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by Liang, R and Liu, Y
STEM CELL RESEARCH & THERAPY, ISSN 1757-6512, 10/2018, Volume 9, Issue 1, pp. 267 - 7
The T-cell factor/lymphoid enhancer factor (TCF/LEF) family protein Tcf7l1 is highly abundant in embryonic stem cells (ESCs), regulating pluripotency and... 
MEDICINE, RESEARCH & EXPERIMENTAL | STIMULATION | T-cell factor | lymphoid enhancer factor | SELF-RENEWAL | PLURIPOTENCY | SPECIFICATION | BETA-CATENIN | Cardiac myocytes | CELL BIOLOGY | XENOPUS | WNT/BETA-CATENIN | TCF3 REPRESSION | Tcf3 | Wnt | CARDIOGENESIS | Catenin | TRANSCRIPTION FACTOR | Embryonic Stem Cells - metabolism | MEF2 Transcription Factors - genetics | Embryonic Stem Cells - cytology | Lentivirus - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Time Factors | Lentivirus - genetics | Cell Differentiation | Germ Layers - cytology | Cell Lineage - genetics | Transcription Factor 7-Like 1 Protein - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | GATA4 Transcription Factor - metabolism | Genetic Vectors - chemistry | Myocytes, Cardiac - cytology | Germ Layers - metabolism | Transcription Factor 7-Like 1 Protein - deficiency | Gene Expression Regulation | Genetic Vectors - metabolism | GATA4 Transcription Factor - genetics | Mice, Knockout | Animals | Organogenesis - genetics | MEF2 Transcription Factors - metabolism | Myocytes, Cardiac - metabolism | Mice | Cellular signal transduction | Research | Embryonic stem cells | Cell differentiation | T cells | Heart cells | Heart | Cardiovascular system | Transcription factors | Embryo cells | Stem cell transplantation | Mesoderm | Cardiomyocytes | Lymphocytes T | Tcf protein | Mammals | Gene expression | Kinases | Embryos | Defects | Proteins | β-catenin | LEF protein | Stem cells | Cell cycle | Ligands | Pluripotency | VP16 protein | β-Catenin | T-cell factor/lymphoid enhancer factor
Journal Article
International journal of medical sciences, ISSN 1449-1907, 2018, Volume 15, Issue 12, pp. 1415 - 1422
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, p. e101748
In the present study we explored the role of beta-catenin in mediating chick retina regeneration. The chick can regenerate its retina by activating... 
TADPOLE TAIL REGENERATION | OPTIC CUP | MUSCLE REGENERATION | SIGNALING PATHWAYS | CILIARY MARGINAL ZONE | WNT/BETA-CATENIN | PIGMENT EPITHELIUM | MULTIDISCIPLINARY SCIENCES | CELL PROLIFERATION | VERTEBRATE RETINA | ZEBRAFISH RETINA | Retina - drug effects | Cell Proliferation | Heterocyclic Compounds, 3-Ring - pharmacology | Lymphoid Enhancer-Binding Factor 1 - genetics | Fibroblast Growth Factor 2 - pharmacology | Retina - embryology | SOXB1 Transcription Factors - metabolism | TCF Transcription Factors - metabolism | Cell Nucleus - metabolism | Retina - cytology | SOXB1 Transcription Factors - genetics | Retinal Pigment Epithelium - physiology | Transcription, Genetic | Cell Differentiation | Gene Expression | Gene Expression Regulation, Developmental - drug effects | Chick Embryo | Lymphoid Enhancer-Binding Factor 1 - metabolism | beta Catenin - metabolism | beta Catenin - genetics | Protein Transport | Retina - physiology | Regeneration | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Retinal Pigment Epithelium - embryology | TCF Transcription Factors - genetics | Fibroblast growth factor 2 | Immunohistochemistry | Fibroblast growth factor | Phosphorylation | Deactivation | Retina | Biology | Kinases | Inactivation | Epithelium | Progenitor cells | Retinal pigment epithelium | Cell adhesion & migration | Proteins | LEF protein | β-catenin | Signaling | Cell growth | Injury prevention | Eye injuries | Stem cells | Cells (biology) | Cell cycle
Journal Article
Molecules, ISSN 1420-3049, 09/2017, Volume 22, Issue 9, p. 1505
Hair loss (alopecia) is a universal problem for numerous people in the world. The present study was conducted to investigate the effects of red ginseng oil... 
Sitosterol | Androgenic alopecia | Shh/Gli pathway | Wnt/β-catenin pathway | Hair re-growth | Red ginseng oil | Linoleic acid | androgenic alopecia | MOLECULAR MECHANISMS | TOPICAL APPLICATION | sitosterol | Wnt/beta-catenin pathway | linoleic acid | CHEMISTRY, ORGANIC | hair re-growth | red ginseng oil | DERMAL PAPILLA CELLS | FOLLICLE MORPHOGENESIS | ANDROGENETIC ALOPECIA | WNT/BETA-CATENIN | SIGNALING PATHWAY | MOUSE MODEL | IN-VIVO | SONIC-HEDGEHOG | Zinc Finger Protein GLI1 - metabolism | Proto-Oncogene Proteins c-bcl-2 - agonists | Lymphoid Enhancer-Binding Factor 1 - genetics | Sitosterols - pharmacology | Cyclins - genetics | Hedgehog Proteins - metabolism | Male | Smoothened Receptor - metabolism | Smoothened Receptor - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Alopecia - genetics | Cyclins - metabolism | Hedgehog Proteins - genetics | Regeneration - genetics | Transforming Growth Factor beta - antagonists & inhibitors | Linoleic Acid - pharmacology | Disease Models, Animal | Plant Oils - pharmacology | Zinc Finger Protein GLI1 - genetics | Mice, Inbred C57BL | Gene Expression Regulation | Plant Oils - isolation & purification | Lymphoid Enhancer-Binding Factor 1 - metabolism | beta Catenin - metabolism | beta Catenin - genetics | Alopecia - pathology | Hair Follicle - drug effects | Regeneration - drug effects | Testosterone - administration & dosage | Animals | Transforming Growth Factor beta - genetics | Panax - chemistry | Alopecia - drug therapy | Hair Follicle - metabolism | Hair Follicle - growth & development | Alopecia - chemically induced | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Transforming Growth Factor beta - metabolism | Hair | Wnt protein | Baldness | Bcl-2 protein | Gene expression | Cyclin D1 | Delay | Testosterone | β-catenin | LEF protein | Alopecia | Hedgehog protein | Rodents | Cyclin E | Topical application | Ginseng | Apoptosis
Journal Article
Oncogene, ISSN 0950-9232, 02/2011, Volume 30, Issue 8, pp. 944 - 955
An elevated DNA-repair capacity in cancer cells leads to radiation resistance and severely limits the efficacy of radiation therapy. Activation of Akt is... 
DSB repair | Mre11 | Akt | ionizing radiation | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | STRAND-BREAK REPAIR | HISTONE H2AX | CERVICAL-CANCER | TUMOR-CELLS | KINASE-B | CELL BIOLOGY | COLON-CANCER | INHIBITION | ONCOLOGY | SIGNALING PATHWAY | GENETICS & HEREDITY | DNA-REPAIR | Neoplasms - metabolism | Oligonucleotide Array Sequence Analysis | Humans | Lymphoid Enhancer-Binding Factor 1 - genetics | Glycogen Synthase Kinase 3 beta | DNA Repair - genetics | DNA Breaks, Double-Stranded - radiation effects | Gene Knockdown Techniques | MRE11 Homologue Protein | Transfection | Neoplasms - genetics | Proto-Oncogene Proteins c-akt - metabolism | Gene Expression Regulation, Neoplastic - physiology | Radiation, Ionizing | Gene Expression | Radiation Tolerance - genetics | Glycogen Synthase Kinase 3 - metabolism | Lymphoid Enhancer-Binding Factor 1 - metabolism | beta Catenin - metabolism | beta Catenin - genetics | Glycogen Synthase Kinase 3 - genetics | Signal Transduction - physiology | Gene Expression Regulation, Neoplastic - radiation effects | HeLa Cells | DNA-Binding Proteins - biosynthesis | Enzyme Activation - physiology | Control | Cancer cells | Physiological aspects | Genetic aspects | Research | DNA binding proteins | Radiotherapy | Health aspects | Proteins | Signal transduction | DNA damage | Radiation therapy | Gene expression | DNA repair | Cancer | Chromatin | Immunoprecipitation | Transcription | catenin | AKT protein | siRNA | Double-strand break repair | Promoters | LEF protein | Ionizing radiation | MRE11 protein | Plasmids
Journal Article
PloS one, ISSN 1932-6203, 2009, Volume 4, Issue 12, p. e8294
Background: Aberrant activation of Wnt/beta-catenin signaling promotes the development of several cancers. It has been demonstrated that the Wnt signaling... 
MULTIPLE-MYELOMA | COLON-CANCER | APOPTOSIS | WNT PROTEINS | SIGNALING PATHWAY | CYCLIN D1 | MULTIDISCIPLINARY SCIENCES | BETA-CATENIN | NF-KAPPA-B | EXPRESSION | LEF-1 | Cell Survival - drug effects | Cyclin D1 - metabolism | Ethacrynic Acid - toxicity | Receptors, G-Protein-Coupled - metabolism | Humans | Lymphoid Enhancer-Binding Factor 1 - genetics | Frizzled Receptors - metabolism | Gene Expression Regulation, Leukemic - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Wnt Proteins - metabolism | Lymphoid Enhancer-Binding Factor 1 - metabolism | beta Catenin - metabolism | Fibronectins - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Frizzled Receptors - genetics | Cyclin D1 - genetics | Signal Transduction - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Protein Binding - drug effects | Acetylcysteine - pharmacology | Cell Line, Tumor | Fibronectins - genetics | Receptors, G-Protein-Coupled - genetics | Drug Screening Assays, Antitumor | Drugs | Wnt protein | Toxicity | Leukemia | Oxidizing agents | Multiple myeloma | Acetylcysteine | Cytotoxicity | Activation | Malignancy | Kinases | Assaying | Cyclin D1 | Drug resistance | Ethacrynic acid | Fibronectin | Immunosuppressive agents | Proteins | Antioxidants | β-catenin | Signal transduction | Oxidants | Lymphocytes | Inhibition | Library collections | Chronic lymphatic leukemia | Medical treatment | Lymphatic leukemia | Bioavailability | Gene expression | LEF protein | Signaling | Acids | Plasmids | Cell death | LEF-1 protein | N-Acetyl-L-cysteine | Lymphomas | Aberration | Viability | Apoptosis | Cancer
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 10/1999, Volume 56, Issue 5, pp. 523 - 537
β-Catenin plays a structural role in cell adhesion by binding to cadherins at the intracellular surface of the plasma membrane and a signaling role in the... 
glycogen synthase kinase 3 (GSK3) | integrin-linked kinase (ILK) | dishevelled (dsh) | β-Catenin | adenomatous polyposis coli (APC) | cadherin | lymphoid enhancer factor/T cell factor (Lef/Tcf) | wnt | Lymphoid enhancer factor/T cell factor (Lef/Tcf) | Adenomatous polyposis coli (APC) | Integrin-linked kinase (ILK) | Dishevelled (dsh) | Glycogen synthase kinase 3 (GSK3) | Cadherin | beta-catenin | INTEGRIN-LINKED KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOGEN-SYNTHASE KINASE-3 | ANIMAL-VEGETAL AXIS | TRANSCRIPTION FACTOR LEF-1 | SEA-URCHIN EMBRYO | CELL BIOLOGY | CARCINOMA-ASSOCIATED ANTIGEN | C-ELEGANS EMBRYOS | BIOLOGY | XENOPUS EMBRYOS | TUMOR-SUPPRESSOR PROTEIN | TCR-ALPHA ENHANCER | Neoplasms - metabolism | Phosphoprotein Phosphatases - metabolism | Repressor Proteins | Glycogen Synthase Kinase 3 | Wnt Proteins | Adenomatous Polyposis Coli Protein | Promoter Regions, Genetic - genetics | Alzheimer Disease - pathology | DNA-Binding Proteins - metabolism | Glycogen Synthase Kinases | Lymphoid Enhancer-Binding Factor 1 | Cytoskeletal Proteins - metabolism | Phosphoproteins - physiology | Dishevelled Proteins | Insect Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Frizzled Receptors | Drosophila Proteins | Proteins - physiology | Signal Transduction | beta Catenin | Trans-Activators | Cell Cycle Proteins - metabolism | Zebrafish Proteins | Transcription Factors - metabolism | Ubiquitin-Protein Ligases | Adaptor Proteins, Signal Transducing | Animals | Proteins - metabolism | Models, Biological | Alzheimer Disease - metabolism | Axin Protein | Proto-Oncogene Proteins - physiology | Neoplasms - pathology | Calcium-Calmodulin-Dependent Protein Kinases - metabolism
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 08/2018, Volume 37, Issue 15, p. n/a
Glioblastoma is the most common and aggressive brain tumor, with a subpopulation of stem‐like cells thought to mediate its recurring behavior and therapeutic... 
cancer stem‐like cells | Zeb1 | glioblastoma multiforme | Wnt signaling | transcription | cancer stem-like cells | RAC-GEF | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | NEURAL STEM | PROLIFERATION | E-CADHERIN | FEEDBACK LOOP | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | REGULATORY CIRCUIT | BRAIN | Guanine Nucleotide Exchange Factors - genetics | Transcriptional Activation - genetics | Humans | Lymphoid Enhancer-Binding Factor 1 - genetics | DNA-Binding Proteins - genetics | Epithelial-Mesenchymal Transition - genetics | Zinc Finger E-box-Binding Homeobox 1 - genetics | Cell Movement - genetics | Zinc Finger E-box-Binding Homeobox 1 - metabolism | Glioblastoma - genetics | Wnt Signaling Pathway - genetics | Guanine Nucleotide Exchange Factors - metabolism | Glioblastoma - pathology | Transcription, Genetic - genetics | Neoplasm Invasiveness - genetics | Glioblastoma - mortality | Brain | Regulators | Chromatin | Transcription factors | Wnt protein | Mesenchyme | Brain tumors | Genes | Glioblastoma | Activation | Genomes | Regulatory sequences | Guanine | Recruitment | Repressors | Guanine nucleotide exchange factor | Deoxyribonucleic acid--DNA | Binding | Cell survival | Lef1 gene | Invasiveness | Gene expression | LEF protein | Gene silencing | Signaling | Stem cells | Regulatory mechanisms (biology) | Glioblastoma cells | Gene mapping | Cell migration | Tumors | Signal Transduction | Cancer
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2011, Volume 437, Issue 1, pp. 1 - 12
Wnt signalling pathways have been shown to play key roles in both normal development and tumorigenesis. Progression of many human cancers is associated with... 
β-catenin | T-cell factor/lipoprotein receptor-related (Tcf/Lef) | Endothelin | Integrin | Lysophosphatidic acid | Microenvironment | Wnt | Ovarian cancer | beta-catenin | BETA-CATENIN GENE | CARCINOMA-CELLS | INTEGRIN-LINKED KINASE | ovarian cancer | CYCLIN D1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PAPILLARY THYROID-CANCER | microenvironment | endothelin | COLON-CANCER CELLS | lysophosphatidic acid | integrin | MATRIX-METALLOPROTEINASE ACTIVITY | ENDOMETRIOID-ADENOCARCINOMAS | ENDOTHELIAL GROWTH-FACTOR | Ovarian Neoplasms - genetics | Wnt Proteins - genetics | Signal Transduction | Models, Biological | Humans | Ovarian Neoplasms - pathology | Female | Ovarian Neoplasms - metabolism | Tumor Microenvironment - physiology | Wnt Proteins - metabolism | beta Catenin - metabolism | EGFR, EGF receptor | COX2,cyclo-oxygenase 2 | LPAR, LPA receptor | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | SFRP, secreted Fzd-related protein | T-cell factor | ETAR, ET type A receptor | Review | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | Dvl, Dishevelled 1 | GPCR, G-protein-coupled receptor | VEGFR, vascular EGFR | APC, adenomatous polyposis coli | TGF, transforming growth factor | E-cadherin, epithelial cadherin | WIF-1, Wnt-inhibitory factor 1 | CTGF, connective tissue growth factor | FRAT1, frequently rearranged in advanced T-cell lymphomas 1 | IGF-1, insulin-like growth factor-1 | ETBR, ET type B receptor | LRP, lipoprotein receptor-related protein | ILK, integrin-linked kinase | NF-κB, nuclear factor κB | Fzd, Frizzled | Lef, lymphoid enhancer factor | VEGF, vascular endothelial growth factor | Dkk, Dickkopf | GSK3β, glycogen synthase kinase 3β | Lef | LPA, lysophosphatidic acid | MCA, multi-cellular aggregate | Tcf, T-cell factor | EOC, epithelial ovarian carcinoma | IDAX, inhibitor of the Dvl and Axin complex | IL, interleukin | lipoprotein receptor-related (Tcf | ET, endothelin | MMP, matrix metalloproteinase
Journal Article