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European Journal of Endocrinology, ISSN 0804-4643, 06/2017, Volume 176, Issue 6, pp. 685 - 693
Journal Article
Cell metabolism, ISSN 1550-4131, 2005, Volume 1, Issue 2, pp. 107 - 119
.... Here, we developed mice with targeted mutations in two related adipocyte FABPs, aP2 and mal1, to resolve their role in systemic lipid, glucose, and energy metabolism... 
LEPTIN | OXIDATION | TARGETED DISRUPTION | GLUCOSE | ENDOCRINOLOGY & METABOLISM | MUSCLE | MICE | TNF-ALPHA | WEIGHT | INDUCED INSULIN-RESISTANCE | APOLIPOPROTEIN-E | CELL BIOLOGY | Fatty Acid-Binding Proteins | Phosphorylation | Body Weight | Adipose Tissue - cytology | Multienzyme Complexes - metabolism | Adipocytes - cytology | Immunoblotting | RNA, Messenger - metabolism | AMP-Activated Protein Kinases | Oxygen - metabolism | Tissue Distribution | Adipose Tissue - metabolism | Time Factors | Fatty Acids - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cytokines - metabolism | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Insulin Resistance | Diabetes Mellitus - metabolism | Lipid Metabolism | Mice, Transgenic | Inflammation | Macrophages - cytology | Obesity - metabolism | Triglycerides - metabolism | Insulin - metabolism | Macrophages - metabolism | Phenotype | Animals | Carrier Proteins - metabolism | Adipocytes - metabolism | Glucose - metabolism | Stearoyl-CoA Desaturase - metabolism | Receptor, Insulin - metabolism | Arteriosclerosis - metabolism | Mice | Mutation | Type 2 diabetes | Obesity | Glucose | Macrophages | Fatty acids | Dextrose | Glucose metabolism | Atherosclerosis | Physiological aspects | Insulin resistance | Binding proteins | Public health | Protein binding | Diabetes therapy
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2011, Volume 54, Issue 4, pp. 773 - 794
... when the administered daily dosage is higher than 50 mg or when the drug undergoes significant liver metabolism [4]. The mechanisms of DILI are not always known... 
Gastroenterology and Hepatology | Drugs | Obesity | Oxidative stress | Mitochondria | Cell death | Lipids | Hepatotoxicity | Steatosis | TRIGLYCERIDE TRANSFER PROTEIN | DNA-POLYMERASE-GAMMA | PREGNANE X-RECEPTOR | PROLIFERATOR-ACTIVATED RECEPTOR | HEPATIC CYTOCHROME-P450 2E1 | ELEMENT-BINDING PROTEINS | FATTY-ACID OXIDATION | CONSTITUTIVE ANDROSTANE RECEPTOR | MANGANESE SUPEROXIDE-DISMUTASE | STRESS-RELATED PARAMETERS | GASTROENTEROLOGY & HEPATOLOGY | Carbohydrate Metabolism - drug effects | Reactive Oxygen Species - metabolism | Mitochondria, Liver - metabolism | Humans | Leptin - metabolism | Oxidative Phosphorylation - drug effects | Adipose Tissue - metabolism | Adiponectin - metabolism | Hepatitis C - complications | Cell Death - drug effects | Fatty Acids - metabolism | Chemical and Drug Induced Liver Injury - etiology | Diabetes Mellitus, Type 2 - complications | Genetic Predisposition to Disease | Fatty Liver - metabolism | Oxidation-Reduction | Obesity - complications | Insulin Resistance | Mitochondrial Membrane Transport Proteins - drug effects | Chemical and Drug Induced Liver Injury - genetics | Mitochondria, Liver - drug effects | Animals | Chemical and Drug Induced Liver Injury - metabolism | Models, Biological | Lipid Metabolism - drug effects | Alcoholic Intoxication - complications | Genome, Mitochondrial | Adipose Tissue - drug effects | Energy Metabolism - drug effects | Fatty Liver - etiology | Divalproex | Liver diseases | Thiols | Liver | Cytochrome P-450 | Mitochondrial DNA | Triglycerides | Stavudine | Permeability | Valproic acid | Fatty acids | Cells | Carnitine | Metabolites | Glutathione transferase | Acetaminophen | Physiological aspects | DNA polymerases | Health aspects | Zidovudine | Index Medicus | Reactive Oxygen Species | Fatty Acids | Adiponectin | Mitochondria, Liver | Life Sciences | Mitochondrial Membrane Transport Proteins | Cell Death | Diabetes Mellitus, Type 2 | Adipose Tissue | Alcoholic Intoxication | Hépatology and Gastroenterology | Oxidative Phosphorylation | Carbohydrate Metabolism | Lipid Metabolism | Drug-Induced Liver Injury | Fatty Liver | Human health and pathology | Energy Metabolism | Leptin | Hepatitis C
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e33814
.... Although evidence points to consider exposure to BPA as a risk factor for insulin resistance, its actions on whole body metabolism and on insulin-sensitive tissues are still unclear... 
LEPTIN | SKELETAL-MUSCLE | CELLS | ENDOCRINE DISRUPTORS | MULTIDISCIPLINARY SCIENCES | INSULIN-SECRETION | SENSITIVITY | MECHANISMS | EXPRESSION | ESTROGEN-RECEPTOR | EXPOSURE | Phosphorylation | Benzhydryl Compounds | Phenols - toxicity | Liver - metabolism | Male | Muscle, Skeletal - metabolism | Insulin Receptor Substrate Proteins - metabolism | Insulin - metabolism | Animals | Liver - drug effects | Signal Transduction - drug effects | Estrogens, Non-Steroidal - toxicity | Injections, Subcutaneous | Muscle, Skeletal - drug effects | Glucose - metabolism | Receptor, Insulin - metabolism | Mice | Proto-Oncogene Proteins c-akt - metabolism | Energy Metabolism - drug effects | Mitogen-Activated Protein Kinases - metabolism | Tyrosine | Type 2 diabetes | Bisphenol-A | Liver | Muscles | Glucose | Insulin | Risk factors | Dextrose | Epoxy resins | Analysis | Polycarbonates | Physiological aspects | Insulin resistance | Mitogens | Protein kinases | Endocrine disruptors | Energy metabolism | Homeostasis | AKT protein | Signal transduction | Rodents | Animal tissues | Polymers | Polycarbonate | Locomotor activity | Body temperature | Abnormalities | Diabetes mellitus | MAP kinase | Metabolism | Resistance factors | Skeletal muscle | Energy balance | Bisphenol A | Signaling | Insulin receptor substrate 1 | Protein kinase | Food intake | Phenols | Calorimetry
Journal Article
Journal Article
Cell metabolism, ISSN 1550-4131, 2012, Volume 15, Issue 6, pp. 848 - 860
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 556, Issue 7702, pp. 505 - 509
Leptin, a hormone produced in white adipose tissue, acts in the brain to communicate fuel status, suppress appetite following a meal, promote energy... 
POMC NEURONS | SYSTEM | OBESITY | METABOLISM | MULTIDISCIPLINARY SCIENCES | INSULIN-SECRETION | MOUSE | MICE | AGRP NEURONS | ARCUATE NUCLEUS | SUPPRESSION | Satiety Response | Body Weight | Receptors, Leptin - genetics | Leptin - metabolism | Diabetes Mellitus, Experimental - genetics | Homeostasis | Male | Neural Pathways - physiology | Obesity - genetics | Potassium Channels - metabolism | Female | Neurons - metabolism | GABAergic Neurons - metabolism | Diabetes Mellitus, Experimental - metabolism | Eating | Agouti-Related Protein - metabolism | Gene Editing | Obesity - metabolism | Hyperglycemia - metabolism | Receptors, Leptin - deficiency | Animals | Energy Metabolism | Hyperphagia - physiopathology | Presynaptic Terminals - metabolism | Mice | Receptors, Leptin - metabolism | Blood Glucose - metabolism | Glucose metabolism | Energy metabolism | Neural circuitry | Bioenergetics | Leptin | Physiological aspects | Genetic aspects | Gene expression | Observations | Potentiation | Brain | Adipose tissue | Circuits | Streptozocin | Proopiomelanocortin | Genomes | Glucose | Hypothalamus | Receptors | Hyperglycemia | Replicating | Energy | Rodents | Inhibition | Hyperphagia | Appetite | CRISPR | Obesity | Phenotypes | Neurons | Therapeutic applications | Diabetes mellitus | Energy expenditure | Potassium channels | Ablation | Insulin | Molecular chains | Energy balance | Weight control | Neural networks | Diabetes | Potassium | Neurotransmission | Metabolic disorders | KATP | blood glucose | fuel metabolism | GABA | AgRP | leptin | and diabetes | obesity
Journal Article
Gastroenterology, ISSN 0016-5085, 2017, Volume 152, Issue 7, pp. 1707 - 1717.e2
Abstract The gastrointestinal (GI) tract, the key interface between ingested nutrients and the body, plays a critical role in regulating energy homeostasis.... 
Gastroenterology and Hepatology | Enteroendocrine Cells | Obesity | Gastrointestinal Peptides | L-CELLS | INTESTINAL GUANYLATE-CYCLASE | PLASMA GHRELIN LEVELS | PERIPHERAL NEUROTENSIN | APOLIPOPROTEIN-A-IV | BODY-WEIGHT | GASTRIC BYPASS-SURGERY | GLUCOSE-HOMEOSTASIS | GLUCAGON-LIKE PEPTIDE-1 | GASTROENTEROLOGY & HEPATOLOGY | PRADER-WILLI-SYNDROME | Apolipoproteins A - metabolism | Obesity - drug therapy | Peptide YY - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Leptin - metabolism | Homeostasis | Neurotensin - metabolism | DNA-Binding Proteins - metabolism | Cholecystokinin - metabolism | Neurons, Afferent | Gastrointestinal Tract - physiology | Gastrointestinal Hormones - metabolism | Oxyntomodulin - metabolism | Enteroendocrine Cells - metabolism | Calcium-Binding Proteins - metabolism | Eating | Glucagon-Like Peptide 1 - metabolism | Natriuretic Peptides - metabolism | Obesity - physiopathology | Gastrointestinal Tract - metabolism | Nucleobindins | Obesity - metabolism | Ghrelin - metabolism | Nerve Tissue Proteins - metabolism | Animals | Energy Metabolism | Medical research | Glucagon | Food habits | Body weight | Weight loss maintenance | Homeopathy | Materia medica and therapeutics | Hospitals | Gastrointestinal system | Therapeutics | Medicine, Experimental | Genetic engineering | Research institutes | Health aspects | Type 2 diabetes | Bile acids | Goats | Apolipoproteins | Fatty acids | Membrane proteins | G proteins | Cholecystokinin
Journal Article