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Cancer, ISSN 0008-543X, 2017, Volume 123, Issue 9, pp. 1566 - 1575
BACKGROUND Human papillomavirus (HPV) is a well‐established prognostic marker for oropharyngeal squamous cell cancer (OPSCC). Because of the limited numbers of... 
human papillomavirus (HPV) | head and neck squamous cell cancer (HNSCC) | p16 | race | sex | oropharyngeal squamous cell cancer (OPSCC) | prognosis | UNITED-STATES | POSITIVE HEAD | IN-SITU HYBRIDIZATION | IMPROVED SURVIVAL | TRIAL | NASOPHARYNGEAL CARCINOMA | HPV STATUS | THERAPY | ONCOLOGY | IMMUNOHISTOCHEMISTRY | Oropharyngeal Neoplasms - ethnology | Head and Neck Neoplasms - virology | Nasopharyngeal Neoplasms - mortality | Prognosis | Asian Americans - statistics & numerical data | Carcinoma, Squamous Cell - pathology | Carcinoma, Squamous Cell - virology | Humans | Nasopharyngeal Neoplasms - ethnology | Nasopharyngeal Neoplasms - virology | Oropharyngeal Neoplasms - mortality | Hispanic Americans - statistics & numerical data | Male | Oropharyngeal Neoplasms - pathology | Carcinoma, Squamous Cell - ethnology | Laryngeal Neoplasms - pathology | Nasopharyngeal Neoplasms - pathology | Mouth Neoplasms - ethnology | Squamous Cell Carcinoma of Head and Neck | Carcinoma, Squamous Cell - mortality | Head and Neck Neoplasms - ethnology | Laryngeal Neoplasms - ethnology | Female | Papillomavirus Infections - virology | Retrospective Studies | Repressor Proteins - metabolism | Oncogene Proteins, Viral - metabolism | Ethnic Groups - statistics & numerical data | Papillomavirus Infections - epidemiology | Proportional Hazards Models | European Continental Ancestry Group - statistics & numerical data | Oropharyngeal Neoplasms - virology | Mouth Neoplasms - virology | Mouth Neoplasms - mortality | Human papillomavirus 16 - metabolism | Head and Neck Neoplasms - pathology | African Americans - statistics & numerical data | Papillomavirus E7 Proteins - metabolism | Laryngeal Neoplasms - mortality | Sex Factors | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Mouth Neoplasms - pathology | Head and Neck Neoplasms - mortality | Neoplasm Staging | DNA, Viral | Human papillomavirus 16 - genetics | Laryngeal Neoplasms - virology | Complications and side effects | Care and treatment | DNA | Head and neck cancer | Research | Papillomavirus infections | Risk factors | Sex | Risk | Population studies | mRNA | Nasopharynx | Human papillomavirus | Race | Larynx | Deoxyribonucleic acid--DNA | Squamous cell carcinoma | Head | Adjustment | Mortality | Health risks | Hazards | Ribonucleic acid--RNA | Minority & ethnic groups | Patients | Survival | Oral cavity | Tobacco | Medical prognosis | Men | Health hazards | Health risk assessment | Hispanics | Cancer | Tumors
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2014, Volume 88, Issue 4, pp. 806 - 813
Purpose To investigate, in a large cohort of patients, the immunophenotypic and clinical differences of nasal and extranasal extranodal nasal-type natural... 
Radiology | Hematology, Oncology and Palliative Medicine | CHINA ANALYSIS | PROGNOSTIC-FACTORS | NEOPLASMS | ONCOLOGY | WALDEYER RING | CLASSIFICATION | RADIOTHERAPY | MODEL | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | RADIATION-THERAPY | FEATURES | Doxorubicin - therapeutic use | Humans | Middle Aged | Ki-67 Antigen - metabolism | Male | Pharyngeal Neoplasms - drug therapy | Young Adult | Pharyngeal Neoplasms - immunology | Aged, 80 and over | Antigens, Neoplasm - metabolism | Laryngeal Neoplasms - drug therapy | Immunophenotyping - methods | Lymphoma, Extranodal NK-T-Cell - immunology | Child | Nose Neoplasms - pathology | Survival Rate | Lymphatic Metastasis | Laryngeal Neoplasms - immunology | Pharyngeal Neoplasms - mortality | Lymphoma, T-Cell - drug therapy | Lymphoma, Extranodal NK-T-Cell - pathology | Adolescent | Vincristine - therapeutic use | Lymphoma, Extranodal NK-T-Cell - mortality | Pharyngeal Neoplasms - pathology | Tongue Neoplasms - immunology | Prednisone - therapeutic use | Cohort Studies | Nose Neoplasms - mortality | Lymphoma, T-Cell - immunology | Prognosis | Cyclophosphamide - therapeutic use | Tongue Neoplasms - drug therapy | Laryngeal Neoplasms - pathology | Lymphoma, Extranodal NK-T-Cell - drug therapy | Doxorubicin - analogs & derivatives | Adult | Female | Retrospective Studies | Severity of Illness Index | Tongue Neoplasms - mortality | CD56 Antigen - metabolism | Tracheal Neoplasms - pathology | Tracheal Neoplasms - mortality | Tongue Neoplasms - pathology | Tracheal Neoplasms - immunology | Laryngeal Neoplasms - mortality | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Nose Neoplasms - drug therapy | Lymphoma, T-Cell - pathology | Aged | Lymphoma, T-Cell - mortality | Nose Neoplasms - immunology | Neoplasm Staging | Medical colleges | Nuclear radiation | Lymphomas | LYMPHOMAS | DIAGNOSIS | PATIENTS | RADIOLOGY AND NUCLEAR MEDICINE | LYMPH NODES | NOSE
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2015, Volume 91, Issue 4, pp. 721 - 729
Purpose To evaluate candidate fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) imaging biomarkers for head-and-neck... 
Radiology | Hematology, Oncology and Palliative Medicine | FDG-PET/CT | PREDICTS | POSITRON-EMISSION-TOMOGRAPHY | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | HUMAN-PAPILLOMAVIRUS | RADIOTHERAPY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | ACCURACY | Fluorodeoxyglucose F18 - pharmacokinetics | Confidence Intervals | Prognosis | Follow-Up Studies | Humans | Middle Aged | Tomography, X-Ray Computed - methods | Laryngeal Neoplasms - diagnostic imaging | Male | Oropharyngeal Neoplasms - pathology | Positron-Emission Tomography - instrumentation | Head and Neck Neoplasms - metabolism | Laryngeal Neoplasms - pathology | Laryngeal Neoplasms - therapy | Adult | Female | Tomography, X-Ray Computed - instrumentation | Chemoradiotherapy - methods | Radiopharmaceuticals - pharmacokinetics | Blood Glucose - analysis | Head and Neck Neoplasms - diagnostic imaging | Laryngeal Neoplasms - metabolism | Head and Neck Neoplasms - therapy | Lymphatic Metastasis | Positron-Emission Tomography - methods | Head and Neck Neoplasms - pathology | Hypopharyngeal Neoplasms - therapy | Disease-Free Survival | Phenotype | Hypopharyngeal Neoplasms - metabolism | Hypopharyngeal Neoplasms - pathology | Aged | Neoplasm Staging | Hypopharyngeal Neoplasms - diagnostic imaging | Sects | Radiotherapy | Radiation | Cancer | HEAD | PATIENTS | NEOPLASMS | BIOMEDICAL RADIOGRAPHY | BIOLOGICAL MARKERS | POSITRON COMPUTED TOMOGRAPHY | FLUORODEOXYGLUCOSE | UPTAKE | RADIOLOGY AND NUCLEAR MEDICINE | NECK | COMBINED THERAPY
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2012, Volume 287, Issue 9, pp. 6668 - 6678
Activity of heparanase is implicated strongly in dissemination of metastatic tumor cells and cells of the immune system. In addition, heparanase enhances the... 
LOCALIZATION | REGULATOR | PROTEOGLYCANS | METASTASIS | TUMOR PROGRESSION | CONSTITUTIVE ACTIVATION | SULFATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | EXPRESSION | CONTRIBUTES | Phosphorylation - physiology | Prostatic Neoplasms - metabolism | Fibroblasts - enzymology | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Glucuronidase - metabolism | Male | Head and Neck Neoplasms - metabolism | Breast Neoplasms - metabolism | Laryngeal Neoplasms - pathology | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Receptor, Epidermal Growth Factor - metabolism | STAT1 Transcription Factor - metabolism | Tumor Suppressor Proteins - genetics | Female | Nose Neoplasms - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Tongue Neoplasms - metabolism | Prostatic Neoplasms - pathology | Nose Neoplasms - pathology | Tumor Suppressor Proteins - metabolism | Laryngeal Neoplasms - metabolism | Cells, Cultured | Multiple Myeloma - metabolism | STAT1 Transcription Factor - genetics | Tongue Neoplasms - pathology | Disease Progression | Head and Neck Neoplasms - pathology | Multiple Myeloma - pathology | Animals | Breast Neoplasms - pathology | Fibroblasts - cytology | Mice | Phosphorylation | Epidermal Growth Factor Receptor (EGFR) | STAT3 | Cell Signaling | Heparan Sulfate | Heparanase | Glycosaminoglycan | Glycobiology and Extracellular Matrices | Cancer Biology | Head And Neck Cancer | Localization
Journal Article
Journal Article
Journal Article
ANZ Journal of Surgery, ISSN 1445-1433, 01/2009, Volume 79, Issue 1, pp. 48 - 54
Background:  Field cancerization is a feature of head and neck squamous cell carcinoma. No biological marker in the index tumour has been correlated to the... 
mut-p53 | second primary tumour | survival | cyclin A1 | head and neck squamous cell carcinoma | mut‐p53 | Second primary tumour | Cyclin A1 | Head and neck squamous cell carcinoma | Mut-p53 | Survival | SURGERY | FIELD CANCERIZATION | PRIMARY CANCERS | UPPER AERODIGESTIVE TRACT | LEUKEMIA | Immunohistochemistry | Neoplasms, Multiple Primary - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Head and Neck Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Laryngeal Neoplasms - pathology | Female | Laryngeal Neoplasms - genetics | Neoplasms, Multiple Primary - genetics | Neoplasm Recurrence, Local - metabolism | Cyclin A - metabolism | Laryngeal Neoplasms - metabolism | Tumor Suppressor Protein p53 - metabolism | Neoplasms, Multiple Primary - pathology | Head and Neck Neoplasms - pathology | Disease-Free Survival | Head and Neck Neoplasms - genetics | Neoplasm Recurrence, Local - genetics | Cyclin A, metabolism | Neoplasm Recurrence, Local, metabolism | Tumor Suppressor Protein p53, genetics | Neoplasms, Multiple Primary, pathology | Neoplasms, Multiple Primary, genetics | Carcinoma, Squamous Cell, genetics | Laryngeal Neoplasms, genetics | Laryngeal Neoplasms, pathology | Neoplasm Recurrence, Local, genetics | Carcinoma, Squamous Cell, metabolism | Head and Neck Neoplasms, pathology | Carcinoma, Squamous Cell, pathology | Laryngeal Neoplasms, metabolism | Head and Neck Neoplasms, genetics | Neoplasms, Multiple Primary, metabolism | Head and Neck Neoplasms, metabolism | Tumor Suppressor Protein p53, metabolism | Squamous cell carcinoma | Universities and colleges | Tumor proteins | Proteins | Laryngeal cancer | Pathology | Mutation | Gene expression | Cell cycle
Journal Article
Cancer Biology & Therapy, ISSN 1555-8576, 2014, Volume 4, Issue 7, pp. 720 - 727
We have earlier reported that the inhibition of apoptosis in head and neck squamous cell carcinomas (HNSCC) is because of upregulated expression of Bcl-2,... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Bcl-2 | Bcl-X | HNSCC | Antisense | Survivin | Chemoadjuvant | Mismatch | Apoptosis | survivin | SURVIVIN EXPRESSION | CANCER CELLS | Bcl-X-L | apoptosis | NEUROBLASTOMA | chemoadjuvant | BCL-X(L) | OLIGONUCLEOTIDES | CYTOCHROME-C | MESSENGER-RNA | GENE | ONCOLOGY | mismatch | MULTIDRUG-RESISTANCE | BCL-2 FAMILY-MEMBERS | antisense | Microtubule-Associated Proteins - genetics | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Humans | bcl-X Protein - genetics | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Tongue Neoplasms - drug therapy | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspases - metabolism | Flow Cytometry | bcl-X Protein - antagonists & inhibitors | Caspase 3 | Laryngeal Neoplasms - drug therapy | Antineoplastic Agents - pharmacology | Tumor Cells, Cultured | Neoplasm Proteins - genetics | Tongue Neoplasms - metabolism | In Situ Nick-End Labeling | Laryngeal Neoplasms - genetics | Oligonucleotides, Antisense - pharmacology | Inhibitor of Apoptosis Proteins | Tongue Neoplasms - genetics | Down-Regulation | Laryngeal Neoplasms - metabolism | Etoposide - pharmacology | Cisplatin - pharmacology | Microtubule-Associated Proteins - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Carcinoma, Squamous Cell - drug therapy | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Antineoplastic Agents, Phytogenic - pharmacology | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Messenger
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 03/2006, Volume 12, Issue 5, pp. 1639 - 1646
Purpose: Stomatin-like protein 2 (SLP-2) is a novel and unusual stomatin homologue of unknown functions. It has been implicated in interaction with erythrocyte... 
esophageal squamous cell carcinoma | cDNA microarray | SLP-2 | FREQUENT | AMPLIFICATION | GENE | ONCOLOGY | CLONING | CHINA | TISSUES | EXPRESSION | HIGH-INCIDENCE AREA | LINES | MEMBER | Adenocarcinoma - pathology | Cell Proliferation | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | Endometrial Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Blood Proteins - immunology | Lung Neoplasms - pathology | Male | Membrane Proteins - pharmacology | RNA, Neoplasm - metabolism | Blood Proteins - pharmacology | Esophageal Neoplasms - pathology | Laryngeal Neoplasms - pathology | Adenocarcinoma - metabolism | Flow Cytometry | Endometrial Neoplasms - genetics | Blood Proteins - genetics | Esophageal Neoplasms - metabolism | Female | Adenocarcinoma - genetics | Tumor Cells, Cultured | Lung Neoplasms - genetics | Laryngeal Neoplasms - genetics | Tumor Stem Cell Assay | Membrane Proteins - genetics | DNA, Antisense - pharmacology | Laryngeal Neoplasms - metabolism | Membrane Proteins - immunology | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion | Blotting, Western | Animals | Esophageal Neoplasms - genetics | Mice, Nude | RNA, Neoplasm - genetics | Endometrial Neoplasms - pathology | Mice | Mice, Inbred BALB C | Mutation
Journal Article
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 36, pp. 58218 - 58233
MicroRNA controls cancer invasion by governing the expression of gene regulating migration and invasion. Here, we reported a novel regulatory pathway... 
PDCD4 | PTEN | MiR-744-3p | Metastasis | Laryngeal squamous cell carcinoma | CANCER-CELLS | HEAD | DEATH | CELL BIOLOGY | INVASION | metastasis | PATHWAY | INFLAMMATION | NECK | laryngeal squamous cell carcinoma | NF-KAPPA-B | EXPRESSION | CONTRIBUTES | RNA-Binding Proteins - genetics | Head and Neck Neoplasms - secondary | TOR Serine-Threonine Kinases - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | MicroRNAs - metabolism | Laryngeal Neoplasms - pathology | Matrix Metalloproteinase 9 - metabolism | Squamous Cell Carcinoma of Head and Neck | Lung Neoplasms - secondary | RNA Interference | Apoptosis Regulatory Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | Oncogenes | Lung Neoplasms - genetics | Laryngeal Neoplasms - genetics | PTEN Phosphohydrolase - genetics | Lung - pathology | PTEN Phosphohydrolase - metabolism | Lymphatic Metastasis | Signal Transduction - genetics | Apoptosis Regulatory Proteins - metabolism | Head and Neck Neoplasms - pathology | Xenograft Model Antitumor Assays | Larynx - pathology | Animals | Transcription Factor RelA - metabolism | Mice, Nude | Cell Line, Tumor | Carcinoma, Squamous Cell - secondary | Head and Neck Neoplasms - genetics | Mice | MicroRNAs - genetics | Neoplasm Staging | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism
Journal Article
Anticancer Research, ISSN 0250-7005, 01/2016, Volume 36, Issue 1, pp. 49 - 60
Background: The survival rate of patients with head and neck squamous cell carcinoma (HNSCC) stands at approximately 50% and this has not improved in decades.... 
Sirtuins | Oral cancer | HNSCC | ROS | Sirtuin inhibitor | Sirtuin-3 | SIRT3 | OXIDATIVE STRESS | LYSINE | ACTIVATORS | sirtuin inhibitor | IDENTIFICATION | ONCOLOGY | TUMOR-SUPPRESSOR | SIRT3 EXPRESSION | sirtuin-3 | CARCINOMA | TUMORIGENESIS | oral cancer | PROGRESSION | Laryngeal Neoplasms - radiotherapy | Mouth Neoplasms - drug therapy | Reactive Oxygen Species - metabolism | Sirtuin 3 - metabolism | Apoptosis - drug effects | Carcinoma, Squamous Cell - pathology | Humans | Radiation Tolerance | Sirtuin 3 - antagonists & inhibitors | Carcinoma, Squamous Cell - radiotherapy | Chemoradiotherapy | Heterocyclic Compounds, 4 or More Rings - pharmacology | Laryngeal Neoplasms - pathology | Dose-Response Relationship, Drug | Squamous Cell Carcinoma of Head and Neck | Laryngeal Neoplasms - drug therapy | Indoles - pharmacology | Laryngeal Neoplasms - enzymology | Mouth Neoplasms - radiotherapy | Antineoplastic Agents - pharmacology | Head and Neck Neoplasms - enzymology | Mouth Neoplasms - enzymology | Carcinoma, Squamous Cell - enzymology | Head and Neck Neoplasms - drug therapy | Antineoplastic Combined Chemotherapy Protocols | Cisplatin - pharmacology | Head and Neck Neoplasms - pathology | Head and Neck Neoplasms - radiotherapy | Keratinocytes - pathology | Carcinoma, Squamous Cell - drug therapy | Keratinocytes - drug effects | Signal Transduction - drug effects | Keratinocytes - metabolism | Cell Line, Tumor | Mouth Neoplasms - pathology | Histone Deacetylase Inhibitors - pharmacology | Cell Proliferation - drug effects
Journal Article
Diagnostic Pathology, ISSN 1746-1596, 04/2015, Volume 10, Issue 1, p. 22
Background: MicroRNA-23a (miR-23a) has been demonstrated to play an important role in the development of several types of cancer, but its role in tumorigenesis... 
Biomarker | Prognosis | MicroRNA-23a | Laryngeal squamous cell carcinoma | CIRCULATING MICRORNAS | SURVIVAL | DIAGNOSIS | MIR-23A | METASTASIS | PATHOLOGY | BIOMARKERS | PROSTATE-CANCER | RECURRENCE | UP-REGULATION | PROMOTES | Multivariate Analysis | Predictive Value of Tests | Up-Regulation | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | MicroRNAs - metabolism | Head and Neck Neoplasms - metabolism | Laryngeal Neoplasms - pathology | Laryngeal Neoplasms - therapy | Squamous Cell Carcinoma of Head and Neck | Carcinoma, Squamous Cell - mortality | Transfection | Time Factors | Biomarkers, Tumor - metabolism | Female | Real-Time Polymerase Chain Reaction | Laryngeal Neoplasms - genetics | Neoplasm Invasiveness | Laryngeal Neoplasms - metabolism | Risk Factors | Head and Neck Neoplasms - therapy | Kaplan-Meier Estimate | Proportional Hazards Models | Carcinoma, Squamous Cell - therapy | Treatment Outcome | Lymphatic Metastasis | Chi-Square Distribution | Head and Neck Neoplasms - pathology | Laryngeal Neoplasms - mortality | Cell Line, Tumor | Carcinoma, Squamous Cell - secondary | Head and Neck Neoplasms - genetics | Biomarkers, Tumor - genetics | MicroRNAs - genetics | Head and Neck Neoplasms - mortality | Neoplasm Staging | Cell Movement | Development and progression | Squamous cell carcinoma | MicroRNA | Metastasis | Analysis
Journal Article
by Zhou, Z and Wang, M and Li, J and Xiao, M and Chin, Y.E and Cheng, J and Yeh, E.T.H and Yang, J and Yi, J
Oncogene, ISSN 0950-9232, 11/2016, Volume 35, Issue 45, pp. 5826 - 5838
Journal Article