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Nature Methods, ISSN 1548-7091, 02/2006, Volume 3, Issue 2, pp. 109 - 116
Drug-inducible systems allowing the control of gene expression in mammalian cells are invaluable tools for genetic research, and could also fulfill essential roles in gene- and cell-based therapy... 
RNA INTERFERENCE | TRANSGENES | NEUROTROPHIC FACTOR | BIOCHEMICAL RESEARCH METHODS | DOWN-REGULATION | POLYMERASE-II | PROTEINS | MAMMALIAN-CELLS | LENTIVIRAL VECTORS | PARKINSONS-DISEASE | DELIVERY | Gene Targeting - methods | RNA, Small Interfering - genetics | DNA Polymerase III - genetics | Rats, Wistar | Humans | Male | Green Fluorescent Proteins - genetics | Stem Cells - cytology | Stem Cells - metabolism | Promoter Regions, Genetic - genetics | Tumor Suppressor Protein p53 - genetics | Brain - metabolism | Cell Differentiation - genetics | Glial Cell Line-Derived Neurotrophic Factor - metabolism | Transfection | RNA Interference | Female | Lentivirus - genetics | DNA Polymerase II - genetics | Genetic Engineering - methods | Cell Line | Green Fluorescent Proteins - metabolism | Gene Expression Regulation - genetics | Transgenes - genetics | Bacterial Proteins - genetics | Gene Silencing | Glial Cell Line-Derived Neurotrophic Factor - genetics | Rats | Repressor Proteins - genetics | Mice, Transgenic | Mice, Inbred Strains | Rats, Sprague-Dawley | Genetic Vectors - genetics | Gene Expression Regulation - drug effects | Xenograft Model Antitumor Assays | Carrier Proteins - genetics | Animals | Mice, Nude | GATA1 Transcription Factor - genetics | Cell Line, Tumor | Stem Cells - drug effects | Doxycycline - pharmacology | Mice
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2014, Volume 343, Issue 6166, pp. 84 - 87
Journal Article
Human Gene Therapy Methods, ISSN 1946-6536, 08/2012, Volume 23, Issue 4, pp. 242 - 254
Journal Article
Molecular Therapy, ISSN 1525-0016, 01/2011, Volume 19, Issue 1, pp. 122 - 132
X-linked chronic granulomatous disease (X-CGD) is a primary immunodeficiency caused by mutations in the CYBB gene encoding the phagocyte nicotinamide adenine... 
MEDICINE, RESEARCH & EXPERIMENTAL | NADPH OXIDASE | GP91(PHOX) | CHRONIC GRANULOMATOUS-DISEASE | C-MYB | PU.1 | GENOMIC INSTABILITY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MOUSE MODEL | GENETICS & HEREDITY | HOST-DEFENSE | GENE-THERAPY | LEUKEMIA | Genetic Vectors - administration & dosage | Humans | Myeloid Cells - physiology | Granulomatous Disease, Chronic - genetics | Granulomatous Disease, Chronic - metabolism | NADPH Oxidases - metabolism | Molecular Sequence Data | Stem Cells - metabolism | Recombinant Fusion Proteins - metabolism | DNA Copy Number Variations | Lentivirus - metabolism | Cell Differentiation - genetics | Genes, X-Linked | Retroviridae - metabolism | Retroviridae - genetics | Base Sequence | NADPH Oxidases - genetics | Lentivirus - genetics | Granulocytes - metabolism | Terminal Repeat Sequences | Transgenes | Binding Sites | CCAAT-Enhancer-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Recombinant Fusion Proteins - biosynthesis | Promoter Regions, Genetic | Cathepsin G - genetics | Proto-Oncogene Proteins c-fes - genetics | Gene Expression Regulation | Mutagenesis - genetics | Genetic Vectors - metabolism | Spleen Focus-Forming Viruses - metabolism | Granulomatous Disease, Chronic - therapy | Hematopoietic Stem Cells - metabolism | Spleen Focus-Forming Viruses - genetics | Genetic Vectors - genetics | Animals | Enhancer Elements, Genetic | Cell Line, Tumor | Myeloid Cells - metabolism | Recombinant Fusion Proteins - genetics | Trans-Activators - metabolism | Granulomatous Disease, Chronic - enzymology | Mice | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Genetic Therapy - methods | Index Medicus | Original
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 33, pp. 13481 - 13486
Journal Article
Cell Reports, ISSN 2211-1247, 09/2015, Volume 12, Issue 12, pp. 1978 - 1985
.... We performed an RNA-interference-based genetic screen in BRAF mutant colon cancer cells to search for phosphatases whose knockdown induces sensitivity to BRAF inhibition... 
Humans | RNA, Small Interfering/genetics | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins B-raf/genetics | Genomic Library | MAP Kinase Signaling System | Indoles/pharmacology | ras Proteins/genetics | Antineoplastic Agents/pharmacology | Melanoma/drug therapy | Transduction, Genetic | Drug Resistance, Neoplasm/drug effects | Xenograft Model Antitumor Assays | ErbB Receptors/genetics | Vemurafenib | Protein Tyrosine Phosphatase, Non-Receptor Type 11/antagonists & inhibitors | Animals | Sulfonamides/pharmacology | Cell Line, Tumor | Mice, Inbred NOD | High-Throughput Nucleotide Sequencing | Mice | Genetic Vectors | Colonic Neoplasms/drug therapy | Lentivirus/genetics | COLON-CANCER | SHP2 PTPN11 | LUNG-CANCER | MEK INHIBITION | BRAF(V600E) INHIBITION | GROWTH | PROTEIN-TYROSINE PHOSPHATASES | RAF INHIBITORS | MUTATIONS | NOONAN-SYNDROME | CELL BIOLOGY | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Colonic Neoplasms - genetics | Colonic Neoplasms - drug therapy | ras Proteins - metabolism | Colonic Neoplasms - metabolism | Receptor, Epidermal Growth Factor - metabolism | Melanoma - genetics | Indoles - pharmacology | Lentivirus - genetics | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Melanoma - pathology | Sulfonamides - pharmacology | Drug Resistance, Neoplasm - genetics | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Melanoma - drug therapy | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Drug Resistance, Neoplasm - drug effects | RNA, Small Interfering - metabolism
Journal Article
Molecular cell, ISSN 1097-2765, 10/2017, Volume 68, Issue 1, pp. 210 - 223.e6
.... Here, we present a two-tiered CRISPR-mediated chemical-genetic strategy for target identification... 
CRISPRi | chemical genetics | genome-wide CRISPR screening | rigosertib | microtubules | CRISPRa | drug target identification | drug mechanism of action | Myelodysplastic Syndromes | Genetic Testing | Vinblastine | Tubulin Modulators | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents | Drug Resistance, Neoplasm | Glycine | Lentivirus | Recombinant Fusion Proteins | Journal Article | Tubulin | Small Molecule Libraries | Microtubules | CRISPR-Cas Systems | K562 Cells | RNA, Guide | Colchicine | HeLa Cells | Mutation | Genetic Vectors | Kinesin | Sulfones | PROTEIN | COLCHICINE | SMALL MOLECULES | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENOMIC ASSAYS | TARGETS | RISK MYELODYSPLASTIC SYNDROMES | TUBULIN | INHIBITOR | BINDING AGENTS | CELL BIOLOGY | Colchicine - pharmacology | Glycine - analogs & derivatives | Small Molecule Libraries - pharmacology | RNA, Guide - genetics | RNA, Guide - metabolism | Tubulin Modulators - pharmacology | Tubulin - genetics | Sulfones - pharmacology | Genetic Testing - methods | Recombinant Fusion Proteins - metabolism | Lentivirus - metabolism | Microtubules - metabolism | Tubulin - metabolism | Glycine - chemistry | Microtubules - drug effects | Sulfones - chemistry | Microtubules - ultrastructure | Kinesin - genetics | Lentivirus - genetics | Antineoplastic Agents - pharmacology | Tubulin - chemistry | Myelodysplastic Syndromes - metabolism | Tubulin Modulators - chemistry | Genetic Vectors - chemistry | Genetic Vectors - metabolism | Antineoplastic Agents - chemistry | Kinesin - metabolism | Glycine - pharmacology | Recombinant Fusion Proteins - genetics | Myelodysplastic Syndromes - genetics | Vinblastine - pharmacology | Myelodysplastic Syndromes - pathology | Tubulins | Genomics | Genetic screening | Biochemical genetics | Cells
Journal Article