X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (434) 434
lysophospholipase-d (376) 376
lysophosphatidic acid (302) 302
humans (284) 284
autotaxin (258) 258
animals (257) 257
biochemistry & molecular biology (220) 220
identification (138) 138
lysophospholipids - metabolism (130) 130
phosphoric diester hydrolases - metabolism (130) 130
expression (125) 125
female (119) 119
cell biology (116) 116
mice (113) 113
lysophospholipase d (98) 98
lipids (97) 97
cancer (87) 87
lysophospholipase-d activity (87) 87
male (85) 85
lpa (82) 82
phosphoric diester hydrolases (81) 81
sphingosine 1-phosphate (80) 80
protein-coupled receptor (76) 76
signal transduction (75) 75
activation (67) 67
article (67) 67
motility (67) 67
pyrophosphatases - metabolism (64) 64
receptors, lysophosphatidic acid - metabolism (59) 59
rats (57) 57
oncology (56) 56
phosphoric diester hydrolases - genetics (56) 56
plasma (56) 56
cells (53) 53
multienzyme complexes - metabolism (53) 53
receptor (53) 53
biophysics (52) 52
lysophosphatidylcholine (52) 52
phosphoric diester hydrolases - chemistry (51) 51
enzymes (50) 50
growth (50) 50
lysophosphatidic acid production (49) 49
cell line, tumor (48) 48
physiological aspects (48) 48
research (48) 48
lysophospholipids - pharmacology (47) 47
motility-stimulating protein (46) 46
phosphodiesterase i - metabolism (46) 46
receptors (46) 46
phosphodiesterase (45) 45
ovarian-cancer (44) 44
chemistry, medicinal (43) 43
pharmacology & pharmacy (42) 42
pyrophosphatases - genetics (41) 41
analysis (38) 38
lysophospholipids - chemistry (38) 38
multienzyme complexes - genetics (38) 38
adult (36) 36
metastasis (36) 36
phosphoric diester hydrolases - blood (36) 36
lysophosphatidic acid receptor (35) 35
lysophospholipids - blood (35) 35
inflammation (34) 34
middle aged (34) 34
receptors, lysophosphatidic acid - genetics (34) 34
lysophospholipids - biosynthesis (33) 33
cells, cultured (32) 32
neurosciences (32) 32
phosphodiesterase i - genetics (32) 32
phospholipids (32) 32
proteins (32) 32
protein (31) 31
fibrosis (30) 30
in-vitro (30) 30
breast-cancer (28) 28
enzyme inhibitors - pharmacology (28) 28
lysophospholipids - physiology (28) 28
migration (28) 28
pyrophosphatases - antagonists & inhibitors (28) 28
mice, inbred c57bl (27) 27
molecular sequence data (27) 27
aged (26) 26
cancer cells (26) 26
cell motility (26) 26
lpa receptors (26) 26
lysophosphatidylcholines - metabolism (26) 26
molecular-cloning (26) 26
pyrophosphatases - chemistry (26) 26
substrate specificity (26) 26
cyclic phosphatidic-acid (25) 25
growth-factor (25) 25
multidisciplinary sciences (25) 25
amino acid sequence (24) 24
biological phenomena, cell phenomena, and immunity (24) 24
cell line (24) 24
endothelial-cells (24) 24
hydrolysis (24) 24
metabolism (24) 24
rna, messenger - metabolism (24) 24
signal transduction - physiology (24) 24
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


BLOOD, ISSN 0006-4971, 11/2014, Volume 124, Issue 20, pp. 3141 - 3150
Autotaxin (ATX), through its lysophospholipase D activity controls physiological levels of lysophosphatidic acid (LPA) in blood. ATX is overexpressed in... 
LYSOPHOSPHOLIPASE-D | ACTIVATION | PLASMA | MOUSE | MEGAKARYOCYTES | IDENTIFICATION | HEMATOLOGY | EXPRESSION | PROMOTES | LYSOPHOSPHATIDIC ACID PRODUCTION | FIBRINOGEN
Journal Article
JOURNAL OF BIOCHEMISTRY, ISSN 0021-924X, 02/2015, Volume 157, Issue 2, pp. 81 - 89
Lysophosphatidic acid (LPA) is one of the simplest glycerophospholipids with one fatty acid chain and a phosphate group as a polar head. Although LPA had been... 
G protein-coupled receptor | PA-PLA | autotaxin | LYSOPHOSPHOLIPASE-D ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | lipid mediator | BIOCHEMICAL-CHARACTERIZATION | LUNG INJURY | LPA-PRODUCING ENZYME | NEUROPATHIC PAIN | IN-VITRO | lysophosphatidic acid | PROTEIN-COUPLED RECEPTOR | HUMAN HAIR-GROWTH | EDG-FAMILY | MOUSE UTERUS
Journal Article
PLOS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6
Background Autotaxin (ATX) is a secreted enzyme that converts lysophosphatidylcholine to lysophosphatidic acid, a potent bioactive lipid mediator, through its... 
LYSOPHOSPHOLIPASE-D | ACTIVATION | PROTEIN | LYSOPHOSPHATIDIC ACID | MULTIDISCIPLINARY SCIENCES | BIOCHEMICAL-CHARACTERIZATION | DIFFERENTIATION | IDENTIFICATION | EXPRESSION | CANCER | MOTILITY
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 8, pp. 3697 - 3711
Autotaxin (ATX) catalyzes the hydrolysis of lysophosphatidylcholine (LPC) generating the lipid mediator lysophosphatidic acid (LPA). Both ATX and LPA are... 
BINDING MODE | DESIGN | CHEMISTRY, MEDICINAL | ENZYME | LYSOPHOSPHOLIPASE-D ACTIVITY | PATENT | PHOSPHOLIPASE A | AGENTS | HISTONE DEACETYLASE INHIBITORS | IDENTIFICATION | DISCOVERY | Index Medicus
Journal Article
MOLECULAR CANCER RESEARCH, ISSN 1541-7786, 01/2015, Volume 13, Issue 1, pp. 174 - 185
Autotaxin (ENPP2/ATX) and lysophosphatidic acid (LPA) receptors represent two key players in regulating cancer progression. The present study sought to... 
OVARIAN-CANCER CELLS | LYSOPHOSPHOLIPASE-D | BREAST-CANCER | MIGRATION | LYSOPHOSPHATIDIC ACID RECEPTOR | ONCOLOGY | BONE METASTASES | CYCLIC PHOSPHATIDIC-ACID | EXPRESSION | PROGRESSION | MOTILITY | CELL BIOLOGY
Journal Article
MOLECULAR BIOLOGY OF THE CELL, ISSN 1059-1524, 12/2008, Volume 19, Issue 12, pp. 5435 - 5445
Lysophosphatidic acid (LPA) is a ligand of multiple G protein-coupled receptors. The LPA(1-3) receptors are members of the endothelial cell differentiation... 
OVARIAN-CANCER CELLS | LYSOPHOSPHOLIPASE-D | LYSOPHOSPHATIDIC ACID RECEPTOR | ACTIVATION | PROTEIN-COUPLED RECEPTOR | EDG-FAMILY | MOLECULAR-CLONING | LPA | AUTOTAXIN | OBVIOUS PHENOTYPIC ABNORMALITY | CELL BIOLOGY
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 17, pp. 7942 - 7951
Autotaxin is an extracellular phospholipase D that catalyzes the hydrolysis of lysophosphatidyl choline (LPC) to generate the bioactive lipid lysophosphatidic... 
OVARIAN-CANCER CELLS | MIGRATION | 5-FLUOROURACIL | INVASION | ACTIVATION | CHEMISTRY, MEDICINAL | PROTEIN | LYSOPHOSPHATIDIC ACID | LYSOPHOSPHOLIPASE-D ACTIVITY | GENE-EXPRESSION | IDENTIFICATION
Journal Article
BLOOD, ISSN 0006-4971, 12/2010, Volume 116, Issue 23, pp. 5060 - 5070
Lysophosphatidic acid (LPA) is a potent lipid mediator with a wide variety of biological actions mediated through G protein-coupled receptors (LPA(1-6)).... 
LYSOPHOSPHOLIPASE-D | PDGFR-BETA | LYSOPHOSPHATIDIC ACID RECEPTOR | EMBRYONIC-DEVELOPMENT | EDG FAMILY | ANGIOGENESIS | PROTEIN-COUPLED RECEPTOR | GROWTH-FACTOR-C | ENDOTHELIAL-CELLS | HEMATOLOGY | BETA-RECEPTOR
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 02/2011, Volume 18, Issue 2, pp. 198 - 204
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 03/2016, Volume 6
The lipid mediator lysophosphatidic acid (LPA) signals via six distinct G protein-coupled receptors to mediate both unique and overlapping biological effects,... 
LYSOPHOSPHOLIPASE-D | MATRIX | ZEBRAFISH | LYSOPHOSPHATIDIC ACID | CELL MOTILITY | MULTIDISCIPLINARY SCIENCES | GROWTH | CRANIOFACIAL DEVELOPMENT | LPA | IDENTIFICATION | AUTOTAXIN
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2004, Volume 279, Issue 17, pp. 17634 - 17639
Autotaxin (ATX) is a tumor cell motility-stimulating factor originally isolated from melanoma cell supernatant that has been implicated in regulation of... 
LYSOPHOSPHOLIPASE-D | MIGRATION | RHO-ASSOCIATED KINASE | INVASION | PHOSPHODIESTERASE-I | PROTEIN-COUPLED RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | EDG-FAMILY | IDENTIFICATION | EXPRESSION | CANCER
Journal Article
Clinica Chimica Acta, ISSN 0009-8981, 06/2018, Volume 481, pp. 184 - 188
Measurement of lipoprotein-associated phospholipase A (Lp-PLA ) can be used as an adjunct to traditional cardiovascular risk factors for identifying... 
PAF-AH (platelet-activating factor-acetylhydrolase) | Enzymatic assay method | 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine | Lysophospholipase D | PAF | Lp-PLA2 | Lp-PLA | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2018, Volume 148, pp. 397 - 409
Autotaxin (ATX) is a potential target for the treatment of various cancers. A new series of ATX inhibitors was rationally designed and synthesized based on our... 
ATX inhibitors | Pharmacokinetics | Autotaxin | Molecular docking | Cancer | PATHWAYS | AUTOTAXIN INHIBITORS | CHEMISTRY, MEDICINAL | IDENTIFICATION | LYSOPHOSPHOLIPASE-D | PATENT | THERAPEUTIC TARGET | EXPRESSION | Models | Drug discovery | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2010, Volume 139, Issue 3, pp. 1008 - 1018.e1
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 03/2019, Volume 33, Issue 3, pp. 3623 - 3635
Autotaxin (ATX or ENPP2) is a secreted lysophospholipase D that produces lysophosphatidic acid (LPA), a pleiotropic lipid mediator acting on specific GPCRs.... 
lymphocytes | CANCER CELLS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | CELL BIOLOGY | LYSOPHOSPHOLIPASE-D | NA+/H+ EXCHANGER 3 | ACID RECEPTOR 1 | lysophosphatidic acid | inflammation | ENTEROENDOCRINE CELLS | BIOLOGY | BINDING | T-CELLS
Journal Article
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 02/2018, Volume 59, Issue 2, pp. 693 - 701
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 02/2011, Volume 18, Issue 2, pp. 205 - 212
Journal Article
Lipids, ISSN 0024-4201, 06/2018, Volume 53, Issue 6, pp. 615 - 625
Some lipid digestion pathways in fish deviate from those in mammals, and many differences may also be species dependent. This report describes a pathway for... 
Hydrolysis | Enterocytes | Monoacylglycerol | Lysophosphatidylcholine | Proteomics | RAT | TRIACYLGLYCEROLS | SN-2-MONOACYLGLYCEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | LYSOPHOSPHOLIPASE-D | NUTRITION & DIETETICS | ENZYME | METABOLISM | LIPASE | PHOSPHATIDYLCHOLINE | ATLANTIC SALMON | SALAR | Index Medicus
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2019, Volume 9, Issue 1, pp. 7414 - 14
The accumulation of fibroblasts is a critical step in the development of fibrosis, and lysophosphatidic acid (LPA) promotes fibrosis by regulating multiple... 
LYSOPHOSPHOLIPASE-D | RECRUITMENT | ACTIVATION | MULTIDISCIPLINARY SCIENCES | GROWTH | LUNG INJURY | RECEPTOR | SECRETION | MEDIATORS LYSOPHOSPHATIDIC ACID | SPHINGOSINE 1-PHOSPHATE | INSIGHTS | Kidneys | Lysophosphatidic acid | Rodents | Migration | Fibrosis | Fibroblasts | mRNA | Permeability
Journal Article