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Biochemical journal, ISSN 1470-8728, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | drug discovery | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | inhibitor specificity | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | anti-cancer drugs | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | protein kinase | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | kinase profiling | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
The Journal of Immunology, ISSN 0022-1767, 02/2010, Volume 184, Issue 3, pp. 1436 - 1444
Mycolactone is a diffusible lipid toxin produced by Mycobacterium ulcerans, the causative agent of a necrotizing skin disease referred to as Buruli ulcer.... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Intracellular Fluid - immunology | T-Lymphocytes - enzymology | Humans | Bacterial Toxins - toxicity | Buruli Ulcer - enzymology | Mycobacterium ulcerans - immunology | Signal Transduction - immunology | Buruli Ulcer - immunology | Intracellular Fluid - drug effects | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Immunity, Cellular - drug effects | Protein Processing, Post-Translational - drug effects | Time Factors | T-Lymphocytes - drug effects | Protein Processing, Post-Translational - immunology | Immunosuppressive Agents - pharmacology | Immunity, Cellular - genetics | Jurkat Cells | Macrolides | Mice, Inbred C57BL | Cells, Cultured | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | Immunosuppressive Agents - toxicity | Intracellular Fluid - enzymology | Animals | Signal Transduction - drug effects | Bacterial Toxins - pharmacology | Lymphocyte Activation - drug effects | T-Lymphocytes - immunology | Mice | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - physiology | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) | Immunosuppressive Agents | Signal Transduction | T-Lymphocytes | Lymphocyte Activation | Life Sciences | Microbiology and Parasitology | Mycobacterium ulcerans | Bacterial Toxins | Protein Processing, Post-Translational | Buruli Ulcer | Intracellular Fluid | Immunity, Cellular
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 07/2008, Volume 118, Issue 7, pp. 2427 - 2437
Cancer is associated with immune deficiency, but the biologic basis of this is poorly defined. Here we demonstrate that impaired actin polymerization results... 
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Protein-Tyrosine Kinases - metabolism | Humans | Actins - metabolism | Lymphocyte Function-Associated Antigen-1 - metabolism | Thalidomide - pharmacology | Lymphocyte Culture Test, Mixed | CD4-Positive T-Lymphocytes - immunology | Thalidomide - analogs & derivatives | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | CD8-Positive T-Lymphocytes - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - blood | Antineoplastic Agents - pharmacology | Microfilament Proteins - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Interleukin-2 - metabolism | T-Lymphocytes, Cytotoxic - immunology | Receptors, Antigen, T-Cell - metabolism | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | Superantigens - immunology | Antigen Presentation - immunology | Mice, Inbred Strains | B-Lymphocytes - drug effects | Animals | B-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - drug effects | T-Lymphocytes - immunology | Antigen Presentation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | CD4-Positive T-Lymphocytes - drug effects | Immunologic Factors - pharmacology | Polymerization | Chronic lymphocytic leukemia | T cells | Muscle proteins | Tumors
Journal Article
Biochemical journal, ISSN 1470-8728, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B (also known as Akt), PKC, S6K p70 (ribosomal S6 kinase), RSK... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | phosphorylation | protein kinase C | kinase-specific inhibitor | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | mitogen-activated protein kinase (MAPK) | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Nature communications, ISSN 2041-1723, 04/2016, Volume 7, Issue 1, p. 11389
Aurora A is a serine/threonine kinase that contributes to the progression of mitosis by inducing microtubule nucleation... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cytoplasmic Vesicles - drug effects | Antigens, CD - immunology | Phosphorylation | Humans | Lectins, C-Type - immunology | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - immunology | Male | Aurora Kinase A - antagonists & inhibitors | Lectins, C-Type - genetics | T-Lymphocytes - ultrastructure | Antigens, CD - genetics | Cytoplasmic Vesicles - immunology | Signal Transduction - immunology | Aurora Kinase A - immunology | Lymphocyte Activation - genetics | CD3 Complex - genetics | Interleukin-2 - immunology | Interleukin-2 Receptor alpha Subunit - genetics | Microtubules - drug effects | T-Lymphocytes - drug effects | Microtubules - ultrastructure | Female | Receptors, Antigen, T-Cell - immunology | Aurora Kinase A - genetics | Interleukin-2 Receptor alpha Subunit - immunology | Antigens, Differentiation, T-Lymphocyte - immunology | Gene Expression Regulation | Microtubules - immunology | Mice, Transgenic | Immunological Synapses - genetics | Pyrimidines - pharmacology | Azepines - pharmacology | Interleukin-2 - genetics | Immunological Synapses - drug effects | Animals | Lymphocyte Activation - drug effects | Cytoplasmic Vesicles - ultrastructure | Antigens, Differentiation, T-Lymphocyte - genetics | CD3 Complex - immunology | T-Lymphocytes - immunology | Mice | Protein Kinase Inhibitors - pharmacology | Receptors, Antigen, T-Cell - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 06/2013, Volume 33, Issue 11, pp. 2188 - 2201
Journal Article
Cellular and molecular life sciences : CMLS, ISSN 1420-682X, 09/2012, Volume 70, Issue 4, pp. 743 - 759
Journal Article