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Seminars in Cancer Biology, ISSN 1044-579X, 06/2018, Volume 50, pp. 77 - 89
The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are... 
TO-MESENCHYMAL TRANSITION | IN-VITRO | ACTIVATED PROTEIN-KINASE | STEM-LIKE CELLS | ONCOLOGY | DNA-DAMAGE RESPONSE | ESTROGEN-RECEPTOR-ALPHA | JUN NH2-TERMINAL KINASE | FOXO TRANSCRIPTION FACTORS | FORKHEAD BOX M1 | NEGATIVE BREAST-CANCER | DNA Repair - drug effects | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents - therapeutic use | Neoplasms - drug therapy | Cell Self Renewal - genetics | Forkhead Box Protein O3 - genetics | Drug Resistance, Neoplasm - genetics | Neoplasms - genetics | Forkhead Box Protein M1 - genetics | Cell Proliferation - drug effects | Neoplasms - pathology | Drug Resistance, Neoplasm - drug effects | AURKA, aurora kinase A | Fox, forkhead box | Bim, B-cell lymphoma 2 interacting mediator | EGF, epidermal growth factor | JNK | BRIP1, BRCA1-interacting protein-terminal helicase 1 | GICs, glioma-initiating cells | MCL, mantle cell lymphoma | PKB, protein kinase B | SCs, stem cells | LEF, T-cell factor | Skp2, S-phase kinase-associated protein 2 | SSBs, single-strand breaks | mTOR, mammalian target of rapamycin | NBS1, Nijmegen breakage syndrome 1 | stress activated protein kinase | MEK, mitogen-activated protein kinase kinase | PIP3, phosphatidylinositol- 3,4,5-trisphosphate | BER, base excision repair | lymphoid enhancer factor | VEGF, vascular endothelial growth factor | AML, acute myeloid leukaemia | ER+ve, estreogen receptor positive | EXO1, exonuclease 1 | EGFR, epidermal growth factor receptor | MDR1, multidrug resistance protein 1 | ChIP-seq, chromatin immunoprecipitation with massively parallel DNA sequencing | ABCB1, ATP-binding cassette sub-family B member 1 | TCF | SOD-2, superoxide dismutase | TKIs, tyrosine kinase inhibitors | PDK, phosphoinositide-dependent kinase | IFNɣ, interferon-ɣ | BRCA2, breast cancer-associated gene 2 | DDR, DNA damage response | Cks1, cyclin-dependent kinases regulatory subunit 1 | ESR1, estrogen receptor alpha gene | NHEJ, non-homologous end joining | XRCC1, X-ray cross-complementing group 1 | OTUB1, OUT domain-containing ubiquitin aldehyde-binding protein 1 | IGF, insulin growth factor | TRAIL, tumour necrosis factor-related apoptosis inducing ligand | ER, estrogen receptor | MRN, MER11-RAD50-NBS1 | BRCA1, breast cancer susceptibility gene product 1 | FasL, fas ligand | RTKs, receptor tyrosine kinases | Sox1, sex determining region Y box 2 | GADD45, DNA damage-inducible protein 45 | MMR, mismatch repair | PI3K, phosphatidylinositol 3-kinase | ROS, reactive oxygen species | NAMPT, nicotinamide-phosphribosyltransferase | miRs, Micro-RNAs | FHRE, forkhead response element | ATM, Ataxia-telangiectasia mutated | NER, nucleotide excision repair | ERK, extracellular signal-regulated kinase | HR, homologous recombination | AMPK, adenosine monophosphate-activated protein kinase | DSBs, double strands breaks | PA, Psammaplysene A | CML, chronic myeloid leukaemia | HCC, hepatocellular carcinoma | Mst1, macrophage stimulating 1 | Rb2, retinoblastoma-related p130 | SAPK, c-Jun N-terminal kinase | CSCs, cancer stem cells
Journal Article
Neuropharmacology, ISSN 0028-3908, 03/2012, Volume 62, Issue 3, pp. 1230 - 1241
In the decade since Disrupted in Schizophrenia 1 (DISC1) was first identified it has become one of the most convincing risk genes for major mental illness. As... 
Schizophrenia | Neurodevelopment | Association studies | Synapse | DISC1 | Signalling | NEURONAL MIGRATION | ASSOCIATION ANALYSIS | CANDIDATE GENES | AMYLOID PRECURSOR PROTEIN | BIPOLAR DISORDER | NEUROSCIENCES | PERICENTRIN PCNT GENE | PHARMACOLOGY & PHARMACY | MAJOR DEPRESSIVE DISORDER | CENTROSOMAL PROTEINS | TRANSCRIPTION FACTOR | GRAY-MATTER | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Schizophrenia - metabolism | Animals | Carrier Proteins - metabolism | Schizophrenia - genetics | Signal Transduction | Humans | Nerve Tissue Proteins - genetics | Neurogenesis | Enzymes | Synthesis | Glycogen | Genes | Medical genetics | Amyloid beta-protein | Chemical properties | DNA binding proteins | Glutamate | T cells | Protein binding | PI3 K, Phosphatidylinositiol 3-kinase | DISC1, Disrupted in schizophrenia 1 | CRE, cAMP response element | LIS1, Lissencephaly 1 | APP, Amyloid precursor protein | PACAP, Pituitary adenylate cyclase-activating polypeptide | TCF, Lymphoid enhancer factor | T cell factor | CNV, Copy number variation | PDE4, Phosphodiesterase 4 | PCNT, Pericentrin | DBZ, DISC1-binding zinc finger | FEZ1, Fasciculation and elongation protein zeta 1 | BACE1, β-site APP-cleaving enzyme-1 | Rac1, Ras-related C3 botulinum toxin substrate 1 | NDEL1, NDE-like 1 | PCM1, Pericentriolar material 1 | GSK3β, Glycogen synthase kinase 3β | BBS4, Bardet–Biedl syndrome 4 | LEF | Dixdc1, Dishevelled-axin domain containing-1 | NRG, Neuregulin | CEP290, Centrosomal protein 290 kDa | TNIK, Traf2 and Nck interacting kinase | NDE1, Nuclear distribution factor E homologue 1 or Nuclear distribution element 1 | PSD, Post-synaptic density | GluR, Glutamate receptor | mTOR, Mammalian target of rapamycin | ATF4, Activating transcription factor 4 | Kal7, Kalirin-7
Journal Article
Journal Article
by Sui, H and Zhao, JH and Zhou, LH and Wen, HT and Deng, WL and Li, CP and Ji, Q and Liu, X and Feng, YY and Chai, N and Zhang, QB and Cai, JF and Li, Q
CANCER LETTERS, ISSN 0304-3835, 09/2017, Volume 403, pp. 86 - 97
In a previous study, we demonstrated that Tanshinone IIA effectively inhibits CRC angiogenesis in vivo, but the underlying mechanisms were not elucidated. In... 
Tanshinone IIA | CELLS | beta-catenin/TCF/LEF signaling pathway | HIF-1 alpha | METASTASIS | Colorectal cancer | PANCREATIC-CANCER | DOWN-REGULATION | TUMOR ANGIOGENESIS | CHEMOTHERAPY | EPITHELIAL-MESENCHYMAL TRANSITION | Angiogenesis | TGF-beta | ONCOLOGY | SIGNALING PATHWAY | Hypoxia | ACCUMULATION | EXPRESSION
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 04/2020, Volume 235, Issue 4, pp. 3894 - 3904
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2011, Volume 50, Issue 6, pp. 928 - 938
Abstract Angiotensin-II (Ang-II) plays a key role in myocardial hypertrophy, remodeling and failure. We investigated whether Ang-II-induced cardiomyocyte... 
Cardiovascular | Cell growth | CREB | TCF/LEF | RAAS | CCN family | WISP1 | Hypertrophy | NADPH OXIDASE | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | KAPPA-B | KNOCKOUT MICE | BLOOD-PRESSURE | CELL BIOLOGY | SIGNALING PATHWAY | CARDIAC-HYPERTROPHY | GENE-EXPRESSION | SMOOTH-MUSCLE-CELLS | NADPH Oxidases - metabolism | Glycogen Synthase Kinase 3 beta | Male | Intracellular Signaling Peptides and Proteins - metabolism | RNA, Messenger - metabolism | TCF Transcription Factors - metabolism | CCN Intercellular Signaling Proteins | Superoxides - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Proto-Oncogene Proteins - metabolism | Vasoconstrictor Agents - pharmacology | Angiotensin II - pharmacology | Angiotensin II - metabolism | Rats | Proto-Oncogene Proteins - genetics | Glycogen Synthase Kinase 3 - metabolism | Rats, Sprague-Dawley | beta Catenin - metabolism | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Cardiomyopathy, Hypertrophic - physiopathology | Vasoconstrictor Agents - metabolism | Receptor, Angiotensin, Type 1 - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Protein Binding - physiology | Oxidases | Superoxide
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 03/2017, Volume 232, Issue 3, pp. 517 - 525
Identification of cellular proteins, in addition to already known transcription factors such as NF‐κB, Sp1, C‐EBPβ, NFAT, ATF/CREB, and LEF‐1, which interact... 
CD4+T CELLS | PHYSIOLOGY | LONG TERMINAL REPEAT | PROTEIN-KINASE | PYRUVATE-KINASE M2 | VIRION PRODUCTION | HUMAN-IMMUNODEFICIENCY-VIRUS | NF-KAPPA-B | T-CELLS | NUCLEAR TRANSLOCATION | GENE-TRANSCRIPTION | CELL BIOLOGY | Sequence Deletion | Tetradecanoylphorbol Acetate - pharmacology | Humans | Monocytes - metabolism | Protein Transport - drug effects | Protein Subunits - metabolism | Cell Nucleus - metabolism | U937 Cells | Protein Binding - drug effects | Membrane Proteins - metabolism | Binding Sites | Promoter Regions, Genetic | Virus Replication - drug effects | HIV-1 - drug effects | HIV Long Terminal Repeat - genetics | HIV-1 - genetics | Monocytes - drug effects | Macrophages - metabolism | Carrier Proteins - metabolism | Transcription Factor RelA - metabolism | Models, Biological | Thyroid Hormones - metabolism | Macrophages - drug effects | Cell Nucleus - drug effects | Protein Multimerization - drug effects | Physiological aspects | Cellular proteins | HIV (Viruses) | Analysis | NF-κB protein | Chromatin | Transcription factors | Immunoprecipitation | Pyruvate kinase | Pyruvic acid | Activation | Infections | CCAAT/enhancer-binding protein | Cyclic AMP response element-binding protein | NF-AT protein | Kinases | Macrophages | Sp1 protein | Latency | Proteins | Lysates | LEF protein | Monocytes | Clonal deletion | Human immunodeficiency virus--HIV | Binding sites
Journal Article
Journal of Cutaneous Pathology, ISSN 0303-6987, 05/2018, Volume 45, Issue 5, pp. 318 - 324
Background The Wnt signaling pathway has been implicated in the pathogenesis of pilomatrical tumors. Lymphoid enhancer‐binding factor 1 (LEF‐1) is a downstream... 
pilomatricoma | CDX2 | LEF‐1 | pilomatrical carcinoma | LEF-1 | NEOPLASMS | LESSONS | PATHOLOGY | BETA-CATENIN | CANCER | HAIR KERATINS | DERMATOLOGY | SKIN | DIFFERENTIATION | MUTATIONS | Carcinoma | Diagnosis | Cancer | Protein binding | Immunohistochemistry | Transcription factors | Wnt protein | Amino acid sequence | CDX2 protein | Cadherin | Ca2+-transporting ATPase | Homeobox | LEF protein | Signal transduction | Tumorigenesis | Catenin
Journal Article
FEBS Letters, ISSN 0014-5793, 2005, Volume 579, Issue 21, pp. 4837 - 4842
Our previous study indicated that interleukin (IL)-1β induces expression of several Wnt proteins in chondrocytes and causes chondrocyte dedifferentiation via... 
β-Catenin | Chondrocyte | Chondrogenesis | Dedifferentiation | Wnt-3a | c-Jun N-terminal kinase | PNA | peanut agglutinin | activator protein-1 | JNK | T cell-factor/lymphoid-enhancer-factor | IL-1β | AP-1 | Dulbecco's modified Eagle's medium | interleukin-1β | DMEM | reverse transcription-polymerase chain reaction | RT-PCR | Tcf/Lef | GAPDH | glyceraldehyde 3-phosphate dehydrogenase | beta-catenin | RHEUMATOID-ARTHRITIS | APOPTOSIS | PROTEIN-KINASE-C | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHENOTYPE | dedifferentiation | MECHANISMS | CELL BIOLOGY | LIMB | chondrocyte | BIOPHYSICS | GENE-EXPRESSION | ARTICULAR CHONDROCYTES | chondrogenesis | Chondrocytes - cytology | JNK Mitogen-Activated Protein Kinases - metabolism | Wnt Proteins | Mesoderm - cytology | Transcription Factor AP-1 - metabolism | Collagen Type II - metabolism | DNA-Binding Proteins - metabolism | Lymphoid Enhancer-Binding Factor 1 | Chondrocytes - physiology | Cytoskeletal Proteins - metabolism | Cell Differentiation - physiology | Rabbits | beta Catenin | Cells, Cultured | Chick Embryo | Transcription Factors - metabolism | Chondrogenesis - physiology | Culture Media, Conditioned | Animals | Proteins - metabolism | Cell Adhesion - physiology | Proto-Oncogene Proteins c-jun - metabolism | Signal Transduction - physiology | Trans-Activators - metabolism | Wnt3 Protein | Mice | Enzyme Activation | Wnt3A Protein | Agglutinins | Collagen | Sugars | Stem cells | Monosaccharides
Journal Article