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Journal of Cardiovascular Pharmacology, ISSN 0160-2446, 06/2017, Volume 70, Issue 3, pp. 159 - 167
Journal Article
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 07/2016, Volume 26, Issue 13, pp. 3207 - 3211
Previously we disclosed the discovery of potent Late I-Na current inhibitor 2 (GS-458967, IC50 of 333 nM) that has a good separation of late versus peak... 
GS-462808 | Late I-Na current inhibitor | CHEMISTRY, MEDICINAL | PHARMACOLOGY | CHEMISTRY, ORGANIC | Angina | Anti-ischemic | Ranolazine
Journal Article
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, ISSN 0160-2446, 09/2017, Volume 70, Issue 3, pp. 159 - 167
Late sodium channel current (late I-Na) is considered to be an antiarrhythmic target. The prime antiarrhythmic mechanisms of late INa inhibition have been... 
LATE SODIUM CURRENT | CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | repolarization | CHANNEL BLOCK | INTRACELLULAR SODIUM | ACTION-POTENTIAL PROLONGATION | late I-Na | sodium channel | arrhythmias | TORSADE-DE-POINTES | EARLY AFTERDEPOLARIZATIONS | pharmacology | PHARMACOLOGY & PHARMACY | ATRIAL-SELECTIVE BLOCK | RAT VENTRICULAR MYOCYTES | T-WAVE ALTERNANS
Journal Article
International Journal of Cardiology, ISSN 0167-5273, 2016, Volume 227, pp. 556 - 564
Journal Article
Circulation, ISSN 0009-7322, 10/2012, Volume 126, Issue 18, pp. 2208 - 2219
Background-Heart failure is a growing cause of morbidity and mortality. Cardiac phosphatidylinositol 3-kinase signaling promotes cardiomyocyte survival and... 
heart failure | ion channels or ion channel | signal transduction | arrhythmia | LATE SODIUM CURRENT | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN | AKT ACTIVATION | HEART-FAILURE | LONG-QT SYNDROME | CARDIAC NA+ CHANNELS | SGK | IN-VIVO | RANOLAZINE | PERIPHERAL VASCULAR DISEASE | MODULATION | Consensus Sequence | Tachycardia, Ventricular - enzymology | Protein-Serine-Threonine Kinases - deficiency | Phosphorylation | Cardiomyopathy, Dilated - enzymology | Heart Failure - enzymology | Humans | Ranolazine | Immediate-Early Proteins - metabolism | NAV1.5 Voltage-Gated Sodium Channel - drug effects | Immediate-Early Proteins - chemistry | Acetanilides - therapeutic use | Electrocardiography | Immediate-Early Proteins - deficiency | Sodium Channel Blockers - therapeutic use | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Immediate-Early Proteins - physiology | Protein-Serine-Threonine Kinases - physiology | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Tachycardia, Ventricular - etiology | Enzyme Induction | Mice, Transgenic | Sodium Channel Blockers - pharmacology | Piperazines - therapeutic use | NAV1.5 Voltage-Gated Sodium Channel - physiology | Ventricular Remodeling - physiology | Protein Interaction Mapping | Cardiomegaly, Exercise-Induced | Animals | Immediate-Early Proteins - genetics | Hypertension - complications | Phosphatidylinositol 3-Kinases - physiology | Mice | Protein Processing, Post-Translational | Protein-Serine-Threonine Kinases - chemistry | NAV1.5 Voltage-Gated Sodium Channel - chemistry | Ion Channel Gating - drug effects | Heart failure | Care and treatment | Prognosis | Physiological aspects | Serum | Cellular signal transduction | Research | Phosphotransferases
Journal Article
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 10/2013, Volume 305, Issue 7, pp. H1068 - H1079
The treatment of heart failure (HF) is challenging and morbidity and mortality are high. The goal of this study was to determine if inhibition of the late Na+... 
Heart failure | Late I | T-tubule | Calcium handling | Ranolazine | heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | calcium handling | CONTRACTILITY | VENTRICULAR MYOCYTES | CA2+ OVERLOAD | FAILURE | late I-Na | HYPERTROPHY | TRANSIENT ALTERNANS | CARDIAC ALTERNANS | FAILING HEART | RYANODINE RECEPTORS | t-tubule | ranolazine | NA+ | PERIPHERAL VASCULAR DISEASE | Heart Failure - physiopathology | Hypertension - drug therapy | Male | NAV1.5 Voltage-Gated Sodium Channel - metabolism | Ryanodine Receptor Calcium Release Channel - metabolism | Sodium - metabolism | Dose-Response Relationship, Drug | Heart Failure - prevention & control | Sodium-Calcium Exchanger - drug effects | Time Factors | Sodium-Calcium Exchanger - metabolism | NAV1.5 Voltage-Gated Sodium Channel - drug effects | Sodium Channels - metabolism | Ultrasonography | Heart Failure - etiology | Disease Models, Animal | Rats, Inbred SHR | Acetanilides - pharmacology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Hypertrophy, Left Ventricular - etiology | Hypertrophy, Left Ventricular - metabolism | Hypertrophy, Left Ventricular - prevention & control | Rats | Sodium Channel Blockers - pharmacology | Heart Failure - metabolism | Ryanodine Receptor Calcium Release Channel - drug effects | Sodium Channels - drug effects | Piperazines - pharmacology | Disease Progression | Hypertension - physiopathology | Hypertension - metabolism | Animals | Myocytes, Cardiac - drug effects | Calcium Signaling - drug effects | Calcium Channels, L-Type - drug effects | Hypertension - complications | Myocytes, Cardiac - metabolism | Calcium Channels, L-Type - metabolism | Hypertension - diagnostic imaging | Hypertrophy, Left Ventricular - physiopathology | Physiological aspects | Sodium channels | Research | Calcium-binding proteins | Cardiac Excitation and Contraction | late INa
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2018, Volume 314, Issue 2, pp. H236 - H245
Journal Article
Circulation, ISSN 0009-7322, 04/2011, Volume 123, Issue 16, pp. 1713 - 1720
Journal Article