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Diabetes, Obesity and Metabolism, ISSN 1462-8902, 12/2017, Volume 19, Issue 12, pp. 1762 - 1772
Aims To assess the safety, tolerability, pharmacokinetics and pharmacodynamics of PF‐05231023, a long‐acting fibroblast growth factor 21 (FGF21) analogue, in... 
fibroblast growth factor 21 | IGF‐1 | blood pressure | heart rate | type 2 diabetes | bone biomarkers | IGF-1 | FATTY LIVER-DISEASE | ENERGY-EXPENDITURE | PF-05231023 | PROFILE | PHARMACOKINETICS | ENDOCRINOLOGY & METABOLISM | MICE | FGF21 | Hypertriglyceridemia - drug therapy | Fibroblast Growth Factors - adverse effects | Follow-Up Studies | Obesity - drug therapy | Species Specificity | Humans | Middle Aged | Half-Life | Anti-Obesity Agents - adverse effects | Male | Obesity - blood | Anti-Obesity Agents - therapeutic use | Bone Remodeling - drug effects | Delayed-Action Preparations - administration & dosage | Dose-Response Relationship, Drug | Anti-Obesity Agents - pharmacokinetics | Antibodies, Monoclonal, Humanized - administration & dosage | Antibodies, Monoclonal, Humanized - pharmacokinetics | Fibroblast Growth Factors - administration & dosage | Hypertension - chemically induced | Delayed-Action Preparations - pharmacokinetics | Female | Drug Resistance | Fibroblast Growth Factors - therapeutic use | Body Mass Index | Severity of Illness Index | Antibodies, Monoclonal, Humanized - adverse effects | Hypolipidemic Agents - adverse effects | Anti-Obesity Agents - administration & dosage | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Drug Administration Schedule | Obesity - complications | Biomarkers - blood | Hypertension - physiopathology | Hypertriglyceridemia - blood | Animals | Fibroblast Growth Factors - pharmacokinetics | Delayed-Action Preparations - adverse effects | Hypertriglyceridemia - complications | Hypolipidemic Agents - administration & dosage | Delayed-Action Preparations - therapeutic use | Hypolipidemic Agents - therapeutic use | Infusions, Intravenous | Hypolipidemic Agents - pharmacokinetics | Type 2 diabetes | Obesity | Heart beat | Blood cholesterol | Collagen | Analysis | Body weight | Primates | Fibroblast growth factors | Blood pressure | Fibroblast growth factor | Pharmacodynamics | Diabetes mellitus | Homeostasis | Lipids | Triglycerides | Body weight loss | Bone turnover | Monkeys & apes | Cholesterol | Adiponectin | Heart rate | Rodents | Fibroblasts | Atorvastatin | Lead | Safety | Pharmacokinetics | Growth factors | Diabetes mellitus (non-insulin dependent) | Lipoproteins (high density)
Journal Article
Cancer Biotherapy and Radiopharmaceuticals, ISSN 1084-9785, 02/2014, Volume 29, Issue 1, pp. 12 - 17
Journal Article
Journal Article
Annals of Nutrition & Metabolism, ISSN 0250-6807, 10/2017, Volume 71, p. 925
Background and objectives: Cardiovascular disease is connected with inflammation and oxidative stress. Previous studies indicated administration of oxidized... 
Myocardial infarction | Oxidative stress | Organs | Rats | Cardiovascular disease | Food processing | Tumor necrosis factor-α | Gene expression | Coronary artery disease | Proteins | Antioxidants | Heart rate | Interleukin 6 | Mitochondria | Ultrastructure | Collagen | Biomarkers | Myocardium | Lead | Infarction | Blood pressure | Cardiovascular diseases | Angiotensin II | Heart diseases
Journal Article
Public Administration Review, ISSN 0033-3352, 9/2002, Volume 62, Issue 5, pp. 527 - 540
The evolution of the New Public Management movement has increased pressure on state bureaucracies to become more responsive to citizens as clients. Without a... 
Politicians | Social interaction | Public administration | Collaboration | Educational administration | Democracy | Citizenship | Government bureaucracy | Governance | Public sector | Lead Article | MANAGERIALISM | PUBLIC ADMINISTRATION | MANAGEMENT | GOVERNMENT | PRIVATE PARTNERSHIPS | Political participation | Models | Management | Government agencies | Management theory | Citizens | Bureaucracy
Journal Article
JAMA Dermatology, ISSN 2168-6068, 03/2018, Volume 154, Issue 3, pp. 273 - 280
IMPORTANCE: The US Food and Drug Administration approves Class III medical devices via the premarket approval pathway, often requiring clinical data on safety... 
INJECTION | ORTHOPEDIC DEVICES | LEADS | SOFT-TISSUE FILLERS | TECHNOLOGY | FDA PREMARKET APPROVAL | ADVERSE EVENTS | RECALLS | DERMATOLOGY | Online First | Original Investigation | Research
Journal Article
Journal Article
Environmental Toxicology and Pharmacology, ISSN 1382-6689, 2016, Volume 43, pp. 175 - 181
Highlights • Supplementation with α-tocopherol resulted in a decreased blood lead level. • Effects of supplementation with α-tocopherol on oxidative damage... 
Emergency | Antioxidants | Lipid peroxidation | Oxidative stress | Alfa-tocopherol | Lead poisoning | Glutathione - metabolism | Humans | Malondialdehyde - blood | Male | Antioxidants - pharmacology | Lead Poisoning - drug therapy | alpha-Tocopherol - pharmacology | Dietary Supplements | Occupational Exposure - statistics & numerical data
Journal Article
Journal Article