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PLoS ONE, ISSN 1932-6203, 10/2016, Volume 11, Issue 10, p. e0165004
Osteoclasts are giant bone-resorbing cells originating from monocytes/macrophages. During their differentiation, they overexpress two lysosomal enzymes,... 
IN-VITRO | CATHEPSIN-K | MULTIDISCIPLINARY SCIENCES | MACROPHAGE MANNOSE RECEPTOR | LIVER LYSOSOMES | H+-ATPASE | MICE | PLASMA-MEMBRANE | PROCESSED FORMS | EXPRESSION | BONE-RESORPTION | Mannose-Binding Lectins - metabolism | Up-Regulation | Chondroitin Sulfates - metabolism | RANK Ligand - metabolism | Hyaluronoglucosaminidase - metabolism | Monocytes - cytology | Monocytes - metabolism | Exocytosis | Osteoclasts - cytology | Endosomes - metabolism | Lectins, C-Type - metabolism | Hyaluronoglucosaminidase - deficiency | Lysosomes - metabolism | Cell Differentiation | Bone Marrow Cells - cytology | Cells, Cultured | Receptors, Cell Surface - metabolism | Macrophages - cytology | Osteoclasts - metabolism | GPI-Linked Proteins - metabolism | Mice, Knockout | Macrophages - metabolism | Animals | Cathepsin K - metabolism | Hyaluronic Acid - metabolism | Tartrate-Resistant Acid Phosphatase - metabolism | RAW 264.7 Cells | Mice | Hyaluronoglucosaminidase - genetics | Osteogenesis | GPI-Linked Proteins - genetics | Hydrolysis | Cathepsins | Physiological aspects | RNA | Hyaluronic acid | Macrophages | Glycosaminoglycans | Lysosomes | Acidification | Mannose | Phosphatase | Cell surface | Degradation | Proteins | Bone resorption | Lysosomal enzymes | Bone marrow | Biocompatibility | Bone matrix | Enzymes | Fractionation | Cathepsin K | Hydrolase | Secretion | Bone remodelling | Metabolism | Gene expression | Osteoclastogenesis | Monocytes | Acids | Osteoclasts | Acid phosphatase (tartrate-resistant) | Chondroitin sulfate | Sulfate | Differentiation | Endosomes | Trafficking
Journal Article
Journal Article
Journal Article