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index medicus (197) 197
humans (99) 99
animals (86) 86
pharmacology & pharmacy (70) 70
lanosterol - analogs & derivatives (61) 61
antifungal agents - pharmacology (56) 56
lanosterol (52) 52
chemistry, medicinal (49) 49
biochemistry & molecular biology (45) 45
lanosterol 14-alpha-demethylase (45) 45
lanosterol - pharmacology (43) 43
mice (43) 43
microbial sensitivity tests (43) 43
cholesterol (39) 39
male (38) 38
candida-albicans (35) 35
antifungal activity (33) 33
female (32) 32
analysis (31) 31
antifungal agents (31) 31
biosynthesis (31) 31
antifungal agents - chemistry (29) 29
molecular structure (29) 29
structure-activity relationship (29) 29
lanosterol - therapeutic use (28) 28
microbiology (28) 28
antifungal agents - chemical synthesis (26) 26
cyp51 (26) 26
fluconazole (26) 26
enzymes (25) 25
lanosterol - chemistry (25) 25
physiological aspects (23) 23
fungi (22) 22
inhibition (21) 21
inhibitors (21) 21
molecular docking (21) 21
drug design (20) 20
models, molecular (20) 20
proteins (19) 19
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sterols (19) 19
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article (18) 18
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azoles - pharmacology (17) 17
cancer (17) 17
fungicides (17) 17
gene expression (17) 17
resistance (17) 17
cholesterol - biosynthesis (16) 16
cytochrome p-450 enzyme system - metabolism (16) 16
dose-response relationship, drug (16) 16
ergosterol (16) 16
in-vitro (16) 16
lanosterol 14 alpha-demethylase (16) 16
triazoles - pharmacology (16) 16
candida albicans - drug effects (15) 15
cell line, tumor (15) 15
cells (15) 15
fluconazole - pharmacology (15) 15
lanosterol - metabolism (15) 15
pharmacology (15) 15
chemistry, multidisciplinary (14) 14
ganoderma lucidum (14) 14
lanosterol 14α-demethylase (14) 14
molecular docking simulation (14) 14
phytosterols (14) 14
rats (14) 14
synthesis (14) 14
chemistry (13) 13
docking (13) 13
health aspects (13) 13
infectious diseases (13) 13
lipids (13) 13
mass spectrometry (13) 13
saccharomyces-cerevisiae (13) 13
yeast (13) 13
antineoplastic agents - pharmacology (12) 12
candida - drug effects (12) 12
cell biology (12) 12
chemistry, organic (12) 12
drugs (12) 12
metabolism (12) 12
reishi - chemistry (12) 12
sterol 14-alpha-demethylase (12) 12
14-alpha demethylase inhibitors - pharmacology (11) 11
apoptosis (11) 11
aspergillus-fumigatus (11) 11
azole (11) 11
azole antifungals (11) 11
biological evaluation (11) 11
biotechnology & applied microbiology (11) 11
cytochrome p450 (11) 11
enzyme inhibitors - pharmacology (11) 11
fungi - drug effects (11) 11
heterocyclic compounds (11) 11
lanosterol - isolation & purification (11) 11
multidisciplinary sciences (11) 11
sterols - biosynthesis (11) 11
antifungal agents - therapeutic use (10) 10
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Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2012, Volume 56, Issue 11, pp. 5898 - 5906
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, pp. e27122 - e27122
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7562, pp. 607 - 611
The human lens is comprised largely of crystallin proteins assembled into a highly ordered, interactive macro-structure essential for lens transparency and... 
SELENITE-INDUCED CATARACTOGENESIS | MULTIDISCIPLINARY SCIENCES | MUTATION | PREVENTION | ALPHA-B-CRYSTALLIN | DOMINANT CONGENITAL CATARACT | HUMAN OXIDOSQUALENE CYCLASE | SEQUENCING DATA | CHINESE FAMILY | LENS | EXPRESSION | Crystallins - metabolism | Humans | Cataract - pathology | Molecular Sequence Data | Lanosterol - pharmacology | Male | Amyloid - chemistry | Amyloid - ultrastructure | Lens, Crystalline - pathology | Mutant Proteins - ultrastructure | Amyloid - metabolism | Protein Aggregation, Pathological - pathology | Base Sequence | Amyloid - drug effects | Adult | Female | Child | Crystallins - chemistry | Protein Aggregates - drug effects | Amino Acid Sequence | Cell Line | Crystallins - ultrastructure | Lanosterol - administration & dosage | Mutant Proteins - genetics | Lens, Crystalline - metabolism | Models, Molecular | Mutant Proteins - metabolism | Crystallins - genetics | Cataract - metabolism | Lanosterol - therapeutic use | Protein Aggregation, Pathological - drug therapy | Animals | Cataract - congenital | Pedigree | Mutant Proteins - chemistry | Dogs | Cataract - genetics | Cataract - drug therapy | Lens, Crystalline - drug effects | Proteins | Cataract | Physiological aspects | Development and progression | Genetic aspects | Research | Gene expression | Drug therapy | Cataracts | Studies | Older people | Mortality | Mutation | Cholesterol | Index Medicus
Journal Article
Journal Article
Molecules, ISSN 1420-3049, 07/2017, Volume 22, Issue 7, p. 1172
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 11/2017, Volume 18, Issue 11, p. 2314
This study was designed to investigate the antidiabetic and antihyperlipidemic effects and mechanisms of eburicoic acid (TRR); one component of Antrodia... 
Peroxisome proliferator-activated receptor α | Fatty acid synthase | Diabetes | Antrodia camphorata | Forkhead box protein O1 | Eburicoic acid | ACTIVATED PROTEIN-KINASE | DEHYDROEBURICOIC ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLUCOSE TRANSPORTERS | ADIPONECTIN LEVELS | CHEMISTRY, MULTIDISCIPLINARY | INDUCED INSULIN-RESISTANCE | eburicoic acid | forkhead box protein O1 | SKELETAL-MUSCLE | fatty acid synthase | GLUT4 TRANSLOCATION | RAT ADIPOCYTES | peroxisome proliferator-activated receptor | diabetes | TYPE-2 DIABETES-MELLITUS | TRANSCRIPTION FACTOR | Diabetes Mellitus, Experimental - drug therapy | Hyperlipidemias - blood | Glucose Transporter Type 4 - metabolism | Diet, High-Fat - adverse effects | Lanosterol - pharmacology | Lanosterol - analogs & derivatives | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Insulin - blood | Diabetes Mellitus, Experimental - blood | Fatty Acids - blood | Hypolipidemic Agents - chemistry | Diabetes Mellitus, Experimental - metabolism | Fatty Acids - metabolism | Hypoglycemic Agents - therapeutic use | Cell Line | Blood Glucose - analysis | Hyperlipidemias - metabolism | Hyperlipidemias - drug therapy | Mice, Inbred C57BL | Hypoglycemic Agents - chemistry | Hypolipidemic Agents - pharmacology | Lanosterol - therapeutic use | Mice, Inbred ICR | Hypoglycemic Agents - pharmacology | Triglycerides - metabolism | Antrodia - chemistry | Insulin - metabolism | Animals | Lanosterol - chemistry | Muscle Fibers, Skeletal - pathology | Triglycerides - blood | Diabetes Mellitus, Experimental - pathology | Hyperlipidemias - pathology | Hypolipidemic Agents - therapeutic use | Mice | Palmitates - metabolism | Blood Glucose - metabolism | Phosphorylation | Liver | Body weight | AKT protein | Fuel consumption | Glucose | Kinases | Palmitic acid | Blood | Adiponectin | High fat diet | Proteins | Fatty liver | FOXO1 protein | Rodents | Forkhead protein | Oxidation | Degeneration | Glucose transporter | Myotubes | Adenosine monophosphate | AMP | Hyperlipidemia | Diabetes mellitus | Distilled water | Muscles | Triglycerides | Insulin | Fatty acids | Fatty-acid synthase | Skeletal muscle | Fenofibrate | Diet | Ribonucleic acids | Protein kinase | Adenosine kinase | Leptin | Metformin | Transporter | Index Medicus | peroxisome proliferator-activated receptor α
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2013, Volume 698, Issue 1-3, pp. 413 - 420
Inflammation underlies the development and progression of a number of skin disorders including psoriasis, atopic dermatitis and cancer. Therefore, novel... 
PKC | Inflammation | TPA | COX-2 | MAPK | Euphol | CELLS | PROTEIN-KINASE-C | CYCLOOXYGENASE-2 | ESTER-INDUCED EXPRESSION | EPSILON | TUMOR PROMOTION | ALPHA-AMYRIN | EPIDERMIS | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | MOUSE SKIN | Inflammation - chemically induced | Inflammation - pathology | Tetradecanoylphorbol Acetate - adverse effects | Lanosterol - pharmacology | Male | Lanosterol - analogs & derivatives | Extracellular Signal-Regulated MAP Kinases - metabolism | Skin Diseases - pathology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Leukocytes - immunology | Inflammation - drug therapy | Protein Kinase C - metabolism | Skin Diseases - chemically induced | Edema - immunology | Lanosterol - administration & dosage | Skin Diseases - drug therapy | Skin Diseases - immunology | Edema - drug therapy | Inflammation - immunology | Enzyme Activation - drug effects | Lanosterol - therapeutic use | Up-Regulation - drug effects | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Cyclooxygenase 2 - metabolism | Leukocytes - drug effects | Mice | Edema - chemically induced | Administration, Topical | Edema - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Care and treatment | Psoriasis | Anti-inflammatory drugs | Isoenzymes | Atopic dermatitis | Skin | Protein kinases | Cancer | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7562, pp. 540 - 541
Mutations underlying hereditary cataracts in two families impair the function of an enzyme that synthesizes the lens molecule lanosterol. The finding may lead... 
EYE | CONGENITAL CATARACT | LENS | TRANSPARENCY | MULTIDISCIPLINARY SCIENCES | AGGREGATION | Animals | Humans | Female | Lanosterol - pharmacology | Male | Cataract - drug therapy | Cataract - metabolism | Lanosterol - therapeutic use | Protein Aggregation, Pathological - drug therapy | Protein Aggregates - drug effects | Index Medicus
Journal Article