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Nature Communications, ISSN 2041-1723, 02/2017, Volume 8, Issue 1, pp. 14450 - 14450
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 04/2016, Volume 11, Issue 4, pp. 876 - 881
Ansatrienins are a group of ansamycins with an N-cyclohexanoyl d-alanyl side chain. Though ansatrienins have been identified for decades, the mechanism for the... 
Alanine - metabolism | Lactams, Macrocyclic - chemistry | Catalysis | Lactams, Macrocyclic - metabolism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2010, Volume 107, Issue 26, pp. 11692 - 11697
A combination of small molecule chemistry, biosynthetic analysis, and genome mining has revealed the unexpected conservation of polycyclic tetramate... 
Enzymes | Polyketides | Streptomyces | Genetic loci | Multigene family | Bacteria | Biosynthesis | Genomes | Actinomycetes | Hybridity | Genome-mining | Frontalamide | Tetramic acid | NONRIBOSOMAL PEPTIDE SYNTHETASES | MULTIDISCIPLINARY SCIENCES | BEETLE | tetramic acid | STREPTOMYCES SP | LACTAM | frontalamide | biosynthesis | SEQUENCE | POLYKETIDE | ADENYLATION DOMAINS | genome-mining | Multigene Family | Lactams, Macrocyclic - metabolism | Antifungal Agents - chemistry | Phylogeny | Coleoptera - microbiology | Streptomyces - metabolism | Lactams, Macrocyclic - chemistry | Base Sequence | Actinobacteria - genetics | Antifungal Agents - metabolism | Actinobacteria - metabolism | Bacteria - classification | Actinobacteria - isolation & purification | Molecular Structure | Antifungal Agents - pharmacology | Genes, Bacterial | Bacteria - metabolism | Streptomyces - genetics | Lactams, Macrocyclic - pharmacology | Bacteria - genetics | Streptomyces - isolation & purification | Animals | DNA, Bacterial - genetics | Environmental Microbiology | Mutation | Ophiostoma - drug effects | Microbiological chemistry | Microbiological synthesis | Genetic aspects | Research | Molecules | Molecular structure | Peptides | Genomics | Phylogenetics | Index Medicus | Growth conditions | Hybrids | Gene clusters | Conservation | Amino acids | polyketides | Fungi | Mining | Polyketide synthase | Antibiotics | Biological Sciences | Physical Sciences
Journal Article
Biochemistry, ISSN 0006-2960, 08/2018, Volume 57, Issue 33, pp. 5005 - 5013
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 10/2010, Volume 8, Issue 20, pp. 4682 - 4689
A Streptomyces sp. isolated from a shallow water sediment sample collected off Heron Island, Australia, afforded three new polyketide macrolactams, heronamides... 
ELUCIDATION | CHEMISTRY, ORGANIC | MACROCYCLIC LACTAM | ACTINOMYCETE | VICENISTATIN | CYCLAMENOL | Streptomyces - metabolism | Lactams, Macrocyclic - chemistry | Macrolides - chemistry | Lactams, Macrocyclic - metabolism | Streptomyces - chemistry | Chromatography, High Pressure Liquid | Australia | Index Medicus
Journal Article
Gene, ISSN 0378-1119, 02/2019, Volume 684, pp. 30 - 38
Anti-proliferative, anti-metastatic and anti-angiogenic effects of 17‑allylamino‑17‑demethoxy geldanamycin (17-AAG) were studied alone and in combination with... 
Oxidative stress | Wound healing | Anti-cancer | Anti-angiogenesis | Anti-metastasis | CPT-11 | VEGF | COMBINATION | BREAST-CANCER | 5-FLUOROURACIL | PHASE-II TRIAL | TANESPIMYCIN 17-AAG | IN-VITRO | INHIBITION | GROWTH | GENETICS & HEREDITY | Capecitabine - metabolism | Gene Expression - drug effects | Lactams, Macrocyclic - metabolism | Colonic Neoplasms - drug therapy | Colorectal Neoplasms - genetics | Humans | Vascular Endothelial Growth Factor A - genetics | Deoxycytidine - metabolism | Matrix Metalloproteinase 9 - genetics | Colorectal Neoplasms - drug therapy | Vascular Endothelial Growth Factor A - drug effects | Irinotecan - pharmacology | Benzoquinones - metabolism | Colorectal Neoplasms - metabolism | Gene Expression Regulation, Neoplastic - genetics | Camptothecin - analogs & derivatives | Fluorouracil - metabolism | Camptothecin - metabolism | Antineoplastic Combined Chemotherapy Protocols - metabolism | Fluorouracil - analogs & derivatives | Capecitabine - pharmacology | Irinotecan - metabolism | Lactams, Macrocyclic - pharmacology | Benzoquinones - pharmacology | HT29 Cells | Matrix Metalloproteinase 9 - drug effects | Neovascularization, Pathologic - metabolism | Deoxycytidine - analogs & derivatives | Endothelial growth factors | RNA | Capecitabine | Genes | Colorectal cancer | Metastasis | Gene expression | Antioxidants | Nitric oxide | Analysis | Genetic research | Genetic aspects | Cancer | Index Medicus
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 10/2018, Volume 143, Issue 8, pp. 2029 - 2038
Lorlatinib (PF‐06463922) is a promising oral anaplastic lymphoma kinase (ALK) and ROS1 inhibitor currently in Phase III clinical trials for treatment of... 
brain accumulation | P‐glycoprotein | cytochrome P450‐3A | oral availability | lorlatinib | P-glycoprotein | cytochrome P450-3A | RESISTANCE PROTEIN | ALK INHIBITORS | TRANSPORTERS | METASTASES | CLINICAL-EXPERIENCE | PF-06463922 | CELL LUNG-CANCER | LIQUID-CHROMATOGRAPHY | ONCOLOGY | CERITINIB | CRIZOTINIB | Cell Line | Lung Neoplasms - drug therapy | Administration, Oral | Lactams, Macrocyclic - metabolism | Humans | Lung Neoplasms - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Cytochrome P-450 Enzyme System - metabolism | Biological Availability | Male | Lactams, Macrocyclic - pharmacology | Mice, Knockout | Brain - metabolism | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Pilot Projects | Animals | Dogs | Madin Darby Canine Kidney Cells | Female | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Anaplastic Lymphoma Kinase - antagonists & inhibitors | Protein-Tyrosine Kinases - antagonists & inhibitors | Plasma physics | Genetically modified organisms | Cytochrome P-450 | Lymphomas | Genetic engineering | Permeability | Lung cancer, Non-small cell | Cytochrome | Brain | Liver | Lung cancer | Membrane permeability | Clinical trials | Transgenic | Blood | Accumulation | Metastases | MDR1 protein | Intestine | Protein-tyrosine kinase | Genetic modification | Cytochromes P450 | Medical research | Efflux | Cytochrome P450 | Glycoprotein | Data processing | Pharmacology | Exposure | Lymphoma | Inhibitors | Plasma levels | Pharmacokinetics | Cancer | Index Medicus
Journal Article
Angewandte Chemie - International Edition, ISSN 1433-7851, 01/2012, Volume 51, Issue 3, pp. 752 - 757
Journal Article