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1. Full Text Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses
by Lenaerts, Anne and Barry, Clifton E and Dartois, Véronique
Immunological Reviews, ISSN 0105-2896, 03/2015, Volume 264, Issue 1, pp. 288 - 307
Summary Tuberculosis (TB) lesions are extremely complex and dynamic. Here, we review the multiple types and fates of pulmonary lesions that form following... 
lesion dynamics | animal models | immunopathology | biomarkers | tuberculosis | Biomarkers | Immunopathology | Animal models | Tuberculosis | Lesion dynamics | LATENT TUBERCULOSIS | MYCOBACTERIUM-BOVIS BCG | RABBIT MODEL | IMMUNOLOGY | IN-VITRO | NONREPLICATING PERSISTENCE | MOUSE MODEL | PULMONARY TUBERCULOSIS | GUINEA-PIG MODEL | ANAEROBIC NITRATE REDUCTASE | INNATE IMMUNITY | Humans | Antitubercular Agents - pharmacology | Mycobacterium tuberculosis - immunology | Treatment Outcome | Latent Tuberculosis - immunology | Host-Pathogen Interactions - immunology | Tuberculosis - immunology | Granuloma - pathology | Animals | Tuberculosis - drug therapy | Granuloma - drug therapy | Granuloma - immunology | Latent Tuberculosis - pathology | Antitubercular Agents - therapeutic use | Disease Models, Animal | Tuberculosis - pathology | Health aspects | Invited Reviews
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2. Full Text Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers
by Lyadova, I.V and Panteleev, A.V
Mediators of Inflammation, ISSN 0962-9351, 2015, Volume 2015, pp. 854507 - 13
The outcome of Mycobacterium tuberculosis (Mtb) infection ranges from a complete pathogen clearance through asymptomatic latent infection (LTBI) to active... 
MYCOBACTERIUM-TUBERCULOSIS | COLONY-STIMULATING FACTOR | INTERFERON-GAMMA | ACTIVE TUBERCULOSIS | NITRIC-OXIDE SYNTHASE | IFN-GAMMA | CD4(+) T-CELLS | REGULATES BETA-DEFENSIN-2 EXPRESSION | IMMUNOLOGY | GAMMA RELEASE ASSAYS | NEUTROPHIL RECRUITMENT | CELL BIOLOGY | Biomarkers - metabolism | Th1 Cells - pathology | Tuberculosis, Pulmonary - microbiology | Cytokines - metabolism | Lymphocyte Activation | Humans | Interferon-gamma - metabolism | Latent Tuberculosis - immunology | Tuberculosis, Pulmonary - pathology | Th1 Cells - immunology | Host-Pathogen Interactions - immunology | Interleukin-17 - metabolism | Tuberculosis, Pulmonary - immunology | Animals | Th17 Cells - immunology | Cell Differentiation | Mice | Th17 Cells - pathology | Host-bacteria relationships | Physiological aspects | Tuberculosis | T cells | Observations | Health aspects | Antigens | Pathogens | Transcription factors | Cytokines | Pathogenesis | Laboratories | T cell receptors | Infections | Inflammation | Studies | Pathology | Immunology | Lymphocytes | Biomarkers | Ligands | Review
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3. Full Text S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis
by Gopal, Radha and Monin, Leticia and Torres, Diana and Slight, Samantha and Mehra, Smriti and McKenna, Kyle C and Junecko, Beth A. Fallert and Reinhart, Todd A and Kolls, Jay and Báez-Saldańa, Renata and Cruz-Lagunas, Alfredo and Rodríguez-Reyna, Tatiana S and Kumar, Nathella Pavan and Tessier, Phillipe and Roth, Johannes and Selman, Moisés and Becerril-Villanueva, Enrique and Baquera-Heredia, Javier and Cumming, Bridgette and Kasprowicz, Victoria O and Steyn, Adrie J.C and Babu, Subash and Kaushal, Deepak and Zúñiga, Joaquín and Vogl, Thomas and Rangel-Moreno, Javier and Khader, Shabaana A
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 11/2013, Volume 188, Issue 9, pp. 1137 - 1146
Rationale: A hallmark of pulmonary tuberculosis (TB) is the formation of granulomas. However, the immune factors that drive the formation of a protective... 
Granuloma | Inflammation | Tuberculosis | Neutrophil | S100A8/A9 proteins | MYCOBACTERIUM-TUBERCULOSIS | RHEUMATOID-ARTHRITIS | IMMUNE-RESPONSE | LATENT TUBERCULOSIS | tuberculosis | neutrophil | S100 PROTEINS | DISEASE-ACTIVITY | IN-VITRO | inflammation | RESPIRATORY SYSTEM | granuloma | SERUM-LEVELS | INFECTION | T-CELLS | CRITICAL CARE MEDICINE | Granuloma, Respiratory Tract - immunology | Inflammation Mediators - immunology | Chemotactic Factors - immunology | Humans | Mice, Inbred C57BL | Neutrophils - immunology | Macaca mulatta | Tuberculosis, Pulmonary - immunology | Animals | Calgranulin B - immunology | Mice | Calgranulin A - immunology | Chemokines - immunology | Cytokines - immunology | Disease Models, Animal | S100A8 | A9 proteins
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4. Full Text Heterogeneity in tuberculosis
by Cadena, Anthony M and Fortune, Sarah M and Flynn, Joanne L
Nature Reviews Immunology, ISSN 1474-1733, 10/2017, Volume 17, Issue 11, pp. 691 - 702
Infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), results in a range of clinical presentations in humans. Most infections... 
MYCOBACTERIUM-TUBERCULOSIS | POSITRON-EMISSION | LATENT TUBERCULOSIS | T-CELL DEPLETION | INNATE IMMUNE-RESPONSE | CYNOMOLGUS MACAQUES | HOST-DIRECTED THERAPY | GRANULOMATOUS INFLAMMATION | INFECTION | DRUG-RESISTANCE | IMMUNOLOGY | Granuloma - microbiology | Disease Susceptibility | Humans | Antitubercular Agents - pharmacology | Mycobacterium tuberculosis - immunology | Treatment Outcome | Tuberculosis - microbiology | Patient Outcome Assessment | Host-Pathogen Interactions - immunology | Tuberculosis - immunology | Granuloma - pathology | Animals | Tuberculosis - drug therapy | Granuloma - immunology | Antitubercular Agents - therapeutic use | Disease Models, Animal | Tuberculosis - pathology | Development and progression | Tuberculosis | Immune response | B cells | Health aspects | Heterogeneity | Infections | Host-pathogen interactions
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5. Full Text Risk of Progression to Active Tuberculosis Following Reinfection With Mycobacterium tuberculosis
by Jason R. Andrews and Farzad Noubary and Rochelle P. Walensky and Rodrigo Cerda and Elena Losina and C. Robert Horsburgh
Clinical Infectious Diseases, ISSN 1058-4838, 3/2012, Volume 54, Issue 6, pp. 784 - 791
Background. The risk of progression to active tuberculosis is greatest in the several years following initial infection. The extent to which latent... 
Tuberculosis | Infectious diseases | Mycobacterium tuberculosis | Nurses | Latent tuberculosis | Disease risk | Infections | Tuberculosis vaccine | ARTICLES AND COMMENTARIES | Reinfection | Epidemiology | IMMUNITY | TESTS | INFECTIOUS DISEASES | EXOGENOUS REINFECTION | MICROBIOLOGY | IMMUNOLOGY | PATHOGENESIS | RELAPSE | MEDICAL-STUDENTS | DISEASE | INFECTION | RECURRENCE | EPIDEMICS | Tuberculosis - epidemiology | Prevalence | Prospective Studies | Humans | Risk Factors | Latent Tuberculosis - epidemiology | Latent Tuberculosis - pathology | Disease Progression | Incidence | Tuberculosis - pathology | Research | Risk factors | and Commentaries
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6. Full Text Incipient and subclinical tuberculosis: A clinical review of early stages and progression of infection
by Drain, Paul K and Bajema, Kristina L and Dowdy, David and Dheda, Keertan and Naidoo, Kogieleum and Schumacher, Samuel G and Ma, Shuyi and Meermeier, Erin and Lewinsohn, David M and Sherman, David R
Clinical Microbiology Reviews, ISSN 0893-8512, 10/2018, Volume 31, Issue 4, p. e00021-18
Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a limited understanding of its clinical pathogenic spectrum of... 
Mycobacterium tuberculosis | Tuberculosis | MYCOBACTERIUM-TUBERCULOSIS | tuberculosis | GENE-EXPRESSION PROFILES | MICROBIOLOGY | RANDOMIZED CONTROLLED-TRIAL | HIGH HIV PREVALENCE | ISONIAZID PREVENTIVE THERAPY | T-CELL RESPONSES | ACTIVE TUBERCULOSIS | EXTENSIVELY DRUG-RESISTANT | PULMONARY TUBERCULOSIS | HOST RNA SIGNATURES | Tuberculosis - immunology | Latent Tuberculosis - prevention & control | Latent Tuberculosis - drug therapy | Humans | Tuberculosis - drug therapy | Tuberculosis - prevention & control | Latent Tuberculosis - immunology | Latent Tuberculosis - pathology | Antitubercular Agents - therapeutic use | Tuberculosis - pathology
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7. Full Text Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis
by Kaushal, Deepak and Foreman, Taylor W and Gautam, Uma S and Alvarez, Xavier and Adekambi, Toidi and Rangel-Moreno, Javier and Golden, Nadia A and Johnson, Ann-Marie F and Phillips, Bonnie L and Ahsan, Muhammad H and Russell-Lodrigue, Kasi E and Doyle, Lara A and Roy, Chad J and Didier, Peter J and Blanchard, James L and Rengarajan, Jyothi and Lackner, Andrew A and Khader, Shabaana A and Mehra, Smriti
Nature Communications, ISSN 2041-1723, 10/2015, Volume 6, Issue 1, p. 8533
Tuberculosis (TB) is a global pandaemic, partially due to the failure of vaccination approaches. Novel anti-TB vaccines are therefore urgently required. Here... 
NONHUMAN-PRIMATES | FACTOR SIGMA(H) | T-CELL MEMORY | SIMIAN IMMUNODEFICIENCY VIRUS | LATENT TUBERCULOSIS | MULTIDISCIPLINARY SCIENCES | PULMONARY TUBERCULOSIS | CYNOMOLGUS MACAQUES | AEROSOL VACCINATION | CALMETTE-GUERIN | RHESUS MACAQUES | Tuberculosis Vaccines - pharmacology | Lung - pathology | Mycobacterium tuberculosis - immunology | Bronchoalveolar Lavage | Tuberculosis - microbiology | Macaca mulatta | Sigma Factor - immunology | Immunologic Memory - drug effects | Animals | Vaccination - methods | BCG Vaccine | T-Lymphocytes - drug effects | Tuberculosis - prevention & control | Aerosols | Bacterial Proteins - immunology | Lung - immunology | Lymphoid Tissue - drug effects | Tuberculosis - pathology
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8. Full Text Tuberculosis as a three-act play: A new paradigm for the pathogenesis of pulmonary tuberculosis
by Hunter, Robert L
Tuberculosis, ISSN 1472-9792, 2015, Volume 97, pp. 8 - 17
Summary Lack of access to human tissues with untreated tuberculosis (TB) has forced generations of researchers to use animal models and to adopt a paradigm... 
Infectious Disease | Pulmonary/Respiratory | Human | Pathology | Cavity | Pathogenesis | Post primary | Lung | MYCOBACTERIUM-TUBERCULOSIS | POSTPRIMARY TUBERCULOSIS | LIPOID PNEUMONIA | T-CELL EPITOPES | MICROBIOLOGY | ANTIGENS | IMMUNOLOGY | HOST RESPONSE | POST PRIMARY TUBERCULOSIS | LUNG-CANCER | RESPIRATORY SYSTEM | CORD FACTOR | Granuloma - microbiology | Lung - microbiology | Tuberculosis, Pulmonary - microbiology | Lung - pathology | Granuloma - diagnostic imaging | Humans | Antigens, Bacterial - immunology | Mycobacterium tuberculosis - immunology | Lung - diagnostic imaging | Latent Tuberculosis - immunology | Tuberculosis, Pulmonary - pathology | Disease Progression | Host-Pathogen Interactions | Mycobacterium tuberculosis - pathogenicity | Granuloma - pathology | Tuberculosis, Pulmonary - immunology | Animals | Latent Tuberculosis - diagnostic imaging | Granuloma - immunology | Tuberculosis, Pulmonary - diagnostic imaging | Epitopes, T-Lymphocyte - immunology | Latent Tuberculosis - microbiology | Latent Tuberculosis - pathology | Lung - immunology | Antigens | Pneumonia | Tuberculosis | Disease transmission | Analysis | Bacterial pneumonia
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