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Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e79977
We previously demonstrated that mitochondrial bioenergetic deficits in the female brain accompanied reproductive senescence and was accompanied by a shift from... 
MECHANISM | ASTROCYTE | MULTIDISCIPLINARY SCIENCES | LACTATE | DISEASE | HIPPOCAMPAL | ESTRADIOL | COGNITIVE IMPAIRMENT | ENERGY-METABOLISM | EXPRESSION | OLIGODENDROCYTES | Adaptation, Physiological | Ketone Oxidoreductases - metabolism | Neurons - pathology | Humans | Ketone Bodies - metabolism | Astrocytes - pathology | Glucose Transporter Type 1 - metabolism | Alzheimer Disease - pathology | Biological Transport, Active | Monocarboxylic Acid Transporters - metabolism | Aging - genetics | Female | Neurons - metabolism | Hexokinase - genetics | Disease Models, Animal | Gene Expression | Lactic Acid - metabolism | Mice, Transgenic | Hippocampus - pathology | Mitochondria - metabolism | Ketone Oxidoreductases - genetics | Aging - pathology | Blood-Brain Barrier - metabolism | Hippocampus - metabolism | Animals | Energy Metabolism | Glucose Transporter Type 1 - genetics | Alzheimer Disease - metabolism | Glucose - metabolism | Mice | Monocarboxylic Acid Transporters - genetics | Alzheimer Disease - genetics | Hexokinase - metabolism | Aging - metabolism | Astrocytes - metabolism | Lactates | Glucose metabolism | Enzymes | Brain | Neurons | Glucose | Alzheimer's disease | Dextrose | Neurosciences | Senescence | Adaptive systems | Dehydrogenases | Pyruvic acid | Ketone bodies | Fuels | Mitochondria | Bioenergetics | Blood-brain barrier | Rodents | Aging | Pharmaceutical sciences | Age | Glucose transporter | Phenotypes | Medical imaging | Neurodegenerative diseases | Ketones | Astrocytes | Pharmacology | Metabolism | Glucose transport | Fatty acids | Hexokinase | Utilization | Pharmacy | Glycolysis | Lactic acid | Laboratory animals | Transport | Alzheimers disease | Axonal transport | Transporter | Hippocampus | Animal cognition
Journal Article
Journal Article
Cancer Letters, ISSN 0304-3835, 2014, Volume 356, Issue 2, pp. 156 - 164
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2014, Volume 111, Issue 1, pp. 279 - 284
Journal Article
Journal of Pineal Research, ISSN 0742-3098, 11/2018, Volume 65, Issue 4, pp. e12520 - n/a
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 11/2016, Volume 53, Issue 9, pp. 6459 - 6475
We investigated the effects of an acute intrastriatal QUIN administration on cellular redox and bioenergetics homeostasis, as well as on important signaling... 
Signaling pathways | Neurology | Neurosciences | Energy metabolism | Biomedicine | Glutaric acidemia | Redox homeostasis | Neurobiology | Inflammatory response | Quinolinic acid | Cell Biology | PLASMA-MEMBRANES | 3-HYDROXYGLUTARIC ACID | NMDA RECEPTORS | NITRIC-OXIDE SYNTHASE | FACTOR-KAPPA-B | GLUTAMATE UPTAKE | NEUROSCIENCES | CEREBRAL-CORTEX | PRIMARY NEURONAL CULTURES | ANTIOXIDANT RESPONSE ELEMENT | CREATINE-KINASE | Brain Diseases, Metabolic - pathology | Glutaryl-CoA Dehydrogenase - metabolism | Glutathione - metabolism | Antioxidants - metabolism | Fluoresceins - metabolism | Nitrites - metabolism | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Electron Transport Complex IV - metabolism | Amino Acid Metabolism, Inborn Errors - metabolism | Sulfhydryl Compounds - metabolism | Neostriatum - drug effects | Lipid Peroxidation - drug effects | Neostriatum - metabolism | Quinolinic Acid - administration & dosage | Quinolinic Acid - toxicity | Amino Acid Metabolism, Inborn Errors - pathology | Brain Diseases, Metabolic - enzymology | Proto-Oncogene Proteins c-akt - metabolism | Superoxide Dismutase - metabolism | Malondialdehyde - metabolism | Glutathione Peroxidase - metabolism | Neostriatum - pathology | Oxidation-Reduction | Brain Diseases, Metabolic - metabolism | Mice, Knockout | Nitrates - metabolism | Animals | Lactates - metabolism | Diet | Signal Transduction - drug effects | Models, Biological | NF-E2-Related Factor 2 - metabolism | Oxidative Stress - drug effects | Amino Acid Metabolism, Inborn Errors - enzymology | Energy Metabolism - drug effects | Glutaryl-CoA Dehydrogenase - deficiency | Antioxidants | Lysine | Creatine kinase | Glutathione transferase | Physiological aspects | Superoxide | Inflammation | Creatine | Homeostasis | Signal transduction | Oxidative stress | Bioenergetics | Index Medicus
Journal Article
Plant Cell, ISSN 1040-4651, 12/2017, Volume 29, Issue 12, pp. 3234 - 3254
Methylglyoxal (MGO) and glyoxal (GO) are toxic reactive carbonyl species generated as by-products of glycolysis. The pre-emption pathway for detoxification of... 
ARABIDOPSIS-THALIANA | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | GLYCATION | D-LACTATE DEHYDROGENASE | PLANT SCIENCES | CELL BIOLOGY | SUBSTRATE-SPECIFICITY | ENCODING GENES | GENOME-WIDE ANALYSIS | METHYLGLYOXAL | GLYOXALASE-I | Inactivation, Metabolic | Arabidopsis - enzymology | Glutathione - metabolism | Eukaryotic Cells - metabolism | RNA, Messenger - metabolism | Arabidopsis Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Protoplasts - metabolism | Pyruvaldehyde - metabolism | Isoenzymes - metabolism | Gene Expression Regulation, Plant | Free Radicals - metabolism | Plant Cells - metabolism | Lactoylglutathione Lyase - metabolism | Stress, Physiological - genetics | Alternative Splicing - genetics | Arabidopsis - cytology | RNA, Messenger - genetics | Mutation - genetics | Subcellular Fractions - metabolism | Chloroplasts - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Metals - metabolism | Plant Leaves - metabolism | Models, Biological | Cytosol - metabolism | Sugars - metabolism | Arabidopsis thaliana | Glucose metabolism | Defense industry | Germination | Glutamine | Alternative splicing | Yeast | Transcription | Splicing | Detoxification | Byproducts | Chemical reactions | Homology | Cytosol | Seedlings | Mitochondria | Developmental stages | Chloroplasts | Coding | Compartments | Isoforms | Glycolysis | Biocompatibility | Lactoylglutathione lyase | Pyruvaldehyde | Species | Sugar | Carbonyls | Index Medicus
Journal Article
Glia, ISSN 0894-1491, 10/2018, Volume 66, Issue 10, pp. 2233 - 2245
Astrocytes are a glial cell type, which is indispensable for brain energy metabolism. Within cells, the NADH/NAD + redox state is a crucial node in metabolism... 
NBCe1 | redox state | Peredox | astrocyte | NADH/NAD | OXIDATIVE-PHOSPHORYLATION | HIPPOCAMPAL SLICES | NAD(+)/NADH RATIO | NICOTINAMIDE-ADENINE DINUCLEOTIDE | GLUCOSE-UTILIZATION | EXTRACELLULAR K | NEUROSCIENCES | NADH/NAD(+) redox state | AEROBIC GLYCOLYSIS | BRAIN METABOLISM | ENERGY-METABOLISM | NAD(P)H FLUORESCENCE TRANSIENTS | L-Lactate Dehydrogenase - metabolism | Potassium - metabolism | Adenosine Triphosphate - administration & dosage | Oxidation-Reduction | Tissue Culture Techniques | Lactic Acid - metabolism | Mice, Inbred C57BL | Cells, Cultured | Cerebral Cortex - metabolism | Receptors, Purinergic - metabolism | Sodium-Bicarbonate Symporters - metabolism | Extracellular Space - metabolism | Glutamic Acid - administration & dosage | Animals | Adenosine Triphosphate - metabolism | Intracellular Space - metabolism | Cytosol - metabolism | Glutamic Acid - metabolism | Neurons - metabolism | NAD - metabolism | Astrocytes - metabolism | Neurons | Brain | Energy metabolism | Phosphorylation | Purine receptors | Brain slice preparation | Bicarbonates | Neuronal-glial interactions | Bicarbonate | Heterogeneity | Genetic code | Mitochondria | Receptors | NADH | Coding | Inhibition | Redox properties | Astrocytes | Cortex | Lactate dehydrogenase | Calibration | Metabolism | L-Lactate dehydrogenase | NAD | Neurotransmitters | Oxidative phosphorylation | Sodium | Nicotinamide adenine dinucleotide | Energy demand | Lactic acid | ATP | Potassium
Journal Article