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index medicus (273) 273
humans (178) 178
animals (158) 158
mice (110) 110
phosphorylation (106) 106
immunology (97) 97
lymphocyte specific protein tyrosine kinase p56 - metabolism (97) 97
signal transduction (93) 93
activation (87) 87
lck (78) 78
lymphocyte specific protein tyrosine kinase p56 (76) 76
t-lymphocytes - immunology (71) 71
t cells (67) 67
biochemistry & molecular biology (61) 61
molecular sequence data (59) 59
lymphocyte activation (58) 58
lymphocyte specific protein tyrosine kinase p56 - genetics (57) 57
protein-tyrosine kinases - metabolism (57) 57
receptors, antigen, t-cell - metabolism (54) 54
t-lymphocytes - metabolism (53) 53
cell biology (52) 52
amino acid sequence (49) 49
lymphocytes (48) 48
proteins (42) 42
lck protein (40) 40
cell line (39) 39
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chemical and pharmacologic phenomena (38) 38
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expression (36) 36
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multidisciplinary sciences (36) 36
cells, cultured (35) 35
hemic and immune systems (35) 35
signal-transduction (35) 35
antigen receptor (34) 34
kinases (33) 33
lymphocytes t (33) 33
p56 (33) 33
t cell receptors (33) 33
t-lymphocytes - enzymology (33) 33
protein-tyrosine kinase (32) 32
mice, inbred c57bl (31) 31
research (31) 31
t-cell receptor (31) 31
mice, transgenic (28) 28
female (27) 27
research article (26) 26
tyrosine - metabolism (26) 26
article (25) 25
gene expression (25) 25
protein binding (25) 25
antigens (24) 24
base sequence (24) 24
receptors, antigen, t-cell - immunology (24) 24
signal transduction - immunology (24) 24
tyrosine kinase (24) 24
protein-tyrosine kinases - physiology (22) 22
proto-oncogene proteins - metabolism (22) 22
tumor cells, cultured (22) 22
abridged index medicus (21) 21
apoptosis (21) 21
phosphoproteins - metabolism (21) 21
proto-oncogene proteins c-fyn (21) 21
mice, knockout (20) 20
mutation (20) 20
oncology (20) 20
src-family kinases - metabolism (20) 20
t lymphocytes (20) 20
transfection (20) 20
cd4-positive t-lymphocytes - immunology (19) 19
lymphocyte activation - immunology (19) 19
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physiological aspects (19) 19
protein-tyrosine kinases - genetics (19) 19
signaling (19) 19
tcr (19) 19
lymphocyte specific protein tyrosine kinase p56 - immunology (18) 18
protein tyrosine kinase (18) 18
t-cells (18) 18
transgenic mice (18) 18
zap-70 protein-tyrosine kinase (18) 18
blotting, western (17) 17
lipid rafts (17) 17
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science (17) 17
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t-lymphocytes - physiology (17) 17
adaptor proteins, signal transducing - metabolism (16) 16
enzyme activation (16) 16
p56lck (16) 16
analysis (15) 15
cancer (15) 15
receptors (15) 15
receptors, antigen, t-cell - genetics (15) 15
signal transduction - drug effects (15) 15
src homology domains (15) 15
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t-lymphocytes - drug effects (15) 15
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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 2017, Volume 24, Issue 12, pp. 1155 - 1163
Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 07/2016, Volume 185, Issue 1, pp. 107 - 118
Besides mobilizing stem cells into the periphery, granulocyte colony‐stimulating factor (G‐CSF) has been shown to influence various types of innate and... 
antigen‐specific T cells | G‐CSF | mobilization | T cell activation | immunotherapy | Mobilization | Antigen-specific T cells | G-CSF | Immunotherapy | antigen-specific T cells | STEM-CELLS | DENDRITIC CELLS | BONE-MARROW | IMMUNOLOGY | VERSUS-HOST-DISEASE | BLOOD MONONUCLEAR-CELLS | TRANSPLANTATION | CYTOKINE PRODUCTION | IN-VIVO | VIVO INDUCTION | Cell Communication - immunology | RNA, Messenger - immunology | Granzymes - antagonists & inhibitors | Antigen-Presenting Cells - cytology | Coculture Techniques | Humans | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - immunology | Granzymes - genetics | T-Lymphocytes, Regulatory - immunology | T-Lymphocytes, Cytotoxic - drug effects | CD3 Complex - genetics | CD28 Antigens - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Interferon-gamma - antagonists & inhibitors | T-Lymphocytes, Regulatory - cytology | Granzymes - immunology | Interferon-gamma - genetics | T-Lymphocytes, Cytotoxic - immunology | Mitogen-Activated Protein Kinase 3 - immunology | Mitogen-Activated Protein Kinase 1 - immunology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Antigen-Presenting Cells - drug effects | RNA, Messenger - genetics | Gene Expression Regulation | CD28 Antigens - immunology | MicroRNAs - immunology | Antigen-Presenting Cells - immunology | Granulocyte Colony-Stimulating Factor - pharmacology | T-Lymphocytes, Regulatory - drug effects | Lymphocyte Activation - drug effects | Interferon-gamma - immunology | CD3 Complex - immunology | Cell Communication - drug effects | Cell Line, Tumor | MicroRNAs - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | Primary Cell Culture | T-Lymphocytes, Cytotoxic - cytology | Tyrosine | Antigens | MicroRNA | Granulocyte colony-stimulating factor | Analysis | Stem cells | Interferon | Macrophage colony stimulating factor | Biological response modifiers | T cells | Cytotoxicity | T cell receptors | Granulocytes | Lymphocytes | Index Medicus | Original
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2011, Volume 121, Issue 12, pp. 4758 - 4774
Many autoimmune diseases exhibit familial aggregation, indicating that they have genetic determinants. Single nucleotide polymorphisms in PTPN2, which encodes... 
LCK ACTIVITY | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | TCR AFFINITY | POSITIVE SELECTION | THYMIC SELECTION | SRC-FAMILY KINASES | ANTIGEN RECEPTOR | LYMPHOCYTE-PROLIFERATION | NEGATIVE REGULATOR | DELETION | T-Lymphocyte Subsets - immunology | CD8-Positive T-Lymphocytes - cytology | Antibodies, Antinuclear - biosynthesis | Phosphorylation | CD8-Positive T-Lymphocytes - transplantation | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - physiology | Autoimmune Diseases - etiology | Inflammation - blood | Signal Transduction - immunology | Immune Tolerance - immunology | src-Family Kinases - metabolism | Receptors, Antigen, T-Cell - immunology | Autoimmune Diseases - enzymology | Lymphocyte Activation | Mice, Inbred C57BL | Autoimmune Diseases - immunology | ZAP-70 Protein-Tyrosine Kinase - physiology | Mice, Transgenic | Inflammation - immunology | Radiation Chimera | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - deficiency | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Mice, Knockout | Animals | T-Lymphocyte Subsets - enzymology | Inflammation - genetics | Mice | Protein Processing, Post-Translational | CD8-Positive T-Lymphocytes - immunology | Thymocytes - pathology | Tyrosine | Genetic aspects | Cellular signal transduction | Phosphatases | Properties | T cells | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article