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2009, Medical intelligence unit, ISBN 9781587063206, 165
Book
Immunobiology, ISSN 0171-2985, 2013, Volume 218, Issue 12, pp. 1439 - 1451
Abstract Background Although the etiology of two major forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC) are unknown... 
Allergy and Immunology | Advanced Basic Science | Pegylated | Inflammatory bowel disease (IBD) | Leptin | Inflammation | Crohn's disease (CD) | Antagonist | Ulcerative colitis (UC) | IMMUNE-RESPONSE | TGF-BETA | CROHNS-DISEASE | ULCERATIVE-COLITIS | IMMUNOLOGY | AUTOIMMUNE ENCEPHALOMYELITIS | CUTTING EDGE | INTESTINAL INFLAMMATION | STAT3 ACTIVATION | INFLAMMATORY-BOWEL-DISEASE | REGULATORY T-CELLS | Body Weight - drug effects | Polyethylene Glycols - chemistry | Intestinal Mucosa - drug effects | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | STAT1 Transcription Factor - metabolism | Intestinal Mucosa - immunology | Leptin - analogs & derivatives | Female | Leptin - administration & dosage | Colitis - drug therapy | Colitis - immunology | Smad7 Protein - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Smad7 Protein - metabolism | Leptin - chemistry | Mice, Inbred C57BL | Apyrase - metabolism | Recombinant Proteins - chemistry | Down-Regulation - drug effects | STAT1 Transcription Factor - genetics | Recombinant Proteins - administration & dosage | Mice, Knockout | Insulin - metabolism | T-Lymphocytes, Regulatory - drug effects | Animals | Signal Transduction - drug effects | Interleukin-10 - genetics | Mice | Chronic Disease | Transforming Growth Factor beta - metabolism | Crohn’s Disease (CD) | Ulcerative Colitis (UC)
Journal Article
Journal Article
Journal Article
Journal of Endocrinology, ISSN 0022-0795, 12/2010, Volume 207, Issue 3, pp. 343 - 353
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 32, pp. 19888 - 19899
Farnesoid X receptor alpha (FXR alpha) as a bile acid sensor plays potent roles in multiple metabolic processes, and its antagonist has recently revealed... 
OBESITY | HOMEOSTASIS | NATURAL PRODUCT | CHOLESTEROL | METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | BILE-ACID RECEPTOR | LIGAND | IDENTIFICATION | ORPHAN NUCLEAR RECEPTOR | AGONIST | Glucose-6-Phosphatase - genetics | Receptors, Leptin - genetics | Humans | Phosphoenolpyruvate Carboxykinase (ATP) - antagonists & inhibitors | Crystallography, X-Ray | Male | Hepatocytes - metabolism | Hepatocytes - cytology | Protein Isoforms - metabolism | ATP-Binding Cassette Transporters - genetics | Protein Isoforms - agonists | Receptors, Cytoplasmic and Nuclear - chemistry | ATP-Binding Cassette Transporters - metabolism | Benzamides - pharmacology | Retinoid X Receptors - genetics | Retinoid X Receptors - metabolism | Hepatocytes - drug effects | Benzamides - chemistry | Recombinant Proteins - metabolism | Signal Transduction | Isoxazoles - antagonists & inhibitors | Gene Expression Regulation | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Recombinant Proteins - genetics | Glucose-6-Phosphatase - metabolism | Hep G2 Cells | Mice, Knockout | Isoxazoles - pharmacology | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Receptors, Leptin - deficiency | Animals | ATP Binding Cassette Subfamily B Member 11 | Retinoid X Receptors - agonists | Glucose-6-Phosphatase - antagonists & inhibitors | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Mice | Molecular Docking Simulation | Mutation | Primary Cell Culture | Protein Isoforms - antagonists & inhibitors | ATP-Binding Cassette Transporters - antagonists & inhibitors | Protein Isoforms - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Protein Structure and Folding | FXR | homodimerization | molecular pharmacology | crystal structure | nuclear receptor | transcription target gene | metabolic disease | antagonist
Journal Article
Diabetes, ISSN 0012-1797, 05/2013, Volume 62, Issue 5, pp. 1500 - 1504
C-type natriuretic peptide (CNP) and its receptor are abundantly distributed in the brain, especially in the arcuate nucleus (ARC) of the hypothalamus... 
LEPTIN | LOCALIZATION | MESSENGER-RNA | PARAVENTRICULAR NUCLEUS | GHRELIN | ENDOCRINOLOGY & METABOLISM | RAT HYPOTHALAMUS | RECEPTOR | BRAIN | Hypothalamus - secretion | Melanocortins - metabolism | Injections, Intraventricular | Melanocyte-Stimulating Hormones - pharmacology | Male | Neurons - cytology | Melanocortins - agonists | alpha-MSH - metabolism | Neuropeptide Y - metabolism | Protein Precursors - antagonists & inhibitors | Protein Isoforms - metabolism | Protein Isoforms - agonists | Receptors, Melanocortin - agonists | Receptors, Melanocortin - metabolism | Behavior, Animal - drug effects | Neurons - secretion | Neurons - metabolism | Hypothalamus - drug effects | Nerve Tissue Proteins - administration & dosage | Neurons - drug effects | Neuropeptide Y - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | Receptors, Melanocortin - antagonists & inhibitors | Natriuretic Peptide, C-Type - administration & dosage | Protein Precursors - administration & dosage | Mice, Inbred C57BL | Nerve Tissue Proteins - agonists | Appetite Regulation - drug effects | Feeding Behavior - drug effects | Protein Precursors - metabolism | Ghrelin - antagonists & inhibitors | Ghrelin - metabolism | Nerve Tissue Proteins - metabolism | Up-Regulation - drug effects | Animals | Hypothalamus - metabolism | Hypothalamus - cytology | Natriuretic Peptide, C-Type - metabolism | Signal Transduction - drug effects | alpha-MSH - secretion | Mice | Protein Isoforms - antagonists & inhibitors | Melanocortins - antagonists & inhibitors | Natriuretic Peptide, C-Type - antagonists & inhibitors | Physiological aspects | Research | Food consumption | Analysis | Natriuretic peptides | Original Research
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 2014, Volume 20, Issue 4, pp. 659 - 665
Random mutagenesis of mouse leptin antagonist (L39A/D40A/F41) followed by selection of high-affinity mutants by yeast-surface display indicated that replacing... 
Uremic cachexia | T2DM model | Leptin | Anti-autoimmune diseases | Antagonist | Cancer | Inflammatory disease | RHEUMATOID-ARTHRITIS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | uremic cachexia | inflammatory disease | NONALCOHOLIC STEATOHEPATITIS | antagonist | anti-autoimmune diseases | BLOOD MONONUCLEAR-CELLS | LARGE-SCALE PREPARATION | INTESTINAL INFLAMMATION | HEPATOCELLULAR-CARCINOMA | INFLAMMATORY-BOWEL-DISEASE | PHARMACOLOGY & PHARMACY | cancer | RECEPTOR OB-R | CHRONIC VIRAL-HEPATITIS | Leptin - antagonists & inhibitors | Recombinant Proteins - therapeutic use | Receptors, Leptin - antagonists & inhibitors | Drugs, Investigational - pharmacology | Humans | Immunosuppressive Agents - therapeutic use | Drugs, Investigational - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antineoplastic Agents - therapeutic use | Diabetes Mellitus, Type 2 - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Mutant Proteins - pharmacology | Drugs, Investigational - chemistry | Drug Design | Leptin - analogs & derivatives | Antineoplastic Agents - pharmacology | Immunosuppressive Agents - pharmacology | Mutant Proteins - therapeutic use | Hypoglycemic Agents - therapeutic use | Recombinant Proteins - chemistry | Hypoglycemic Agents - chemistry | Leptin - genetics | Recombinant Proteins - pharmacology | Antineoplastic Agents - chemistry | Hypoglycemic Agents - pharmacology | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Mutant Proteins - chemistry | Ligands | Receptors, Leptin - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Autoimmunity - drug effects | Immunosuppressive Agents - chemistry | Amino Acid Substitution
Journal Article
Peptide Science, ISSN 0006-3525, 2011, Volume 96, Issue 2, pp. 117 - 125
Journal Article
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 03/2012, Volume 132, Issue 3, pp. 711 - 720
Journal Article