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Infection and Immunity, ISSN 0019-9567, 2015, Volume 83, Issue 12, pp. 4693 - 4700
Although Leptospira can infect a wide range of mammalian species, most studies have been conducted in golden Syrian hamsters, a species particularly sensitive... 
INFECTIOUS DISEASES | PATHOGENIC LEPTOSPIRA | LETHAL INFECTION | IN-VIVO | DISEASE | HOST | IMMUNOLOGY | SEROVAR ICTEROHAEMORRHAGIAE | RENAL COLONIZATION | C3H/HEJ MICE | T-CELLS | BRAZIL | Mice - immunology | Bacteremia - immunology | Kidney - pathology | Tumor Necrosis Factor-alpha - genetics | Bacteriuria - microbiology | Hypothermia - immunology | Interleukin-1beta - genetics | Immunoglobulin G - biosynthesis | Tumor Necrosis Factor-alpha - immunology | Hypothermia - microbiology | Leptospirosis - immunology | Chemokines - immunology | Disease Models, Animal | Mice - genetics | Interleukin-6 - genetics | Signal Transduction | Chemokines - genetics | Leptospira interrogans - immunology | Host-Pathogen Interactions | Bacteriuria - pathology | Kidney - microbiology | Chemokine CXCL2 - immunology | Leptospirosis - pathology | Chemokine CCL5 - genetics | Interleukin-6 - immunology | Bacteremia - pathology | Chronic Disease | Hypothermia - genetics | Bacteriuria - genetics | Kidney - immunology | Hypothermia - pathology | Bacteremia - microbiology | Nitric Oxide Synthase Type II - immunology | Weight Loss - immunology | Chemokine CXCL2 - genetics | Female | CD4-Positive T-Lymphocytes | Interferon-gamma - genetics | Leptospirosis - microbiology | Mice - microbiology | Bacteriuria - immunology | Gene Expression Regulation | Interleukin-1beta - immunology | Bacteremia - genetics | Mice, Inbred C3H | Leptospirosis - genetics | Animals | Nitric Oxide Synthase Type II - genetics | Interferon-gamma - immunology | Chemokine CCL5 - immunology | Index Medicus | Bacterial Infections
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, pp. e0148029 - e0148029
Background Dogs with leptospirosis show similar organ manifestations and disease course as human patients, including acute kidney injury and pulmonary... 
FIBROSIS | GROWTH-FACTOR-BETA | CHRONIC ENTEROPATHIES | NITRIC-OXIDE SYNTHASE | HAMSTERS | MULTIDISCIPLINARY SCIENCES | DISEASE | GENE-EXPRESSION | INTERROGANS | SEPSIS | KIDNEY | Interleukin-8 - genetics | Leukocytes, Mononuclear - metabolism | RNA, Messenger - immunology | Interleukin-1alpha - immunology | Arachidonate 5-Lipoxygenase - genetics | Humans | Tumor Necrosis Factor-alpha - genetics | Hemorrhage - mortality | Male | Acute Kidney Injury - genetics | Interleukin-1beta - genetics | Acute Kidney Injury - veterinary | Lung Injury - mortality | Arachidonate 5-Lipoxygenase - immunology | Nitric Oxide Synthase Type II - immunology | Leukocytes, Mononuclear - immunology | Lung Injury - veterinary | Tumor Necrosis Factor-alpha - immunology | Female | Interleukin-1alpha - genetics | Acute Kidney Injury - immunology | Leptospirosis - immunology | Disease Models, Animal | Severity of Illness Index | Transforming Growth Factor beta - immunology | Hemorrhage - genetics | Signal Transduction | Hemorrhage - immunology | RNA, Messenger - genetics | Gene Expression Regulation | Interleukin-1beta - immunology | Disease Progression | Syndrome | Leptospirosis - genetics | Leptospirosis - veterinary | Leukocytes, Mononuclear - pathology | Acute Kidney Injury - mortality | Lung Injury - genetics | Animals | Transforming Growth Factor beta - genetics | Nitric Oxide Synthase Type II - genetics | Dogs | Survival Analysis | Hemorrhage - veterinary | Interleukin-8 - immunology | Lung Injury - immunology | Leptospirosis - mortality | Infection | Leptospirosis | Enzymes | Messenger RNA | Chronic kidney failure | Tumor necrosis factor | Transforming growth factors | Health aspects | Hemorrhage | Health care | Laboratories | Syngeneic grafts | Inflammatory response | Infections | Leukocytes | Veterinary medicine | Blood | Rodents | Physiology | Growth factors | Interleukin 8 | Injuries | Public health | Urine | Cytokines | Internal medicine | Lung diseases | Inflammation | Tumor necrosis factor-α | Gene expression | Disease control | Nitric-oxide synthase | Zoonoses | White blood cells | Nitric oxide | Interleukin 10 | Sepsis | Diagnostic systems | Kidney diseases | Index Medicus
Journal Article
BMC Microbiology, ISSN 1471-2180, 10/2016, Volume 16, Issue 1, pp. 241 - 241
Background: Leptospirosis is an important reemerging zoonosis, with more than half a million cases reported annually, and is caused by pathogenic Leptospira... 
Vaccine | Cross protection | Multi-epitope | Outer membrane protein | Leptospira | OUTER-MEMBRANE | PROTEIN | EFFICACY | MICROBIOLOGY | MODEL | SURFACE-EXPOSED LIPOPROTEIN | PEPTIDE | RESPONSES | PROTECTIVE IMMUNITY | IMMUNOGENICITY | METABOLISM | Recombinant Fusion Proteins - immunology | Immunoglobulin G - blood | Recombinant Fusion Proteins - pharmacology | Bacterial Vaccines - genetics | Lipoproteins - genetics | Antigens, Bacterial - immunology | Epitopes, B-Lymphocyte - immunology | Antigens, Bacterial - genetics | Cross Protection - immunology | Bacterial Vaccines - pharmacology | Epitopes, T-Lymphocyte - immunology | Leptospirosis - immunology | Bacterial Outer Membrane Proteins - genetics | Disease Models, Animal | Rabbits | Bacterial Outer Membrane Proteins - immunology | Guinea Pigs | Cytokines - metabolism | Leptospirosis - prevention & control | Recombinant Fusion Proteins - chemistry | Agglutination Tests | Blotting, Western | Leptospira interrogans - immunology | Cross Reactions | Animals | B-Lymphocytes - immunology | Bacterial Vaccines - immunology | Antibodies, Bacterial - immunology | T-Lymphocytes - immunology | Lipoproteins - immunology | Leptospirosis | Usage | Care and treatment | Immunotherapy | Dosage and administration | Gram-negative bacteria | Research | Antigenic determinants | Membrane proteins | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, pp. e42266 - e42266
Background: Infection with pathogenic Leptospira species causes serious systemic inflammation in patients. Although a few leptospiral proinflammatory molecules... 
LISTERIA-MONOCYTOGENES | TUMOR-NECROSIS-FACTOR | CELL ACTIVATION | ALPHA-HEMOLYSIN | ESCHERICHIA-COLI | GAMMA-INTERFERON | BIOLOGY | INTERROGANS SEROVAR ICTEROHAEMORRHAGIAE | GENE-EXPRESSION | SEELIGERIOLYSIN-O | INNATE IMMUNITY | Hemolysin Proteins - immunology | Toll-Like Receptor 2 - genetics | Hemolysin Proteins - genetics | Humans | JNK Mitogen-Activated Protein Kinases - immunology | NF-kappa B - immunology | Hemolysin Proteins - secretion | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | MAP Kinase Signaling System - immunology | Macrophages - secretion | MAP Kinase Signaling System - genetics | Leptospira interrogans - metabolism | Inflammation Mediators - metabolism | Adult | Female | JNK Mitogen-Activated Protein Kinases - genetics | Cytokines - genetics | Leptospirosis - immunology | Macrophages - immunology | Cytokines - immunology | Inflammation Mediators - immunology | Cell Line | Cytokines - metabolism | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Leptospira interrogans - immunology | Leptospirosis - genetics | Mice, Knockout | Leptospirosis - metabolism | Macrophages - metabolism | Animals | Leptospira interrogans - genetics | NF-kappa B - genetics | Toll-Like Receptor 2 - immunology | Mice | Leptospirosis | Laboratories | Genes | Antibodies | Infections | Genomes | Kinases | Macrophages | Medical diagnosis | Streptococcus infections | Interleukin 6 | Proteins | Stimulators | Signal transduction | Pathways | Listeria | Toll-like receptors | Tumor necrosis factor-TNF | Inducers | Urine | Pathogens | NF-κB protein | Parasitology | Hemolysins | Cytokines | JNK protein | Inflammation | TLR4 protein | Tumor necrosis factor-α | Patients | Immune systems | Medicine | Signaling | Protein arrays | Infectious diseases | TLR2 protein | Index Medicus
Journal Article
Vaccine, ISSN 0264-410X, 2011, Volume 29, Issue 43, pp. 7379 - 7386
Highlights ► Lig protein as protective antigens. ► A novel fusion proteins using as immunogens. ► Recombinant proteins as immunogen to induce protection... 
Allergy and Immunology | Extracellular matrix | Leptospira interrogans | Fusion protein | Lig proteins | MEDICINE, RESEARCH & EXPERIMENTAL | PATHOGENIC LEPTOSPIRA | LIPL32 | IMMUNOGLOBULIN-LIKE PROTEIN | SURFACE PROTEIN | C-TERMINUS | ESCHERICHIA-COLI | IMMUNOLOGY | OUTER-MEMBRANE PROTEINS | PROTECTIVE IMMUNITY | INFECTION | INTERROGANS | Recombinant Fusion Proteins - immunology | Cricetinae | Antigens, Bacterial - chemistry | Bacterial Outer Membrane Proteins - immunology | Adhesins, Bacterial - chemistry | Vaccination | Antigens, Bacterial - immunology | Leptospirosis - prevention & control | Extracellular Matrix - metabolism | Vaccines, Subunit - immunology | Extracellular Matrix - virology | Adhesins, Bacterial - metabolism | Animals | Leptospirosis - pathology | Bacterial Vaccines - administration & dosage | Bacterial Vaccines - immunology | Leptospira - immunology | Peptide Fragments - immunology | Antibodies, Bacterial - immunology | Bacterial Proteins - immunology | Adhesins, Bacterial - immunology | Antigens, Bacterial - metabolism | Leptospirosis - immunology | Antigens | Vaccines | Hamsters | Recombinant proteins | Analysis | Protein binding | Proteins | Leptospirosis | Rodents | Collagen | Mortality | Technological change | Laboratory animals | Experiments | Public health | Deoxyribonucleic acid--DNA | Molecular weight | Index Medicus
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Clinical and Vaccine Immunology, ISSN 1556-6811, 05/2012, Volume 19, Issue 5, pp. 740 - 745
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