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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 10, pp. 4612 - 4617
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, pp. e44071 - e44071
Mortality in head and neck squamous cell carcinoma (HNSCC) is high due to emergence of therapy resistance which results in local and regional recurrences that... 
Gamma Rays | Receptor, Epidermal Growth Factor - genetics | Drug Resistance, Neoplasm - radiation effects | Gene Expression - drug effects | Oligonucleotide Array Sequence Analysis | Neoplastic Stem Cells - drug effects | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Humans | Carcinoma, Squamous Cell - radiotherapy | Epithelial-Mesenchymal Transition - genetics | Cell Lineage - drug effects | Head and Neck Neoplasms - metabolism | Cell Shape - radiation effects | Antibodies, Monoclonal, Humanized | Flow Cytometry | Neoplastic Stem Cells - metabolism | Antineoplastic Agents - pharmacology | Cetuximab | Cell Lineage - genetics | Neoplastic Stem Cells - radiation effects | Receptor, Epidermal Growth Factor - immunology | Antibodies, Monoclonal - pharmacology | Cell Cycle - radiation effects | Head and Neck Neoplasms - drug therapy | Cisplatin - pharmacology | Organ Specificity | Gene Expression - radiation effects | Hyaluronan Receptors - genetics | Cell Lineage - radiation effects | Cell Shape - drug effects | Head and Neck Neoplasms - radiotherapy | Carcinoma, Squamous Cell - drug therapy | Epithelial-Mesenchymal Transition - immunology | Cell Line, Tumor | Head and Neck Neoplasms - genetics | Cell Proliferation - drug effects | Hyaluronan Receptors - immunology | Cell Cycle - drug effects | Quinazolines - pharmacology | Cell Proliferation - radiation effects | Drug Resistance, Neoplasm - drug effects | Cell proliferation | Health sciences | Flow cytometry | Biotechnology | Laryngeal cancer | Mesenchyme | Cytology | Radiation | Fluorescence | Metastasis | Drug resistance | Cancer therapies | Cell surface | Genotype & phenotype | Epidermal growth factor | CD44 antigen | Surgery | Larynx | Neck | Gefitinib | Subpopulations | Squamous cell carcinoma | Epidermal growth factor receptors | Mortality | Breast cancer | Tumor cell lines | Cisplatin | Sensitivity | Antibiotics | Pancreatic cancer | Cell lines | Stem cells | Head and neck cancer | Head & neck cancer | Cancer | Tumors | Index Medicus
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2009, Volume 75, Issue 2, pp. 385 - 392
Purpose To evaluate late dysphagia after chemoradiotherapy for locally advanced head-and-neck squamous cell carcinoma, and to examine its correlation with... 
Radiology | Hematology, Oncology and Palliative Medicine | Head and neck cancer | Dysphagia | IMRT | Chemoradiotherapy | INTENSITY-MODULATED RADIOTHERAPY | ACCELERATED RADIOTHERAPY | CANCER | ASPIRATION | CHEMOTHERAPY | RADIATION-THERAPY | ONCOLOGY | REDUCE DYSPHAGIA | CHEMORADIATION | LOCALLY ADVANCED HEAD | QUALITY-OF-LIFE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Deglutition - drug effects | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Male | Antineoplastic Agents - administration & dosage | Carcinoma, Squamous Cell - radiotherapy | Cisplatin - administration & dosage | Larynx - radiation effects | Antineoplastic Agents - adverse effects | Adult | Deglutition Disorders - etiology | Female | Deglutition - radiation effects | Head and Neck Neoplasms - drug therapy | Radiation Injuries - complications | Combined Modality Therapy - adverse effects | Larynx - drug effects | Head and Neck Neoplasms - pathology | Head and Neck Neoplasms - radiotherapy | Carcinoma, Squamous Cell - drug therapy | Pharyngeal Muscles - drug effects | Cisplatin - adverse effects | Quality of Life | Aged | Combined Modality Therapy - methods | Pharyngeal Muscles - radiation effects | Dose-Response Relationship, Radiation | Care and treatment | Squamous cell carcinoma | Universities and colleges | Deglutition disorders | Cancer | Index Medicus | HEAD | PATIENTS | RADIATION DOSES | STANDARD OF LIVING | LARYNX | MULTIVARIATE ANALYSIS | CARCINOMAS | INVENTORIES | RADIOLOGY AND NUCLEAR MEDICINE | NECK | RADIOTHERAPY | COMBINED THERAPY | MUSCLES
Journal Article
The Laryngoscope, ISSN 0023-852X, 02/2018, Volume 128, Issue 2, pp. E59 - E67
Objective: Management of laryngotracheal stenosis (LTS) remains primarily surgical, with a critical need to identify targets for adjuvant therapy.... 
Human | trachea | laryngotracheal stenosis | collagen | glutamine | stenosis | iatrogenic | larynx | fibroblasts | scar | fibrosis | metabolism | aerobic glycolysis | glutamine antagonism | metabolic inhibitor | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | CELLS | MANAGEMENT | 6-DIAZO-5-OXO-L-NORLEUCINE DON | OTORHINOLARYNGOLOGY | MICE | DIFFERENTIATION | Fibrosis - drug therapy | Gene Expression - drug effects | Tracheal Stenosis - surgery | Humans | Middle Aged | Laryngostenosis - metabolism | Male | Fibrosis - metabolism | Glycolysis - drug effects | Tracheal Stenosis - drug therapy | Young Adult | Cicatrix - metabolism | Collagen - drug effects | Adult | Antimetabolites, Antineoplastic - pharmacology | Diazooxonorleucine - pharmacology | Female | Cell Culture Techniques | Iatrogenic Disease | Real-Time Polymerase Chain Reaction | Fibroblasts - metabolism | Laryngostenosis - drug therapy | Tracheal Stenosis - metabolism | Collagen - metabolism | Cicatrix - drug therapy | Oxygen Consumption - drug effects | Fibroblasts - drug effects | Aged | Cell Proliferation - drug effects | Laryngostenosis - surgery | Glucose metabolism | Medical errors | Collagen | Genes | Fibrosis | Physiological aspects | Stenosis | Muscle proteins | Gene expression | Adenosine triphosphate | Glutamine | Fibroblasts | Phosphorylation | Metabolism | Index Medicus
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2014, Volume 89, Issue 5, pp. 973 - 980
Purpose To describe voice and speech quality changes and their predictors in patients with locally advanced oropharyngeal cancer treated on prospective... 
Radiology | Hematology, Oncology and Palliative Medicine | HEAD | LARYNX-SPARING TECHNIQUES | VOCAL FUNCTION | ONCOLOGY | CHEMO-IMRT | PAROTID-GLANDS | DOSIMETRIC PREDICTORS | CHEMORADIATION | QUALITY-OF-LIFE | RADIOTHERAPY | CARCINOMA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Glottis - drug effects | Chemoradiotherapy - adverse effects | Prospective Studies | Humans | Middle Aged | Male | Radiotherapy, Intensity-Modulated - adverse effects | Larynx - radiation effects | Organ Sparing Treatments - methods | Speech Disorders - etiology | Organ Sparing Treatments - adverse effects | Adult | Female | Tonsillar Neoplasms - therapy | Voice Quality - radiation effects | Radiotherapy Dosage | Voice Disorders - etiology | Tonsillar Neoplasms - pathology | Chemoradiotherapy - methods | Tongue Neoplasms - therapy | Radiotherapy, Intensity-Modulated - methods | Speech - drug effects | Voice Quality - drug effects | Glottis - radiation effects | Larynx - drug effects | Tongue Neoplasms - pathology | Neck Dissection - adverse effects | Quality of Life | Speech - radiation effects | Aged | Observer Variation | Care and treatment | Chemotherapy | Patient outcomes | Oncology, Experimental | Radiation | Research | Throat cancer | Radiotherapy | Cancer | Analysis | Index Medicus | PATIENTS | ORAL CAVITY | NEOPLASMS | RADIATION DOSES | TOXICITY | SPEECH | STANDARD OF LIVING | COMPARATIVE EVALUATIONS | LARYNX | CHEMOTHERAPY | MULTIVARIATE ANALYSIS | ALARA | RADIOLOGY AND NUCLEAR MEDICINE | NECK
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, pp. e111317 - e111317
The anti-inflammatory protein annexin A1 (ANXA1) has been associated with cancer progression and metastasis, suggesting its role in regulating tumor cell... 
FORMYL PEPTIDE RECEPTORS | GALECTIN-1 | DIFFERENTIAL EXPRESSION | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | MAST-CELLS | PANCREATIC-CANCER | TUMOR | NEUTROPHILS | MECHANISMS | POLARIZATION | Inflammation - pathology | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Molecular Sequence Data | Male | Peptide Fragments - pharmacology | Metalloproteases - metabolism | Laryngeal Neoplasms - pathology | Annexin A1 - chemistry | Inflammation - metabolism | Neoplasm Metastasis | Receptors, Formyl Peptide - metabolism | Aged, 80 and over | Receptors, Lipoxin - metabolism | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Tumor Microenvironment - drug effects | Amino Acid Sequence | Receptors, Prostaglandin E, EP3 Subtype - metabolism | Laryngeal Neoplasms - metabolism | Neutrophils - drug effects | Neutrophils - immunology | Inflammation - immunology | Carcinoma, Squamous Cell - immunology | Mast Cells - drug effects | Laryngeal Neoplasms - immunology | Up-Regulation - drug effects | Peptide Fragments - chemistry | Signal Transduction - drug effects | Cell Line, Tumor | Mast Cells - cytology | Annexin A1 - metabolism | Aged | Cell Proliferation - drug effects | Cell Degranulation - drug effects | Prostaglandins - metabolism | Prostaglandins | Squamous cell carcinoma | Inflammation | Corticosteroids | Metastasis | Annexins | Cell proliferation | Laryngeal cancer | Dexamethasone | Cytokines | Immunocytochemistry | Paracrine signalling | Leukocytes (neutrophilic) | Molecular chains | Metastases | Laryngeal carcinoma | Signal transduction | Receptors | Larynx | Mast cells | Position (location) | Localization | Enzyme-linked immunosorbent assay | Cancer | Tumors | Index Medicus
Journal Article
Cancer Letters, ISSN 0304-3835, 2009, Volume 290, Issue 1, pp. 68 - 75
Abstract (−)-Epigallocatechin-3-gallate (EGCG), a major green tea polyphenol, was tested for in vitro cytotoxicity against human laryngeal epidermoid carcinoma... 
Hematology, Oncology and Palliative Medicine | EndoG | Human laryngeal epidermoid carcinoma Hep2 | EGCG | AIF | Apoptosis | ACTIVATION | CANCER CELLS | GREEN TEA POLYPHENOLS | CASPASE-INDEPENDENT DEATH | CHEMOPREVENTION | INDUCTION | Human laryngeal epidermoid carcinoma | INHIBITION | NECROSIS | ONCOLOGY | (-)-EPIGALLOCATECHIN-3-GALLATE | EPIGALLOCATECHIN GALLATE | Hep2 | Immunohistochemistry | In Situ Nick-End Labeling | Reactive Oxygen Species - metabolism | Carcinoma, Squamous Cell - metabolism | Humans | Laryngeal Neoplasms - metabolism | Tumor Suppressor Protein p53 - metabolism | Protein Transport - drug effects | Mitochondria - drug effects | Membrane Potential, Mitochondrial - drug effects | Tumor Suppressor Protein p53 - drug effects | Blotting, Western | Apoptosis Inducing Factor - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Endodeoxyribonucleases - drug effects | Endodeoxyribonucleases - metabolism | Proto-Oncogene Proteins c-bcl-2 - drug effects | Cell Line, Tumor | Catechin - analogs & derivatives | Catechin - pharmacology | Cell Cycle - drug effects | Anticarcinogenic Agents - pharmacology | Apoptosis Inducing Factor - metabolism | Cytochrome c | Nucleases | Catechin | Carcinoma | Mitochondrial DNA | Tumor proteins | Green tea | Cancer | Proteins | Mitochondria | Carcinogens | Cell cycle | Cytotoxicity | Larynx | Kinases | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, pp. e58672 - e58672
The genome is organized and packed into the nucleus through interactions with core histone proteins. Emerging evidence suggests that tumors are highly... 
CARCINOMA-CELLS | TUMOR PROGRESSION | GASTRIC-CANCER | MULTIDISCIPLINARY SCIENCES | ALDEHYDE DEHYDROGENASE-ACTIVITY | PANCREATIC-CANCER | PROSTATE-CANCER | GENE-EXPRESSION | EMERGING MECHANISMS | TRICHOSTATIN-A | LINKING NUMBER CHANGE | Tumor Microenvironment - drug effects | Chromatin - metabolism | Neoplasm Invasiveness | Neoplastic Stem Cells - drug effects | Polycomb Repressive Complex 1 - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Head and Neck Neoplasms - drug therapy | Epithelial-Mesenchymal Transition - drug effects | Head and Neck Neoplasms - pathology | Polycomb Repressive Complex 1 - genetics | Squamous Cell Carcinoma of Head and Neck | Carcinoma, Squamous Cell - drug therapy | Cell Line, Tumor | Neoplastic Stem Cells - pathology | Head and Neck Neoplasms - genetics | Histone Deacetylase Inhibitors - pharmacology | Epigenesis, Genetic - drug effects | Acetylation | Chromatin - genetics | Histones | Epigenetic inheritance | Squamous cell carcinoma | Chromatin | Intermediate filament proteins | Stem cells | Vimentin | Histone deacetylase | Membranes | Mesenchyme | Laboratories | Bmi protein | Genomes | Biology | Tissues | Nuclei | Proteins | DNA methylation | Larynx | Neck | Inhibition | Head | Keratinocytes | Dentistry | Gene expression | Endothelial cells | Body mass | Medical prognosis | Epigenetics | Head and neck cancer | Microvasculature | Head & neck cancer | Tumors | Cancer | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, pp. e0167239 - e0167239
Journal Article