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Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2016, Volume 60, Issue 4, pp. 2532 - 2536
...), the most active of these compounds, showed in vitro inhibition in the single-unit nanomolar range, similar to the activity in the reference drug pentamidine, and presented low toxicity and adequate metabolic stability... 
LEISHMANIA-INFANTUM | CELLS | DNA-BINDING | NIMESULIDE | ASSAY | POLYAMINES | HUMAN AFRICAN TRYPANOSOMIASIS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | CYTOTOXICITY | Trypanosomiasis, African - drug therapy | Mitochondria, Liver - metabolism | Humans | Microsomes, Liver - metabolism | Neurons - cytology | Structure-Activity Relationship | Hepatocytes - metabolism | Hepatocytes - cytology | Naphthalimides - chemical synthesis | Liver - drug effects | Microsomes, Liver - drug effects | Trypanosomiasis, African - mortality | Inhibitory Concentration 50 | Female | Trypanosomiasis, African - pathology | Neurons - metabolism | Neurons - drug effects | Trypanosoma brucei brucei - growth & development | Hepatocytes - drug effects | Pentamidine - pharmacology | Cell Line | Trypanosoma brucei brucei - metabolism | Drug Stability | Liver - metabolism | Parasite Load | Macrophages - cytology | Trypanosoma brucei brucei - drug effects | Mitochondria, Liver - drug effects | Trypanosomiasis, African - parasitology | Macrophages - metabolism | Animals | Naphthalimides - pharmacology | Trypanocidal Agents - pharmacology | Survival Analysis | Trypanocidal Agents - chemical synthesis | Macrophages - drug effects | Mice | Mice, Inbred BALB C | Primary Cell Culture | Index Medicus
Journal Article
Experimental Parasitology, ISSN 0014-4894, 01/2014, Volume 136, Issue 1, pp. 20 - 26
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e20786
Photodynamic therapy, unlikely to elicit drug-resistance, deserves attention as a strategy to counter this outstanding problem common to the chemotherapy of all diseases... 
MHC CLASS-I | CUTANEOUS LEISHMANIASIS | IMMUNOGENICITY | THERAPY | UROPORPHYRIA | DENDRITIC CELLS | CLINICAL-TRIAL | EFFICACY | LEISH-F1+MPL-SE VACCINE | MULTIDISCIPLINARY SCIENCES | SINGLET OXYGEN | Endocytosis - radiation effects | Ovalbumin - immunology | Photochemotherapy - methods | Dendritic Cells - immunology | CD8-Positive T-Lymphocytes - parasitology | Phagosomes - radiation effects | Substrate Specificity | Dendritic Cells - radiation effects | Macrophages - parasitology | CD8-Positive T-Lymphocytes - radiation effects | Leishmania - parasitology | Indoles - metabolism | Light | Leishmania - drug effects | Mitochondria - radiation effects | Dendritic Cells - drug effects | Indoles - pharmacology | Host-Parasite Interactions | Macrophages - radiation effects | Intracellular Space - radiation effects | Macrophages - immunology | Phagosomes - drug effects | Cell Line | Dendritic Cells - parasitology | Intracellular Space - drug effects | Antigen Presentation - radiation effects | Endocytosis - drug effects | Phagosomes - metabolism | Solubility | HLA Antigens - immunology | Mitochondria - metabolism | Mitochondria - drug effects | Drug Discovery | Phagosomes - parasitology | Photolysis - radiation effects | Photolysis - drug effects | Animals | CD8-Positive T-Lymphocytes - drug effects | Intracellular Space - metabolism | Indoles - therapeutic use | Macrophages - drug effects | Antigen Presentation - drug effects | Leishmania - physiology | Mice | CD8-Positive T-Lymphocytes - immunology | Indoles - chemistry | Photolysis | Dendritic cells | Vaccination | Genetic engineering | Drug resistance | T cells | Photochemotherapy | Cancer | Porphyrins | Phagolysosomes | CD8 antigen | Transgenic | Biosynthesis | Lymphocytes T | Parasites | Macrophages | Inactivation | Immunity | Accumulation | Immunity (cell-mediated) | Homing | Mitochondria | Immunology | Lymphocytes | Parasitic diseases | Infectivity | Protozoa | Ovalbumin | Antigens | Photodynamic therapy | Deactivation | Host specificity | Mutants | Medicine | Chemistry | Chemotherapy | Major histocompatibility complex | Antigen-presenting cells | Lysis | Intracellular | Cell migration
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, p. e0174024
Antimicrobial peptides (AMPs) are promising drugs to kill resistant pathogens. In contrast to bacteria, protozoan parasites, such as Leishmania, were little studied... 
HOST-DEFENSE PEPTIDES | MODEL MEMBRANE SYSTEMS | HELICAL ANTIMICROBIAL PEPTIDES | HEMOLYTIC-ACTIVITY | DERMASEPTIN B2 | MULTIDISCIPLINARY SCIENCES | AMPHIBIAN SKIN | DIFFERENTIAL SCANNING CALORIMETRY | FROG-SKIN | DRUG-RESISTANCE | LEISHMANIA-DONOVANI | Apoptosis - drug effects | Humans | Bacteria - drug effects | Drug Resistance, Bacterial | Unilamellar Liposomes - chemistry | Membrane Potential, Mitochondrial - drug effects | Antimicrobial Cationic Peptides - pharmacokinetics | Dose-Response Relationship, Drug | Antiprotozoal Agents - pharmacokinetics | Time Factors | Anti-Bacterial Agents - chemistry | DNA, Protozoan - drug effects | Leishmania - drug effects | Ampicillin - pharmacology | Anti-Bacterial Agents - toxicity | DNA Fragmentation - drug effects | Drug Evaluation, Preclinical | Antiprotozoal Agents - toxicity | Membrane Potentials - drug effects | Cell Line | Antimicrobial Cationic Peptides - chemistry | Antimicrobial Cationic Peptides - pharmacology | Antiprotozoal Agents - chemistry | Antiprotozoal Agents - pharmacology | Antimicrobial Cationic Peptides - toxicity | Trypanosoma - drug effects | Cell Membrane Permeability - drug effects | Anti-Bacterial Agents - pharmacokinetics | Anti-Bacterial Agents - pharmacology | Drug resistance in microorganisms | Escherichia coli | Dosage and administration | Research | Comparative analysis | Pharmacokinetics | Antibacterial agents | Drugs | Yeasts | Atomic force microscopy | Membranes | Promastigotes | Nuclear magnetic resonance--NMR | Peptides | Field emission | Mitochondrial DNA | Parasites | Hydrophobicity | Reptiles & amphibians | Fungi | Depolarization | Mitochondria | E coli | Antibiotic resistance | DNA fragmentation | Antimicrobial peptides | Bacteria | Inserts | Membrane potential | Deoxyribonucleic acid--DNA | Scanning electron microscopy | Differential scanning calorimetry | Image resolution | Antimony | Electron microscopy | Mode of action | Antibiotics | Calorimetry | Surface plasmon resonance | Resonance | Evolution & development | Apoptosis | Life Sciences | Biochemistry, Molecular Biology | Deoxyribonucleic acid | Nuclear magnetic resonance | NMR | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, p. e0135556
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, p. e0171306
Objective The present study aimed to elucidate the cell death mechanism in Leishmania donovani upon treatment with KalsomeTM10, a new liposomal amphotericin B.... 
IMMUNE-RESPONSE | OXIDATIVE STRESS | INHIBITION | LIPID FORMULATIONS | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIAL DYSFUNCTION | MECHANISMS | MEDIATED APOPTOSIS | VISCERAL LEISHMANIASIS | PLASMA-MEMBRANE | PHOSPHATIDYLSERINE | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Glutathione - metabolism | Membrane Potential, Mitochondrial - drug effects | Dose-Response Relationship, Drug | Macrophages - parasitology | Endocytosis | Caspases - metabolism | Adenosine Triphosphate - metabolism | Lipid Peroxidation - drug effects | Cell Membrane - metabolism | DNA Fragmentation - drug effects | Macrophages - immunology | Leishmania donovani - physiology | Oxidation-Reduction | Cell Survival | Leishmania donovani - drug effects | Phosphatidylserines - metabolism | Amphotericin B - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Nitric Oxide | Antiprotozoal Agents - pharmacology | Animals | Cell Cycle Checkpoints - drug effects | Macrophages - drug effects | Mice | Genetic aspects | Amphotericin B | Cell death | Health aspects | Leishmania | Patient outcomes | Oxidative stress | Flow cytometry | Bioluminescence | Reactive oxygen species | Hydrogen peroxide | Promastigotes | Toxicity | Labelling | Lipids | Biology | Parasites | Macrophages | Fragmentation | Mitochondria | Alterations | Immunology | Parasitic diseases | Cell cycle | DNA fragmentation | Membrane potential | Phosphatidylserine | Drug dosages | Deoxyribonucleic acid--DNA | Scanning electron microscopy | Mortality | Committees | Caspase | Superoxide | Exposure | Amastigotes | Electron microscopy | DNA nucleotidylexotransferase | Cytometry | Infectious diseases | Phase contrast | Nitric oxide | Intracellular | Apoptosis | Integrity | Deoxyribonucleic acid | DNA
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 7, pp. 3496 - 3507
Apoptosis is one of the mechanisms used by host cells to remove unwanted intracellular organisms, and often found to be subverted by pathogens through use of... 
ACTIVATION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | INVOLVEMENT | apoptosis | macrophage | CYTOCHROME-C | BCL-2 | INHIBITION | SIGNALING PATHWAY | Leishmania | RESISTANCE | TOXOPLASMA-GONDII | cytochrome c | B-cell lymphoma 2 (Bcl-2) family | Apoptosis - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Protein Transport - drug effects | Spleen - drug effects | Macrophages - parasitology | Dactinomycin - therapeutic use | Protein Processing, Post-Translational - drug effects | RNA Interference | Bone Marrow Cells - drug effects | Female | Leishmaniasis, Visceral - parasitology | Phosphorylation - drug effects | Spleen - pathology | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Leishmania donovani - physiology | Macrophages - pathology | Leishmania donovani - drug effects | Bone Marrow Cells - pathology | Cells, Cultured | Leishmaniasis, Visceral - metabolism | Leishmaniasis, Visceral - pathology | Leishmania donovani - growth & development | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Leishmaniasis, Visceral - drug therapy | Gene Expression Regulation - drug effects | Spleen - parasitology | Antiparasitic Agents - therapeutic use | Cyclic AMP Response Element-Binding Protein - genetics | Host-Parasite Interactions - drug effects | Bone Marrow Cells - parasitology | Macrophages - metabolism | Animals | Spleen - metabolism | Antiparasitic Agents - pharmacology | Cyclic AMP Response Element-Binding Protein - antagonists & inhibitors | Cyclic AMP Response Element-Binding Protein - metabolism | Macrophages - drug effects | RAW 264.7 Cells | Mice | Mice, Inbred BALB C | Dactinomycin - pharmacology | Bone Marrow Cells - metabolism | Molecular Bases of Disease
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e89939
.... However, these current drugs are limited due to their toxicity, development of biological resistance, length of treatment and high cost... 
PROGRAMMED CELL-DEATH | DNA-TOPOISOMERASE | APOPTOSIS | IN-VITRO | THERAPY | ASSAY | MULTIDISCIPLINARY SCIENCES | DRUGS | LEISHMANIA-DONOVANI PROMASTIGOTES | AGENTS | CHEMOTHERAPY | Cell Line | Cell Survival - drug effects | Triterpenes - pharmacology | Imidazoles - pharmacology | Structure-Activity Relationship | Phosphorylcholine - analogs & derivatives | Antiprotozoal Agents - pharmacology | Drug Synergism | Leishmania infantum - growth & development | Triterpenes - chemistry | Animals | Triterpenes - chemical synthesis | Phosphorylcholine - pharmacology | Leishmania infantum - drug effects | Inhibitory Concentration 50 | Antiprotozoal Agents - chemical synthesis | Macrophages - drug effects | Mice | Imidazoles - chemical synthesis | Life Cycle Stages - drug effects | Life Cycle Stages - physiology | Amphotericin B | Antiparasitic agents | Leishmaniasis | Drugs | Toxicity | Triterpenoids | Cytology | Cytotoxicity | Drug development | Drug resistance | Macrophages | Tropical diseases | Necrosis | Synergistic effects | Immunology | Parasitic diseases | Imidazole | DNA fragmentation | Cell cycle | Phosphatidylserine | Deoxyribonucleic acid--DNA | G1 phase | Vector-borne diseases | Antimony | Pentamidine | Derivatives | Studies | Miltefosine | Acids | Cell death | Pharmacy | Cell lines | Betulinic acid | Antimony compounds | Cancer | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2017, Volume 61, Issue 4
We report the feasibility of enterocin AS-48, a circular cationic peptide produced by Enterococcus faecalis, as a new leishmanicidal agent. AS-48 is lethal to... 
Enterocin AS-48 | Bioenergetics | Intracellular parasite | Antimicrobial peptide | ACID | MEMBRANE | enterocin AS-48 | DRUG DISCOVERY | MITOCHONDRIA | ANTIBACTERIAL | MICROBIOLOGY | ANTIMICROBIAL PEPTIDES | PROGRAMMED CELL-DEATH | INHIBITION | DISEASES | bioenergetics | PEPTIDE ANTIBIOTIC AS-48 | PHARMACOLOGY & PHARMACY | antimicrobial peptide | intracellular parasite | Staining and Labeling - methods | Species Specificity | Fluorescent Dyes - metabolism | Adenosine Triphosphate - biosynthesis | Mitochondria - ultrastructure | Leishmania donovani - metabolism | Macrophages - parasitology | Adenosine Triphosphate - antagonists & inhibitors | Inhibitory Concentration 50 | Cell Membrane - metabolism | Cell Membrane - drug effects | Life Cycle Stages - drug effects | Life Cycle Stages - physiology | Cell Survival - drug effects | Leishmania donovani - drug effects | Enterococcus faecalis - chemistry | Cell Membrane - ultrastructure | Mitochondria - metabolism | Mitochondria - drug effects | Microscopy, Electron | Antiprotozoal Agents - pharmacology | Leishmania donovani - growth & development | Antiprotozoal Agents - isolation & purification | Enterococcus faecalis - metabolism | Cell Membrane Permeability - drug effects | Bacteriocins - pharmacology | Macrophages - drug effects | Bacteriocins - isolation & purification
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 09/2016, Volume 60, Issue 9, pp. 5122 - 5129