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Parasitology International, ISSN 1383-5769, 2016, Volume 66, Issue 2, pp. 47 - 55
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 4, p. e0154101
During the last decade miltefosine (MIL) has been used as first-line treatment for visceral leishmaniasis in endemic areas with antimonial resistance, but a... 
TRANSLOCATION | TRANSPORTER | INDIAN VISCERAL LEISHMANIASIS | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | PAROMOMYCIN | IN-VITRO SELECTION | KALA-AZAR | DRUG-RESISTANCE | L.-DONOVANI | FAILURE | Parasitic Sensitivity Tests | Genome, Protozoan | Gene Expression Regulation | Selection, Genetic | Genotype | Phosphorylcholine - analogs & derivatives | Protozoan Proteins - genetics | Antiprotozoal Agents - pharmacology | Genetic Complementation Test | Life Cycle Stages - genetics | Carrier Proteins - genetics | Drug Resistance - genetics | Leishmania infantum - growth & development | Phenotype | Carrier Proteins - metabolism | Protozoan Proteins - metabolism | Biological Transport | Phosphorylcholine - pharmacology | Leishmania infantum - drug effects | High-Throughput Nucleotide Sequencing | Leishmania infantum - metabolism | Mutation | Leishmania infantum - genetics | Life Cycle Stages - drug effects | Drug resistance in microorganisms | Kala-azar | Leishmania | Physiological aspects | Genetic aspects | Research | Drug therapy | Promastigotes | Clinical isolates | Genomes | Parasites | Gene deletion | Drug resistance | Inactivation | Gene sequencing | Coupling (molecular) | Transfection | Clonal deletion | Acquired immune deficiency syndrome--AIDS | Parasitic diseases | Visceral leishmaniasis | Human immunodeficiency virus--HIV | Deletion | Deoxyribonucleic acid--DNA | Vector-borne diseases | Genomic analysis | Deactivation | Cloning | Stop codon | Exploration | Leishmaniasis | Amastigotes | Gene expression | Corrosion resistance | Miltefosine | Aberration | Intracellular | Laboratory animals | Transporter | Life Sciences | Microbiology and Parasitology | Parasitology | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | DNA | Human immunodeficiency virus
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2017, Volume 61, Issue 4
Visceral leishmaniasis is a fatal parasitic neglected disease affecting 1.5 million people worldwide. Based on a drug repositioning approach, the aim of this... 
Therapy | Drug delivery | Liposomes | Leishmania | PARASITES | PHAGOCYTOSIS | liposomes | DONOVANI | therapy | BONE-MARROW | HOST | MICROBIOLOGY | drug delivery | RELEASE | MICE LACKING | INJECTION | PHARMACOLOGY & PHARMACY | L. CHAGASI | Bone Marrow - immunology | Spleen - immunology | Male | Leishmaniasis, Visceral - immunology | Spleen - drug effects | Administration, Cutaneous | Tumor Necrosis Factor-alpha - agonists | Macrophages - parasitology | Leishmania infantum - growth & development | Liver - immunology | Liver - drug effects | Leishmaniasis, Visceral - parasitology | Interleukin-10 - agonists | Macrophages - immunology | Bone Marrow - drug effects | Disease Models, Animal | Cricetinae | Immunologic Factors - chemistry | Drug Compounding - methods | Parasite Load | Naphthoquinones - pharmacology | Antiprotozoal Agents - chemistry | Interleukin-6 - agonists | Static Electricity | Antiprotozoal Agents - pharmacology | Leishmaniasis, Visceral - drug therapy | Spleen - parasitology | Bone Marrow - parasitology | Liposomes - chemistry | Animals | Nanostructures - administration & dosage | Leishmania infantum - drug effects | Chemokine CCL2 - biosynthesis | Interleukin-6 - biosynthesis | Nanostructures - chemistry | Chemokine CCL2 - agonists | Interleukin-10 - biosynthesis | Macrophages - drug effects | Naphthoquinones - chemistry | Mice | Liver - parasitology | Tumor Necrosis Factor-alpha - biosynthesis | Immunologic Factors - pharmacology | Liposomes - pharmacokinetics
Journal Article
American Journal of Tropical Medicine and Hygiene, ISSN 0002-9637, 2018, Volume 98, Issue 3, pp. 875 - 882
Manifestations of Leishmania infantum infection range from asymptomatic to symptomatic visceral leishmaniasis (VL). People with symptomatic VL (sVL) have... 
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | MEMORY | ASYMPTOMATIC INFECTION | NORTHEAST BRAZIL | SUBCLINICAL INFECTION | HUMAN VISCERAL LEISHMANIASIS | CD4(+) | KALA-AZAR | DONOVANI INFECTION | TROPICAL MEDICINE | CHAGASI | ANTIGEN | Antigens, CD - immunology | Humans | Middle Aged | Tumor Necrosis Factor-alpha - genetics | CD8-Positive T-Lymphocytes - parasitology | Lectins, C-Type - immunology | Male | Leishmaniasis, Visceral - immunology | Asymptomatic Diseases | CD4-Positive T-Lymphocytes - parasitology | Lectins, C-Type - genetics | Antigens, CD - genetics | Case-Control Studies | CD4-Positive T-Lymphocytes - immunology | Leukocyte Common Antigens - immunology | Leishmania infantum - growth & development | Interleukin-2 Receptor alpha Subunit - genetics | Antigens, Protozoan - pharmacology | Tumor Necrosis Factor-alpha - immunology | Brazil | Adult | Female | Leishmaniasis, Visceral - parasitology | Interferon-gamma - genetics | Child | Interleukin-2 Receptor alpha Subunit - immunology | Gene Expression | Skin Tests | Antigens, Differentiation, T-Lymphocyte - immunology | Animals | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Interferon-gamma - immunology | Adolescent | Antigens, Differentiation, T-Lymphocyte - genetics | Leishmaniasis, Visceral - genetics | Leishmania infantum - immunology | Immunologic Memory | Leukocyte Common Antigens - genetics | Aged | CD8-Positive T-Lymphocytes - immunology | Immunity, Cellular | CD4-Positive T-Lymphocytes - drug effects
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0124183 - e0124183
Chemotherapy against visceral leishmaniasis is associated with high toxicity and drug resistance. Leishmania parasites are purine auxotrophs that obtain their... 
PYRIMIDINE METABOLISM | PURINE NUCLEOSIDE PHOSPHORYLASE | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | KINETIC MECHANISM | CRYSTAL-STRUCTURES | TOXOPLASMA-GONDII | VIVO ACTIVITY | ENTAMOEBA-HISTOLYTICA | VISCERAL LEISHMANIASIS | HYDROLASE | Purine Nucleosides - pharmacology | Humans | Leishmania mexicana - ultrastructure | Adenine - chemistry | Pyrimidinones - chemistry | Pyrrolidines - pharmacology | Leishmania infantum - growth & development | Leishmania infantum - ultrastructure | Enzyme Inhibitors - chemistry | Female | Pyrimidinones - pharmacology | Leishmania mexicana - drug effects | Microscopy, Electron, Transmission | Adenine - analogs & derivatives | N-Glycosyl Hydrolases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Purine Nucleosides - chemistry | Adenine - pharmacology | Antiprotozoal Agents - chemistry | Leishmaniasis, Cutaneous - drug therapy | Antiprotozoal Agents - pharmacology | Pyrrolidines - chemistry | Leishmaniasis, Visceral - drug therapy | Pyrroles - pharmacology | Animals | Leishmania infantum - drug effects | Pyrroles - chemistry | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Kinetics | In Vitro Techniques | Leishmania mexicana - growth & development | Purines | Enzymes | Hydrolases | Chemotherapy | Cancer | Multiplication | Toxicity | Infections | Biochemistry | Parasites | Macrophages | Drug resistance | Tropical diseases | Enzymatic activity | Parasitic diseases | Inhibition | Drug therapy | Deoxyribonucleic acid--DNA | Recombinant | Vector-borne diseases | Protozoa | Metabolism | Substrates | Organic chemistry | Transmission electron microscopy | Dogs | Nucleosides | Replication | Viability | Cytoplasm | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
BMC genomics, ISSN 1471-2164, 2014, Volume 15, Issue 1, pp. 849 - 849
Journal Article
Journal Article
Parasites and Vectors, ISSN 1756-3305, 01/2019, Volume 12, Issue 1, pp. 33 - 13
Journal Article
Journal Article