylic acid, is the major component of many plants including apples, basil, cranberries,... 
SIGNAL-TRANSDUCTION | RESPONSES | ACTIVATION | CYCLOSPORINE-A | CELL-RECEPTOR STIMULATION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | FACTOR-ALPHA GENE | INHALED CORTICOSTEROIDS | T-CELLS | OLEANOLIC ACID | CD8-Positive T-Lymphocytes - cytology | Reactive Oxygen Species - metabolism | Triterpenes - pharmacology | Mitogens - pharmacology | Concanavalin A - pharmacology | NF-kappa B - metabolism | CD4-Positive T-Lymphocytes - enzymology | Graft vs Host Disease - immunology | Transcription Factor AP-1 - metabolism | Lymphocyte Activation - genetics | Macrophages - secretion | B-Lymphocytes - secretion | Oxidation-Reduction - drug effects | B-Lymphocytes - cytology | B-Lymphocytes - enzymology | Anti-Inflammatory Agents - pharmacology | Antibodies, Monoclonal - pharmacology | CD4-Positive T-Lymphocytes - cytology | NFATC Transcription Factors - metabolism | Cytokines - secretion | CD28 Antigens - immunology | Antioxidants - pharmacology | Macrophages - cytology | CD8-Positive T-Lymphocytes - enzymology | Graft vs Host Disease - pathology | Up-Regulation - drug effects | B-Lymphocytes - drug effects | Animals | CD4-Positive T-Lymphocytes - secretion | CD8-Positive T-Lymphocytes - secretion | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | CD3 Complex - immunology | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | CD4-Positive T-Lymphocytes - drug effects | Mitogen-Activated Protein Kinases - metabolism | Graft-versus-host reaction | Transcription factors | Oregano | Cancer therapies | Cranberries | Anticancer properties | Proteins | Antioxidants | Cell activation | Cell growth | Inhibition | Enzymes | NF-κB protein | Cytokines | Albinism | Immunoregulation | Activator protein 1 | Peppermint | Prunes | JNK protein | T cell receptors | Carboxylic acids | Serum levels | Apples | γ-Interferon | Rosemary | Ursolic acid | Cell proliferation | Health sciences | Phosphorylation | Ordination | Homeostasis | Lymphocytes T | Transplantation | Biology | Activation | NF-AT protein | Kinases | Macrophages | Inflammatory diseases | Interleukin 6 | Lymphocytes | Transcription activation | Cell cycle | Tumor necrosis factor-TNF | Statistical analysis | Antiinflammatory agents | Secretion | Extracellular signal-regulated kinase | Inflammation | Pharmacology | Acids | Lymphocytes B | Interferon | Alzheimers disease | Apoptosis | Index Medicus
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 07/2008, Volume 118, Issue 7, pp. 2427 - 2437
Cancer is associated with immune deficiency, but the biologic basis of this is poorly defined. Here we demonstrate that impaired actin polymerization results... 
B-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | RESPONSES | ACTIVATION | LYTIC FUNCTION | IMMUNOTHERAPY | ACTIN POLYMERIZATION | GENE-EXPRESSION | LENALIDOMIDE | MALIGNANCIES | CANCER | Protein-Tyrosine Kinases - metabolism | Humans | Actins - metabolism | Lymphocyte Function-Associated Antigen-1 - metabolism | Thalidomide - pharmacology | Lymphocyte Culture Test, Mixed | CD4-Positive T-Lymphocytes - immunology | Thalidomide - analogs & derivatives | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | CD8-Positive T-Lymphocytes - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - blood | Antineoplastic Agents - pharmacology | Microfilament Proteins - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Interleukin-2 - metabolism | T-Lymphocytes, Cytotoxic - immunology | Receptors, Antigen, T-Cell - metabolism | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | Superantigens - immunology | Antigen Presentation - immunology | Mice, Inbred Strains | B-Lymphocytes - drug effects | Animals | B-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - drug effects | T-Lymphocytes - immunology | Antigen Presentation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | CD4-Positive T-Lymphocytes - drug effects | Immunologic Factors - pharmacology | Polymerization | Chronic lymphocytic leukemia | T cells | Muscle proteins | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 02/2011, Volume 71, Issue 4, pp. 1263 - 1271
The tumor microenvironment includes a complex network of immune T-cell subpopulations. In this study, we systematically analyzed the balance between cytotoxic... 
BREAST-CANCER | SURVIVAL | LUNG-CANCER | FOXP3 EXPRESSION | RECRUITMENT | ONCOLOGY | GASTRIC-CANCER | EOSINOPHILS | MACROPHAGES | CARCINOMA | LYMPHOCYTES | Th1 Cells - pathology | Th1 Cells - physiology | Prognosis | Th2 Cells - physiology | Tissue Array Analysis | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Carcinoma - mortality | Gene Expression Profiling | Th2 Cells - immunology | Th1 Cells - immunology | Colorectal Neoplasms - diagnosis | Lymphocytes, Tumor-Infiltrating - physiology | T-Lymphocytes, Cytotoxic - pathology | Th1 Cells - metabolism | Th17 Cells - metabolism | Forkhead Transcription Factors - metabolism | Microarray Analysis | T-Lymphocytes, Helper-Inducer - immunology | Lymphocytes, Tumor-Infiltrating - metabolism | T-Lymphocytes, Helper-Inducer - pathology | Interleukin-4 - genetics | Th2 Cells - pathology | Th17 Cells - pathology | Colorectal Neoplasms - mortality | T-Lymphocytes, Cytotoxic - immunology | Th17 Cells - physiology | T-Lymphocytes, Helper-Inducer - metabolism | Carcinoma - immunology | Interleukin-4 - metabolism | Carcinoma - diagnosis | Forkhead Transcription Factors - genetics | Th2 Cells - metabolism | T-Lymphocytes, Cytotoxic - physiology | T-Lymphocytes, Helper-Inducer - physiology | Colorectal Neoplasms - immunology | Lymphocytes, Tumor-Infiltrating - pathology | T-Lymphocytes, Cytotoxic - metabolism | Survival Analysis | Th17 Cells - immunology | Carcinoma - genetics | Cohort Studies | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, pp. 20254 - 20254
Tumor cell-derived exosomes (TEX) suppress functions of immune cells. Here, changes in the gene profiles of primary human T lymphocytes exposed in vitro to... 
MESSENGER-RNAS | CANCER-PATIENTS | EXTRACELLULAR VESICLES | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | MICROVESICLES | DIAGNOSTIC BIOMARKERS | INDUCE APOPTOSIS | OVARIAN-CANCER | MODULATION | LYMPHOCYTES | Exosomes - metabolism | Neoplasms - metabolism | CD8-Positive T-Lymphocytes - cytology | T-Lymphocytes, Regulatory - metabolism | T-Lymphocyte Subsets - cytology | Humans | Culture Media, Conditioned - pharmacology | RNA, Messenger - metabolism | Antigens, CD - metabolism | Lectins, C-Type - metabolism | T-Lymphocyte Subsets - drug effects | T-Lymphocytes, Regulatory - cytology | CD8-Positive T-Lymphocytes - metabolism | Real-Time Polymerase Chain Reaction | Microscopy, Electron, Transmission | CD4-Positive T-Lymphocytes - cytology | Apyrase - metabolism | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Antigens, Differentiation, T-Lymphocyte - metabolism | Down-Regulation - drug effects | Up-Regulation - drug effects | T-Lymphocytes, Regulatory - drug effects | T-Lymphocyte Subsets - metabolism | CD8-Positive T-Lymphocytes - drug effects | Adenosine - metabolism | Neoplasms - pathology | CD4-Positive T-Lymphocytes - drug effects | Microscopy, Fluorescence | Adenosine | Dendritic cells | CD8 antigen | Gene regulation | Data processing | T cell receptors | Lymphocytes T | Gene expression | Exosomes | Cell surface | CD4 antigen | Polymerase chain reaction | CD69 antigen | Cell activation | Lymphocytes | Down-regulation | Peripheral blood | Index Medicus
Journal Article
2011, Methods in molecular biology, ISBN 1617379786, Volume 707., xi, 282
Book
European Journal of Immunology, ISSN 0014-2980, 07/2016, Volume 46, Issue 7, pp. 1770 - 1782
We previously demonstrated an accumulation of tumor‐reactive CD4 + CD8 + double positive (DP) T cells within melanoma‐infiltrating lymphocytes, supporting... 
CD4 | double‐positive T lymphocyte | CD8 | TIL | Melanoma | IL‐9R | IL‐9 | IL-9R | double-positive T lymphocyte | IL-9 | TH9 CELLS | CD8(+) | INDUCED APOPTOSIS | INTERLEUKIN-9 | RECEPTOR | PERIPHERAL-BLOOD | IMMUNOLOGY | CYTOKINE EXPRESSION | IN-VIVO | CD4(+) CD8(+) double-positive T lymphocyte | GROWTH-FACTOR | LYMPHOCYTES | T-Lymphocyte Subsets - immunology | Apoptosis - drug effects | Humans | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - immunology | Interleukin-9 - pharmacology | Melanoma - genetics | T-Lymphocyte Subsets - drug effects | CD8-Positive T-Lymphocytes - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Cytotoxicity, Immunologic - drug effects | Melanoma - metabolism | Receptors, Interleukin-9 - metabolism | Gene Expression | Cytokines - metabolism | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Lymphocytes, Tumor-Infiltrating - drug effects | Melanoma - pathology | Cell Survival - immunology | Apoptosis - immunology | Receptors, Interleukin-9 - genetics | Lymphocyte Activation - drug effects | Melanoma - immunology | T-Lymphocyte Subsets - metabolism | CD8-Positive T-Lymphocytes - drug effects | CD8-Positive T-Lymphocytes - immunology | Interleukin-9 - immunology | CD4-Positive T-Lymphocytes - drug effects | Lymphocytes, Tumor-Infiltrating - immunology | Parrots | T cells | Tumors | Index Medicus | Life Sciences | Cancer
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 25, pp. 6304 - 6314
Interleukin 7 (IL- 7) is a common gamma chain receptor cytokine implicated in thymopoiesis and in peripheral expansion and survival of T lymphocytes. The... 
INDIVIDUALS | HOMEOSTASIS | CD127 EXPRESSION | DECREASED CD127 | DISEASE | ANTIRETROVIRAL THERAPY | HUMAN-IMMUNODEFICIENCY-VIRUS | HEMATOLOGY | IMMATURE/TRANSITIONAL B-CELLS | INTERLEUKIN-7 RECEPTOR | GAMMA-CHAIN | HIV-1 | Recombinant Proteins - therapeutic use | T-Lymphocyte Subsets - immunology | CD8-Positive T-Lymphocytes - cytology | T-Lymphocyte Subsets - cytology | Humans | Middle Aged | Interleukin-7 - pharmacology | Male | Recombinant Proteins - adverse effects | Immunologic Memory - drug effects | Interleukin-7 Receptor alpha Subunit - biosynthesis | Viral Load | Interleukin-7 - administration & dosage | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | T-Lymphocyte Subsets - drug effects | T-Lymphocytes, Regulatory - cytology | CD8-Positive T-Lymphocytes - metabolism | Adult | Female | Interleukin-7 Receptor alpha Subunit - genetics | Interleukin-7 - blood | Chemical and Drug Induced Liver Injury - etiology | CD4-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - metabolism | Recombinant Proteins - pharmacology | Down-Regulation - drug effects | Recombinant Proteins - administration & dosage | Recombinant Proteins - blood | Maximum Tolerated Dose | T-Lymphocytes, Regulatory - drug effects | CD8-Positive T-Lymphocytes - drug effects | Interleukin-7 - therapeutic use | Lymphocyte Count | HIV Infections - drug therapy | CD8-Positive T-Lymphocytes - immunology | Cell Cycle - drug effects | Interleukin-7 - adverse effects | CD4-Positive T-Lymphocytes - drug effects | Index Medicus | Abridged Index Medicus | Clinical Trials and Observations
Journal Article
Science, ISSN 0036-8075, 5/2011, Volume 332, Issue 6030, pp. 687 - 696
Flow cytometry is an essential tool for dissecting the functional complexity of hematopoiesis. We used single-cell "mass cytometry" to examine healthy human... 
T lymphocytes | Cytometry | Phosphorylation | RESEARCH ARTICLE | B lymphocytes | Stem cells | Cell lines | Bone marrow | Bone marrow cells | Cells | Hematopoietic stem cells | STEM-CELLS | PROTEIN | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | MYELOGENOUS LEUKEMIA | TYROSINE KINASE INHIBITOR | FLOW-CYTOMETRY | DASATINIB | QUANTITATIVE-ANALYSIS | T-CELLS | SIGNALING NETWORKS | Lanthanoid Series Elements | Leukocytes, Mononuclear - metabolism | Flow Cytometry - methods | Humans | Antibodies | Lymphocyte Subsets - immunology | Lymphocyte Subsets - metabolism | T-Lymphocytes - metabolism | Hematopoiesis | Single-Cell Analysis - methods | T-Lymphocytes - drug effects | Bone Marrow Cells - immunology | Leukocytes, Mononuclear - immunology | Mass Spectrometry | Bone Marrow Cells - drug effects | B-Lymphocytes - metabolism | Dasatinib | Leukocytes, Mononuclear - drug effects | Cytokines - metabolism | Bone Marrow Cells - cytology | Lymphocyte Activation | Lymphocyte Subsets - drug effects | Immunophenotyping | Pyrimidines - pharmacology | Transition Elements | B-Lymphocytes - drug effects | Algorithms | B-Lymphocytes - immunology | Signal Transduction - drug effects | T-Lymphocytes - immunology | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Antigens, Surface - analysis | Bone Marrow Cells - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Evaluation | Flow cytometry | Immune response | Research | Immunopharmacology | Methods | Index Medicus
Journal Article