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lanosterol - analogs & derivatives (379) 379
animals (249) 249
index medicus (245) 245
humans (210) 210
lanosterol - pharmacology (195) 195
biochemistry & molecular biology (193) 193
lanosterol - chemistry (172) 172
chemistry, medicinal (169) 169
pharmacology & pharmacy (145) 145
molecular structure (140) 140
lanosterol (120) 120
lanosterol - isolation & purification (120) 120
lanosterol - metabolism (118) 118
triterpenes - chemistry (100) 100
mice (86) 86
biosynthesis (82) 82
plant sciences (81) 81
rats (81) 81
cholesterol - biosynthesis (77) 77
structure-activity relationship (72) 72
male (71) 71
cholesterol (70) 70
triterpenes - isolation & purification (70) 70
chemistry, organic (69) 69
saccharomyces-cerevisiae (67) 67
antifungal agents - pharmacology (66) 66
chemistry, multidisciplinary (63) 63
triterpenes - pharmacology (60) 60
analysis (57) 57
squalene - analogs & derivatives (55) 55
sterols (54) 54
microbial sensitivity tests (53) 53
candida-albicans (51) 51
magnetic resonance spectroscopy (50) 50
intramolecular transferases - metabolism (49) 49
sterol 14-demethylase (49) 49
female (48) 48
inhibition (48) 48
lanosterol 14-alpha-demethylase (48) 48
derivatives (47) 47
nuclear magnetic resonance, biomolecular (46) 46
chemistry, applied (44) 44
cyclization (44) 44
enzymes (44) 44
kinetics (44) 44
lanosterol synthase (43) 43
cells (42) 42
enzyme inhibitors - pharmacology (42) 42
squalene - metabolism (42) 42
fungi (41) 41
antifungal agents - chemical synthesis (40) 40
cholesterol - analogs & derivatives (40) 40
sterol biosynthesis (40) 40
antifungal agents - chemistry (39) 39
biophysics (39) 39
models, molecular (39) 39
oxidosqualene cyclase (39) 39
physiological aspects (39) 39
cell line, tumor (38) 38
cholesterol - metabolism (38) 38
triterpenes - metabolism (38) 38
cell line (37) 37
molecular conformation (37) 37
ganoderma lucidum (36) 36
antifungal agents (35) 35
cytochrome p-450 enzyme system - metabolism (35) 35
inhibitors (35) 35
lanosterol - biosynthesis (35) 35
lipids (35) 35
liver - metabolism (35) 35
stereoisomerism (35) 35
amino acid sequence (34) 34
antifungal activity (34) 34
chemistry (34) 34
cholesterol-biosynthesis (34) 34
intramolecular transferases - genetics (34) 34
enzymatic cyclization (33) 33
mechanism (33) 33
molecular sequence data (33) 33
apoptosis (32) 32
in vitro techniques (32) 32
metabolism (32) 32
triterpenes (32) 32
cyp51 (31) 31
dose-response relationship, drug (31) 31
ergosterol (31) 31
microbiology (31) 31
squalene (31) 31
substrate specificity (31) 31
cytochrome p-450 enzyme inhibitors (30) 30
drug design (30) 30
drug screening assays, antitumor (30) 30
expression (30) 30
sterols - metabolism (30) 30
antineoplastic agents - pharmacology (29) 29
cell biology (29) 29
cytotoxicity (29) 29
research (29) 29
binding sites (28) 28
lanosterol - analysis (28) 28
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Chemistry – A European Journal, ISSN 0947-6539, 08/2018, Volume 24, Issue 43, pp. 11139 - 11157
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 03/2018, Volume 2018, Issue 12, pp. 1477 - 1490
Squalene‐hopene cyclase (SHC) has been found to convert acyclic squalene into 6,6,6,6,5‐fused pentacyclic triterpenes hopene and hopanol. The enzymatic... 
Alkenes | Cyclization | Enzyme catalysis | Terpenoids | Polycycles | 5-MEMBERED D-RING | CHEMISTRY, ORGANIC | SITE-DIRECTED MUTAGENESIS | SUBSTRATE RECOGNITION | CYCLIZATION MECHANISM | ENZYMATIC CYCLIZATION | METHYL-GROUP | FUNCTIONAL-ANALYSIS | PENTACYCLIC SCAFFOLD | OXIDOSQUALENE-LANOSTEROL CYCLASE | BETA-AMYRIN BIOSYNTHESIS
Journal Article
Chemical Biology & Drug Design, ISSN 1747-0277, 11/2011, Volume 78, Issue 5, pp. 800 - 809
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 2017, Volume 58, Issue 12, pp. 2310 - 2323
Ergosterol biosynthesis pathways essential to pathogenic protozoa growth and absent from the human host offer new chokepoint targets. Here, we present... 
Ergosterol biosynthesis inhibitors | Phytosterol biosynthesis | Anti-amoeba drugs | Sterol C24-methyltransferase | Acanthamoeba | anti-amoeba drugs | DELTA(25)-OLEFIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | DELTA(24)-STEROL METHYL TRANSFERASE | TRYPANOSOMA SCHIZOTRYPANUM CRUZI | ACANTHAMOEBA-KERATITIS | MECHANISTIC ANALYSIS | sterol C24-methyltransferase | EVOLUTION | ERGOSTEROL BIOSYNTHESIS | phytosterol biosynthesis | GROWTH | AGENTS | INHIBITORS | ergosterol biosynthesis inhibitors | Sterols - metabolism | Triterpenes - pharmacology | Protozoan Proteins - antagonists & inhibitors | Epithelial Cells - drug effects | Humans | Methyltransferases - metabolism | Methyltransferases - genetics | Substrate Specificity | Lanosterol - pharmacology | Lanosterol - analogs & derivatives | Protozoan Proteins - genetics | Phytosterols - pharmacology | Protozoan Proteins - metabolism | Acanthamoeba - enzymology | Drug Design | Acanthamoeba - genetics | Lanosterol - metabolism | Cholestadienols - metabolism | Epithelial Cells - cytology | Triterpenes - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Cell Survival - drug effects | Gene Expression | Acanthamoeba - drug effects | Kidney - cytology | Recombinant Proteins - genetics | Sequence Homology, Amino Acid | Sequence Alignment | Methyltransferases - antagonists & inhibitors | Phytosterols - metabolism | Protein Binding | Kinetics | Cholestadienols - pharmacology | Ergosterol | Protozoa | Sterols | Methyltransferase | Voriconazole | Substrate preferences | Biosynthesis | Suicide | Drug development | Cholesterol | Intermediates
Journal Article
Biological & pharmaceutical bulletin, ISSN 0918-6158, 07/2007, Volume 30, Issue 7, pp. 1246 - 1253
Our previous publication established a model to predict that the phenyl group of the C-3 side chain of azole antifungal compounds interacts with the phenol... 
Candida albicans | Mutation | Gene deletion | Inhibitor binding | CYP51 | MYCOBACTERIUM-TUBERCULOSIS | CYTOCHROME-P450 | SUBSTITUTION | FLUCONAZOLE RESISTANCE | SACCHAROMYCES-CEREVISIAE | gene deletion | DEMETHYLASE | mutation | inhibitor binding | PHARMACOLOGY & PHARMACY | AGENTS | REDUCED AFFINITY | LANOSTEROL 14-ALPHA-DEMETHYLASE
Journal Article
MedChemComm, ISSN 2040-2503, 04/2012, Volume 3, Issue 4, pp. 484 - 488
Fluconazole based novel mimics containing 1,5-disubstituted 1,2,3-triazoles were synthesized by using Ru catalysed 1,3 dipolar cycloaddition. All the newly... 
AZIDE-ALKYNE CYCLOADDITION | CHEMISTRY, MEDICINAL | CLICK CHEMISTRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | RUTHENIUM-CATALYZED CYCLOADDITION | SOLID-PHASE | TERMINAL ALKYNES | 1,3-DIPOLAR CYCLOADDITION REACTIONS | TRIAZOLE ANTIFUNGAL | ORGANIC AZIDES | LANOSTEROL 14-ALPHA-DEMETHYLASE | FUNGAL-INFECTIONS
Journal Article
Arabian Journal of Chemistry, ISSN 1878-5352, 12/2014
A novel series of compounds containing tertiary amine moiety, substituted benzimidazole and triazole ring, initial design by molecular docking study of this... 
Microwave irradiation | Docking | Triazole | Antifungal | Lanosterol 14-α-demethylase | Benzimidazole
Journal Article
Journal Article
Journal Article