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Neuron, ISSN 0896-6273, 06/2012, Volume 74, Issue 5, pp. 801 - 808
The steroid 17β-estradiol (E2) is well known to influence hippocampal functions such as memory, affective behaviors, and epilepsy. There is growing awareness... 
CA1 | EXCITABILITY | STEROIDS | SYNAPSES | ESTROGEN-RECEPTOR-ALPHA | SYNAPTIC-TRANSMISSION | NEURONS | RELEASE | BINDING | NEUROSCIENCES | Cannabinoid Receptor Modulators - metabolism | CA1 Region, Hippocampal - cytology | Electric Stimulation | Estrogens - pharmacology | Male | Receptors, Metabotropic Glutamate - metabolism | Pyridazines - pharmacology | Lactones - pharmacology | Dose-Response Relationship, Drug | Drug Interactions | Castration | Piperidines - pharmacology | Excitatory Amino Acid Agents - pharmacology | Neurons - physiology | Female | Neurons - drug effects | Endocannabinoids | Estradiol - pharmacology | Pyrazoles - pharmacology | Enzyme Inhibitors - pharmacology | NAD - pharmacology | Cannabinoid Receptor Modulators - agonists | Morpholines - pharmacology | Rats | Biophysics | Rats, Sprague-Dawley | GABA Antagonists - pharmacology | Naphthalenes - pharmacology | Patch-Clamp Techniques | Animals | Benzoxazines - pharmacology | Cannabinoid Receptor Modulators - antagonists & inhibitors | Phenols | In Vitro Techniques | Neural Inhibition - drug effects | Benzodioxoles - pharmacology | Inhibitory Postsynaptic Potentials - drug effects | Brain | Epilepsy | Estrogen | GABA | Hormones, Sex | Estradiol | Studies | Rodents | Gender differences | Behavior | Males | Females | Index Medicus | Presynapse | Emotional behavior | gamma -Aminobutyric acid | Neurosteroids | Memory | Sex | Estrogen receptors | Cannabinoid CB1 receptors | Anandamide | Synaptic transmission | Hippocampus | Steroid hormones | Synapses
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2011, Volume 31, Issue 41, pp. 14600 - 14610
Orexin A and B are hypothalamic peptides known to modulate arousal, feeding, and reward via OX1 and OX2 receptors. Orexins are also antinociceptive in the... 
ENERGY HOMEOSTASIS | SYNAPTIC-TRANSMISSION | FEEDING-BEHAVIOR | PHOSPHOLIPASE-C | NEURONS | SPINAL-CORD | DIACYLGLYCEROL LIPASE | STRESS-INDUCED ANALGESIA | NEUROSCIENCES | HIPPOCAMPAL SYNAPSES | HYPOCRETIN OREXIN | Cannabinoid Receptor Modulators - pharmacology | Benzoxazoles - pharmacology | Electric Stimulation | Neural Pathways - drug effects | Rats, Wistar | Receptors, G-Protein-Coupled - metabolism | gamma-Aminobutyric Acid - metabolism | Periaqueductal Gray - drug effects | Male | Receptors, Neuropeptide - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Pain - metabolism | Neural Pathways - physiology | Lactones - pharmacology | Neural Inhibition - physiology | Biphenyl Compounds - pharmacology | Piperidines - pharmacology | Pain - drug therapy | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Urea - analogs & derivatives | Endocannabinoids | Disease Models, Animal | Pyrazoles - pharmacology | Animals, Newborn | Orexins | Enzyme Inhibitors - pharmacology | Receptors, Neuropeptide - antagonists & inhibitors | Morpholines - pharmacology | Rats | Neuropeptides - metabolism | Pain Measurement - drug effects | Orexin Receptors | Pain - pathology | Arachidonic Acids - pharmacology | Naphthalenes - pharmacology | Calcium Channel Blockers | Glycerides - pharmacology | Patch-Clamp Techniques | Animals | Analysis of Variance | Benzoxazines - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Periaqueductal Gray - physiology | In Vitro Techniques | Neural Inhibition - drug effects | Inhibitory Postsynaptic Potentials - drug effects | Urea - pharmacology | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 12/2002, Volume 137, Issue 7, pp. 1021 - 1030
The mechanism(s) by which vascular endothelial growth factor (VEGF) induces endothelial nitric oxide synthase (eNOS) activation remain(s) unclear up to a... 
NO | eNOS | 2 | PAF | PI3K | PLA | VEGF | PLC | PKC | PROTEIN-KINASE-C | ANGIOGENESIS | PERMEABILITY | PHOSPHORYLATION | NITRIC-OXIDE SYNTHASE | CALMODULIN | CALCIUM | PAF SYNTHESIS | PHARMACOLOGY & PHARMACY | PLATELET-ACTIVATING-FACTOR | GROWTH-FACTOR | Endothelium, Vascular - cytology | Vascular Endothelial Growth Factors | Platelet Activating Factor - pharmacology | Protein-Serine-Threonine Kinases | Type C Phospholipases - metabolism | Endothelium, Vascular - drug effects | Endothelial Growth Factors - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, Cell Surface - antagonists & inhibitors | Lactones - pharmacology | Platelet Membrane Glycoproteins - antagonists & inhibitors | Calcium - antagonists & inhibitors | Time Factors | Cattle | Protein Kinase C - metabolism | Phosphorylation - drug effects | Chromones - pharmacology | Enzyme Inhibitors - pharmacology | Nitric Oxide Synthase Type III | Receptors, G-Protein-Coupled | Chelating Agents - pharmacology | Serine - metabolism | 1-Methyl-3-isobutylxanthine - pharmacology | Ginkgolides | Platelet Activating Factor - metabolism | Cyclic GMP - metabolism | Endothelium, Vascular - metabolism | Intercellular Signaling Peptides and Proteins - pharmacology | Nitric Oxide Synthase - metabolism | Vascular Endothelial Growth Factor A | Maleimides - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Nitroprusside - pharmacology | Type C Phospholipases - antagonists & inhibitors | Dose-Response Relationship, Drug | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Lymphokines - pharmacology | Nitric Oxide Donors - pharmacology | Ionophores - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Proto-Oncogene Proteins - metabolism | Cells, Cultured | Morpholines - pharmacology | Protein Kinase C - antagonists & inhibitors | Calcimycin - pharmacology | Proto-Oncogene Proteins c-akt | Animals | Egtazic Acid - pharmacology | Androstadienes - pharmacology | Diterpenes | Signal Transduction - physiology | Nitric Oxide - metabolism | Index Medicus | Papers | PLA2
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 2007, Volume 113, Issue 2, pp. 312 - 317
L. s.l. is traditionally used not only in the treatment of gastro-intestinal and hepato-biliary disorders, but also as an antiphlogistic drug. As various... 
Human neutrophil elastase | Anti-inflammatory activity | Matrix metalloproteinases | Achillea millefolium L | CHEMISTRY, MEDICINAL | ACID | SERINE PROTEASES | human neutrophil elastase | matrix metalloprotemases | anti-inflammatory activity | PLANT SCIENCES | MATRIX METALLOPROTEINASES | COLITIS | INTEGRATIVE & COMPLEMENTARY MEDICINE | DISEASE | MATRIX-METALLOPROTEINASE-9 | PLANTS | PHARMACOLOGY & PHARMACY | NEUTROPHIL ELASTASE ACTIVITY | Leukocyte Elastase - metabolism | Plant Extracts - chemistry | Sesquiterpenes - isolation & purification | Plant Extracts - pharmacology | Apigenin - isolation & purification | Humans | Rutin - pharmacology | Quinic Acid - isolation & purification | Fluorescence | Leukocyte Elastase - antagonists & inhibitors | Lactones - pharmacology | Apigenin - chemistry | Dose-Response Relationship, Drug | Protease Inhibitors - pharmacology | Rutin - isolation & purification | Matrix Metalloproteinase 9 - metabolism | Protease Inhibitors - isolation & purification | Piperidines - pharmacology | Quercetin - isolation & purification | Luteolin - chemistry | Glucosides - chemistry | Anti-Inflammatory Agents - isolation & purification | Molecular Structure | Quinic Acid - pharmacology | Lactones - chemistry | Quinic Acid - analogs & derivatives | Glucosides - pharmacology | Piperidines - chemistry | Quercetin - chemistry | Sesquiterpenes - chemistry | Lactones - isolation & purification | Anti-Inflammatory Agents - pharmacology | Matrix Metalloproteinase 2 - metabolism | Protease Inhibitors - chemistry | Quinic Acid - chemistry | Plant Extracts - isolation & purification | Luteolin - pharmacology | Glucosides - isolation & purification | Luteolin - isolation & purification | Anti-Inflammatory Agents - chemistry | Quercetin - pharmacology | Achillea - chemistry | Matrix Metalloproteinase Inhibitors | Rutin - chemistry | Sesquiterpenes - pharmacology | Apigenin - pharmacology | Elastases | Anti-inflammatory drugs | Index Medicus
Journal Article
FASEB Journal, ISSN 0892-6638, 03/2006, Volume 20, Issue 3, pp. 542 - 544
It is widely believed that the potencies of nonsteroid anti-inflammatory drugs ( NSAIDs) as inhibitors of cyclooxygenase ( COX) are influenced by protein... 
SITE | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | nonsteroid anti-inflammatory drugs | coxibs | PROSTAGLANDIN H-2 SYNTHASE | CELL BIOLOGY | CYCLO-OXYGENASE-2 | THERAPY | FLUID | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | BIOLOGY | prostaglandins | SELECTIVITY | Organic Chemicals - cerebrospinal fluid | Humans | Naproxen - pharmacology | Synovial Fluid - metabolism | Pyrazoles - cerebrospinal fluid | Sodium Salicylate - pharmacology | Lactones - pharmacology | Aspirin - cerebrospinal fluid | Cell Line - drug effects | Calcium - physiology | Pyrazoles - blood | Organic Chemicals - pharmacology | Dinoprostone - cerebrospinal fluid | Diclofenac - cerebrospinal fluid | Aspirin - pharmacology | Sulfones - cerebrospinal fluid | Aspirin - blood | Thiazines - blood | Sulfonamides - pharmacology | Indomethacin - cerebrospinal fluid | Indomethacin - pharmacology | Cyclooxygenase 1 - drug effects | Cyclooxygenase Inhibitors - adverse effects | Cyclooxygenase Inhibitors - blood | Diclofenac - pharmacology | Thiazoles - blood | Thromboxane A2 - blood | Cerebrospinal Fluid Proteins - pharmacology | Dinoprostone - biosynthesis | Lactones - cerebrospinal fluid | Blood Platelets - enzymology | Cyclooxygenase 2 Inhibitors - cerebrospinal fluid | Sodium Salicylate - cerebrospinal fluid | Sulfones - pharmacology | Blood Proteins - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Sulfonamides - blood | Lactones - blood | Naproxen - cerebrospinal fluid | Sodium Salicylate - blood | Thiazines - pharmacology | Cyclooxygenase 2 Inhibitors - blood | Cyclooxygenase Inhibitors - cerebrospinal fluid | Blood Platelets - drug effects | Sulfones - blood | Organic Chemicals - blood | Ionophores - pharmacology | Pyrazoles - pharmacology | Sulfonamides - cerebrospinal fluid | Cyclooxygenase 2 Inhibitors - pharmacology | Thiazoles - cerebrospinal fluid | Celecoxib | Diclofenac - blood | Dinoprostone - blood | Naproxen - blood | Organ Specificity | Calcimycin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Indomethacin - blood | Protein Binding | Thiazines - cerebrospinal fluid | Thiazoles - pharmacology | Index Medicus
Journal Article
Journal Article
Journal of Investigational Allergology and Clinical Immunology, ISSN 1018-9068, 2017, Volume 27, Issue 3, pp. 160 - 168
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 06/2011, Volume 136, Issue 2, pp. 355 - 362
Journal Article
Circulation, ISSN 0009-7322, 04/2004, Volume 109, Issue 14, pp. 1714 - 1717
Background - Transient (low-conductance) opening of the mitochondrial permeability transition pore (mPTP) may limit mitochondrial calcium load and mediate... 
Myocardial infarction | Free radicals | Reperfusion | Ischemia | MYOCARDIUM | CELLS | free radicals | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCYTES | myocardial infarction | INJURY | ADENOSINE | DIAZOXIDE | ischemia | FREE-RADICALS | CYCLOSPORINE-A | PERIPHERAL VASCULAR DISEASE | RAT-HEART | CHANNELS | HEMATOLOGY | reperfusion | Diazoxide - pharmacology | Reactive Oxygen Species - metabolism | Uncoupling Agents - pharmacology | Cyclosporine - pharmacology | Adrenergic alpha-1 Receptor Agonists | Ion Channels - drug effects | Male | Electric Conductivity | Ion Channels - physiology | Lactones - pharmacology | Oxidative Phosphorylation - drug effects | Mitochondrial Membrane Transport Proteins | Ion Channel Gating - physiology | Myocardial Ischemia - physiopathology | Ion Transport - drug effects | Vasodilator Agents - pharmacology | Cells, Cultured | Rats | Adenosine - pharmacology | Cardiotonic Agents - pharmacology | Rats, Sprague-Dawley | Myocardial Reperfusion Injury - physiopathology | Macromolecular Substances | Animals | Myocytes, Cardiac - drug effects | Ischemic Preconditioning, Myocardial | Mitochondria, Heart - physiology | Myocytes, Cardiac - physiology | Adenosine - analogs & derivatives | 2,4-Dinitrophenol - pharmacology | Adrenergic alpha-Agonists - pharmacology | Signal Transduction - physiology | Ion Transport - physiology | Myocardial Reperfusion Injury - prevention & control | Spiro Compounds - pharmacology | Ion Channel Gating - drug effects | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Natural Products, ISSN 0163-3864, 11/2002, Volume 65, Issue 11, pp. 1517 - 1521
A rapid semi-homogeneous cyclooxygenase-2 (COX-2) enzymatic assay using scintillation proximity assay (SPA) technology was developed, and 49 ubiquitous plant... 
RESVERATROL | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | ACID | PROSTAGLANDIN BIOSYNTHESIS | NITRIC-OXIDE SYNTHASE | PHENOLIC-COMPOUNDS | MACROPHAGES | IDENTIFICATION | DISCOVERY | PLANT SCIENCES | PHARMACOLOGY & PHARMACY | PHORBOL ESTER | Acrolein - analogs & derivatives | Triterpenes - pharmacology | Dinoprostone - biosynthesis | Cyclooxygenase 2 | Alkaloids - isolation & purification | Oleanolic Acid - pharmacology | Nitrobenzenes - pharmacology | Lactones - pharmacology | Dose-Response Relationship, Drug | Syzygium - chemistry | Terpenes - pharmacology | Terpenes - chemistry | Isoenzymes - metabolism | Inhibitory Concentration 50 | Biological Assay | Steroids - pharmacology | Flavonoids - pharmacology | Aspirin - pharmacology | Catalysis | Sulfones | Steroids - chemistry | Acrolein - pharmacology | Pyrogallol - pharmacology | Plants, Medicinal - chemistry | Alkaloids - pharmacology | Terpenes - isolation & purification | Cinnamomum zeylanicum - chemistry | Anthraquinones - isolation & purification | Models, Molecular | Eugenol - pharmacology | Sulfonamides - pharmacology | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Animals | Cyclooxygenase 2 Inhibitors | Prostaglandin-Endoperoxide Synthases - metabolism | Steroids - isolation & purification | Anthraquinones - pharmacology | Flavonoids - isolation & purification | Kinetics | Anthraquinones - chemistry | Flavonoids - chemistry | Alkaloids - chemistry | Index Medicus | Pharmaceutical Sciences | Basic Medicine | PHARMACY | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | FARMACI | Farmaceutiska vetenskaper
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2001, Volume 345, Issue 25, pp. 1809 - 1817
Journal Article
15.