Emerging Infectious Diseases, ISSN 1080-6040, 2014, Volume 20, Issue 7, pp. 1176 - 1182
Sierra Leone in West Africa is in a Lassa fever hyperendemic region that also includes Guinea and Liberia. Each year, suspected Lassa fever cases result in...
ANTIBODIES | DIAGNOSIS | INFECTIOUS DISEASES | INFECTIONS | RIFT-VALLEY-FEVER | WEST-AFRICA | VIRUS | REEMERGENCE | MAURITANIA | IMMUNOLOGY | LASSA HEMORRHAGIC-FEVER | CONGO | Hemorrhagic Fevers, Viral - blood | Virus Diseases - blood | Virus Diseases - immunology | Hemorrhagic Fevers, Viral - immunology | Humans | Hemorrhagic Fevers, Viral - diagnosis | Arthropods - immunology | Virus Diseases - virology | Sierra Leone | Hemorrhagic Fever Virus, Crimean-Congo - immunology | Antibodies, Viral - blood | Immunoglobulin M - immunology | Lassa virus - immunology | Antigens, Viral - blood | Antigens, Viral - immunology | Animals | Immunoglobulin M - blood | Virus Diseases - diagnosis | Antibodies, Viral - immunology | Virus diseases | Evaluation | Care and treatment | Research | Medical case management | Medical geography | undiagnosed | viruses | serologic | hemorrhagic fever | Lassa virus | IgM | diagnostics | vector-borne infections | arthropod-borne | West Africa | febrile | immunodiagnostics | ELISA
ANTIBODIES | DIAGNOSIS | INFECTIOUS DISEASES | INFECTIONS | RIFT-VALLEY-FEVER | WEST-AFRICA | VIRUS | REEMERGENCE | MAURITANIA | IMMUNOLOGY | LASSA HEMORRHAGIC-FEVER | CONGO | Hemorrhagic Fevers, Viral - blood | Virus Diseases - blood | Virus Diseases - immunology | Hemorrhagic Fevers, Viral - immunology | Humans | Hemorrhagic Fevers, Viral - diagnosis | Arthropods - immunology | Virus Diseases - virology | Sierra Leone | Hemorrhagic Fever Virus, Crimean-Congo - immunology | Antibodies, Viral - blood | Immunoglobulin M - immunology | Lassa virus - immunology | Antigens, Viral - blood | Antigens, Viral - immunology | Animals | Immunoglobulin M - blood | Virus Diseases - diagnosis | Antibodies, Viral - immunology | Virus diseases | Evaluation | Care and treatment | Research | Medical case management | Medical geography | undiagnosed | viruses | serologic | hemorrhagic fever | Lassa virus | IgM | diagnostics | vector-borne infections | arthropod-borne | West Africa | febrile | immunodiagnostics | ELISA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2011, Volume 108, Issue 6, pp. 2396 - 2401
Lassa fever virus, a member of the family Arenaviridae, is a highly endemic category A pathogen that causes 300,000-500,000 infections per year in Western...
Proteins | Lassa fever | Double stranded RNA | Lymphocytic choriomeningitis virus | Active sites | RNA | Nucleoproteins | DNA | Viruses | Arenavirus | Immunology | Structural biology | Virology | MECHANISM | RNA HELICASE | DNA-POLYMERASE-I | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | MATRIX PROTEIN-Z | arenavirus | REPLICATION | INHIBITION | virology | DIFFRACTION | structural biology | immunology | FEVER | Nucleoproteins - chemistry | Protein Structure, Tertiary | Cell Line | Viral Proteins - chemistry | Exoribonucleases - immunology | Humans | Exoribonucleases - chemistry | Viral Proteins - immunology | Crystallography, X-Ray | Immunity, Innate | Lassa virus - immunology | RNA, Double-Stranded - immunology | Lassa virus - enzymology | RNA, Double-Stranded - chemistry | Interferon Regulatory Factor-3 - immunology | Nucleoproteins - immunology | Physiological aspects | Exonucleases | Genetic aspects | Arenaviruses | Research | Immune system | Biological Sciences
Proteins | Lassa fever | Double stranded RNA | Lymphocytic choriomeningitis virus | Active sites | RNA | Nucleoproteins | DNA | Viruses | Arenavirus | Immunology | Structural biology | Virology | MECHANISM | RNA HELICASE | DNA-POLYMERASE-I | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | MATRIX PROTEIN-Z | arenavirus | REPLICATION | INHIBITION | virology | DIFFRACTION | structural biology | immunology | FEVER | Nucleoproteins - chemistry | Protein Structure, Tertiary | Cell Line | Viral Proteins - chemistry | Exoribonucleases - immunology | Humans | Exoribonucleases - chemistry | Viral Proteins - immunology | Crystallography, X-Ray | Immunity, Innate | Lassa virus - immunology | RNA, Double-Stranded - immunology | Lassa virus - enzymology | RNA, Double-Stranded - chemistry | Interferon Regulatory Factor-3 - immunology | Nucleoproteins - immunology | Physiological aspects | Exonucleases | Genetic aspects | Arenaviruses | Research | Immune system | Biological Sciences
Journal Article
Nature Communications, ISSN 2041-1723, 05/2016, Volume 7, Issue 1, p. 11544
Lassa fever is a severe multisystem disease that often has haemorrhagic manifestations. The epitopes of the Lassa virus (LASV) surface glycoproteins recognized...
THERAPY | B-CELL | HEMORRHAGIC-FEVER | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | ENVELOPE GLYCOPROTEIN | PROTEINS | TYPE-1 | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | QUATERNARY | PEPTIDE | Antibody Specificity | Epitope Mapping | Sequence Deletion | Viral Envelope Proteins - genetics | Mutagenesis, Site-Directed | Humans | Lassa Fever - prevention & control | Lassa virus - genetics | Models, Molecular | Antigens, Viral - chemistry | Antigens, Viral - genetics | Epitopes - genetics | Lassa virus - immunology | Arenavirus - immunology | Cross Reactions | Epitopes - immunology | Antigens, Viral - immunology | Antibodies, Neutralizing - immunology | Lassa Fever - immunology | Viral Envelope Proteins - chemistry | Antibodies, Viral - immunology | Viral Envelope Proteins - immunology | Epitopes - chemistry | Antibodies, Monoclonal - immunology
THERAPY | B-CELL | HEMORRHAGIC-FEVER | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | ENVELOPE GLYCOPROTEIN | PROTEINS | TYPE-1 | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | QUATERNARY | PEPTIDE | Antibody Specificity | Epitope Mapping | Sequence Deletion | Viral Envelope Proteins - genetics | Mutagenesis, Site-Directed | Humans | Lassa Fever - prevention & control | Lassa virus - genetics | Models, Molecular | Antigens, Viral - chemistry | Antigens, Viral - genetics | Epitopes - genetics | Lassa virus - immunology | Arenavirus - immunology | Cross Reactions | Epitopes - immunology | Antigens, Viral - immunology | Antibodies, Neutralizing - immunology | Lassa Fever - immunology | Viral Envelope Proteins - chemistry | Antibodies, Viral - immunology | Viral Envelope Proteins - immunology | Epitopes - chemistry | Antibodies, Monoclonal - immunology
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 03/2017, Volume 17, Issue 3, pp. 195 - 207
Two of the most important contemporary emerging viruses that affect human health in Africa are Ebola virus (EBOV) and Lassa virus (LASV). The 2013-2016 West...
NONHUMAN-PRIMATES | DOUBLE-STRANDED-RNA | HUMAN DENDRITIC CELLS | WEST-AFRICA | HEMORRHAGIC-FEVER | INTERFERON ANTAGONISM | NEUTRALIZING ANTIBODY | IMMUNE-RESPONSES | SIERRA-LEONE | VP35 PROTEIN | IMMUNOLOGY | Hemorrhagic Fever, Ebola - immunology | Humans | Lassa Fever - immunology | Ebolavirus - immunology | Lassa virus - immunology | Physiological aspects | Ebola virus infections | Development and progression | Lassa fever | Immune response
NONHUMAN-PRIMATES | DOUBLE-STRANDED-RNA | HUMAN DENDRITIC CELLS | WEST-AFRICA | HEMORRHAGIC-FEVER | INTERFERON ANTAGONISM | NEUTRALIZING ANTIBODY | IMMUNE-RESPONSES | SIERRA-LEONE | VP35 PROTEIN | IMMUNOLOGY | Hemorrhagic Fever, Ebola - immunology | Humans | Lassa Fever - immunology | Ebolavirus - immunology | Lassa virus - immunology | Physiological aspects | Ebola virus infections | Development and progression | Lassa fever | Immune response
Journal Article
Emerging Infectious Diseases, ISSN 1080-6040, 2015, Volume 21, Issue 2, pp. 305 - 307
We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV) based Lassa virus vaccine does not alter protective efficacy of subsequent...
ANTIBODIES | CHALLENGE | INFECTIOUS DISEASES | PROTECTS NONHUMAN-PRIMATES | DISEASE | GLYCOPROTEINS | IMMUNOLOGY | Hemorrhagic Fever, Ebola - prevention & control | Humans | Lassa Fever - prevention & control | Vaccination | Macaca fascicularis | Vaccines, Synthetic - immunology | Ebolavirus - immunology | Lassa virus - immunology | Lassa Fever - mortality | Viral Vaccines - administration & dosage | Animals | Hemorrhagic Fever, Ebola - mortality | Genetic Vectors | Viral Vaccines - immunology | Vesicular stomatitis Indiana virus - immunology | Disease Models, Animal | Ebola virus | Stomatitis | Hemorrhagic fever | Vaccines | Health aspects | virus-based vaccines | viruses | Expedited | vaccines | vesicular stomatitis virus | Dispatch | nonhuman primates | Lassa virus | pre-existing immunity | West Africa | Vesicular Stomatitis Virus–based Vaccines against Lassa and Ebola Viruses | VSV | viral hemorrhagic fever | sequential vaccination
ANTIBODIES | CHALLENGE | INFECTIOUS DISEASES | PROTECTS NONHUMAN-PRIMATES | DISEASE | GLYCOPROTEINS | IMMUNOLOGY | Hemorrhagic Fever, Ebola - prevention & control | Humans | Lassa Fever - prevention & control | Vaccination | Macaca fascicularis | Vaccines, Synthetic - immunology | Ebolavirus - immunology | Lassa virus - immunology | Lassa Fever - mortality | Viral Vaccines - administration & dosage | Animals | Hemorrhagic Fever, Ebola - mortality | Genetic Vectors | Viral Vaccines - immunology | Vesicular stomatitis Indiana virus - immunology | Disease Models, Animal | Ebola virus | Stomatitis | Hemorrhagic fever | Vaccines | Health aspects | virus-based vaccines | viruses | Expedited | vaccines | vesicular stomatitis virus | Dispatch | nonhuman primates | Lassa virus | pre-existing immunity | West Africa | Vesicular Stomatitis Virus–based Vaccines against Lassa and Ebola Viruses | VSV | viral hemorrhagic fever | sequential vaccination
Journal Article
Science, ISSN 0036-8075, 06/2017, Volume 356, Issue 6341, pp. 923 - 928
The arenavirus Lassa causes severe hemorrhagic fever and a significant disease burden in West Africa every year. The glycoprotein, GPC, is the sole antigen...
ALPHA-DYSTROGLYCAN | ENTRY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ARENAVIRUS ENVELOPE GLYCOPROTEIN | CELLULAR RECEPTOR | HUMAN MONOCLONAL-ANTIBODIES | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | BINDING | STABLE SIGNAL PEPTIDE | HEMORRHAGIC-FEVER ARENAVIRUSES | Antibodies, Viral - metabolism | Humans | Protein Multimerization | Antibodies, Neutralizing - metabolism | Crystallization | Models, Molecular | Lassa Fever - virology | Lassa virus - immunology | Virus Internalization | Lassa virus - physiology | Antibodies, Neutralizing - chemistry | Lassa Fever - immunology | Viral Envelope Proteins - chemistry | Antibodies, Viral - chemistry | Protein Structure, Quaternary | Viral Envelope Proteins - metabolism | Protein Binding | Lassa virus - chemistry | Protein Conformation | Epitopes - chemistry | Protein Stability | Hydrogen-Ion Concentration | Prevention | Health aspects | Arenaviruses | Hemorrhagic fever | High resolution | Viruses | Biochemistry | Hemorrhagic disease | Design analysis | Hemorrhage | Monomers | Receptors | pH | Inhibition | Assembly | Public health | Crystal structure | Binding | RNA viruses | Antigens | Biochemical analysis | Glycoprotein | Glycoproteins | Fatal | Ribonucleic acid--RNA | Fever | Anchors | Lassa fever | Neutralizing | Neutralization | Antibodies | Vaccines
ALPHA-DYSTROGLYCAN | ENTRY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ARENAVIRUS ENVELOPE GLYCOPROTEIN | CELLULAR RECEPTOR | HUMAN MONOCLONAL-ANTIBODIES | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | BINDING | STABLE SIGNAL PEPTIDE | HEMORRHAGIC-FEVER ARENAVIRUSES | Antibodies, Viral - metabolism | Humans | Protein Multimerization | Antibodies, Neutralizing - metabolism | Crystallization | Models, Molecular | Lassa Fever - virology | Lassa virus - immunology | Virus Internalization | Lassa virus - physiology | Antibodies, Neutralizing - chemistry | Lassa Fever - immunology | Viral Envelope Proteins - chemistry | Antibodies, Viral - chemistry | Protein Structure, Quaternary | Viral Envelope Proteins - metabolism | Protein Binding | Lassa virus - chemistry | Protein Conformation | Epitopes - chemistry | Protein Stability | Hydrogen-Ion Concentration | Prevention | Health aspects | Arenaviruses | Hemorrhagic fever | High resolution | Viruses | Biochemistry | Hemorrhagic disease | Design analysis | Hemorrhage | Monomers | Receptors | pH | Inhibition | Assembly | Public health | Crystal structure | Binding | RNA viruses | Antigens | Biochemical analysis | Glycoprotein | Glycoproteins | Fatal | Ribonucleic acid--RNA | Fever | Anchors | Lassa fever | Neutralizing | Neutralization | Antibodies | Vaccines
Journal Article
Vaccine, ISSN 0264-410X, 2015, Volume 33, Issue 10, pp. 1267 - 1273
Abstract Background Peptide vaccination based on multiple T-cell epitopes can be used to target well-defined ethnic populations. Because the response to T-cell...
Allergy and Immunology | Lassa, Nipah and Hendra viruses | MHC (HLA) class II proteins | Immunodominance | Multi-epitope peptide vaccination | Emerging infectious diseases | MEDICINE, RESEARCH & EXPERIMENTAL | HLA CLASS-II | PROTEIN | G-GLYCOPROTEIN | IMMUNOLOGY | SUBUNIT VACCINE | VIRAL-INFECTION | COMPREHENSIVE ANALYSIS | NIPAH VIRUS-INFECTION | HENDRA-VIRUS | LASSA FEVER | T-CELLS | Henipavirus Infections - immunology | Humans | Lassa Fever - prevention & control | AIDS Vaccines - immunology | Computational Biology | Histocompatibility Antigens Class I - immunology | Epitopes, T-Lymphocyte - genetics | Histocompatibility Antigens Class I - genetics | Vaccines, Subunit - immunology | Continental Population Groups - genetics | Nipah Virus - immunology | Hendra Virus - immunology | Lassa virus - immunology | CD4-Positive T-Lymphocytes - immunology | Henipavirus Infections - prevention & control | Glycoproteins - immunology | HIV-1 - immunology | Histocompatibility Antigens Class II - immunology | Lassa Fever - immunology | Drug Design | Viral Envelope Proteins - immunology | Epitopes, T-Lymphocyte - immunology | Histocompatibility Antigens Class II - genetics | gag Gene Products, Human Immunodeficiency Virus - immunology | Proteins | Multiculturalism | Vaccines | T cells | Vaccination | Antigenic determinants | Bioinformatics | Multiculturalism & pluralism | Mortality
Allergy and Immunology | Lassa, Nipah and Hendra viruses | MHC (HLA) class II proteins | Immunodominance | Multi-epitope peptide vaccination | Emerging infectious diseases | MEDICINE, RESEARCH & EXPERIMENTAL | HLA CLASS-II | PROTEIN | G-GLYCOPROTEIN | IMMUNOLOGY | SUBUNIT VACCINE | VIRAL-INFECTION | COMPREHENSIVE ANALYSIS | NIPAH VIRUS-INFECTION | HENDRA-VIRUS | LASSA FEVER | T-CELLS | Henipavirus Infections - immunology | Humans | Lassa Fever - prevention & control | AIDS Vaccines - immunology | Computational Biology | Histocompatibility Antigens Class I - immunology | Epitopes, T-Lymphocyte - genetics | Histocompatibility Antigens Class I - genetics | Vaccines, Subunit - immunology | Continental Population Groups - genetics | Nipah Virus - immunology | Hendra Virus - immunology | Lassa virus - immunology | CD4-Positive T-Lymphocytes - immunology | Henipavirus Infections - prevention & control | Glycoproteins - immunology | HIV-1 - immunology | Histocompatibility Antigens Class II - immunology | Lassa Fever - immunology | Drug Design | Viral Envelope Proteins - immunology | Epitopes, T-Lymphocyte - immunology | Histocompatibility Antigens Class II - genetics | gag Gene Products, Human Immunodeficiency Virus - immunology | Proteins | Multiculturalism | Vaccines | T cells | Vaccination | Antigenic determinants | Bioinformatics | Multiculturalism & pluralism | Mortality
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 06/2012, Volume 11, Issue 6, pp. 617 - 630
The antiviral response is largely mediated by dendritic cells (DCs), including conventional (c) DCs that function as antigen-presenting cells, and plasmacytoid...
INTERFERON-ALPHA/BETA | LASSA VIRUS | PERSISTENCE | MICROBIOLOGY | CHRONIC VIRAL-INFECTION | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | RESPONSES | ANTIVIRAL DEFENSE | HIV-INFECTION | VIROLOGY | TYPE-1 IFN | IN-VIVO | PARASITOLOGY | Toll-Like Receptor 7 - metabolism | Arenaviridae Infections - virology | Membrane Glycoproteins - metabolism | Receptors, Virus - metabolism | Dendritic Cells - immunology | Mice, Inbred C57BL | Cytokines - secretion | Lassa virus - pathogenicity | Lassa virus - physiology | Animals | Lymphocytic choriomeningitis virus - pathogenicity | Toll-Like Receptor 7 - immunology | Virus Attachment | Receptors, Virus - immunology | Lymphocytic choriomeningitis virus - physiology | Mice | Membrane Glycoproteins - immunology | Dendritic Cells - virology | Arenaviridae Infections - immunology | Disease Models, Animal | Antiviral agents | Medical colleges | Dendritic cells | Health aspects | type I interferon | lymphocytic choriomeningitis virus (LCMV) | Lassa Fever virus (LASV) | arenavirus | plasmacytoid dendritic cells | chronic viral infection | innate | toll like receptor-7 | dendritic cell | interleukin-12
INTERFERON-ALPHA/BETA | LASSA VIRUS | PERSISTENCE | MICROBIOLOGY | CHRONIC VIRAL-INFECTION | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | RESPONSES | ANTIVIRAL DEFENSE | HIV-INFECTION | VIROLOGY | TYPE-1 IFN | IN-VIVO | PARASITOLOGY | Toll-Like Receptor 7 - metabolism | Arenaviridae Infections - virology | Membrane Glycoproteins - metabolism | Receptors, Virus - metabolism | Dendritic Cells - immunology | Mice, Inbred C57BL | Cytokines - secretion | Lassa virus - pathogenicity | Lassa virus - physiology | Animals | Lymphocytic choriomeningitis virus - pathogenicity | Toll-Like Receptor 7 - immunology | Virus Attachment | Receptors, Virus - immunology | Lymphocytic choriomeningitis virus - physiology | Mice | Membrane Glycoproteins - immunology | Dendritic Cells - virology | Arenaviridae Infections - immunology | Disease Models, Animal | Antiviral agents | Medical colleges | Dendritic cells | Health aspects | type I interferon | lymphocytic choriomeningitis virus (LCMV) | Lassa Fever virus (LASV) | arenavirus | plasmacytoid dendritic cells | chronic viral infection | innate | toll like receptor-7 | dendritic cell | interleukin-12
Journal Article
The Journal of Immunology, ISSN 0022-1767, 03/2003, Volume 170, Issue 6, pp. 2797 - 2801
Acute infection of humans with Ebola and Lassa viruses, two principal etiologic agents of hemorrhagic fevers, often results in a paradoxical pattern of immune...
T-Lymphocyte Subsets - immunology | Dendritic Cells - immunology | Humans | Cells, Cultured | Ebolavirus - pathogenicity | Immunity, Active - immunology | Lassa Fever - virology | Monocytes - immunology | Antigen Presentation - immunology | Antigen-Presenting Cells - immunology | Antigen-Presenting Cells - virology | Ebolavirus - immunology | Lassa virus - immunology | T-Lymphocyte Subsets - virology | Lassa virus - pathogenicity | Cell Differentiation - immunology | Monocytes - virology | Cell Division - immunology | Hemorrhagic Fever, Ebola - virology | Lassa Fever - immunology | Hemorrhagic Fever, Ebola - immunology | Dendritic Cells - virology
T-Lymphocyte Subsets - immunology | Dendritic Cells - immunology | Humans | Cells, Cultured | Ebolavirus - pathogenicity | Immunity, Active - immunology | Lassa Fever - virology | Monocytes - immunology | Antigen Presentation - immunology | Antigen-Presenting Cells - immunology | Antigen-Presenting Cells - virology | Ebolavirus - immunology | Lassa virus - immunology | T-Lymphocyte Subsets - virology | Lassa virus - pathogenicity | Cell Differentiation - immunology | Monocytes - virology | Cell Division - immunology | Hemorrhagic Fever, Ebola - virology | Lassa Fever - immunology | Hemorrhagic Fever, Ebola - immunology | Dendritic Cells - virology
Journal Article
Journal of Virology, ISSN 0022-538X, 06/2018, Volume 92, Issue 12, pp. e02230 - 17
Several Old World and New World arenaviruses are responsible for severe endemic and epidemic hemorrhagic fevers, whereas other members of the Arenaviridae...
Innate immunity | Lassa fever | Viral hemorrhagic fevers | Livevector vaccines | Arenavirus | HUMAN DENDRITIC CELLS | LASSA VIRUS | LIVE-ATTENUATED VACCINES | RHESUS-MONKEYS | I INTERFERON RESPONSE | ARGENTINE HEMORRHAGIC-FEVER | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | MASTOMYS-NATALENSIS | arenavirus | VIROLOGY | innate immunity | viral hemorrhagic fevers | NUCLEOPROTEIN | CODON DEOPTIMIZATION | live-vector vaccines | Lassa Fever/prevention & control | Humans | Vaccination | Macaca fascicularis | Cercopithecus aethiops | Hemorrhagic Fevers, Viral/pathology | Life Sciences | Arenaviridae/immunology | HEK293 Cells | Viral Vaccines/immunology | Biomolecules | Arenaviridae/genetics | Interferon Type I/immunology | Lassa virus/immunology | Monkey Diseases/prevention & control | Vero Cells | Monkey Diseases/immunology | Lassa Fever/immunology | Cell Line | Cricetinae | Vaccines, Attenuated/immunology | Biochemistry, Molecular Biology | Lassa Fever/virology | Hemorrhagic Fevers, Viral/virology | Animals | Hemorrhagic Fevers, Viral/transmission | Exoribonucleases/metabolism | Hemorrhagic Fevers, Viral/immunology | Monkey Diseases/virology
Innate immunity | Lassa fever | Viral hemorrhagic fevers | Livevector vaccines | Arenavirus | HUMAN DENDRITIC CELLS | LASSA VIRUS | LIVE-ATTENUATED VACCINES | RHESUS-MONKEYS | I INTERFERON RESPONSE | ARGENTINE HEMORRHAGIC-FEVER | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | MASTOMYS-NATALENSIS | arenavirus | VIROLOGY | innate immunity | viral hemorrhagic fevers | NUCLEOPROTEIN | CODON DEOPTIMIZATION | live-vector vaccines | Lassa Fever/prevention & control | Humans | Vaccination | Macaca fascicularis | Cercopithecus aethiops | Hemorrhagic Fevers, Viral/pathology | Life Sciences | Arenaviridae/immunology | HEK293 Cells | Viral Vaccines/immunology | Biomolecules | Arenaviridae/genetics | Interferon Type I/immunology | Lassa virus/immunology | Monkey Diseases/prevention & control | Vero Cells | Monkey Diseases/immunology | Lassa Fever/immunology | Cell Line | Cricetinae | Vaccines, Attenuated/immunology | Biochemistry, Molecular Biology | Lassa Fever/virology | Hemorrhagic Fevers, Viral/virology | Animals | Hemorrhagic Fevers, Viral/transmission | Exoribonucleases/metabolism | Hemorrhagic Fevers, Viral/immunology | Monkey Diseases/virology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2013, Volume 288, Issue 23, pp. 16949 - 16959
A hallmark of severe Lassa fever is the generalized immune suppression, the mechanism of which is poorly understood. Lassa virus (LASV) nucleoprotein (NP) is...
PATHOGENESIS | SITE | VIRUS | RNA | AUTOIMMUNITY | CRYSTAL-STRUCTURE | DNA | TREX1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | RIG-I | BINDING | Nucleoproteins - chemistry | Exoribonucleases - genetics | Humans | Nucleoproteins - genetics | Exoribonucleases - chemistry | Lassa Fever - genetics | Viral Proteins - immunology | Arenaviruses, New World - genetics | Crystallography, X-Ray | Interferon Type I - immunology | Arenaviruses, New World - immunology | Viral Proteins - metabolism | Arenaviruses, New World - enzymology | RNA, Viral - genetics | Lassa Fever - immunology | Interferon Type I - metabolism | RNA, Double-Stranded - metabolism | RNA, Viral - metabolism | Lassa virus - enzymology | RNA, Double-Stranded - chemistry | Nucleoproteins - immunology | Protein Structure, Tertiary | Cell Line | Viral Proteins - chemistry | Exoribonucleases - immunology | Immune Tolerance | Lassa virus - genetics | Viral Proteins - genetics | Lassa Fever - metabolism | Lassa virus - immunology | RNA, Viral - chemistry | Nucleoproteins - metabolism | RNA, Double-Stranded - genetics | RNA, Double-Stranded - immunology | RNA, Viral - immunology | Exoribonucleases - metabolism | Molecular Bases of Disease | 3′-5′ Exoribonuclease | Immunosuppression | Viral Protein | Immune Evasion | Protein-nucleic Acid Interaction | Nucleic Acid Enzymology | Protein Structure | Type I Interferons | Lassa Fever Virus | Tacaribe Virus
PATHOGENESIS | SITE | VIRUS | RNA | AUTOIMMUNITY | CRYSTAL-STRUCTURE | DNA | TREX1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | RIG-I | BINDING | Nucleoproteins - chemistry | Exoribonucleases - genetics | Humans | Nucleoproteins - genetics | Exoribonucleases - chemistry | Lassa Fever - genetics | Viral Proteins - immunology | Arenaviruses, New World - genetics | Crystallography, X-Ray | Interferon Type I - immunology | Arenaviruses, New World - immunology | Viral Proteins - metabolism | Arenaviruses, New World - enzymology | RNA, Viral - genetics | Lassa Fever - immunology | Interferon Type I - metabolism | RNA, Double-Stranded - metabolism | RNA, Viral - metabolism | Lassa virus - enzymology | RNA, Double-Stranded - chemistry | Nucleoproteins - immunology | Protein Structure, Tertiary | Cell Line | Viral Proteins - chemistry | Exoribonucleases - immunology | Immune Tolerance | Lassa virus - genetics | Viral Proteins - genetics | Lassa Fever - metabolism | Lassa virus - immunology | RNA, Viral - chemistry | Nucleoproteins - metabolism | RNA, Double-Stranded - genetics | RNA, Double-Stranded - immunology | RNA, Viral - immunology | Exoribonucleases - metabolism | Molecular Bases of Disease | 3′-5′ Exoribonuclease | Immunosuppression | Viral Protein | Immune Evasion | Protein-nucleic Acid Interaction | Nucleic Acid Enzymology | Protein Structure | Type I Interferons | Lassa Fever Virus | Tacaribe Virus
Journal Article
Vaccine, ISSN 0264-410X, 2008, Volume 26, Issue 41, pp. 5246 - 5254
Abstract A single injection of ML29 reassortant vaccine for Lassa fever induces low, transient viremia, and low or moderate levels of ML29 replication in...
Allergy and Immunology | Lassa fever | Vaccine | Arenaviruses | Protection | MEDICINE, RESEARCH & EXPERIMENTAL | MOPEIA VIRUSES | RNA | GUINEA-PIGS | IMMUNOLOGY | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | LIVER PATHOLOGY | GENE | NIGERIAN STRAIN | INFECTION | NUCLEOTIDE-SEQUENCE | RHESUS MACAQUES | Gene Expression Regulation - immunology | Humans | Lassa Fever - prevention & control | Cercopithecus aethiops | Lassa virus - genetics | Reassortant Viruses - genetics | Lipopolysaccharide Receptors - immunology | Male | Lassa virus - immunology | Lassa virus - isolation & purification | Immunity, Cellular - immunology | Reassortant Viruses - immunology | Animals | Lassa Fever - pathology | Lassa Fever - immunology | Leukocytes, Mononuclear - immunology | CD3 Complex - immunology | Survival Analysis | Female | T-Lymphocytes - immunology | Viremia - immunology | Safety | Callithrix - immunology | Vero Cells | Primates | Vaccines | Proteins | Studies | Enzymes | Biomedical research | Viruses | Genomes | Histology | RNA polymerase | Kinases | Monkeys & apes | Lassa Fever
Allergy and Immunology | Lassa fever | Vaccine | Arenaviruses | Protection | MEDICINE, RESEARCH & EXPERIMENTAL | MOPEIA VIRUSES | RNA | GUINEA-PIGS | IMMUNOLOGY | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | LIVER PATHOLOGY | GENE | NIGERIAN STRAIN | INFECTION | NUCLEOTIDE-SEQUENCE | RHESUS MACAQUES | Gene Expression Regulation - immunology | Humans | Lassa Fever - prevention & control | Cercopithecus aethiops | Lassa virus - genetics | Reassortant Viruses - genetics | Lipopolysaccharide Receptors - immunology | Male | Lassa virus - immunology | Lassa virus - isolation & purification | Immunity, Cellular - immunology | Reassortant Viruses - immunology | Animals | Lassa Fever - pathology | Lassa Fever - immunology | Leukocytes, Mononuclear - immunology | CD3 Complex - immunology | Survival Analysis | Female | T-Lymphocytes - immunology | Viremia - immunology | Safety | Callithrix - immunology | Vero Cells | Primates | Vaccines | Proteins | Studies | Enzymes | Biomedical research | Viruses | Genomes | Histology | RNA polymerase | Kinases | Monkeys & apes | Lassa Fever
Journal Article