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Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7562, pp. 607 - 611
The human lens is comprised largely of crystallin proteins assembled into a highly ordered, interactive macro-structure essential for lens transparency and... 
SELENITE-INDUCED CATARACTOGENESIS | MULTIDISCIPLINARY SCIENCES | MUTATION | PREVENTION | ALPHA-B-CRYSTALLIN | DOMINANT CONGENITAL CATARACT | HUMAN OXIDOSQUALENE CYCLASE | SEQUENCING DATA | CHINESE FAMILY | LENS | EXPRESSION | Crystallins - metabolism | Humans | Cataract - pathology | Molecular Sequence Data | Lanosterol - pharmacology | Male | Amyloid - chemistry | Amyloid - ultrastructure | Lens, Crystalline - pathology | Mutant Proteins - ultrastructure | Amyloid - metabolism | Protein Aggregation, Pathological - pathology | Base Sequence | Amyloid - drug effects | Adult | Female | Child | Crystallins - chemistry | Protein Aggregates - drug effects | Amino Acid Sequence | Cell Line | Crystallins - ultrastructure | Lanosterol - administration & dosage | Mutant Proteins - genetics | Lens, Crystalline - metabolism | Models, Molecular | Mutant Proteins - metabolism | Crystallins - genetics | Cataract - metabolism | Lanosterol - therapeutic use | Protein Aggregation, Pathological - drug therapy | Animals | Cataract - congenital | Pedigree | Mutant Proteins - chemistry | Dogs | Cataract - genetics | Cataract - drug therapy | Lens, Crystalline - drug effects | Proteins | Cataract | Physiological aspects | Development and progression | Genetic aspects | Research | Gene expression | Drug therapy | Cataracts | Studies | Older people | Mortality | Mutation | Cholesterol | Index Medicus
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 03/2014, Volume 25, Issue 6, pp. 776 - 790
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e78217 - e78217
Curcumin, the active principle present in the yellow spice turmeric, has been shown to exhibit various pharmacological actions such as antioxidant,... 
OXIDATIVE STRESS | IN-VITRO | OFFICINALIS | MULTIDISCIPLINARY SCIENCES | BIOAVAILABILITY | DISEASE | Cataract - blood | Crystallins - metabolism | Diabetes Mellitus, Experimental - drug therapy | Streptozocin | Antioxidants - metabolism | Biocompatible Materials - chemistry | Body Weight - drug effects | Insulin - blood | Protein Carbonylation - drug effects | Lens, Crystalline - pathology | Diabetes Mellitus, Experimental - blood | Sorbitol - metabolism | Nanoparticles - therapeutic use | Aldehyde Reductase - metabolism | Diabetes Mellitus, Experimental - complications | Crystallins - chemistry | Superoxide Dismutase - metabolism | Disease Models, Animal | Biodegradation, Environmental | Malondialdehyde - metabolism | Lactic Acid - chemistry | Curcumin - therapeutic use | Curcumin - pharmacology | Rats | Treatment Outcome | Disease Progression | Feeding Behavior - drug effects | Lens, Crystalline - enzymology | Cataract - complications | Animals | Polyglycolic Acid - chemistry | Cataract - prevention & control | Oxidative Stress - drug effects | Blood Glucose - metabolism | Cataract - drug therapy | Lens, Crystalline - drug effects | Nanoparticles | Antioxidants | Cataract | Polyols | Cataracts | Oxidative stress | Biodegradability | Proteins | Carcinogens | Rodents | Polyvinyl alcohol | Curcumin | Polymers | Biodegradation | Stress concentration | Nutrition | Diabetes mellitus | Oral administration | Dietary supplements | Pharmacology | Inflammation | Glycosylation | Bioavailability | Metabolism | Studies | Crystallin | Acids | Diet | Pharmacy | Diabetes | Laboratory animals | Cancer | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2011, Volume 668, Issue 3, pp. 497 - 506
We have previously shown that treating streptozotocin-induced diabetic rats, an animal model of type 1 diabetes, with Ilepatril (an inhibitor of neutral... 
Diabetic neuropathy | Diabetes | Neutral endopeptidase | Vasopeptidase inhibitor | Angiotensin converting enzyme | Vascular relaxation | IMPROVES INSULIN SENSITIVITY | ENDOTHELIAL DYSFUNCTION | VASOPEPTIDASE INHIBITOR OMAPATRILAT | INCREASED ENERGY-EXPENDITURE | ANGIOTENSIN-CONVERTING-ENZYME | NEUTRAL ENDOPEPTIDASE ACTIVITY | SKELETAL-MUSCLE | NERVE CONDUCTION-VELOCITY | GLUCOSE-TRANSPORT ACTIVITY | PHARMACOLOGY & PHARMACY | ENDONEURIAL BLOOD-FLOW | Blood Vessels - metabolism | Nervous System - metabolism | Thiobarbiturates - metabolism | Body Weight - drug effects | Male | Tyrosine - analogs & derivatives | Nervous System - pathology | Arterioles - physiopathology | Muscle, Skeletal - drug effects | Nociception - drug effects | Diabetes Mellitus, Experimental - complications | Nerve Fibers - pathology | Nerve Fibers - metabolism | Diabetes Complications - physiopathology | Diabetes Complications - metabolism | Enzyme Inhibitors - pharmacology | Lens, Crystalline - metabolism | Rats | Diabetes Complications - drug therapy | Arterioles - drug effects | Enzyme Inhibitors - therapeutic use | Rats, Sprague-Dawley | Tyrosine - metabolism | Heterocyclic Compounds, 3-Ring - therapeutic use | Vasodilation - drug effects | Blood Glucose - metabolism | Lens, Crystalline - drug effects | Adipose Tissue - drug effects | Carbohydrate Metabolism - drug effects | Glutathione - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Blood Vessels - pathology | Diet, High-Fat - adverse effects | Sciatic Nerve - physiopathology | Insulin - blood | Nervous System - physiopathology | Blood Vessels - physiopathology | Dose-Response Relationship, Drug | Sciatic Nerve - metabolism | Leptin - blood | Superoxides - metabolism | Sciatic Nerve - drug effects | Diabetes Complications - pathology | Glucose Tolerance Test | Nerve Fibers - drug effects | Organ Size - drug effects | Animals | Nervous System - drug effects | Blood Vessels - drug effects | Muscle, Skeletal - pathology | Complications and side effects | Obesity | Insulin resistance | Angiotensin | Animal models | Arterioles | Streptozocin | Diabetes mellitus | Insulin | Fibers | High fat diet | Calcitonin gene-related peptide | Nerve conduction | Peptidyl-dipeptidase A | Acetylcholine | Neprilysin | Sciatic nerve | Index Medicus | vasopeptidase inhibitor | vascular relaxation | angiotensin converting enzyme | neutral endopeptidase | diabetic neuropathy | diabetes
Journal Article