Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (375) 375
Publication (68) 68
Book Chapter (11) 11
Book Review (7) 7
Book / eBook (1) 1
Dissertation (1) 1
Government Document (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (175) 175
immunology (165) 165
index medicus (164) 164
lytic granules (157) 157
animals (144) 144
t-lymphocytes, cytotoxic - immunology (88) 88
perforin (87) 87
cell biology (80) 80
mice (74) 74
cytotoxicity (71) 71
lymphocytes (56) 56
biochemistry & molecular biology (55) 55
natural-killer-cells (55) 55
t cells (54) 54
immunological synapse (53) 53
exocytosis (48) 48
killer cells, natural - immunology (47) 47
cytotoxicity, immunologic (46) 46
proteins (45) 45
pore forming cytotoxic proteins (44) 44
article (40) 40
cells, cultured (40) 40
expression (35) 35
granzymes (33) 33
natural killer cells (33) 33
activation (31) 31
cells (31) 31
female (31) 31
male (30) 30
t-lymphocytes, cytotoxic - metabolism (30) 30
apoptosis (28) 28
research (28) 28
target-cells (28) 28
analysis (27) 27
cancer (27) 27
cell line (27) 27
flow cytometry (27) 27
molecular sequence data (27) 27
nk cells (27) 27
microbiology (26) 26
lytic granule polarization (25) 25
mice, inbred c57bl (25) 25
oncology (25) 25
dna fragmentation (24) 24
physiological aspects (24) 24
signal transduction (24) 24
cytotoxic t lymphocytes (23) 23
lymphocyte activation (23) 23
mutation (23) 23
cd8-positive t-lymphocytes - immunology (22) 22
killer cells (22) 22
amino acid sequence (21) 21
ctl (21) 21
granzyme-b (21) 21
killer cells, natural - metabolism (21) 21
lytic activity (21) 21
mediated cytotoxicity (21) 21
calcium (20) 20
cytoplasmic granules - metabolism (20) 20
secretory lysosomes (20) 20
dendritic cells (19) 19
mice, inbred balb c (19) 19
microtubule-organizing center (19) 19
lytic pathways (18) 18
membrane glycoproteins - metabolism (18) 18
t-cells (18) 18
biology (17) 17
cytoplasmic granules - immunology (17) 17
cytotoxic t-lymphocytes (17) 17
cytotoxicity, immunologic - immunology (17) 17
degranulation (17) 17
gene expression (17) 17
gene-expression (17) 17
hematology (17) 17
immune system (17) 17
in-vivo (17) 17
microscopy (17) 17
receptor (17) 17
secretion (17) 17
calcium - metabolism (16) 16
cell line, tumor (16) 16
familial hemophagocytic lymphohistiocytosis (16) 16
immune response (16) 16
innate immunity (16) 16
lymphocytes t (16) 16
lytic granule exocytosis (16) 16
multidisciplinary sciences (16) 16
t-lymphocytes, cytotoxic - cytology (16) 16
abridged index medicus (15) 15
biotechnology & applied microbiology (15) 15
cell death (15) 15
cell-mediated cytotoxicity (15) 15
health aspects (15) 15
immune synapse (15) 15
immunotherapy (15) 15
lytic granule (15) 15
plasma-membrane (15) 15
pore-forming protein (15) 15
protein (15) 15
t-lymphocytes, cytotoxic - enzymology (15) 15
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules
by de Saint Basile, Geneviève and Ménasché, Gaël and Fischer, Alain
Nature Reviews Immunology, ISSN 1474-1733, 08/2010, Volume 10, Issue 8, pp. 568 - 579
Cytotoxic T cells and natural killer cells are crucial for immune surveillance against virus-infected cells and tumour cells. Molecular studies of individuals... 
MEMBRANE-FUSION | CELL IMMUNOLOGICAL SYNAPSE | LYTIC GRANULES | CYTOLYTIC LEUKOCYTES | FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS | CHEDIAK-HIGASHI-SYNDROME | IMMUNOLOGY | PLASMA-MEMBRANE | HERMANSKY-PUDLAK-SYNDROME | T-LYMPHOCYTES | SECRETORY LYSOSOMES | T-Lymphocytes, Cytotoxic - immunology | Humans | Immunological Synapses - physiology | Neurotransmitter Agents - metabolism | Secretory Vesicles - metabolism | Cytotoxicity, Immunologic - physiology | Exocytosis - immunology | Animals | Biological Transport | T-Lymphocytes, Cytotoxic - metabolism | Cytoplasmic Granules - metabolism | Killer Cells, Natural - immunology | Killer Cells, Natural - metabolism | Physiological aspects | Immune response | Research | Exocytosis | T cells
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Syntaxin11 serves as a t‐SNARE for the fusion of lytic granules in human cytotoxic T lymphocytes
by Halimani, Mahantappa and Pattu, Varsha and Marshall, Misty R and Chang, Hsin Fang and Matti, Ulf and Jung, Martin and Becherer, Ute and Krause, Elmar and Hoth, Markus and Schwarz, Eva C and Rettig, Jens
European Journal of Immunology, ISSN 0014-2980, 02/2014, Volume 44, Issue 2, pp. 573 - 584
CTLs kill target cells via fusion of lytic granules (LGs) at the immunological synapse (IS). Soluble N‐ethylmaleimide‐sensitive factor attachment protein... 
Lytic granule fusion | FHL | Syntaxin11 clusters | TIRFM | Cytotoxic T lymphocytes | DEFECTS | EXOCYTOSIS | RELEASE | IMMUNOLOGY | HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS | ENDOSOMES | IMMUNE-SYSTEM | DEGRANULATION | SECRETION | IMMUNOLOGICAL SYNAPSE | PROTEINS | T-Lymphocytes, Cytotoxic - immunology | Endosomes - immunology | Humans | Cells, Cultured | Qa-SNARE Proteins - immunology | Immunological Synapses - metabolism | Endosomes - metabolism | T-Lymphocytes, Cytotoxic - metabolism | Down-Regulation - immunology | Cytoplasmic Granules - metabolism | Lymphohistiocytosis, Hemophagocytic - metabolism | Qa-SNARE Proteins - metabolism | Immunological Synapses - immunology | SNARE Proteins - immunology | Cytoplasmic Granules - immunology | SNARE Proteins - metabolism | Lymphohistiocytosis, Hemophagocytic - immunology | T cells | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Toxoplasma gondii infection induces the formation of host's nuclear granules containing poly(A)-binding proteins
by Fischer, K and Roberts, M and Roscoe, S and Avci, Y and Ananvoranich, S
CANADIAN JOURNAL OF MICROBIOLOGY, ISSN 0008-4166, 08/2018, Volume 64, Issue 8, pp. 551 - 558
To study the mechanism by which human host cells respond to an infection of Toxoplasma gondii, we monitored the level of poly(A)-binding protein (PABP), an... 
PABPs | Toxoplasma infection | cellular response | RNA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | host-parasite interaction | MICROBIOLOGY | LYTIC CYCLE | nuclear granules | BINDING-PROTEINS | Medical research | Toxoplasmosis | Physiological aspects | Host-parasite relationships | Medicine, Experimental | Research | Binding proteins | Cell nuclei
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Calcium negatively regulates secretion from dense granules in Toxoplasma gondii
by Katris, Nicholas J and Ke, Huiling and McFadden, Geoffrey I and Dooren, Giel G and Waller, Ross F
Cellular Microbiology, ISSN 1462-5814, 06/2019, Volume 21, Issue 6, pp. e13011 - n/a
Apicomplexan parasites including Toxoplasma gondii and Plasmodium spp. manufacture a complex arsenal of secreted proteins used to interact with and manipulate... 
Toxoplasma | Protozoa | dense granules | Apicomplexa | calcium | signalling | IDENTIFY | PARASITOPHOROUS VACUOLE | EXOCYTOSIS | ORGANELLES | MICROBIOLOGY | LYTIC CYCLE | CELL BIOLOGY | INVASION | EGRESS | INHIBITORS | PROTEIN-KINASE 1 | MOTILITY | Proteins | Calcium | Secretion | Micronemes | Biology | Parasites | Exocytosis | Kinases | Calcium signalling | Granular materials | Cyclic GMP | Granules | Calcium ions
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Human NK cell lytic granules and regulation of their exocytosis
by Krzewski, K and Coligan, JE
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 2012, Volume 3
Natural killer (NK) cells form a subset of lymphocytes that play a key role in immuno-surveillance and host defense against cancer and viral infections. They... 
cytotoxic lymphocytes | NK cells | lytic granules | lysosomes | exocytosis | IMMUNOLOGY | cytotoxicity | Lysosomes | Cytotoxicity | Exocytosis
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text NAADP Activates Two-Pore Channels on T Cell Cytolytic Granules to Stimulate Exocytosis and Killing
by Davis, Lianne C and Morgan, Anthony J and Chen, Ji-Li and Snead, Charlotte M and Bloor-Young, Duncan and Shenderov, Eugene and Stanton-Humphreys, Megan N and Conway, Stuart J and Churchill, Grant C and Parrington, John and Cerundolo, Vincenzo and Galione, Antony
Current Biology, ISSN 0960-9822, 12/2012, Volume 22, Issue 24, pp. 2331 - 2337
A cytotoxic T lymphocyte (CTL) kills an infected or tumorigenic cell by Ca -dependent exocytosis of cytolytic granules at the immunological synapse formed... 
LYTIC GRANULES | REQUIREMENTS | MEDIATED CYTOTOXICITY | VESICLES | CA2+ RELEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCIUM | MECHANISMS | RECEPTORS | EXPRESSION | LYMPHOCYTES | CELL BIOLOGY | T-Lymphocytes, Cytotoxic - immunology | Animals | Lymphocyte Activation | Cytoplasmic Granules - metabolism | Humans | NADP - analogs & derivatives | NADP - physiology | Exocytosis | Inositol 1,4,5-Trisphosphate - metabolism | Proteins | Phosphates | Purines | Inositol | Immunotherapy | Universities and colleges | T cells | Niacin | Report
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text A unique SNARE machinery for exocytosis of cytotoxic granules and platelets granules
by Tang, Bor Luen
Molecular Membrane Biology, ISSN 0968-7688, 05/2015, Volume 32, Issue 4, pp. 120 - 126
Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells target infected or transformed cells with perforin-containing cytotoxic granules through immune... 
familial hemophagocytic lymphohistiocytosis | platelet | Cytotoxic granules | Munc18b | syntaxin 11 | SEC1/MUNC18 PROTEINS | LYTIC GRANULES | 5 FHL-5 | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING PROTEIN STXBP5 | CELL BIOLOGY | MEDIATED MEMBRANE-FUSION | SECRETION | T-LYMPHOCYTES | MOLECULAR-MECHANISMS | T-Lymphocytes, Cytotoxic - immunology | Munc18 Proteins - genetics | Humans | Munc18 Proteins - metabolism | Exocytosis | Animals | Carrier Proteins - metabolism | T-Lymphocytes, Cytotoxic - metabolism | Blood Platelets - metabolism | Cytoplasmic Granules - metabolism | Lymphohistiocytosis, Hemophagocytic - metabolism | Qa-SNARE Proteins - metabolism | Killer Cells, Natural - immunology | Protein Binding | Killer Cells, Natural - metabolism | Lymphohistiocytosis, Hemophagocytic - genetics | SNARE Proteins - metabolism | Lymphohistiocytosis, Hemophagocytic - immunology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Evidence for lytic transglycosylase and β-N-acetylglucosaminidase activities located at the polyhydroxyalkanoates (PHAs) granules of Thermus thermophilus HB8
by Simou, Olga M and Simou, Olga M and Pantazaki, Anastasia A and Pantazaki, Anastasia A
Applied Microbiology and Biotechnology, ISSN 0175-7598, 2/2014, Volume 98, Issue 3, pp. 1205 - 1221
The thermophilic bacterium Thermus thermophilus HB8 accumulates polyhydroxyalkanoates (PHAs) as intracellular granules used by cells as carbon and energy... 
Life Sciences | Biotechnology | Thermus thermophilus PHAs | Polyhydroxyalkanoates granules PGAPs | Microbiology | Microbial Genetics and Genomics | PHA granules-associated proteins | LTGs | lytic transglycosylases. NAG | β-N-acetylglucosaminidase | FINE-STRUCTURE | ESCHERICHIA-COLI | CELL-SURFACE | beta-N-acetylglucosaminidase | POLY(3-HYDROXYBUTYRATE) | PHB GRANULES | RALSTONIA-EUTROPHA H16 | INTRACELLULAR DEPOLYMERASE | NAG | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ALCALIGENES-EUTROPHUS | lytic transglycosylases | ACID GRANULES | MOLECULAR-BASIS | Peptidoglycan - metabolism | Thermus thermophilus - enzymology | Molecular Weight | Peptidoglycan Glycosyltransferase - metabolism | Peptidoglycan Glycosyltransferase - chemistry | Peptidoglycan Glycosyltransferase - isolation & purification | Electrophoresis, Polyacrylamide Gel | Thermus thermophilus - metabolism | Polyhydroxyalkanoates - metabolism | Acetylglucosaminidase - isolation & purification | Hydrolysis | Micrococcus - metabolism | Acetylglucosaminidase - metabolism | Acetylglucosaminidase - chemistry | Cell Wall - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Heterogeneity in composition of mouse uterine natural killer cell granules
by Patrícia D. A. Lima and Barbara A. Croy and Karina Y. Degaki and Chandrakant Tayade and Áureo T. Yamada
Journal of Leukocyte Biology, ISSN 0741-5400, 07/2012, Volume 92, Issue 1, pp. 195 - 204
Pregnancy‐associated mouse uNK cells constitutively secrete Vegfa from vesicles, and have the capability for induced secretion of Gzma from secretory, and... 
secretory‐lysosome granule | Vegfa | perforin | granule secretion | granzyme‐A | Granzyme-A | Secretory-lysosome granule | Perforin | Granule secretion | LYTIC GRANULES | SERINE PROTEASES | EXOCYTOSIS | METRIAL GLAND-CELLS | secretory-lysosome granule | IMMUNOLOGY | GRANZYMES | SECRETORY LYSOSOMES | CELL BIOLOGY | granzyme-A | NK CELLS | EARLY-PREGNANCY | HEMATOLOGY | LYMPHOCYTES | Biomarkers - metabolism | Cytoplasmic Granules | Uterus - metabolism | Male | Immunoenzyme Techniques | Killer Cells, Natural - classification | Pregnancy | Killer Cells, Natural - cytology | Plant Lectins | Animals | Uterus - cytology | Female | Mice | Mice, Inbred BALB C | Killer Cells, Natural - metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes
by Núñez-Andrade, Norman and Iborra, Salvador and Trullo, Antonio and Moreno-Gonzalo, Olga and Calvo, Enrique and Catalán, Elena and Menasche, Gaël and Sancho, David and Vázquez, Jesús and Yao, Tso-Pang and Martín-Cófreces, Noa Beatriz and Sánchez-Madrid, Francisco
Journal of Cell Science, ISSN 0021-9533, 04/2016, Volume 129, Issue 7, pp. 1305 - 1311
HDAC6 is a tubulin deacetylase involved in many cellular functions related to cytoskeleton dynamics, including cell migration and autophagy. In addition, HDAC6... 
Kinesin 1 | Lytic granule | Histone deacetylase 6 | EFFECTOR | CELLS | DYNEIN | IMMUNE SYNAPSE | TUBULIN CYTOSKELETON | MOTILITY | MTOC | CELL BIOLOGY | T-Lymphocytes, Cytotoxic - immunology | Cytotoxicity, Immunologic - genetics | Histone Deacetylases - genetics | Histone Deacetylase 6 | Mice, Inbred C57BL | Cells, Cultured | Histone Deacetylases - metabolism | Interferon-gamma - metabolism | Dynactin Complex - antagonists & inhibitors | Mice, Knockout | Animals | Cytoplasmic Granules - metabolism | Vaccinia - immunology | Biological Transport - physiology | Mice | Cytotoxicity, Immunologic - immunology | Kinesin - antagonists & inhibitors
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Endocytosis of cytotoxic granules is essential for multiple killing of target cells by T lymphocytes
by Chang, Hsin-Fang and Bzeih, Hawraa and Schirra, Claudia and Chitirala, Praneeth and Halimani, Mahantappa and Cordat, Emmanuelle and Krause, Elmar and Rettig, Jens and Pattu, Varsha
Journal of Immunology, ISSN 0022-1767, 09/2016, Volume 197, Issue 6, pp. 2473 - 2484
CTLs are serial killers that kill multiple target cells via exocytosis of cytotoxic granules (CGs). CG exocytosis is tightly regulated and has been... 
LYTIC GRANULES | CLATHRIN TERMINAL DOMAIN | FUSION | COLOCALIZATION | DYNAMIN | CTL | COMPARTMENTS | IMMUNOLOGY | IMMUNOLOGICAL SYNAPSE | SECRETORY LYSOSOMES | SNARE | T-Lymphocytes, Cytotoxic - immunology | Endosomes - immunology | Dynamins - metabolism | Granzymes - metabolism | Cytoplasmic Granules - physiology | Exocytosis | Clathrin - metabolism | Endosomes - metabolism | Immunological Synapses | Dynamins - immunology | Endocytosis | Animals | R-SNARE Proteins - immunology | Mice | Cytoplasmic Granules - immunology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Chediak-Higashi syndrome: Lysosomal trafficking regulator domains regulate exocytosis of lytic granules but not cytokine secretion by natural killer cells
by Gil-Krzewska, Aleksandra, PhD and Wood, Stephanie M., PhD and Murakami, Yousuke, PhD and Nguyen, Victoria, BSc and Cher Chiang, Samuel Cern, MSc and Cullinane, Andrew R., PhD and Peruzzi, Giovanna, PhD and Gahl, William A., MD, PhD and Coligan, John E., PhD and Introne, Wendy J., MD and Bryceson, Yenan T., PhD and Krzewski, Konrad, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 137, Issue 4, pp. 1165 - 1177
Background Mutations in lysosomal trafficking regulator (LYST) cause Chediak-Higashi syndrome (CHS), a rare immunodeficiency with impaired cytotoxic lymphocyte... 
Allergy and Immunology | immune deficiency | cytotoxic lymphocyte | Chediak-Higashi syndrome | lytic granules | lysosomes | exocytosis | natural killer cell | lysosomal trafficking regulator | cytotoxicity | FUSION | DEFECT | PHENOTYPE | HUMANS | NK-CELL | IMMUNOLOGY | LYST | GENE | BIOGENESIS | ALLERGY | DISEASE | Chediak-Higashi Syndrome - physiopathology | Cytokines - metabolism | Humans | Vesicular Transport Proteins - genetics | Male | Genetic Markers | Mutation, Missense | Exocytosis - physiology | Lysosomes - physiology | Vesicular Transport Proteins - physiology | Adult | Female | Killer Cells, Natural - metabolism | Chediak-Higashi Syndrome - genetics | Immunogenetics | Killer cells | Cytokines | Communicable diseases | Genomics | Genetic research | Research institutes | Cells | Antigens | Phosphatases | Analysis | Immunodeficiency | Protein binding | Proteins | Disease | Lymphocytes | Cytotoxicity | Software | Mutation | Methods | Defects
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text VAMP4‐ and VAMP7‐expressing vesicles are both required for cytotoxic granule exocytosis in NK cells
by Krzewski, Konrad and Gil‐Krzewska, Aleksandra and Watts, James and Stern, Joel N. H and Strominger, Jack L
European Journal of Immunology, ISSN 0014-2980, 11/2011, Volume 41, Issue 11, pp. 3323 - 3329
NK cells eliminate cancer and virus‐infected cells through their cytolytic activity. The last step in NK‐cell cytotoxicity, resulting in exocytosis of granule... 
Immunological synapse | Vesicle fusion | Perforin | Lytic granules | MEMBRANE-FUSION | NATURAL-KILLER-CELLS | ACTIVATION | INVOLVEMENT | LINE | IMMUNOLOGY | PROTEINS | SNARE | Cell Line | Humans | R-SNARE Proteins - metabolism | Secretory Vesicles - metabolism | Cytoplasmic Granules - secretion | Cell Degranulation - immunology | Exocytosis | Blotting, Western | Microscopy, Confocal | Secretory Vesicles - immunology | Lymphocyte Activation - immunology | Killer Cells, Natural - immunology | R-SNARE Proteins - immunology | Killer Cells, Natural - metabolism | Cytotoxicity, Immunologic - immunology | Cytoplasmic Granules - immunology | Cytotoxicity | Immune system | immunological synapse | perforin | vesicle fusion | lytic granules
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights