Biosensors & bioelectronics, ISSN 0956-5663, 06/2017, Volume 92, pp. 509 - 516
This work introduces a new electrochemical sensor based on polyvinyl pyrrolidone capped CoFe O @CdSe core-shell modified electrode for a rapid detection and...
Limit of Detection | Reproducibility of Results | Cadmium Compounds - chemistry | Leprostatic Agents - analysis | Nanoparticles - chemistry | Rifampin - blood | Tablets | Humans | Nanoparticles - ultrastructure | Ferric Compounds - chemistry | Antibiotics, Antitubercular - analysis | Electrochemical Techniques - instrumentation | Leprostatic Agents - blood | Povidone - chemistry | Rifampin - analysis | Antibiotics, Antitubercular - blood | Biosensing Techniques - instrumentation | Selenium Compounds - chemistry | Cobalt - chemistry
Limit of Detection | Reproducibility of Results | Cadmium Compounds - chemistry | Leprostatic Agents - analysis | Nanoparticles - chemistry | Rifampin - blood | Tablets | Humans | Nanoparticles - ultrastructure | Ferric Compounds - chemistry | Antibiotics, Antitubercular - analysis | Electrochemical Techniques - instrumentation | Leprostatic Agents - blood | Povidone - chemistry | Rifampin - analysis | Antibiotics, Antitubercular - blood | Biosensing Techniques - instrumentation | Selenium Compounds - chemistry | Cobalt - chemistry
Journal Article
Journal of Chromatography B, ISSN 1570-0232, 06/2014, Volume 960, pp. 82 - 86
The aim of the present study was to investigate the distribution of clofazimine (CLF) in rat bone marrow cells by a validated reverse phase high performance...
RP-HPLC | Rat bone marrow cells | Clofazimine | Liquid–liquid extraction | Clastogenic effect | Bone marrow distribution | Rat plasma | Liquid-liquid extraction | CHEMISTRY, ANALYTICAL | METABOLITES | ANTILEPROSY DRUG | HUMAN PLASMA | DEPOSITION | BIOCHEMICAL RESEARCH METHODS | SERUM | MASS-SPECTROMETRY | MICE INVIVO | GENOTOXICITY | MS/MS METHOD | TISSUE DISTRIBUTION | Bone Marrow Cells - chemistry | Clofazimine - blood | Reproducibility of Results | Chromatography, High Pressure Liquid - methods | Leprostatic Agents - analysis | Chromatography, Reverse-Phase - methods | Clofazimine - analysis | Drug Stability | Rats | Linear Models | Male | Rats, Sprague-Dawley | Leprostatic Agents - pharmacokinetics | Leprostatic Agents - blood | Tissue Distribution | Animals | Clofazimine - chemistry | Clofazimine - pharmacokinetics | Sensitivity and Specificity | Leprostatic Agents - chemistry | Liquid-Liquid Extraction | Liquid chromatography | Methods | Acetonitrile | Bone marrow | Durability | Bones | Chromatography | Half life
RP-HPLC | Rat bone marrow cells | Clofazimine | Liquid–liquid extraction | Clastogenic effect | Bone marrow distribution | Rat plasma | Liquid-liquid extraction | CHEMISTRY, ANALYTICAL | METABOLITES | ANTILEPROSY DRUG | HUMAN PLASMA | DEPOSITION | BIOCHEMICAL RESEARCH METHODS | SERUM | MASS-SPECTROMETRY | MICE INVIVO | GENOTOXICITY | MS/MS METHOD | TISSUE DISTRIBUTION | Bone Marrow Cells - chemistry | Clofazimine - blood | Reproducibility of Results | Chromatography, High Pressure Liquid - methods | Leprostatic Agents - analysis | Chromatography, Reverse-Phase - methods | Clofazimine - analysis | Drug Stability | Rats | Linear Models | Male | Rats, Sprague-Dawley | Leprostatic Agents - pharmacokinetics | Leprostatic Agents - blood | Tissue Distribution | Animals | Clofazimine - chemistry | Clofazimine - pharmacokinetics | Sensitivity and Specificity | Leprostatic Agents - chemistry | Liquid-Liquid Extraction | Liquid chromatography | Methods | Acetonitrile | Bone marrow | Durability | Bones | Chromatography | Half life
Journal Article
Therapeutic Drug Monitoring, ISSN 0163-4356, 2014, Volume 36, Issue 2, pp. 261 - 263
Background:The physiological changes in obese subjects can modify the pharmacokinetic profiles of drugs influencing the therapeutic efficacy.Methods:In this...
Leprosy | Obesity | Drug therapy | Body weight | body weight | leprosy | drug therapy | THERAPY | DRUGS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | MEDICAL LABORATORY TECHNOLOGY | CLINICAL PHARMACOKINETICS | obesity | CHILDREN | Body Mass Index | Dapsone - pharmacokinetics | Obesity - complications | Humans | Middle Aged | Male | Chromatography, High Pressure Liquid | Obesity - blood | Leprostatic Agents - pharmacokinetics | Leprostatic Agents - blood | Dapsone - blood | Adult | Leprosy, Multibacillary - complications | Leprosy, Multibacillary - drug therapy | Leprosy, Multibacillary - blood
Leprosy | Obesity | Drug therapy | Body weight | body weight | leprosy | drug therapy | THERAPY | DRUGS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | MEDICAL LABORATORY TECHNOLOGY | CLINICAL PHARMACOKINETICS | obesity | CHILDREN | Body Mass Index | Dapsone - pharmacokinetics | Obesity - complications | Humans | Middle Aged | Male | Chromatography, High Pressure Liquid | Obesity - blood | Leprostatic Agents - pharmacokinetics | Leprostatic Agents - blood | Dapsone - blood | Adult | Leprosy, Multibacillary - complications | Leprosy, Multibacillary - drug therapy | Leprosy, Multibacillary - blood
Journal Article
Rapid Communications in Mass Spectrometry, ISSN 0951-4198, 10/2002, Volume 16, Issue 20, pp. 1965 - 1975
Bioanalytical methods using automated 96‐well solid‐phase extraction (SPE) and liquid chromatography with electrospray tandem mass spectrometry (LC/MS/MS) are...
PHARMACOKINETIC INTERACTION | CHEMISTRY, ANALYTICAL | HUMAN PLASMA | BIOLOGICAL-FLUIDS | SAMPLE PREPARATION | BIOCHEMICAL RESEARCH METHODS | PROTEASE INHIBITORS | P-GLYCOPROTEIN | SILICA COLUMNS | SPECTROSCOPY | HUMAN URINE | LC-MS-MS | REVERSED-PHASE | Bronchodilator Agents - blood | Leprostatic Agents - analysis | Rifampin - blood | Ephedrine - blood | Humans | Metoprolol - analysis | Terfenadine - analysis | Robotics | Leprostatic Agents - blood | Histamine H1 Antagonists - analysis | Spectrometry, Mass, Electrospray Ionization | Rifampin - analysis | Bronchodilator Agents - analysis | Chromatography, Liquid | Metoprolol - blood | Terfenadine - blood | Adrenergic beta-Antagonists - analysis | Adrenergic beta-Antagonists - blood | Quality Control | Solvents | Reproducibility of Results | Terfenadine - analogs & derivatives | Histamine H1 Antagonists - blood | Pharmaceutical Preparations - analysis | Ephedrine - analysis
PHARMACOKINETIC INTERACTION | CHEMISTRY, ANALYTICAL | HUMAN PLASMA | BIOLOGICAL-FLUIDS | SAMPLE PREPARATION | BIOCHEMICAL RESEARCH METHODS | PROTEASE INHIBITORS | P-GLYCOPROTEIN | SILICA COLUMNS | SPECTROSCOPY | HUMAN URINE | LC-MS-MS | REVERSED-PHASE | Bronchodilator Agents - blood | Leprostatic Agents - analysis | Rifampin - blood | Ephedrine - blood | Humans | Metoprolol - analysis | Terfenadine - analysis | Robotics | Leprostatic Agents - blood | Histamine H1 Antagonists - analysis | Spectrometry, Mass, Electrospray Ionization | Rifampin - analysis | Bronchodilator Agents - analysis | Chromatography, Liquid | Metoprolol - blood | Terfenadine - blood | Adrenergic beta-Antagonists - analysis | Adrenergic beta-Antagonists - blood | Quality Control | Solvents | Reproducibility of Results | Terfenadine - analogs & derivatives | Histamine H1 Antagonists - blood | Pharmaceutical Preparations - analysis | Ephedrine - analysis
Journal Article
Neurological Sciences, ISSN 1590-1874, 12/2011, Volume 32, Issue 6, pp. 1063 - 1067
Dapsone has shown anti-convulsive properties in animal models of epilepsy. In the present study, we tested the safety and tolerability of dapsone as adjunctive...
Neurology | Drug-resistant epilepsy | Medicine & Public Health | Dapsone | Neurosurgery | Psychiatry | Neuroradiology | Partial-onset epilepsy | Epilepsy treatment | MULTICENTER | RATS | GABAPENTIN | NEUROSCIENCES | CLINICAL NEUROLOGY | ADD-ON THERAPY | PHARMACOKINETICS | REFRACTORY PARTIAL EPILEPSY | DOUBLE-BLIND | AMYGDALA-KINDLED SEIZURES | Anticonvulsants - blood | Epilepsies, Partial - chemically induced | Follow-Up Studies | Epilepsies, Partial - drug therapy | Humans | Middle Aged | Anticonvulsants - therapeutic use | Male | Dapsone - therapeutic use | Leprostatic Agents - blood | Leprostatic Agents - therapeutic use | Young Adult | Anticonvulsants - adverse effects | Drug Interactions | Adolescent | Dapsone - blood | Electrocardiography | Adult | Female | Evaluation | Care and treatment | Nervous system diseases | Sulfonamides | Analysis | Epilepsy | Clinical trials | Adults | Seizures (Medicine) | Drug resistance
Neurology | Drug-resistant epilepsy | Medicine & Public Health | Dapsone | Neurosurgery | Psychiatry | Neuroradiology | Partial-onset epilepsy | Epilepsy treatment | MULTICENTER | RATS | GABAPENTIN | NEUROSCIENCES | CLINICAL NEUROLOGY | ADD-ON THERAPY | PHARMACOKINETICS | REFRACTORY PARTIAL EPILEPSY | DOUBLE-BLIND | AMYGDALA-KINDLED SEIZURES | Anticonvulsants - blood | Epilepsies, Partial - chemically induced | Follow-Up Studies | Epilepsies, Partial - drug therapy | Humans | Middle Aged | Anticonvulsants - therapeutic use | Male | Dapsone - therapeutic use | Leprostatic Agents - blood | Leprostatic Agents - therapeutic use | Young Adult | Anticonvulsants - adverse effects | Drug Interactions | Adolescent | Dapsone - blood | Electrocardiography | Adult | Female | Evaluation | Care and treatment | Nervous system diseases | Sulfonamides | Analysis | Epilepsy | Clinical trials | Adults | Seizures (Medicine) | Drug resistance
Journal Article
Therapeutic Drug Monitoring, ISSN 0163-4356, 10/2009, Volume 31, Issue 5, pp. 602 - 603
Thalidomide is used for the acute treatment and suppression of the cutaneous manifestations of erythema nodosum leprosum (ENL). In this study, comparisons were...
Leprosy | Erythema nodosum leprosum | Thalidomide | leprosy | erythema nodosum leprosum | thalidomide | PHARMACOKINETICS | FORMULATIONS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | MEDICAL LABORATORY TECHNOLOGY | Thalidomide - metabolism | Leprosy, Lepromatous - drug therapy | Humans | Male | Metabolic Clearance Rate | Thalidomide - blood | Erythema Nodosum - drug therapy | Leprosy, Lepromatous - blood | Erythema Nodosum - blood | Leprostatic Agents - blood | Leprostatic Agents - therapeutic use | Young Adult | Vasculitis - drug therapy | Adult | Chromatography, Liquid - methods | Vasculitis - chemically induced | Index Medicus
Leprosy | Erythema nodosum leprosum | Thalidomide | leprosy | erythema nodosum leprosum | thalidomide | PHARMACOKINETICS | FORMULATIONS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | MEDICAL LABORATORY TECHNOLOGY | Thalidomide - metabolism | Leprosy, Lepromatous - drug therapy | Humans | Male | Metabolic Clearance Rate | Thalidomide - blood | Erythema Nodosum - drug therapy | Leprosy, Lepromatous - blood | Erythema Nodosum - blood | Leprostatic Agents - blood | Leprostatic Agents - therapeutic use | Young Adult | Vasculitis - drug therapy | Adult | Chromatography, Liquid - methods | Vasculitis - chemically induced | Index Medicus
Journal Article
Tuberculosis, ISSN 1472-9792, 2004, Volume 84, Issue 6, pp. 365 - 373
Background: Clofazimine is potentially useful for the treatment of disease due to multidrug resistant Mycobacterium tuberculosis, as well as leprosy and...
Food-effect | Clofazimine | Pharmacokinetics | Bioavaibility | FASTING CONDITIONS | clofazimine | RESPIRATORY SYSTEM | pharmacokinetics | food-effect | MICROBIOLOGY | IMMUNOLOGY | bioavaibility | Clofazimine - blood | Citrus sinensis | Administration, Oral | Food-Drug Interactions | Humans | Biological Availability | Leprostatic Agents - pharmacokinetics | Cross-Over Studies | Leprostatic Agents - blood | Antacids - metabolism | Ethionamide - administration & dosage | Drug Interactions | Pyridoxine - administration & dosage | Clofazimine - pharmacokinetics | Dietary Fats | Antitubercular Agents - administration & dosage | Adult | Aminosalicylic Acid - administration & dosage | Beverages | Cycloserine - administration & dosage | Drug Combinations | Food
Food-effect | Clofazimine | Pharmacokinetics | Bioavaibility | FASTING CONDITIONS | clofazimine | RESPIRATORY SYSTEM | pharmacokinetics | food-effect | MICROBIOLOGY | IMMUNOLOGY | bioavaibility | Clofazimine - blood | Citrus sinensis | Administration, Oral | Food-Drug Interactions | Humans | Biological Availability | Leprostatic Agents - pharmacokinetics | Cross-Over Studies | Leprostatic Agents - blood | Antacids - metabolism | Ethionamide - administration & dosage | Drug Interactions | Pyridoxine - administration & dosage | Clofazimine - pharmacokinetics | Dietary Fats | Antitubercular Agents - administration & dosage | Adult | Aminosalicylic Acid - administration & dosage | Beverages | Cycloserine - administration & dosage | Drug Combinations | Food
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 11/1999, Volume 39, Issue 11, pp. 1162 - 1168
Thalidomide was recently approved in the United States for the treatment of erythema nodosum leprosum, a complication of leprosy. The present study determined...
DEGRADATION | PHARMACOLOGY & PHARMACY | TUMOR-NECROSIS-FACTOR | PLASMA | Thalidomide - adverse effects | Fasting | Humans | Male | Thalidomide - blood | Leprostatic Agents - adverse effects | Leprostatic Agents - pharmacokinetics | Thalidomide - pharmacokinetics | Cross-Over Studies | Leprostatic Agents - blood | Time Factors | Models, Biological | Adult | Therapeutic Equivalency
DEGRADATION | PHARMACOLOGY & PHARMACY | TUMOR-NECROSIS-FACTOR | PLASMA | Thalidomide - adverse effects | Fasting | Humans | Male | Thalidomide - blood | Leprostatic Agents - adverse effects | Leprostatic Agents - pharmacokinetics | Thalidomide - pharmacokinetics | Cross-Over Studies | Leprostatic Agents - blood | Time Factors | Models, Biological | Adult | Therapeutic Equivalency
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 06/2001, Volume 41, Issue 6, pp. 662 - 667
Thalidomide is approved in the United States for treating erythema nodosum leprosum, a complication of leprosy. The present study determined the single‐dose...
MALE-VOLUNTEERS | TERATOGEN | TUMOR-NECROSIS-FACTOR | PHARMACOKINETICS | METABOLISM | FORMULATIONS | DISEASE | PHARMACOLOGY & PHARMACY | EXPERIENCE | EXCRETION | CYTOCHROME-P-450 | Thalidomide - adverse effects | Body Weight | Area Under Curve | Humans | Middle Aged | Male | Thalidomide - administration & dosage | Thalidomide - blood | Leprostatic Agents - adverse effects | Leprostatic Agents - pharmacokinetics | Thalidomide - pharmacokinetics | Leprostatic Agents - blood | Adult | Female | Leprostatic Agents - administration & dosage
MALE-VOLUNTEERS | TERATOGEN | TUMOR-NECROSIS-FACTOR | PHARMACOKINETICS | METABOLISM | FORMULATIONS | DISEASE | PHARMACOLOGY & PHARMACY | EXPERIENCE | EXCRETION | CYTOCHROME-P-450 | Thalidomide - adverse effects | Body Weight | Area Under Curve | Humans | Middle Aged | Male | Thalidomide - administration & dosage | Thalidomide - blood | Leprostatic Agents - adverse effects | Leprostatic Agents - pharmacokinetics | Thalidomide - pharmacokinetics | Leprostatic Agents - blood | Adult | Female | Leprostatic Agents - administration & dosage
Journal Article
Bulletin of Experimental Biology and Medicine, ISSN 0007-4888, 4/2008, Volume 145, Issue 4, pp. 446 - 448
Antileprosy activity of dialkyldithiocarbamate derivatives was studied in experiments on mice infected with M. leprae into paw pads. We found that...
Pathology | dialkyldithiocarbamate | Biomedicine | preliminary toxicological characteristics | Internal Medicine | antileprosy activity | Laboratory Medicine | M. leprae | Biomedicine general | Cell Biology | Dialkyldithiocarbamate | Preliminary toxicological characteristics | Antileprosy activity | MEDICINE, RESEARCH & EXPERIMENTAL | M. leprae, dialkyldithiocarbamate | Leprosy - blood | Microbial Viability - drug effects | Leprosy - veterinary | Thiocarbamates - therapeutic use | Male | Treatment Outcome | Thiocarbamates - chemistry | Dose-Response Relationship, Drug | Leprostatic Agents - blood | Leprostatic Agents - therapeutic use | Thiocarbamates - blood | Leprosy - drug therapy | Animals | Mycobacterium leprae - drug effects | Mice, Inbred CBA | Mice | Drug Evaluation, Preclinical | Mycobacterium leprae - physiology | Leprosy - mortality
Pathology | dialkyldithiocarbamate | Biomedicine | preliminary toxicological characteristics | Internal Medicine | antileprosy activity | Laboratory Medicine | M. leprae | Biomedicine general | Cell Biology | Dialkyldithiocarbamate | Preliminary toxicological characteristics | Antileprosy activity | MEDICINE, RESEARCH & EXPERIMENTAL | M. leprae, dialkyldithiocarbamate | Leprosy - blood | Microbial Viability - drug effects | Leprosy - veterinary | Thiocarbamates - therapeutic use | Male | Treatment Outcome | Thiocarbamates - chemistry | Dose-Response Relationship, Drug | Leprostatic Agents - blood | Leprostatic Agents - therapeutic use | Thiocarbamates - blood | Leprosy - drug therapy | Animals | Mycobacterium leprae - drug effects | Mice, Inbred CBA | Mice | Drug Evaluation, Preclinical | Mycobacterium leprae - physiology | Leprosy - mortality
Journal Article
Biomedical Chromatography, ISSN 0269-3879, 05/2002, Volume 16, Issue 3, pp. 203 - 208
A validated high‐performance liquid chromatographic method with ultraviolet detection for the quantitative determination of dapsone (4,4′‐diaminodifenyl...
CHEMISTRY, ANALYTICAL | PHARMACOLOGY & PHARMACY | TOXICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | Leprostatic Agents - blood | Reference Standards | Reproducibility of Results | Chromatography, High Pressure Liquid - methods | Dapsone - pharmacokinetics | Hydroxylation | Spectrophotometry, Ultraviolet - methods | Humans | Sensitivity and Specificity | Dapsone - blood | Calibration | Leprostatic Agents - pharmacokinetics
CHEMISTRY, ANALYTICAL | PHARMACOLOGY & PHARMACY | TOXICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | Leprostatic Agents - blood | Reference Standards | Reproducibility of Results | Chromatography, High Pressure Liquid - methods | Dapsone - pharmacokinetics | Hydroxylation | Spectrophotometry, Ultraviolet - methods | Humans | Sensitivity and Specificity | Dapsone - blood | Calibration | Leprostatic Agents - pharmacokinetics
Journal Article
International Journal of Antimicrobial Agents, ISSN 0924-8579, 01/1999, Volume 11, Issue 1, pp. 75 - 79
A simple HPLC method is described for the determination of clofazimine in mouse tissues and in serum. The main application of the method was the determination...
Clofazimine | Nanosuspensions | Tissue concentrations | HPLC | PERFORMANCE LIQUID-CHROMATOGRAPHY | nanosuspensions | INFECTIOUS DISEASES | PLASMA | clofazimine | tissue concentrations | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | Clofazimine - blood | Leprostatic Agents - metabolism | Reproducibility of Results | Humans | Clofazimine - metabolism | Clofazimine - administration & dosage | Chromatography, High Pressure Liquid | Drug Carriers | Leprostatic Agents - blood | Animals | Mice | Leprostatic Agents - administration & dosage | Liposomes
Clofazimine | Nanosuspensions | Tissue concentrations | HPLC | PERFORMANCE LIQUID-CHROMATOGRAPHY | nanosuspensions | INFECTIOUS DISEASES | PLASMA | clofazimine | tissue concentrations | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | Clofazimine - blood | Leprostatic Agents - metabolism | Reproducibility of Results | Humans | Clofazimine - metabolism | Clofazimine - administration & dosage | Chromatography, High Pressure Liquid | Drug Carriers | Leprostatic Agents - blood | Animals | Mice | Leprostatic Agents - administration & dosage | Liposomes
Journal Article
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, ISSN 0037-8682, 03/2010, Volume 43, Issue 2, pp. 201 - 204
Introduction: Thalidomide is a drug currently used in Brazil for treating erythema nodosum leprosum. Methods: This was a prospective study to follow up...
Leprosy | PHARMACOKINETICS | Thalidomide | Erythema nodosum leprosum | PARASITOLOGY | TROPICAL MEDICINE | Thalidomide - adverse effects | Prospective Studies | Leprosy, Lepromatous - drug therapy | Humans | Middle Aged | Male | Thalidomide - blood | Erythema Nodosum - drug therapy | Leprosy, Lepromatous - blood | Leprostatic Agents - adverse effects | Erythema Nodosum - blood | Leprostatic Agents - blood | Leprostatic Agents - therapeutic use | Young Adult | Adolescent | Adult | Female | Thalidomide - therapeutic use
Leprosy | PHARMACOKINETICS | Thalidomide | Erythema nodosum leprosum | PARASITOLOGY | TROPICAL MEDICINE | Thalidomide - adverse effects | Prospective Studies | Leprosy, Lepromatous - drug therapy | Humans | Middle Aged | Male | Thalidomide - blood | Erythema Nodosum - drug therapy | Leprosy, Lepromatous - blood | Leprostatic Agents - adverse effects | Erythema Nodosum - blood | Leprostatic Agents - blood | Leprostatic Agents - therapeutic use | Young Adult | Adolescent | Adult | Female | Thalidomide - therapeutic use
Journal Article
Journal of Analytical Toxicology, ISSN 0146-4760, 07/1995, Volume 19, Issue 4, pp. 229 - 235
A case of nonfatal, acute poisoning following the ingestion of an undetermined amount of dapsone (DDS) in a 49-year-old woman is presented. The clinical...
CHARCOAL | PLASMA | MONOACETYLDAPSONE | PHARMACOKINETICS | METHEMOGLOBINEMIA | ELIMINATION | TOXICOLOGY | ANEMIA | INTOXICATION | Leprostatic Agents - blood | Dyspnea - chemically induced | Leprostatic Agents - poisoning | Humans | Middle Aged | Dapsone - blood | Female | Chromatography, High Pressure Liquid | Dapsone - poisoning | Cyanosis - chemically induced
CHARCOAL | PLASMA | MONOACETYLDAPSONE | PHARMACOKINETICS | METHEMOGLOBINEMIA | ELIMINATION | TOXICOLOGY | ANEMIA | INTOXICATION | Leprostatic Agents - blood | Dyspnea - chemically induced | Leprostatic Agents - poisoning | Humans | Middle Aged | Dapsone - blood | Female | Chromatography, High Pressure Liquid | Dapsone - poisoning | Cyanosis - chemically induced
Journal Article
Human & Experimental Toxicology, ISSN 0960-3271, 08/1996, Volume 15, Issue 8, pp. 625 - 628
We report clinical findings and pharmacokinetic data regarding a combined dapsone and clofazimine intoxica tion in a man, who ingested 50 tablets of dapsone...
Dapsone | methaemo globinaemia | Clofazimine | Activated charcoal | Methaemoglobinaemia | Methylene blue | ACTIVATED-CHARCOAL | HEMOLYTIC-ANEMIA | methylene blue | activated charcoal | dapsone | methaemoglobinaemia | clofazimine | METHEMOGLOBINEMIA | ELIMINATION | TOXICOLOGY | CLINICAL PHARMACOKINETICS | Clofazimine - blood | Leprostatic Agents - poisoning | Drug Overdose | Humans | Male | Dapsone - poisoning | Leprostatic Agents - blood | Sulfates - therapeutic use | Methemoglobinemia - drug therapy | Suicide, Attempted | Methylene Blue - therapeutic use | Dapsone - blood | Rifampin - poisoning | Adult | Methemoglobinemia - chemically induced | Methemoglobinemia - blood | Clofazimine - poisoning | Gastric Lavage | Dapsone - analogs & derivatives | Charcoal
Dapsone | methaemo globinaemia | Clofazimine | Activated charcoal | Methaemoglobinaemia | Methylene blue | ACTIVATED-CHARCOAL | HEMOLYTIC-ANEMIA | methylene blue | activated charcoal | dapsone | methaemoglobinaemia | clofazimine | METHEMOGLOBINEMIA | ELIMINATION | TOXICOLOGY | CLINICAL PHARMACOKINETICS | Clofazimine - blood | Leprostatic Agents - poisoning | Drug Overdose | Humans | Male | Dapsone - poisoning | Leprostatic Agents - blood | Sulfates - therapeutic use | Methemoglobinemia - drug therapy | Suicide, Attempted | Methylene Blue - therapeutic use | Dapsone - blood | Rifampin - poisoning | Adult | Methemoglobinemia - chemically induced | Methemoglobinemia - blood | Clofazimine - poisoning | Gastric Lavage | Dapsone - analogs & derivatives | Charcoal
Journal Article
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, ISSN 0037-8682, 03/2005, Volume 38, Issue 2, pp. 167 - 172
Leprosy, a chronic granulomatous infectocontagious disease transmitted by Mycobacterium leprae, continues to be prevalent today, especially in underdeveloped...
ROM scheme | OXIDATIVE-STRESS | MINOCYCLINE | RIFAMPIN | INJURY | plasma concentration | hepatic and renal changes | PARASITOLOGY | TROPICAL MEDICINE | LEPROSY | Minocycline - blood | Leprosy - blood | Anti-Bacterial Agents - blood | Kidney - drug effects | Ofloxacin - blood | Rats, Wistar | Rifampin - blood | Rats | Male | Liver - chemistry | Leprosy - drug therapy | Animals | Liver - drug effects | Ofloxacin - administration & dosage | Kidney - chemistry | Minocycline - administration & dosage | Leprostatic Agents - administration & dosage | Rifampin - administration & dosage | Drug Therapy, Combination | Anti-Bacterial Agents - administration & dosage
ROM scheme | OXIDATIVE-STRESS | MINOCYCLINE | RIFAMPIN | INJURY | plasma concentration | hepatic and renal changes | PARASITOLOGY | TROPICAL MEDICINE | LEPROSY | Minocycline - blood | Leprosy - blood | Anti-Bacterial Agents - blood | Kidney - drug effects | Ofloxacin - blood | Rats, Wistar | Rifampin - blood | Rats | Male | Liver - chemistry | Leprosy - drug therapy | Animals | Liver - drug effects | Ofloxacin - administration & dosage | Kidney - chemistry | Minocycline - administration & dosage | Leprostatic Agents - administration & dosage | Rifampin - administration & dosage | Drug Therapy, Combination | Anti-Bacterial Agents - administration & dosage
Journal Article
Journal of Chromatography B: Biomedical Sciences and Applications, ISSN 0378-4347, 1996, Volume 681, Issue 2, pp. 307 - 315
A rapid and sensitive HPLC method is described for the analysis of synthetic phenazines, including clofazimine, from a variety of biological samples....
Phenazine | Clofazimine | clofazimine | phenazine | PERFORMANCE LIQUID-CHROMATOGRAPHY | CHEMISTRY, ANALYTICAL | PLASMA | BIOCHEMICAL RESEARCH METHODS | LEPROSY | B663 | Clofazimine - blood | Chromatography, High Pressure Liquid - methods | Chromatography, High Pressure Liquid - statistics & numerical data | Leprostatic Agents - analysis | Phenazines - pharmacokinetics | Clofazimine - analysis | Phenazines - blood | Rats | Organ Specificity | Leprostatic Agents - blood | Animals | Clofazimine - pharmacokinetics | Sensitivity and Specificity | Phenazines - analysis | Adipose Tissue - chemistry
Phenazine | Clofazimine | clofazimine | phenazine | PERFORMANCE LIQUID-CHROMATOGRAPHY | CHEMISTRY, ANALYTICAL | PLASMA | BIOCHEMICAL RESEARCH METHODS | LEPROSY | B663 | Clofazimine - blood | Chromatography, High Pressure Liquid - methods | Chromatography, High Pressure Liquid - statistics & numerical data | Leprostatic Agents - analysis | Phenazines - pharmacokinetics | Clofazimine - analysis | Phenazines - blood | Rats | Organ Specificity | Leprostatic Agents - blood | Animals | Clofazimine - pharmacokinetics | Sensitivity and Specificity | Phenazines - analysis | Adipose Tissue - chemistry
Journal Article
18.
High-performance liquid chromatographic determination of rifapentine in serum using column switching
Journal of chromatography, 02/1992, Volume 574, Issue 1, p. 175
A high-performance liquid chromatographic method with column switching has been developed for the determination of rifapentine in serum. The serum samples were...
Leprostatic Agents - blood | Rifampin - analogs & derivatives | Reproducibility of Results | Animals | Rifampin - blood | Dogs | Chromatography, High Pressure Liquid
Leprostatic Agents - blood | Rifampin - analogs & derivatives | Reproducibility of Results | Animals | Rifampin - blood | Dogs | Chromatography, High Pressure Liquid
Journal Article
Journal of chromatography, 05/1981, Volume 223, Issue 2, p. 379
The simultaneous analysis of main antileprosy drugs such as 4,4'-diaminodiphenyl sulfone (DDS), clofazimine, rifampicin and their main metabolites in serum was...
Clofazimine - blood | Leprostatic Agents - metabolism | Chromatography, High Pressure Liquid - methods | Guinea Pigs | Rifampin - blood | Humans | Clofazimine - metabolism | Reference Values | Dapsone - metabolism | Leprostatic Agents - blood | Chemistry | Animals | Chemical Phenomena | Dapsone - blood | Rifampin - metabolism
Clofazimine - blood | Leprostatic Agents - metabolism | Chromatography, High Pressure Liquid - methods | Guinea Pigs | Rifampin - blood | Humans | Clofazimine - metabolism | Reference Values | Dapsone - metabolism | Leprostatic Agents - blood | Chemistry | Animals | Chemical Phenomena | Dapsone - blood | Rifampin - metabolism
Journal Article
20.
Full Text
Clinical oxidative stress during leprosy multidrug therapy: Impact of dapsone oxidation
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e85712
This study aims to assess the oxidative stress in leprosy patients under multidrug therapy (MDT; dapsone, clofazimine and rifampicin), evaluating the nitric...
CYTOCHROME-P450 | METABOLISM | GLUTATHIONE | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | METHEMOGLOBINEMIA | GROWTH | TOXICITY | SUPEROXIDE-DISMUTASE | ANTIOXIDANT CAPACITY | N-HYDROXYLATION | Catalase - blood | Humans | Middle Aged | Male | Dapsone - therapeutic use | Heinz Bodies - drug effects | Leprostatic Agents - therapeutic use | Young Adult | Leprosy - drug therapy | Time Factors | Dapsone - blood | Adult | Female | Methemoglobin - metabolism | Rifampin - therapeutic use | Drug Therapy, Combination | Clofazimine - therapeutic use | Heinz Bodies - metabolism | Leprosy - blood | Oxidation-Reduction | Reactive Oxygen Species - blood | Treatment Outcome | Dapsone - metabolism | Analysis of Variance | Protein Binding | Cytochrome P-450 CYP2C19 - metabolism | Oxidative Stress - drug effects | Glutathione - blood | Oxidative stress | Medical research | Care and treatment | Medical examination | Cytochrome P-450 | Leprosy | Dapsone | Lipid peroxidation | Superoxide | Blood | Antioxidants | Nitric oxide | Medicine, Experimental | Therapy | Reactive oxygen species | Superoxide dismutase | Catalase | Metabolites | Vitamin E | Rodents | Oxidation | Glutathione | Peroxidation | Clofazimine | Hematology | Methemoglobin | Patients | Studies | Molecular modelling | Acids | Plasma levels | Skin | Methemoglobinemia | Rifampin
CYTOCHROME-P450 | METABOLISM | GLUTATHIONE | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | METHEMOGLOBINEMIA | GROWTH | TOXICITY | SUPEROXIDE-DISMUTASE | ANTIOXIDANT CAPACITY | N-HYDROXYLATION | Catalase - blood | Humans | Middle Aged | Male | Dapsone - therapeutic use | Heinz Bodies - drug effects | Leprostatic Agents - therapeutic use | Young Adult | Leprosy - drug therapy | Time Factors | Dapsone - blood | Adult | Female | Methemoglobin - metabolism | Rifampin - therapeutic use | Drug Therapy, Combination | Clofazimine - therapeutic use | Heinz Bodies - metabolism | Leprosy - blood | Oxidation-Reduction | Reactive Oxygen Species - blood | Treatment Outcome | Dapsone - metabolism | Analysis of Variance | Protein Binding | Cytochrome P-450 CYP2C19 - metabolism | Oxidative Stress - drug effects | Glutathione - blood | Oxidative stress | Medical research | Care and treatment | Medical examination | Cytochrome P-450 | Leprosy | Dapsone | Lipid peroxidation | Superoxide | Blood | Antioxidants | Nitric oxide | Medicine, Experimental | Therapy | Reactive oxygen species | Superoxide dismutase | Catalase | Metabolites | Vitamin E | Rodents | Oxidation | Glutathione | Peroxidation | Clofazimine | Hematology | Methemoglobin | Patients | Studies | Molecular modelling | Acids | Plasma levels | Skin | Methemoglobinemia | Rifampin
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