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1. Full Text Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
by Gomez Perdiguero, Elisa and Klapproth, Kay and Schulz, Christian and Busch, Katrin and Azzoni, Emanuele and Crozet, Lucile and Garner, Hannah and Trouillet, Celine and De Bruijn, Marella F and Geissmann, Frederic and Rodewald, Hans-Reimer
Nature, ISSN 0028-0836, 02/2015, Volume 518, Issue 7540, pp. 547 - 551
Most haematopoietic cells renew from adult haematopoietic stem cells (HSCs)(1-3), however, macrophages in adult tissues can self-maintain independently of... 
CIRCULATING MONOCYTES | MICROGLIA DERIVE | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC STEM-CELLS | IN-VIVO | ONTOGENY | DIFFERENTIATION | ADULT LIFE | MATURATION | FETAL LIVER | MOUSE EMBRYO | Microglia - cytology | Granulocytes - cytology | Cell Proliferation | Kupffer Cells - cytology | Monocytes - cytology | Male | Stem Cells - cytology | Macrophages - cytology | Liver - embryology | Receptor, Macrophage Colony-Stimulating Factor - metabolism | Yolk Sac - cytology | fms-Like Tyrosine Kinase 3 - metabolism | Cell Tracking | Fetus - cytology | Cell Lineage | Animals | Hematopoiesis | Erythrocytes - cytology | Female | Macrophages, Alveolar - cytology | Receptor, TIE-2 - metabolism | Liver - cytology | Mice | Langerhans Cells - cytology | Physiological aspects | Genetic aspects | Research | Macrophages | Hematopoietic stem cells | Studies | Tissue | Rodents | Stem cells | Bone marrow | Embryos | Blood
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2. Full Text A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
by Christian Schulz and Elisa Gomez Perdiguero and Laurent Chorro and Heather Szabo-Rogers and Nicolas Cagnard and Katrin Kierdorf and Marco Prinz and Bishan Wu and Sten Eirik W. Jacobsen and Jeffrey W. Pollard and Jon Frampton and Karen J. Liu and Frederic Geissmann
Science, ISSN 0036-8075, 4/2012, Volume 336, Issue 6077, pp. 86 - 90
Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs).... 
Bacteriophages | Kidneys | Lungs | Blood cells | Liver | REPORTS | Islets of Langerhans | Macrophages | Embryos | Blood | Hematopoietic stem cells | MICROGLIA DERIVE | IMMUNOHISTOCHEMICAL LOCALIZATION | YOLK-SAC | MULTIDISCIPLINARY SCIENCES | FLT3 EXPRESSION | SELF-RENEWAL | C-MYB | MONONUCLEAR PHAGOCYTE SYSTEM | TRANSCRIPTION FACTOR | AORTIC ENDOTHELIUM | LANGERHANS CELLS | Myeloid Cells - cytology | Cell Proliferation | Myeloid Cells - physiology | Dendritic Cells - physiology | Genes, myb | Liver - embryology | Yolk Sac - cytology | Microglia - physiology | Gene Expression Regulation, Developmental | Gene Deletion | Trans-Activators - genetics | Hematopoietic Stem Cells - physiology | Myelopoiesis | Macrophages - physiology | Microglia - cytology | Proto-Oncogene Proteins - metabolism | Kupffer Cells - cytology | Kupffer Cells - physiology | Proto-Oncogene Proteins - genetics | Macrophages - cytology | Chick Embryo | Proto-Oncogene Proteins c-myb - metabolism | Cell Lineage | Animals | Embryo, Mammalian - cytology | Hematopoietic Stem Cells - cytology | Langerhans Cells - physiology | Trans-Activators - metabolism | Dendritic Cells - cytology | Mice | Langerhans Cells - cytology | Physiological aspects | Transcription factors | Dendritic cells | Health aspects | Infections | Rodents | Inflammatory diseases | Stem cells
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3. Full Text Generation of Functional Human Pancreatic β Cells In Vitro
by Pagliuca, Felicia W and Millman, Jeffrey R and Gürtler, Mads and Segel, Michael and Van Dervort, Alana and Ryu, Jennifer Hyoje and Peterson, Quinn P and Greiner, Dale and Melton, Douglas A
Cell, ISSN 0092-8674, 10/2014, Volume 159, Issue 2, pp. 428 - 439
The generation of insulin-producing pancreatic β cells from stem cells in vitro would provide an unprecedented cell source for drug discovery and cell... 
PROGENITORS | ISLETS | MODELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EMBRYONIC STEM-CELLS | INSULIN-SECRETION | ENDODERM | MICE | DIFFERENTIATION | MATURATION | EXPRESSION | CELL BIOLOGY | Pluripotent Stem Cells - metabolism | Insulin - metabolism | Animals | Pluripotent Stem Cells - cytology | Humans | Insulin-Secreting Cells - cytology | Mice | Cell Culture Techniques | Islets of Langerhans | Induced Pluripotent Stem Cells - cytology | Insulin - genetics | Induced Pluripotent Stem Cells - metabolism
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4. Full Text Origins and Functional Specialization of Macrophages and of Conventional and Monocyte-Derived Dendritic Cells in Mouse Skin
by Tamoutounour, Samira and Guilliams, Martin and Montanana Sanchis, Frédéric and Liu, Hong and Terhorst, Dorothea and Malosse, Camille and Pollet, Emeline and Ardouin, Laurence and Luche, Hervé and Sanchez, Cindy and Dalod, Marc and Malissen, Bernard and Henri, Sandrine
Immunity, ISSN 1074-7613, 11/2013, Volume 39, Issue 5, pp. 925 - 938
In the skin, the lack of markers permitting the unambiguous identification of macrophages and of conventional and monocyte-derived dendritic cells (DCs)... 
PATHWAYS | LYMPHOID ORGANS | DISTINCT | MICE | IMMUNOLOGY | EXPRESSION | LINEAGE | LANGERHANS CELLS | REVEALS | Chemotaxis, Leukocyte | Staining and Labeling - methods | Skin - cytology | Skin - microbiology | Monocytes - cytology | Dendritic Cells - immunology | Transcriptome | Dermatitis, Contact - immunology | CD11b Antigen - analysis | Gene Expression Regulation, Developmental | Receptors, IgG - analysis | Langerhans Cells - immunology | Lymphocyte Cooperation | Immunophenotyping - methods | Dermis - cytology | Principal Component Analysis | Skin - immunology | Macrophages - physiology | Antigens, Differentiation - analysis | Dermatitis, Contact - pathology | Microbiota - immunology | Specific Pathogen-Free Organisms | Radiation Chimera | Macrophages - cytology | Receptors, CCR2 - analysis | Cell Lineage | Animals | Dendritic Cells - cytology | Mice | Chromatography, Gel | Langerhans Cells - cytology | Fc receptors | Skin | Dendritic cells | T cells | Macrophages | Analysis | Genotype & phenotype | Kinases | Gene expression | Lymphocytes | Rodents
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5. Full Text Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages
by Hoeffel, Guillaume and Wang, Yilin and Greter, Melanie and See, Peter and Teo, Pearline and Malleret, Benoit and Leboeuf, Marylène and Low, Donovan and Oller, Guillaume and Almeida, Francisca and Choy, Sharon H.Y and Grisotto, Marcos and Renia, Laurent and Conway, Simon J and Stanley, E. Richard and Chan, Jerry K.Y and Ng, Lai Guan and Samokhvalov, Igor M and Merad, Miriam and Ginhoux, Florent
Journal of Experimental Medicine, ISSN 0022-1007, 06/2012, Volume 209, Issue 6, pp. 1167 - 1181
Langerhans cells (LCs) are the dendritic cells (DCs) of the epidermis, forming one of the first hematopoietic lines of defense against skin pathogens. In... 
COLONY-STIMULATING-FACTOR | MEDICINE, RESEARCH & EXPERIMENTAL | DENDRITIC CELLS | DEVELOPING MOUSE | HEMATOPOIETIC STEM-CELLS | IN-VIVO | ONTOGENY | STEADY-STATE | SKIN | DIFFERENTIATION | IMMUNOLOGY | MYELOID CELLS | Microglia - cytology | Skin - cytology | Age Factors | Mice, Inbred C57BL | Macrophages - cytology | Liver - embryology | Myeloid Progenitor Cells | Yolk Sac - cytology | Pregnancy | Stem Cells | Cell Lineage | Monocytes | Animals | Yolk Sac - embryology | Female | Liver - cytology | Mice | Langerhans Cells - cytology | Skin - embryology
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6. Full Text Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential
by D'Ippolito, Gianluca and Diabira, Sylma and Howard, Guy A and Menei, Philippe and Roos, Bernard A and Schiller, Paul C
Journal of Cell Science, ISSN 0021-9533, 06/2004, Volume 117, Issue 14, pp. 2971 - 2981
We report here the isolation of a population of non-transformed pluripotent human cells from bone marrow after a unique expansion/selection procedure. This... 
Aging | Bone marrow | Neurogenesis | Reparative medicine | Stem cells | Pluripotential | PROGENITOR CELLS | stem cells | GAP-JUNCTIONAL COMMUNICATION | reparative medicine | PHENOTYPES | bone marrow | MESENCHYMAL STEM-CELLS | CELL BIOLOGY | IN-VITRO | PANCREATIC-ISLETS | pluripotential | HUMAN BONE-MARROW | neurogenesis | aging | STROMAL CELLS | EX-VIVO | PRECURSOR CELLS | Chondrocytes - cytology | Cell Proliferation | Bone Marrow Cells - cytology | Humans | Middle Aged | Cells, Cultured | Child, Preschool | Adipocytes - cytology | Male | Neurons - cytology | Stem Cells - cytology | Mesoderm - cytology | Cell Lineage | Ectoderm - cytology | Endoderm - cytology | Islets of Langerhans - cytology | Adolescent | Adult | Female | Aged | Cell Differentiation | Cell Culture Techniques | Osteoblasts - cytology | Child
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7. Full Text Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β
by Mohammed, Javed and Beura, Lalit K and Bobr, Aleh and Astry, Brian and Chicoine, Brian and Kashem, Sakeen W and Welty, Nathan E and Igyártó, Botond Z and Wijeyesinghe, Sathi and Thompson, Emily A and Matte, Catherine and Bartholin, Laurent and Kaplan, Alesia and Sheppard, Dean and Bridges, Alina G and Shlomchik, Warren D and Masopust, David and Kaplan, Daniel H
Nature Immunology, ISSN 1529-2908, 04/2016, Volume 17, Issue 4, pp. 414 - 421
Cells of the immune system that reside in barrier epithelia provide a first line of defense against pathogens. Langerhans cells (LCs) and CD8(+)... 
INTESTINAL EPITHELIUM | DENDRITIC CELLS | AUTOCRINE/PARACRINE TGF-BETA-1 | TISSUE | CONTACT HYPERSENSITIVITY | STEADY-STATE | MICE | INTEGRIN ALPHA(V)BETA | SKIN | IMMUNOLOGY | LANGERHANS CELLS | T-Lymphocyte Subsets - immunology | CD8-Positive T-Lymphocytes - cytology | T-Lymphocyte Subsets - cytology | Humans | Immunity, Mucosal | Intestinal Mucosa - cytology | Stromal Cells | Transforming Growth Factor beta1 - immunology | Flow Cytometry | Intestinal Mucosa - immunology | Langerhans Cells - immunology | Polymerase Chain Reaction | Mink | Intestine, Small - immunology | Transforming Growth Factor beta - immunology | Antigens, Neoplasm - immunology | Integrins - immunology | Keratinocytes - immunology | Mice, Knockout | Animals | Epidermis - immunology | Intestine, Small - cytology | T-Lymphocytes - cytology | Fluorescent Antibody Technique | T-Lymphocytes - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | Langerhans Cells - cytology | Cell Movement | Epidermis - cytology | Life Sciences | Cancer
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8. Full Text Development of Monocytes, Macrophages, and Dendritic Cells
by Frederic Geissmann and Markus G. Manz and Steffen Jung and Michael H. Sieweke and Miriam Merad and Klaus Ley
Science, ISSN 0036-8075, 2/2010, Volume 327, Issue 5966, pp. 656 - 661
Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system.... 
Phagocytes | Monocytes | Myeloid cells | Dendritic cells | Stem cells | Bone marrow | Inflammation | Review | Macrophages | Progenitor cells | Blood | STEM-CELLS | HEMATOPOIETIC PROGENITOR CELLS | COLONY-STIMULATING FACTOR | MULTIDISCIPLINARY SCIENCES | IN-VIVO | BONE-MARROW | STEADY-STATE CONDITIONS | RECEPTOR | BLOOD MONOCYTES | FUNCTIONAL-PROPERTIES | LANGERHANS CELLS | Macrophages - physiology | Cell Proliferation | Cytokines - metabolism | Monocytes - cytology | Dendritic Cells - immunology | Humans | Dendritic Cells - physiology | Homeostasis | Inflammation - immunology | Monocytes - immunology | Macrophages - cytology | Cell Lineage | Animals | Myeloid Progenitor Cells - physiology | Myeloid Progenitor Cells - cytology | Transcription, Genetic | Dendritic Cells - cytology | Mice | Myelopoiesis | Monocytes - physiology | Macrophages - immunology | Phagocytosis | Properties | Immunology | Cellular biology | Developmental biology | Rodents | Inflammatory diseases | Dendritic Cells | Cytokines | Myeloid Progenitor Cells | Life Sciences
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9. Full Text The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells
by Collombat, Patrick and Xu, Xiaobo and Ravassard, Philippe and Sosa-Pineda, Beatriz and Dussaud, Sébastien and Billestrup, Nils and Madsen, Ole D and Serup, Palle and Heimberg, Harry and Mansouri, Ahmed
Cell, ISSN 0092-8674, 2009, Volume 138, Issue 3, pp. 449 - 462
We have previously reported that the loss of Arx and/or Pax4 gene activity leads to a shift in the fate of the different endocrine cell subtypes in the mouse... 
CELLBIO | PROTEINS | DEVBIO | INACTIVATION | REPLACEMENT | ENDOCRINE PANCREAS | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARX | ADULT PANCREAS | DIFFERENTIATION | KNOCKOUT MICE | LINEAGES | GLUCAGON | CELL BIOLOGY | Glucagon-Secreting Cells - cytology | Glucagon - deficiency | Homeodomain Proteins - metabolism | Pancreas - cytology | Stem Cells - cytology | Nerve Tissue Proteins - metabolism | Animals | Basic Helix-Loop-Helix Transcription Factors - metabolism | Islets of Langerhans - cytology | Cell Differentiation | Insulin-Secreting Cells - cytology | Mice | Pancreas - growth & development | Diabetes Mellitus, Experimental - metabolism | Paired Box Transcription Factors - metabolism | Fate specification | Mouse | Arx | Pax4 | Endocrine pancreas development | Diabetes | Facultative endocrine progenitor cell
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10. Full Text Beyond Stem Cells: Self-Renewal of Differentiated Macrophages
by Michael H. Sieweke and Judith E. Allen
Science, ISSN 0036-8075, 11/2013, Volume 342, Issue 6161, pp. 946 - 946
In many mammalian tissues, mature differentiated cells are replaced by self-renewing stem cells, either continuously during homeostasis or in response to... 
Cell growth | Adult stem cells | Cell cycle | Stem cells | Adults | REVIEW SUMMARY | Macrophages | Embryological stage | Cellular differentiation | Hematopoietic stem cells | HEMATOPOIETIC-CELLS | COLONY-STIMULATING FACTOR | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | TISSUE MACROPHAGES | C-MYB | CENTRAL-NERVOUS-SYSTEM | BLOOD MONOCYTES | FACTOR-I | ALVEOLAR MACROPHAGE | LANGERHANS CELLS | Animals | Cell Proliferation | Embryonic Stem Cells - cytology | Cytokines - metabolism | Signal Transduction | Monocytes - cytology | Humans | Rats | Cell Differentiation | Mice | Stem Cells - cytology | Macrophages - cytology | Cell proliferation | Physiological aspects | Research | Health aspects | Bone marrow | Homeostasis | Origins | Repair
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