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PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e23183
Elevated concentrations of serum non-esterified fatty acids (NEFA), associated with maternal disorders such as obesity and type II diabetes, alter the ovarian... 
IN-VITRO | OBESITY | INFERTILE WOMEN | METABOLISM | GLUCOSE-TRANSPORTER | MULTIDISCIPLINARY SCIENCES | PREIMPLANTATION DEVELOPMENT | STEARIC-ACID | BODY-MASS INDEX | PALMITIC ACID | INDUCE APOPTOSIS | Palmitic Acid - pharmacology | Apoptosis - drug effects | Cell Count | Zygote - metabolism | Blastocyst - physiology | Male | Fatty Acids, Nonesterified - pharmacology | Oxygen - metabolism | Receptor, IGF Type 2 - genetics | Amino Acids - metabolism | Oocytes - cytology | Oleic Acid - pharmacology | Palmitic Acid - blood | Cattle | Oleic Acid - blood | Pyruvic Acid - metabolism | Fatty Acids, Nonesterified - blood | Female | Zygote - cytology | Oocytes - metabolism | Blastocyst - metabolism | Gene Expression Regulation, Developmental - drug effects | Blastocyst - cytology | Reverse Transcriptase Polymerase Chain Reaction | DNA (Cytosine-5-)-Methyltransferases - genetics | Animals | Lactates - metabolism | Oocytes - physiology | Glucose Transporter Type 1 - genetics | Stearic Acids - blood | Glucose - metabolism | Zygote - physiology | Stearic Acids - pharmacology | Lactates | Obesity | Embryonic development | Embryo | Methyltransferases | RNA | Genes | Amino acids | Fatty acids | Apoptosis | Laboratories | Oxidative metabolism | Pyruvic acid | mRNA | Biochemistry | Oocytes | Insulin-like growth factor II receptors | Fertility | Quality | DNA methylation | Physiology | Carbohydrates | Oxygen | Maturation | Diabetes mellitus | Oxygen consumption | Blastocysts | Gene expression | Metabolism | Embryos | Esterification | Zygotes | Cell number | Insulin resistance | Hypoxia | Reproductive technologies | Diabetes | Lactic acid | Miscarriage | Viability | Metabolic disorders | Pharmaceuticals
Journal Article
Annals of Biomedical Engineering, ISSN 0090-6964, 1/2017, Volume 45, Issue 1, pp. 297 - 305
.... With an alginate shell and a poly(lactic-co-glycolic acid) (PLGA) core, the fabricated tubes displayed sequential release of distinct fluorescent dyes and showed no cytotoxicity when incubated with the human embryonic kidney (HEK293... 
Biomedicine, general | Biomedical Engineering | Biochemistry, general | Controlled delivery | Biomedicine | PLGA | Composite materials | Classical Mechanics | Differential delivery | Alginate | Biological and Medical Physics, Biophysics | Extrusion printing | SYSTEM | ENGINEERING, BIOMEDICAL | TISSUE | RELEASE PROFILES | TABLETS | MATRICES | BONE REGENERATION | MULTIPLE-DRUGS | Alginates - pharmacology | Fluorescent Dyes - chemistry | Fluorescent Dyes - pharmacokinetics | Lactic Acid - chemistry | Humans | Polyglycolic Acid - pharmacology | Delayed-Action Preparations - chemistry | Glucuronic Acid - pharmacokinetics | Hexuronic Acids - chemistry | Hexuronic Acids - pharmacokinetics | Lactic Acid - pharmacokinetics | Glucuronic Acid - pharmacology | Polyglycolic Acid - pharmacokinetics | Alginates - chemistry | Delayed-Action Preparations - pharmacology | Polyglycolic Acid - chemistry | Delayed-Action Preparations - pharmacokinetics | HEK293 Cells | Fluorescent Dyes - pharmacology | Glucuronic Acid - chemistry | Lactic Acid - pharmacology | Printing, Three-Dimensional | Alginates - pharmacokinetics | Hexuronic Acids - pharmacology | Drugs | Proteins | Drug delivery systems | Pharmacy | Therapeutics | Stem cells | Computer-aided design | 3D printing | Homeopathy | Materia medica and therapeutics | Vehicles | Biomedical engineering | Sequential delivery | Toxicity | Control systems | Tubes | Devices | Controlled Delivery | Differential Delivery | Composite Materials
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 7/2014, Volume 111, Issue 28, pp. 10287 - 10292
.... The NPs consist of poly(D,L-lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG), and bisphosphonate... 
Nanoparticles | Femur | Emulsions | Antineoplastics | Multiple myeloma | Fluorescence | Bones | Pretreatment | Polymers | Cancer | Alendronate-PLGA-PEG | Targeting nanomedicine | Bisphosphonate | Bone metastasis | MULTIPLE-MYELOMA | CELLS | DEXAMETHASONE | ACTIVATION | bone metastasis | VIVO | MULTIDISCIPLINARY SCIENCES | BORTEZOMIB | ANTITUMOR-ACTIVITY | targeting nanomedicine | IN-VITRO | THERAPY | PATHWAY | alendronate-PLGA-PEG | bisphosphonate | Neoplasm Transplantation | Polyglycolic Acid - chemical synthesis | Nanoparticles - chemistry | Humans | Polyglycolic Acid - pharmacology | Polyethylene Glycols - chemistry | Boronic Acids - chemistry | Bone Neoplasms - pathology | Alendronate - chemistry | Bone Neoplasms - metabolism | Drug Delivery Systems | Neoplasms, Experimental - pathology | Multiple Myeloma - drug therapy | Heterografts | Antineoplastic Agents - pharmacology | Bone Neoplasms - drug therapy | Lactic Acid - pharmacology | Tumor Microenvironment - drug effects | Bortezomib | Lactic Acid - chemistry | Nanoparticles - ultrastructure | Polyethylene Glycols - pharmacokinetics | Antineoplastic Agents - chemistry | Multiple Myeloma - metabolism | Xenograft Model Antitumor Assays | Pyrazines - chemistry | Multiple Myeloma - pathology | Animals | Mice, Nude | Polyglycolic Acid - chemistry | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Polyethylene Glycols - chemical synthesis | Lactic Acid - chemical synthesis | Neoplasms, Experimental - metabolism | Pyrazines - pharmacology | Neoplasms, Experimental - drug therapy | Boronic Acids - pharmacology | Biological Sciences | Physical Sciences
Journal Article
The Journal of Physiology, ISSN 0022-3751, 12/2017, Volume 595, Issue 23, pp. 7167 - 7183
Key points Chronic limb ischaemia, characterized by inflammatory mediator release and a low extracellular pH, leads to acid... 
acid‐sensing ion channels | muscle ischemia | opioid | acid-sensing ion channels | LOCALIZATION | PHYSIOLOGY | NEUROSCIENCES | SENSORY NEURONS | RAT MODEL | SKELETAL-MUSCLE | PAIN | PHARMACOLOGY | EXPRESSION | ASIC3 | Blood Pressure | Acid Sensing Ion Channel Blockers - pharmacology | Analgesics, Opioid - pharmacology | Male | Action Potentials | Sensory Receptor Cells - metabolism | Lactic Acid - pharmacology | Lactic Acid - administration & dosage | Peripheral Arterial Disease - metabolism | Reflex | Cell Line | Cells, Cultured | Ischemia - metabolism | Rats | Ischemia - physiopathology | Rats, Sprague-Dawley | Drug Synergism | Peripheral Arterial Disease - physiopathology | Animals | Sensory Receptor Cells - drug effects | Analgesics, Opioid - administration & dosage | Hindlimb - blood supply | Naloxone - pharmacology | Mice | Oligopeptides - administration & dosage | Ganglia, Spinal - drug effects | Naloxone - administration & dosage | Oligopeptides - pharmacology | Acid Sensing Ion Channels - metabolism | Ganglia, Spinal - metabolism | Blood pressure | Lactic acid | Ischemia | Analysis | Membrane proteins | Potentiation | Femur | Femoral artery | Pressure effects | Opioid receptors (type mu) | Stimulation | Activation | pH effects | Pertussis toxin | Arteries | Proteins | Pertussis | Dorsal root ganglia | Vascular diseases | Endomorphin-1 | Rodents | Modulation | Endomorphin-2 | Sensory neurons | Ion channels | Mathematical models | Inhibition | Pretreatment | Reflexes | Sodium channels | Deactivation | Narcotics | Computer simulation | Neurons | Endomorphin | Muscles | Inflammation | Acidity | Patients | Naloxone | Acids | Circulatory system | Detection | Research Paper | Neuroscience ‐ Cellular | Molecular
Journal Article
Acta biomaterialia, ISSN 1742-7061, 2016, Volume 29, pp. 248 - 260
.... Here, a dual coating of poly (ethylene glycol)-poly (d,l-lactic acid) (PEG-PDLLA) and water-soluble chitosan oligosaccharide (CO... 
Interstitial penetration | Dual coating | Polymeric nanoparticles | Chitosan oligosaccharide | Poly (ethylene glycol)-poly (d,l-lactic acid) (PEG-PDLLA) | Tumor accumulation | CORE NANOPARTICLES | DRUG | MATERIALS SCIENCE, BIOMATERIALS | DEEP PENETRATION | ENGINEERING, BIOMEDICAL | DELIVERY-SYSTEMS | BIOLOGICAL-ACTIVITIES | PEG CHAIN-LENGTH | SURFACE-CHARGE | Poly (ethylene glycol)-poly (D,L-lactic acid) (PEG-PDLLA) | IN-VITRO | CATIONIC NANOPARTICLES | Nanoparticles - chemistry | Humans | Polyglycolic Acid - pharmacology | Polyethylene Glycols - chemistry | Breast Neoplasms - metabolism | Oligosaccharides - pharmacology | Lactic Acid - pharmacokinetics | Oligosaccharides - chemistry | Chitosan - pharmacology | Polyesters | Female | Lactic Acid - pharmacology | Polyethylene Glycols - pharmacology | Oligosaccharides - pharmacokinetics | Lactic Acid - chemistry | Polyethylene Glycols - pharmacokinetics | Breast Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Chitosan - chemistry | Polyglycolic Acid - pharmacokinetics | Breast Neoplasms - pathology | Chitosan - pharmacokinetics | Mice, Nude | Polyglycolic Acid - chemistry | Polymers - pharmacokinetics | Polymers - pharmacology | Cell Line, Tumor | Polymers - chemistry | Mice | Mice, Inbred BALB C | Lactic acid | Coatings | Polyethylene glycol | Tumors | Drugs | Nanoparticles | Yuan (China) | Drug delivery systems | Nanotechnology | Vehicles | Penetration | Cationic | Interstitials | Charge | Coating | Oligosaccharides
Journal Article
International journal of nanomedicine, ISSN 1178-2013, 2017, Volume 12, pp. 5745 - 5760
.... In this study, a facilely prepared poly(lactic-co-glycolic acid) (PLGA)-polyethylene glycol (PEG)-folic acid (FA) copolymer was able to self-assemble into nanoparticle... 
Biodegradable nanoparticle | Drug delivery | Security | Tumor therapy | Efficient | Tumor target | tumor target | efficient | ANTICANCER DRUG | NANOSCIENCE & NANOTECHNOLOGY | CANCER THERAPY | drug delivery | PLGA-PEG NANOPARTICLES | tumor therapy | CELLULAR UPTAKE | POROUS SILICON | security | IN-VIVO | SILICA NANOPARTICLES | PHARMACOLOGY & PHARMACY | BIOMEDICAL APPLICATIONS | POLYMER NANOPARTICLES | biodegradable nanoparticle | COPOLYMER MICELLES | Folic Acid - pharmacology | Nanoparticles - chemistry | Humans | Drug Carriers - administration & dosage | Polyethylene Glycols - chemistry | Antineoplastic Agents - administration & dosage | Zebrafish - embryology | Embryo, Nonmammalian - drug effects | Tetrazolium Salts | Thiazoles | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Doxorubicin - administration & dosage | Cell Survival - drug effects | Rabbits | Lactic Acid - chemistry | Polyglactin 910 | Folic Acid - chemistry | Materials Testing | Nanoparticles - toxicity | Doxorubicin - pharmacokinetics | Animals | Polyglycolic Acid - chemistry | Drug Carriers - pharmacokinetics | Nanoparticles - administration & dosage | HeLa Cells | Drug Delivery Systems - methods | Doxorubicin - pharmacology | Drugs | Drug delivery systems | Usage | Pharmacology, Experimental | Research | Antineoplastic agents | Folic acid | Vehicles | Antimitotic agents | Nanoparticles | Polyethylene glycol | Polymers in medicine | Dosage and administration | Health aspects | Nanomedicine | Cytotoxicity | Nanomaterials | Permeability | Bioavailability | Acids | Microscopy | Efficiency | Vitamin B | Biocompatibility | Laboratory animals | Apoptosis
Journal Article
Biomaterials, ISSN 0142-9612, 2009, Volume 30, Issue 8, pp. 1627 - 1634
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2012, Volume 75, Issue 6, pp. 1094 - 1104
Astrocytes are proposed to participate in brain energy metabolism by supplying substrates to neurons from their glycogen stores and from glycolysis. However,... 
CENTRAL WHITE-MATTER | MOUSE-BRAIN | GLYCOGEN-METABOLISM | SYNAPTIC FUNCTION | VASOACTIVE-INTESTINAL-PEPTIDE | RAT HIPPOCAMPAL SLICES | GLUCOSE DEPRIVATION | ENERGY-METABOLISM | EXTRACELLULAR PH | PRIMARY CULTURES | NEUROSCIENCES | Potassium - metabolism | Microtubule-Associated Proteins - metabolism | Bicarbonates - pharmacology | Green Fluorescent Proteins - genetics | Astrocytes - enzymology | Glial Fibrillary Acidic Protein - metabolism | Excitatory Postsynaptic Potentials - drug effects | Microscopy, Immunoelectron | Dose-Response Relationship, Drug | Monocarboxylic Acid Transporters - antagonists & inhibitors | Monocarboxylic Acid Transporters - metabolism | Glycogen - metabolism | Neurons - ultrastructure | Tetrodotoxin - pharmacology | Neurons - drug effects | Cyclic AMP - metabolism | Animals, Newborn | Astrocytes - drug effects | Green Fluorescent Proteins - metabolism | 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology | Lactic Acid - metabolism | Phosphodiesterase Inhibitors - pharmacology | Rats | Sodium Channel Blockers - pharmacology | Adenylyl Cyclases - metabolism | Hippocampus - cytology | Rats, Sprague-Dawley | 1-Methyl-3-isobutylxanthine - pharmacology | Astrocytes - ultrastructure | Glucose - deficiency | Patch-Clamp Techniques | Animals | Models, Biological | Neurons - enzymology | In Vitro Techniques | Coumaric Acids - pharmacology | Lactates | Glucose metabolism | Medical colleges | Neurosciences | Neurons | Glycogen | Carbonates | Proteins | Medical research | Enzymes | Brain research | Rodents | Labeling | Communication
Journal Article
Biomaterials, ISSN 0142-9612, 2006, Volume 27, Issue 28, pp. 4894 - 4903
.... We developed novel 3-D chitosan/poly(lactic acid-glycolic acid) (PLAGA) composite porous scaffolds by sintering together composite chitosan/PLAGA microspheres for bone tissue engineering applications... 
Poly(lactic acid-glycolic acid) | Bone tissue engineering | Microsphere | Chitosan | Scaffold | chitosan | CELLS | ATTACHMENT | MATERIALS SCIENCE, BIOMATERIALS | bone tissue engineering | ENGINEERING, BIOMEDICAL | REGENERATION | SURFACE MODIFICATION | PROLIFERATION | CHITOSAN SPONGE | TRABECULAR BONE | scaffold | GROWTH | CHITIN | microsphere | BIOMATERIALS | poly(lactic acid-glycolic acid) | Polyglycolic Acid - chemical synthesis | Biocompatible Materials - chemistry | Sialoglycoproteins - metabolism | Alkaline Phosphatase - metabolism | Polyglycolic Acid - pharmacology | Microspheres | Alkaline Phosphatase - analysis | Chitosan - pharmacology | Osteoblasts - cytology | Lactic Acid - pharmacology | Chitosan - chemical synthesis | Microscopy, Electron, Scanning | Reproducibility of Results | Lactic Acid - chemistry | Tissue Engineering - methods | Polymers - chemical synthesis | Osteocalcin - metabolism | Osteoblasts - drug effects | Osteopontin | Biocompatible Materials - pharmacology | Tissue Engineering - instrumentation | Animals | Chitosan - chemistry | Polyglycolic Acid - chemistry | Polymers - pharmacology | Polymers - chemistry | Mice | Lactic Acid - chemical synthesis | Osteoblasts - metabolism | 3T3 Cells | Mechanical properties | Biological products | Phosphatases | Gene expression | Analysis | Sintering
Journal Article