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Molecular systems biology, ISSN 1744-4292, 2013, Volume 9, Issue 1, pp. 700 - n/a
The evolution of resistance to a single antibiotic is frequently accompanied by increased resistance to multiple other antimicrobial agents... 
collateral sensitivity network | trade off | evolutionary experiment | antibiotic resistance | Antibiotic resistance | PERMEABILITY | ENTERICA SEROVAR TYPHIMURIUM | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | SUSCEPTIBILITY | SALMONELLA | AMINOGLYCOSIDE | RESISTANCE | MULTIDRUG EFFLUX | STAPHYLOCOCCUS-AUREUS | Genome, Bacterial | Escherichia coli - drug effects | Selection, Genetic | Anti-Bacterial Agents - metabolism | Escherichia coli Proteins - metabolism | Drug Resistance, Microbial - genetics | Biological Evolution | Microbial Sensitivity Tests | Aminoglycosides - metabolism | Biological Transport | Metabolic Networks and Pathways | Escherichia coli - genetics | Membrane Transport Proteins - genetics | Escherichia coli - metabolism | Escherichia coli Proteins - genetics | Membrane Transport Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Cell Membrane - metabolism | High-Throughput Nucleotide Sequencing | Mutation | Aminoglycosides - pharmacology | Cell Membrane - drug effects | Laboratories | Genes | Aminoglycosides | Genomes | Biosynthesis | Drug resistance | Experiments | Gene sequencing | Proteins | E coli | Evolution | Aminoglycoside antibiotics | Adaptation | Efflux | Integrated approach | Hypersensitivity | Antimicrobial agents | Acids | Antibiotics | Plasmids | Protein synthesis | Sensitivity enhancement | Transporter | Life Sciences | Medication | Pharmaceutical sciences
Journal Article
Nature reviews. Molecular cell biology, ISSN 1471-0080, 2009, Volume 10, Issue 12, pp. 866 - 876
Directed evolution circumvents our profound ignorance of how a protein's sequence encodes its function by using iterative rounds of random mutation and artificial selection to discover new and useful proteins... 
STRUCTURE-GUIDED RECOMBINATION | SUBSTRATE SPECIFICITIES | IN-VITRO EVOLUTION | LABORATORY EVOLUTION | SEQUENCE SPACE | COMPUTATIONAL DESIGN | METABOLIC PATHWAYS | RNA ENZYME | CATALYTIC-ACTIVITY | RED FLUORESCENT PROTEIN | CELL BIOLOGY | Directed Molecular Evolution | Animals | Proteins - chemistry | Mutation - genetics | Humans | Molecular evolution | Usage | Amino acid sequence | Physiological aspects | Influence | Research | Mutation (Biology)
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 560, Issue 7718, pp. 325 - 330
Journal Article
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2015, Volume 524, Issue 7565, pp. 347 - 350
Journal Article
PLoS pathogens, ISSN 1553-7374, 2019, Volume 15, Issue 7, p. e1007727
Journal Article
Molecular systems biology, ISSN 1744-4292, 2011, Volume 7, Issue 1, pp. 509 - n/a